SZGR2

Summary ?

GeneID	9943
Symbol	OXSR1
Synonyms	OSR1
Description	oxidative stress responsive 1
Reference	MIM:604046\|HGNC:HGNC:8508\|Ensembl:ENSG00000172939\|HPRD:06809\|Vega:OTTHUMG00000131084
Gene type	protein-coding
Map location	3p22.2
Pascal p-value	0.312
Fetal beta	0.937

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I	Genome scan meta-analysis	Psr: 0.006
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000166	nucleotide binding	IEA		-
GO:0000287	magnesium ion binding	IDA		14707132
GO:0005524	ATP binding	IDA		14707132
GO:0004674	protein serine/threonine kinase activity	IDA		14707132
GO:0016740	transferase activity	IEA		-
GO:0042802	identical protein binding	IPI		17353931
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006468	protein amino acid phosphorylation	IDA		14707132
GO:0007243	protein kinase cascade	IDA		14707132
GO:0006979	response to oxidative stress	TAS		10083736
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005737	cytoplasm	IDA		18029348

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
HOLLMANN APOPTOSIS VIA CD40 DN	267	178	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN	508	354	All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN	800	473	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN	855	609	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN	483	336	All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN	584	395	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK	1442	892	All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK	779	480	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP	1037	673	All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY DN	382	224	All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS MODERATELY DN	110	64	All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND UP	77	52	All SZGR 2.0 genes in this pathway
BILD HRAS ONCOGENIC SIGNATURE	261	166	All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE UP	442	263	All SZGR 2.0 genes in this pathway
YAGI AML WITH T 8 21 TRANSLOCATION	368	247	All SZGR 2.0 genes in this pathway
BILANGES RAPAMYCIN SENSITIVE GENES	39	20	All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 36HR	152	88	All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D	882	506	All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A	770	480	All SZGR 2.0 genes in this pathway
ZWANG CLASS 1 TRANSIENTLY INDUCED BY EGF	516	308	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-124.1	647	653	1A	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
				hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
				hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-124/506	309	315	1A	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	309	315	1A	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-137	932	938	1A	hsa-miR-137	UAUUGCUUAAGAAUACGCGUAG
miR-148/152	987	994	1A,m8	hsa-miR-148a	UCAGUGCACUACAGAACUUUGU
				hsa-miR-152^brain	UCAGUGCAUGACAGAACUUGGG
				hsa-miR-148b	UCAGUGCAUCACAGAACUUUGU
miR-149	2408	2414	m8	hsa-miR-149^brain	UCUGGCUCCGUGUCUUCACUCC
miR-182	81	87	1A	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-186	1122	1129	1A,m8	hsa-miR-186	CAAAGAAUUCUCCUUUUGGGCUU
miR-191	209	216	1A,m8	hsa-miR-191^brain	CAACGGAAUCCCAAAAGCAGCU
miR-218	2306	2312	1A	hsa-miR-218^brain	UUGUGCUUGAUCUAACCAUGU
miR-218	2306	2312	1A	hsa-miR-218^brain	UUGUGCUUGAUCUAACCAUGU
miR-25/32/92/363/367	1153	1159	1A	hsa-miR-25^brain	CAUUGCACUUGUCUCGGUCUGA
				hsa-miR-32	UAUUGCACAUUACUAAGUUGC
				hsa-miR-92	UAUUGCACUUGUCCCGGCCUG
				hsa-miR-367	AAUUGCACUUUAGCAAUGGUGA
				hsa-miR-92b^SZ	UAUUGCACUCGUCCCGGCCUC
miR-31	306	312	m8	hsa-miR-31	AGGCAAGAUGCUGGCAUAGCUG
miR-320	116	122	1A	hsa-miR-320	AAAAGCUGGGUUGAGAGGGCGAA
miR-324-3p	2149	2155	1A	hsa-miR-324-3p	CCACUGCCCCAGGUGCUGCUGG
miR-326	453	460	1A,m8	hsa-miR-326	CCUCUGGGCCCUUCCUCCAG
miR-33	1151	1157	1A	hsa-miR-33	GUGCAUUGUAGUUGCAUUG
miR-33	1151	1157	1A	hsa-miR-33b	GUGCAUUGCUGUUGCAUUGCA
miR-34/449	79	85	1A	hsa-miR-34a^brain	UGGCAGUGUCUUAGCUGGUUGUU
				hsa-miR-34c	AGGCAGUGUAGUUAGCUGAUUGC
				hsa-miR-449	UGGCAGUGUAUUGUUAGCUGGU
				hsa-miR-449b	AGGCAGUGUAUUGUUAGCUGGC
miR-485-5p	526	533	1A,m8	hsa-miR-485-5p	AGAGGCUGGCCGUGAUGAAUUC
miR-495	509	515	1A	hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU
miR-496	2503	2509	1A	hsa-miR-496	AUUACAUGGCCAAUCUC
miR-9	83	89	1A	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA
miR-96	81	87	1A	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC
miR-96	81	87	1A	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: OXSR1