Gene Page: BCAR1

Summary ?
GeneID9564
SymbolBCAR1
SynonymsCAS|CAS1|CASS1|CRKAS|P130Cas
Descriptionbreast cancer anti-estrogen resistance 1
ReferenceMIM:602941|HGNC:HGNC:971|Ensembl:ENSG00000050820|HPRD:04248|Vega:OTTHUMG00000137604
Gene typeprotein-coding
Map location16q23.1
Pascal p-value0.13
Sherlock p-value0.531
Fetal beta-0.467
DMG2 (# studies)
eGeneMyers' cis & trans
SupportAscano FMRP targets

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 2
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2
ExpressionMeta-analysis of gene expressionP value: 2.094 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg049140571675283093BCAR11.729E-4-0.3060.033DMG:Wockner_2014
cg024386531675285726BCAR12.66E-8-0.0128.45E-6DMG:Jaffe_2016

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs9592471chr1334989794BCAR195640.1trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004871signal transducer activityTAS8070403 
GO:0005515protein bindingIEA-
GO:0005515protein bindingIPI9748234 |10339567 |10587647 
|11782456 |14688263 
|16105984 
GO:0017124SH3 domain bindingIEA-
GO:0019903protein phosphatase bindingIPI9285683 
GO:0019901protein kinase bindingIPI8070403 |8649368 |9020138 
|9472046 |10026197 
|16245368 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001558regulation of cell growthTAS11607844 
GO:0007186G-protein coupled receptor protein signaling pathwayISS-
GO:0007186G-protein coupled receptor protein signaling pathwayNAS10092204 
GO:0007173epidermal growth factor receptor signaling pathwayISS-
GO:0007155cell adhesionIEA-
GO:0007229integrin-mediated signaling pathwayIDA8649368 
GO:0007229integrin-mediated signaling pathwayISS-
GO:0008283cell proliferationTAS10639512 
GO:0008286insulin receptor signaling pathwayISS-
GO:0048011nerve growth factor receptor signaling pathwayISS-
GO:0048008platelet-derived growth factor receptor signaling pathwayISS-
GO:0007015actin filament organizationIDA16105984 
GO:0007015actin filament organizationISS-
GO:0042981regulation of apoptosisTAS11607844 
GO:0050852T cell receptor signaling pathwayNAS9295052 
GO:0051301cell divisionNAS10675905 
GO:0030335positive regulation of cell migrationIDA9472046 
GO:0030335positive regulation of cell migrationISS-
GO:0050853B cell receptor signaling pathwayIDA9020138 
GO:0050853B cell receptor signaling pathwayISS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0001726ruffleIDA9472046 
GO:0001726ruffleISS-
GO:0005624membrane fractionIDA8070403 
GO:0005624membrane fractionISS-
GO:0005737cytoplasmIDA8070403 
GO:0005737cytoplasmISS-
GO:0030027lamellipodiumIEA-
GO:0005925focal adhesionISS-
GO:0030054cell junctionIEA-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABL1ABL | JTK7 | bcr/abl | c-ABL | p150 | v-ablc-abl oncogene 1, receptor tyrosine kinase-HPRD,BioGRID7780740 
BCAR3KIAA0554 | NSP2 | SH2D3Bbreast cancer anti-estrogen resistance 3Affinity Capture-WesternBioGRID12517963 
CD2APCMS | DKFZp586H0519CD2-associated protein-HPRD,BioGRID10339567 
CRKCRKIIv-crk sarcoma virus CT10 oncogene homolog (avian)Affinity Capture-Western
Reconstituted Complex		BioGRID9581808 |9920935 
