Gene Page: ALDH1A2

Summary ?
GeneID8854
SymbolALDH1A2
SynonymsRALDH(II)|RALDH2|RALDH2-T
Descriptionaldehyde dehydrogenase 1 family member A2
ReferenceMIM:603687|HGNC:HGNC:15472|Ensembl:ENSG00000128918|HPRD:04733|Vega:OTTHUMG00000132624
Gene typeprotein-coding
Map location15q21.3
Pascal p-value0.823
Sherlock p-value0.335
Fetal beta-0.566
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenics,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 3 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs6693444chr198690213ALDH1A288540.08trans
rs16909877chr998216644ALDH1A288540.12trans
rs9303674chr1732458848ALDH1A288540.16trans
rs12951337chr1758154206ALDH1A288540.09trans
rs17255719chrX12144766ALDH1A288540.1trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SCYL10.900.87
GRINA0.880.86
ATP6AP10.880.88
C3orf390.870.85
PNPLA60.870.84
ACP20.860.87
ATP6V0C0.860.87
AP2A10.860.86
CAPNS10.860.83
GPI0.860.84
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.21-0.62-0.44
AF347015.18-0.56-0.44
AF347015.8-0.55-0.40
MT-CO2-0.54-0.39
AF347015.2-0.54-0.36
MT-ATP8-0.53-0.42
AF347015.31-0.53-0.38
MT-CYB-0.52-0.37
NOSTRIN-0.52-0.38
AF347015.26-0.51-0.35

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0001758retinal dehydrogenase activityIEA-
GO:00040283-chloroallyl aldehyde dehydrogenase activityIEA-
GO:00040283-chloroallyl aldehyde dehydrogenase activityTAS8663198 
GO:0009055electron carrier activityTAS8797830 
GO:0016491oxidoreductase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0030182neuron differentiationIEAneuron (GO term level: 8)-
GO:0030902hindbrain developmentIEABrain (GO term level: 8)-
GO:0030900forebrain developmentIEABrain (GO term level: 8)-
GO:0003007heart morphogenesisIEA-
GO:0009954proximal/distal pattern formationIEA-
GO:0009952anterior/posterior pattern formationIEA-
GO:0008284positive regulation of cell proliferationIEA-
GO:0009855determination of bilateral symmetryIEA-
GO:0008152metabolic processIEA-
GO:0014032neural crest cell developmentIEA-
GO:0016331morphogenesis of embryonic epitheliumIEA-
GO:0031016pancreas developmentIEA-
GO:0042573retinoic acid metabolic processIEA-
GO:0048384retinoic acid receptor signaling pathwayIEA-
GO:0043010camera-type eye developmentIEA-
GO:0035115embryonic forelimb morphogenesisIEA-
GO:0055114oxidation reductionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG RETINOL METABOLISM 6437All SZGR 2.0 genes in this pathway
GRABARCZYK BCL11B TARGETS DN 5735All SZGR 2.0 genes in this pathway
BASAKI YBX1 TARGETS DN 384230All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY DN 367220All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC UP 185126All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION MONOCYTE UP 204140All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION ERYTHROCYTE UP 157104All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION SUSTAINED IN MONOCYTE UP 2115All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION SUSTAINDED IN ERYTHROCYTE UP 4430All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER DN 232154All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF DN 228137All SZGR 2.0 genes in this pathway
CONCANNON APOPTOSIS BY EPOXOMICIN UP 239157All SZGR 2.0 genes in this pathway
MAHADEVAN IMATINIB RESISTANCE DN 2011All SZGR 2.0 genes in this pathway
WONG ENDMETRIUM CANCER DN 8253All SZGR 2.0 genes in this pathway
EBAUER TARGETS OF PAX3 FOXO1 FUSION UP 207128All SZGR 2.0 genes in this pathway
YORDY RECIPROCAL REGULATION BY ETS1 AND SP100 DN 8748All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK 423265All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR UP 487286All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882572All SZGR 2.0 genes in this pathway
YAO HOXA10 TARGETS VIA PROGESTERONE DN 1912All SZGR 2.0 genes in this pathway
URS ADIPOCYTE DIFFERENTIATION UP 7451All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE UP 249170All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
NIELSEN GIST AND SYNOVIAL SARCOMA UP 2015All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL DN 216143All SZGR 2.0 genes in this pathway
ALONSO METASTASIS UP 198128All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069729All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 AND H3K27ME3 349234All SZGR 2.0 genes in this pathway
MIKKELSEN NPC HCP WITH H3K27ME3 341243All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 11 10368All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745475All SZGR 2.0 genes in this pathway
SCHMIDT POR TARGETS IN LIMB BUD DN 87All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR UP 199143All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM A 182108All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725838All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-137174417501Ahsa-miR-137UAUUGCUUAAGAAUACGCGUAG
miR-203.15025081Ahsa-miR-203UGAAAUGUUUAGGACCACUAG
miR-23168816951A,m8hsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
miR-323168816941Ahsa-miR-323brainGCACAUUACACGGUCGACCUCU
miR-329737743m8hsa-miR-329brainAACACACCUGGUUAACCUCUUU