Gene Page: HAND1

Summary
GeneID  9421
Symbol  HAND1
Synonyms  Hxt|Thing1|bHLHa27|eHand
Description  heart and neural crest derivatives expressed 1
See related  HGNC:4807|MIM:602406|Ensembl:ENSG00000113196|HPRD:03871|
Locus tag  -
Gene type  protein-coding
Map location  5q33
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0032 
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.01718 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00459 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
MAVS0.890.88
NUP2100.870.87
EIF2C10.870.82
SP10.870.84
MAML10.860.83
ZNF5160.860.87
PDPR0.850.84
FAM53B0.840.86
CTDSP20.840.85
KIAA03550.840.84
Top 10 negatively co-expressed genes
AF347015.31-0.48-0.55
AF347015.21-0.47-0.64
C5orf53-0.47-0.50
RERGL-0.47-0.61
IFI27-0.46-0.50
GMFG-0.46-0.60
C1orf54-0.46-0.60
SYCP3-0.46-0.58
CARD16-0.45-0.56
MYL3-0.45-0.53
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityTAS9931445 
GO:0008134transcription factor bindingIEA-
GO:0016564transcription repressor activityIEA-
GO:0042803protein homodimerization activityIEA-
GO:0046982protein heterodimerization activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000122negative regulation of transcription from RNA polymerase II promoterIEA-
GO:0001525angiogenesisIEA-
GO:0001707mesoderm formationIEA-
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0007507heart developmentTAS9931445 
GO:0007275multicellular organismal developmentIEA-
GO:0030154cell differentiationIEA-
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
HAND2DHAND2 | FLJ16260 | Hed | MGC125303 | MGC125304 | Thing2 | bHLHa26 | dHandheart and neural crest derivatives expressed 2-HPRD10924525 |11812799 
HEY2CHF1 | GRIDLOCK | GRL | HERP1 | HESR2 | HRT2 | MGC10720 | bHLHb32hairy/enhancer-of-split related with YRPW motif 2Reconstituted ComplexBioGRID10924525 
HEYLHRT3 | MGC12623 | bHLHb33hairy/enhancer-of-split related with YRPW motif-like-HPRD,BioGRID10924525 
MYOD1MYF3 | MYOD | PUM | bHLHc1myogenic differentiation 1-HPRD10924525 
PPP2R5DB56D | MGC2134 | MGC8949protein phosphatase 2, regulatory subunit B', delta isoformTwo-hybridBioGRID14636580 
PRKACAMGC102831 | MGC48865 | PKACAprotein kinase, cAMP-dependent, catalytic, alphaBiochemical ActivityBioGRID14636580 
PRKCAAAG6 | MGC129900 | MGC129901 | PKC-alpha | PKCA | PRKACAprotein kinase C, alphaBiochemical ActivityBioGRID14636580 
TCF12HEB | HTF4 | HsT17266 | bHLHb20transcription factor 12-HPRD11802795 
TCF3E2A | ITF1 | MGC129647 | MGC129648 | bHLHb21transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)-HPRD10924525 |11802795 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
BIOCARTA_NFAT_PATHWAY 5645All SZGR genes in this pathway
MAHADEVAN_IMATINIB_RESISTANCE_DN 2011All SZGR genes in this pathway
DARWICHE_PAPILLOMA_PROGRESSION_RISK 7444All SZGR genes in this pathway
RIZ_ERYTHROID_DIFFERENTIATION_12HR 4335All SZGR genes in this pathway
PEREZ_TP53_TARGETS 1174695All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM5 9459All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_AND_BRAIN_QTL_TRANS 185114All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
NOUZOVA_METHYLATED_IN_APL 6839All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_LONG_TERM 302191All SZGR genes in this pathway
XU_GH1_EXOGENOUS_TARGETS_UP 8550All SZGR genes in this pathway
XU_GH1_AUTOCRINE_TARGETS_UP 268157All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3_UNMETHYLATED 536296All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K27ME3 269159All SZGR genes in this pathway
MIKKELSEN_MEF_HCP_WITH_H3K27ME3 590403All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_UP 857456All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
let-7/987447511A,m8hsa-let-7abrainUGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrainUGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrainUGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrainAGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrainUGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrainUGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brainUGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZUGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrainUGAGGUAGUAGUUUGUGCUGU
miR-1966846911A,m8hsa-miR-196aUAGGUAGUUUCAUGUUGUUGG
hsa-miR-196bUAGGUAGUUUCCUGUUGUUGG
miR-25/32/92/363/367175181m8hsa-miR-25brainCAUUGCACUUGUCUCGGUCUGA
hsa-miR-32UAUUGCACAUUACUAAGUUGC
hsa-miR-92UAUUGCACUUGUCCCGGCCUG
hsa-miR-367AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZUAUUGCACUCGUCCCGGCCUC
hsa-miR-25brainCAUUGCACUUGUCUCGGUCUGA
hsa-miR-32UAUUGCACAUUACUAAGUUGC
hsa-miR-92UAUUGCACUUGUCCCGGCCUG
hsa-miR-367AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZUAUUGCACUCGUCCCGGCCUC
miR-334314371Ahsa-miR-33GUGCAUUGUAGUUGCAUUG
hsa-miR-33bGUGCAUUGCUGUUGCAUUGCA
miR-3358038101A,m8hsa-miR-335brainUCAAGAGCAAUAACGAAAAAUGU
miR-363174180m8hsa-miR-363AUUGCACGGUAUCCAUCUGUAA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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