|10085298 |10329689 
|11369773 |12615911 
|14657239 |15492270 
CRKL-v-crk sarcoma virus CT10 oncogene homolog (avian)-like-HPRD,BioGRID10753828 
CSPG4HMW-MAA | MCSP | MCSPG | MEL-CSPG | MSK16 | NG2chondroitin sulfate proteoglycan 4-HPRD10587647 
DOCK1DOCK180 | ced5dedicator of cytokinesis 1-HPRD,BioGRID12615911 
E2F2E2F-2E2F transcription factor 2Two-hybridBioGRID16169070 
EFSCAS3 | CASS3 | EFS1 | EFS2 | HEFS | SINembryonal Fyn-associated substrateTwo-hybridBioGRID16169070 
FESFPSfeline sarcoma oncogeneAffinity Capture-Western
Biochemical Activity
Reconstituted Complex		BioGRID8999909 
FXYD6-FXYD domain containing ion transport regulator 6Two-hybridBioGRID16169070 
FYNMGC45350 | SLK | SYNFYN oncogene related to SRC, FGR, YES-HPRD,BioGRID9188452 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2-HPRD8649368 |8700507 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2Affinity Capture-Western
Reconstituted Complex		BioGRID10085298 |10822386 
GSNDKFZp313L0718gelsolin (amyloidosis, Finnish type)-HPRD11577104 
HCKJTK9hemopoietic cell kinase-HPRD,BioGRID9020138 
HSPA5BIP | FLJ26106 | GRP78 | MIF2heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)Two-hybridBioGRID16169070 
ID2GIG8 | ID2A | ID2H | MGC26389 | bHLHb26inhibitor of DNA binding 2, dominant negative helix-loop-helix proteinAffinity Capture-WesternBioGRID10502414 
INPPL1SHIP2inositol polyphosphate phosphatase-like 1-HPRD,BioGRID11158326 
JUBAjuba | MGC15563jub, ajuba homolog (Xenopus laevis)-HPRD15728191 
LCKYT16 | p56lck | pp58lcklymphocyte-specific protein tyrosine kinase-HPRD,BioGRID9020138 
LYNFLJ26625 | JTK8v-yes-1 Yamaguchi sarcoma viral related oncogene homolog-HPRD,BioGRID9581808 
MAPK8JNK | JNK1 | JNK1A2 | JNK21B1/2 | PRKM8 | SAPK1mitogen-activated protein kinase 8Affinity Capture-WesternBioGRID11432831 
NCK1MGC12668 | NCK | NCKalphaNCK adaptor protein 1-HPRD,BioGRID12135674 
NEDD9CAS-L | CAS2 | CASL | CASS2 | HEF1 | dJ49G10.2 | dJ761I2.1neural precursor cell expressed, developmentally down-regulated 9-HPRD8668148 |9366405 
NEDD9CAS-L | CAS2 | CASL | CASS2 | HEF1 | dJ49G10.2 | dJ761I2.1neural precursor cell expressed, developmentally down-regulated 9Affinity Capture-WesternBioGRID10502414 
NPHP1FLJ97602 | JBTS4 | NPH1 | SLSN1nephronophthisis 1 (juvenile)-HPRD,BioGRID10739664 |11493697 
PIK3R1GRB1 | p85 | p85-ALPHAphosphoinositide-3-kinase, regulatory subunit 1 (alpha)-HPRD,BioGRID10799562 
PKD1PBPpolycystic kidney disease 1 (autosomal dominant)-HPRD11113628 
PPP1R15AGADD34protein phosphatase 1, regulatory (inhibitor) subunit 15ATwo-hybridBioGRID16169070 
PTK2FADK | FAK | FAK1 | pp125FAKPTK2 protein tyrosine kinase 2-HPRD11514617 
PTK2FADK | FAK | FAK1 | pp125FAKPTK2 protein tyrosine kinase 2Affinity Capture-Western
Reconstituted Complex		BioGRID8649427 |8810278 
|11577104 |12135674 
|12615911 
PTK2FADK | FAK | FAK1 | pp125FAKPTK2 protein tyrosine kinase 2-HPRD7479864 |11514617 
PTK2FADK | FAK | FAK1 | pp125FAKPTK2 protein tyrosine kinase 2CAS interacts with FAK. This interaction was modeled on a demonstrated interaction between human CAS and mouse FAK.BIND9148935 
