Gene Page: LDB1

Summary
GeneID  8861
Symbol  LDB1
Synonyms  CLIM2|NLI
Description  LIM domain binding 1
See related  HGNC:6532|MIM:603451|Ensembl:ENSG00000198728|HPRD:09144|
Locus tag  -
Gene type  protein-coding
Map location  10q24-q25
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
SMPD40.950.95
TSC20.950.95
CIZ10.940.93
PPRC10.940.94
EDC40.940.95
PPIL20.930.93
DHX340.930.92
KIAA08920.930.93
MAST20.930.92
AC145098.20.930.93
Top 10 negatively co-expressed genes
AF347015.31-0.76-0.86
AF347015.27-0.74-0.84
MT-CO2-0.74-0.85
AF347015.8-0.72-0.84
MT-CYB-0.72-0.82
AF347015.33-0.72-0.80
AF347015.21-0.70-0.91
AF347015.15-0.69-0.81
HIGD1B-0.68-0.79
C5orf53-0.68-0.70
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003714transcription corepressor activityTAS9391090 
GO:0030274LIM domain bindingIPI12792813 
GO:0030274LIM domain bindingISS-
GO:0042803protein homodimerization activityISS-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0030182neuron differentiationISSneuron (GO term level: 8)-
GO:0007275multicellular organismal developmentNAS12792813 
GO:0045647negative regulation of erythrocyte differentiationISS-
GO:0045892negative regulation of transcription, DNA-dependentIDA10767331 
GO:0045892negative regulation of transcription, DNA-dependentISS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusISS-
GO:0043234protein complexISS-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CBFA2T3ETO2 | MTG16 | MTGR2 | ZMYND4core-binding factor, runt domain, alpha subunit 2; translocated to, 3Affinity Capture-WesternBioGRID16407974 
LMO2RBTN2 | RBTNL1 | RHOM2 | TTG2LIM domain only 2 (rhombotin-like 1)-HPRD,BioGRID9391090 |12727888 
LMO3DAT1 | MGC26081 | RBTN3 | RBTNL2 | RHOM3 | Rhom-3LIM domain only 3 (rhombotin-like 2)Two-hybridBioGRID16189514 
LMO4-LIM domain only 4Affinity Capture-Western
Co-crystal Structure		BioGRID12727888 |12925972 
-HPRD9736723 
SP1-Sp1 transcription factorReconstituted ComplexBioGRID12239153 
SSBP2DKFZp686F03273 | HSPC116single-stranded DNA binding protein 2Two-hybridBioGRID16189514 
SSBP4MGC3181single stranded DNA binding protein 4Two-hybridBioGRID16189514 
TAL1SCL | TCL5 | bHLHa17 | tal-1T-cell acute lymphocytic leukemia 1Affinity Capture-MS
Affinity Capture-Western		BioGRID16407974 
TCF3E2A | ITF1 | MGC129647 | MGC129648 | bHLHb21transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)Affinity Capture-WesternBioGRID16407974 
TOLLIPFLJ33531 | IL-1RAcPIPtoll interacting proteinTwo-hybridBioGRID16189514 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
BIOCARTA_PITX2_PATHWAY 1515All SZGR genes in this pathway
HUTTMANN_B_CLL_POOR_SURVIVAL_UP 276187All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP 633376All SZGR genes in this pathway
PEREZ_TP53_TARGETS 1174695All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_UP 479299All SZGR genes in this pathway
YAGI_AML_FAB_MARKERS 191131All SZGR genes in this pathway
LEE_CALORIE_RESTRICTION_NEOCORTEX_UP 8366All SZGR genes in this pathway
MEDINA_SMARCA4_TARGETS 4429All SZGR genes in this pathway
KIM_GASTRIC_CANCER_CHEMOSENSITIVITY 10364All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_UNSTIMULATED 1229713All SZGR genes in this pathway
SANSOM_APC_MYC_TARGETS 217138All SZGR genes in this pathway
SANSOM_APC_TARGETS_REQUIRE_MYC 210123All SZGR genes in this pathway
SANSOM_WNT_PATHWAY_REQUIRE_MYC 5843All SZGR genes in this pathway
IWANAGA_CARCINOGENESIS_BY_KRAS_PTEN_UP 181112All SZGR genes in this pathway
SAGIV_CD24_TARGETS_UP 2315All SZGR genes in this pathway
SAGIV_CD24_TARGETS_DN 4626All SZGR genes in this pathway
CHANG_CORE_SERUM_RESPONSE_DN 209137All SZGR genes in this pathway
YAGI_AML_WITH_11Q23_REARRANGED 351238All SZGR genes in this pathway
PEDRIOLI_MIR31_TARGETS_UP 221120All SZGR genes in this pathway
RAO_BOUND_BY_SALL4_ISOFORM_B 517302All SZGR genes in this pathway
RAO_BOUND_BY_SALL4 227149All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-125/3511211271Ahsa-miR-125bbrainUCCCUGAGACCCUAACUUGUGA
hsa-miR-125abrainUCCCUGAGACCCUUUAACCUGUG
miR-365282288m8hsa-miR-365UAAUGCCCCUAAAAAUCCUUAU
miR-96151157m8hsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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