Gene Page: CDKN1B

Summary
GeneID  1027
Symbol  CDKN1B
Synonyms  CDKN4|KIP1|MEN1B|MEN4|P27KIP1
Description  cyclin-dependent kinase inhibitor 1B (p27, Kip1)
See related  HGNC:1785|MIM:600778|Ensembl:ENSG00000111276|HPRD:02867|
Locus tag  -
Gene type  protein-coding
Map location  12p13.1-p12
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0925 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
MAD2L10.900.72
CCNB10.900.72
CENPN0.890.74
CKS20.870.59
CHEK20.870.65
PBK0.860.32
KIAA01010.860.31
HMGB20.860.55
RAD51AP10.860.46
AURKA0.860.52
Top 10 negatively co-expressed genes
AF347015.26-0.34-0.28
AF347015.15-0.33-0.26
AF347015.8-0.33-0.25
MT-CYB-0.33-0.26
APOL1-0.32-0.27
AF347015.2-0.32-0.24
AF347015.33-0.31-0.24
MT-CO2-0.31-0.22
SLC9A3R2-0.31-0.23
AF347015.18-0.31-0.31
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005072transforming growth factor beta receptor, cytoplasmic mediator activityTAS8033212 
GO:0005515protein bindingIPI8756624 |9106657 |9840943 
|12082530 |15057270 
|15652749 |15890360 
|17254966 |17254967 
GO:0004861cyclin-dependent protein kinase inhibitor activityTAS10918569 
GO:0004860protein kinase inhibitor activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000079regulation of cyclin-dependent protein kinase activityTAS8033212 
GO:0000082G1/S transition of mitotic cell cycleIDA10208428 
GO:0006917induction of apoptosisIDA10208428 
GO:0007049cell cycleIEA-
GO:0007050cell cycle arrestIMP12093740 
GO:0008285negative regulation of cell proliferationTAS8033212 
GO:0048102autophagic cell deathIDA12698196 
GO:0042326negative regulation of phosphorylationIDA10208428 
GO:0030308negative regulation of cell growthIDA10208428 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP12244303 
GO:0005634nucleusIDA12093740 
GO:0005737cytoplasmIDA12093740 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AKT1AKT | MGC99656 | PKB | PKB-ALPHA | PRKBA | RAC | RAC-ALPHAv-akt murine thymoma viral oncogene homolog 1Affinity Capture-Western
Biochemical Activity		BioGRID12042314 
ARHGDIAGDIA1 | MGC117248 | RHOGDI | RHOGDI-1Rho GDP dissociation inhibitor (GDI) alphaTwo-hybridBioGRID16169070 
CCNA1-cyclin A1cyclin A1 interacts with p27.BIND10022926 
CCNA2CCN1 | CCNAcyclin A2p27 interacts with Cyc A.BIND15469821 
p27 interacts with cyclin A.BIND9632134 
-HPRD,BioGRID12501191 
p27 interacts with cyclin A.BIND15652749 
CCND1BCL1 | D11S287E | PRAD1 | U21B31cyclin D1in vitro
Reconstituted Complex		BioGRID10908655 |11360184 
p27 interacts with cyclin D.BIND9632134 
-HPRD7478582 |10908655 
CCND2KIAK0002 | MGC102758cyclin D2Two-hybridBioGRID16189514 
CCND3-cyclin D3Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID10342870 |11360184 
|16189514 
CCNE1CCNEcyclin E1p27 interacts with cyclin E.BIND9632134 
p27 interacts with Cyc E.BIND15469821 
Affinity Capture-WesternBioGRID9891079 |12529437 
CCNE2CYCE2cyclin E2-HPRD9858585 
CDK2p33(CDK2)cyclin-dependent kinase 2p27 interacts with an unspecified isoform of CDK2.BIND15652749 
Cdk2 interacts with p27kip1.BIND15619620 
-HPRD,BioGRID12972555 
Cdk2 interacts with p27.BIND15469821 
CDK4CMM3 | MGC14458 | PSK-J3cyclin-dependent kinase 4-HPRD,BioGRID10908655 
CDK6MGC59692 | PLSTIRE | STQTL11cyclin-dependent kinase 6Affinity Capture-WesternBioGRID11360184 
CDKN1ACAP20 | CDKN1 | CIP1 | MDA-6 | P21 | SDI1 | WAF1 | p21CIP1cyclin-dependent kinase inhibitor 1A (p21, Cip1)-HPRD9858585 
CKS1BCKS1 | PNAS-16 | PNAS-18 | ckshs1CDC28 protein kinase regulatory subunit 1BBiochemical Activity
Reconstituted Complex		BioGRID12140288 |12813041 
COPS5CSN5 | JAB1 | MGC3149 | MOV-34 | SGN5COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)Affinity Capture-WesternBioGRID12082530 
COPS5 (CSN5) interacts with CDKN1B (p27).BIND15688030 
FOXO3AF6q21 | DKFZp781A0677 | FKHRL1 | FKHRL1P2 | FOXO2 | FOXO3A | MGC12739 | MGC31925forkhead box O3FOXO3a interacts with p27Kip1 promoter.BIND15084260 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2-HPRD,BioGRID11278754 