PTK2BCADTK | CAKB | FADK2 | FAK2 | FRNK | PKB | PTK | PYK2 | RAFTKPTK2B protein tyrosine kinase 2 beta-HPRD,BioGRID8995252 
PTPN1PTP1Bprotein tyrosine phosphatase, non-receptor type 1-HPRD,BioGRID8940134 
PTPN11BPTP3 | CFC | MGC14433 | NS1 | PTP-1D | PTP2C | SH-PTP2 | SH-PTP3 | SHP2protein tyrosine phosphatase, non-receptor type 11Affinity Capture-WesternBioGRID9188452 
PTPN12PTP-PEST | PTPG1protein tyrosine phosphatase, non-receptor type 12Affinity Capture-Western
Biochemical Activity
Reconstituted Complex		BioGRID8887669 |9285683 
|9748319 |12714323 
PTPN12PTP-PEST | PTPG1protein tyrosine phosphatase, non-receptor type 12-HPRD8887669 |9285683 
|9748319 |9920935 
|12714323 
PTPRFFLJ43335 | FLJ45062 | FLJ45567 | LARprotein tyrosine phosphatase, receptor type, F-HPRD10822386 
PTPRHFLJ39938 | MGC133058 | MGC133059 | SAP-1protein tyrosine phosphatase, receptor type, H-HPRD,BioGRID11278335 
PXNFLJ16691paxillinAffinity Capture-WesternBioGRID8810278 |11577104 
RAPGEF1C3G | DKFZp781P1719 | GRF2Rap guanine nucleotide exchange factor (GEF) 1-HPRD,BioGRID9748234 
RICSGC-GAP | GRIT | KIAA0712 | MGC1892 | p200RhoGAP | p250GAPRho GTPase-activating protein-HPRD,BioGRID12446789 |12819203 
SFNYWHASstratifinAffinity Capture-MSBioGRID15778465 
SH2D3ANSP1SH2 domain containing 3A-HPRD,BioGRID10187783 
SH2D3CCHAT | FLJ39664 | NSP3 | PRO34088SH2 domain containing 3CAffinity Capture-WesternBioGRID10692442 
SH3KBP1CIN85 | GIG10 | MIG18SH3-domain kinase binding protein 1Affinity Capture-WesternBioGRID11071869 
SNIPKIAA1684SNAP25-interacting protein-HPRD,BioGRID14657239 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)c-Src interacts with CAS.BIND9148935 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID10085298 |10487518 
|10739664 |11514617 
|12397603 |12615911 
TNS1DKFZp586K0617 | MGC88584 | MST091 | MST122 | MST127 | MSTP122 | MSTP127 | MXRA6 | TNStensin 1Affinity Capture-WesternBioGRID8810278 
TRIP6MGC10556 | MGC10558 | MGC29959 | MGC3837 | MGC4423 | OIP1 | ZRP-1thyroid hormone receptor interactor 6-HPRD,BioGRID11782456 |14688263 
VCLCMD1W | MVCLvinculinAffinity Capture-WesternBioGRID11577104 
VPS11END1 | PEP5 | RNF108 | hVPS11vacuolar protein sorting 11 homolog (S. cerevisiae)Two-hybridBioGRID16169070 
YWHAZKCIP-1 | MGC111427 | MGC126532 | MGC138156tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide-HPRD,BioGRID10026197 
ZYXESP-2 | HED-2zyxinAffinity Capture-WesternBioGRID11782456 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG CHEMOKINE SIGNALING PATHWAY 190128All SZGR 2.0 genes in this pathway
KEGG FOCAL ADHESION 201138All SZGR 2.0 genes in this pathway
KEGG LEUKOCYTE TRANSENDOTHELIAL MIGRATION 11878All SZGR 2.0 genes in this pathway
KEGG REGULATION OF ACTIN CYTOSKELETON 216144All SZGR 2.0 genes in this pathway
BIOCARTA CELL2CELL PATHWAY 1411All SZGR 2.0 genes in this pathway
BIOCARTA CXCR4 PATHWAY 2422All SZGR 2.0 genes in this pathway
BIOCARTA INTEGRIN PATHWAY 3829All SZGR 2.0 genes in this pathway
BIOCARTA PYK2 PATHWAY 3124All SZGR 2.0 genes in this pathway
BIOCARTA PTEN PATHWAY 1814All SZGR 2.0 genes in this pathway
ST INTEGRIN SIGNALING PATHWAY 8262All SZGR 2.0 genes in this pathway
