Gene Page: REC8

Summary ?
GeneID9985
SymbolREC8
SynonymsHR21spB|REC8L1|Rec8p
DescriptionREC8 meiotic recombination protein
ReferenceMIM:608193|HGNC:HGNC:16879|Ensembl:ENSG00000100918|HPRD:09739|Vega:OTTHUMG00000171916
Gene typeprotein-coding
Map location14q12
Pascal p-value0.154
Sherlock p-value0.187
Fetal beta2.191
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_IGenome scan meta-analysisPsr: 0.047 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs16829545chr2151977407REC899855.229E-8trans
rs3845734chr2171125572REC899850trans
rs17762315chr576807576REC899850.07trans
rs16878317chr831657853REC899850.14trans
rs4075663chr1118793398REC899850.15trans
rs16955618chr1529937543REC899851.67E-11trans
rs1041786chr2122617710REC899850.16trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
P4HB0.910.89
COPB20.900.88
PDIA40.890.90
CALR0.890.87
CSTF2T0.880.87
SMU10.870.84
G3BP10.870.86
BZW10.870.87
DDB10.870.85
HSPD10.870.83
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MT-CO2-0.70-0.77
AF347015.33-0.69-0.76
AF347015.27-0.68-0.76
FXYD1-0.68-0.75
AF347015.31-0.68-0.76
AF347015.8-0.68-0.76
AF347015.21-0.67-0.72
MT-CYB-0.64-0.73
AF347015.15-0.63-0.74
AF347015.2-0.63-0.73

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007131reciprocal meiotic recombinationTAS10207075 
GO:0007283spermatogenesisTAS10207075 
GO:0007062sister chromatid cohesionTAS10207075 
GO:0007126meiosisTAS10207075 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000228nuclear chromosomeIEA-
GO:0000800lateral elementIEA-
GO:0005634nucleusTAS10207075 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG OOCYTE MEIOSIS 11479All SZGR 2.0 genes in this pathway
REACTOME MEIOSIS 11681All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE 421253All SZGR 2.0 genes in this pathway
REACTOME CHROMOSOME MAINTENANCE 12280All SZGR 2.0 genes in this pathway
REACTOME MEIOTIC SYNAPSIS 7357All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER LMP DN 199124All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821933All SZGR 2.0 genes in this pathway
WANG HCP PROSTATE CANCER 11169All SZGR 2.0 genes in this pathway
HATADA METHYLATED IN LUNG CANCER UP 390236All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024594All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR DN 428306All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS UP 12684All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
ZHU CMV ALL UP 12089All SZGR 2.0 genes in this pathway
ZHU CMV 24 HR UP 9365All SZGR 2.0 genes in this pathway
ENGELMANN CANCER PROGENITORS DN 7044All SZGR 2.0 genes in this pathway
WEBER METHYLATED HCP IN FIBROBLAST DN 4222All SZGR 2.0 genes in this pathway
WEBER METHYLATED HCP IN SPERM UP 2013All SZGR 2.0 genes in this pathway
MATZUK MEIOTIC AND DNA REPAIR 3926All SZGR 2.0 genes in this pathway
MATZUK SPERMATOCYTE 7255All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3 UNMETHYLATED 228119All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN 841431All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3 TARGETS DN 242146All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A 770480All SZGR 2.0 genes in this pathway
PEDRIOLI MIR31 TARGETS UP 221120All SZGR 2.0 genes in this pathway