SZGR2

Summary ?

GeneID	9615
Symbol	GDA
Synonyms	CYPIN\|GUANASE\|NEDASIN
Description	guanine deaminase
Reference	MIM:139260\|HGNC:HGNC:4212\|Ensembl:ENSG00000119125\|HPRD:08849\|Vega:OTTHUMG00000020005
Gene type	protein-coding
Map location	9q21.13
Pascal p-value	0.002
Fetal beta	-3.8
eGene	Hypothalamus
Support	CELL METABOLISM G2Cdb.human_TAP-PSD-95-CORE Potential synaptic genes

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias	Click to show details
GO_Annotation	Mapping neuro-related keywords to Gene Ontology annotations	Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
CEP68	0.91	0.94
UBN1	0.90	0.94
KSR1	0.90	0.92
SRGAP3	0.90	0.94
POM121	0.90	0.92
POM121C	0.89	0.93
LARP4B	0.89	0.93
BICD2	0.89	0.93
TBC1D24	0.89	0.93
TGFBRAP1	0.89	0.92

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AF347015.31	-0.65	-0.71
MT-CO2	-0.65	-0.72
FXYD1	-0.64	-0.68
AF347015.21	-0.63	-0.77
HIGD1B	-0.63	-0.70
C1orf54	-0.62	-0.80
AC021016.1	-0.62	-0.68
S100B	-0.62	-0.67
AF347015.33	-0.61	-0.65
MT-CYB	-0.61	-0.66

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0016787	hydrolase activity	IEA		-
GO:0008892	guanine deaminase activity	EXP		10075721
GO:0008892	guanine deaminase activity	IEA		-
GO:0008892	guanine deaminase activity	TAS		10075721
GO:0008270	zinc ion binding	TAS		10075721
GO:0046872	metal ion binding	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007399	nervous system development	TAS	neurite (GO term level: 5)	10542258
GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	TAS		10075721
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005829	cytosol	EXP		10075721
GO:0005622	intracellular	TAS		10542258

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG PURINE METABOLISM	159	96	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF NUCLEOTIDES	72	45	All SZGR 2.0 genes in this pathway
REACTOME PURINE CATABOLISM	10	6	All SZGR 2.0 genes in this pathway
REACTOME PURINE METABOLISM	33	24	All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 DN	175	82	All SZGR 2.0 genes in this pathway
RODRIGUES NTN1 TARGETS DN	158	102	All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER GRADES 1 2 UP	137	84	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP	1821	933	All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS A UP	191	128	All SZGR 2.0 genes in this pathway
RICKMAN HEAD AND NECK CANCER E	89	44	All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS	1038	678	All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS	1062	725	All SZGR 2.0 genes in this pathway
WANG IMMORTALIZED BY HOXA9 AND MEIS1 UP	31	24	All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS LATE PROGENITOR	544	307	All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE DN	409	268	All SZGR 2.0 genes in this pathway
COATES MACROPHAGE M1 VS M2 UP	81	52	All SZGR 2.0 genes in this pathway
SARRIO EPITHELIAL MESENCHYMAL TRANSITION UP	180	114	All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C D DN	252	155	All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS CTNNB1 DN	170	105	All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2	491	319	All SZGR 2.0 genes in this pathway
ZEMBUTSU SENSITIVITY TO NIMUSTINE	17	13	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN	1972	1213	All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP	745	475	All SZGR 2.0 genes in this pathway
TORCHIA TARGETS OF EWSR1 FLI1 FUSION TOP20 UP	20	14	All SZGR 2.0 genes in this pathway
TORCHIA TARGETS OF EWSR1 FLI1 FUSION UP	271	165	All SZGR 2.0 genes in this pathway
WANG MLL TARGETS	289	188	All SZGR 2.0 genes in this pathway
ALTEMEIER RESPONSE TO LPS WITH MECHANICAL VENTILATION	128	81	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-129-5p	80	86	1A	hsa-miR-129^brain	CUUUUUGCGGUCUGGGCUUGC
miR-129-5p	80	86	1A	hsa-miR-129-5p	CUUUUUGCGGUCUGGGCUUGCU
miR-130/301	569	575	m8	hsa-miR-130a^brain	CAGUGCAAUGUUAAAAGGGCAU
				hsa-miR-301	CAGUGCAAUAGUAUUGUCAAAGC
				hsa-miR-130b^brain	CAGUGCAAUGAUGAAAGGGCAU
				hsa-miR-454-3p	UAGUGCAAUAUUGCUUAUAGGGUUU
miR-19	568	574	m8	hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
miR-19	568	574	m8	hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
miR-485-3p	3800	3806	m8	hsa-miR-485-3p	GUCAUACACGGCUCUCCUCUCU
miR-505	2146	2153	1A,m8	hsa-miR-505	GUCAACACUUGCUGGUUUCCUC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: GDA