PID ENDOTHELIN PATHWAY 6352All SZGR 2.0 genes in this pathway
PID PRL SIGNALING EVENTS PATHWAY 2317All SZGR 2.0 genes in this pathway
PID LYSOPHOSPHOLIPID PATHWAY 6653All SZGR 2.0 genes in this pathway
PID ER NONGENOMIC PATHWAY 4135All SZGR 2.0 genes in this pathway
PID MET PATHWAY 8060All SZGR 2.0 genes in this pathway
PID PTP1B PATHWAY 5240All SZGR 2.0 genes in this pathway
PID AVB3 OPN PATHWAY 3129All SZGR 2.0 genes in this pathway
PID CDC42 PATHWAY 7051All SZGR 2.0 genes in this pathway
PID RET PATHWAY 3929All SZGR 2.0 genes in this pathway
PID NETRIN PATHWAY 3227All SZGR 2.0 genes in this pathway
PID INTEGRIN A9B1 PATHWAY 2518All SZGR 2.0 genes in this pathway
PID CXCR4 PATHWAY 10278All SZGR 2.0 genes in this pathway
PID IGF1 PATHWAY 3023All SZGR 2.0 genes in this pathway
PID AVB3 INTEGRIN PATHWAY 7553All SZGR 2.0 genes in this pathway
PID UPA UPAR PATHWAY 4230All SZGR 2.0 genes in this pathway
PID PDGFRB PATHWAY 129103All SZGR 2.0 genes in this pathway
PID EPHA2 FWD PATHWAY 1916All SZGR 2.0 genes in this pathway
PID INTEGRIN A4B1 PATHWAY 3324All SZGR 2.0 genes in this pathway
PID RAC1 PATHWAY 5437All SZGR 2.0 genes in this pathway
PID FAK PATHWAY 5945All SZGR 2.0 genes in this pathway
REACTOME INTEGRIN CELL SURFACE INTERACTIONS 7948All SZGR 2.0 genes in this pathway
REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 1511All SZGR 2.0 genes in this pathway
REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING 2717All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY PDGF 12293All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNAL TRANSDUCTION 9576All SZGR 2.0 genes in this pathway
REACTOME PLATELET AGGREGATION PLUG FORMATION 3623All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466331All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION 208138All SZGR 2.0 genes in this pathway
WINTER HYPOXIA UP 9257All SZGR 2.0 genes in this pathway
CHEMNITZ RESPONSE TO PROSTAGLANDIN E2 DN 391222All SZGR 2.0 genes in this pathway
SENESE HDAC1 TARGETS DN 260143All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821933All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142669All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP 612367All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR 681420All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 9 9259All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022619All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 2D DN 6435All SZGR 2.0 genes in this pathway
ACEVEDO METHYLATED IN LIVER CANCER DN 940425All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
SUBTIL PROGESTIN TARGETS 3625All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP 504321All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080713All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882506All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS DN 784464All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM B 517302All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL UP 489314All SZGR 2.0 genes in this pathway
ZWANG CLASS 1 TRANSIENTLY INDUCED BY EGF 516308All SZGR 2.0 genes in this pathway