KPNA2IPOA1 | QIP2 | RCH1 | SRP1alphakaryopherin alpha 2 (RAG cohort 1, importin alpha 1)p27 interacts with importin-alpha.BIND15579463 
NUP50MGC39961 | NPAP60 | NPAP60Lnucleoporin 50kDa-HPRD,BioGRID10891500 
SKP2FBL1 | FBXL1 | FLB1 | MGC1366S-phase kinase-associated protein 2 (p45)-HPRD10559916 
Affinity Capture-Western
Biochemical Activity
Reconstituted Complex		BioGRID12042314 |12140288 
|12813041 
CDKN1B (p27Kip1) interacts with SKP2 (p45Skp2).BIND15735731 
Skp2 interacts with p27.BIND15469821 
SPDYAMGC110856 | MGC57218 | Ringo3 | SPDY1 | SPY1speedy homolog A (Drosophila)Affinity Capture-Western
Reconstituted Complex		BioGRID12972555 
STMN1LAP18 | Lag | OP18 | PP17 | PP19 | PR22 | SMNstathmin 1/oncoprotein 18p27 interacts with stathmin.BIND15652749 
TRAF2MGC:45012 | TRAP | TRAP3TNF receptor-associated factor 2Two-hybridBioGRID16189514 
TSC1KIAA0243 | LAM | MGC86987 | TSCtuberous sclerosis 1Affinity Capture-WesternBioGRID15355997 
TSC2FLJ43106 | LAM | TSC4tuberous sclerosis 2Affinity Capture-WesternBioGRID15355997 
UBBFLJ25987 | MGC8385ubiquitin BUb interacts with p27.BIND15469821 
UCHL1PARK5 | PGP9.5 | Uch-L1ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)-HPRD,BioGRID12082530 
XPO1CRM1 | DKFZp686B1823exportin 1 (CRM1 homolog, yeast)p27Kip1 interacts with CRM1.BIND11889117 
-HPRD,BioGRID11889117 |12529437 
YWHAE14-3-3E | FLJ45465 | KCIP-1 | MDCR | MDStyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide-HPRD12042314 
YWHAHYWHA1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide-HPRD12042314 
YWHAQ14-3-3 | 1C5 | HS1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide-HPRD,BioGRID12042314 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_ERBB_SIGNALING_PATHWAY 8771All SZGR genes in this pathway
KEGG_CELL_CYCLE 12884All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_PROSTATE_CANCER 8975All SZGR genes in this pathway
KEGG_CHRONIC_MYELOID_LEUKEMIA 7359All SZGR genes in this pathway
KEGG_SMALL_CELL_LUNG_CANCER 8467All SZGR genes in this pathway
BIOCARTA_MCM_PATHWAY 188All SZGR genes in this pathway
BIOCARTA_G1_PATHWAY 2821All SZGR genes in this pathway
BIOCARTA_CTCF_PATHWAY 2318All SZGR genes in this pathway
BIOCARTA_CELLCYCLE_PATHWAY 2315All SZGR genes in this pathway
BIOCARTA_RACCYCD_PATHWAY 2623All SZGR genes in this pathway
BIOCARTA_PTEN_PATHWAY 1814All SZGR genes in this pathway
BIOCARTA_P27_PATHWAY 1310All SZGR genes in this pathway
SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES 6754All SZGR genes in this pathway
SA_G1_AND_S_PHASES 1510All SZGR genes in this pathway
SA_REG_CASCADE_OF_CYCLIN_EXPR 137All SZGR genes in this pathway
PID_RHOA_PATHWAY 4533All SZGR genes in this pathway
PID_E2F_PATHWAY 7448All SZGR genes in this pathway
PID_RHOA_REG_PATHWAY 4630All SZGR genes in this pathway
PID_TELOMERASE_PATHWAY 6848All SZGR genes in this pathway
PID_FOXO_PATHWAY 4943All SZGR genes in this pathway
PID_AVB3_INTEGRIN_PATHWAY 7553All SZGR genes in this pathway
PID_AP1_PATHWAY 7060All SZGR genes in this pathway
PID_CMYB_PATHWAY 8461All SZGR genes in this pathway
PID_PI3KCI_AKT_PATHWAY 3530All SZGR genes in this pathway
PID_MYC_REPRESS_PATHWAY 6352All SZGR genes in this pathway
PID_RB_1PATHWAY 6546All SZGR genes in this pathway
PID_HNF3A_PATHWAY 4429All SZGR genes in this pathway
PID_HES_HEY_PATHWAY 4839All SZGR genes in this pathway
REACTOME_SIGNALLING_BY_NGF 217167All SZGR genes in this pathway
REACTOME_SIGNALING_BY_SCF_KIT 7859All SZGR genes in this pathway
REACTOME_CELL_CYCLE 421253All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ERBB4 9067All SZGR genes in this pathway
REACTOME_ORC1_REMOVAL_FROM_CHROMATIN 6737All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ERBB2 10178All SZGR genes in this pathway
REACTOME_SIGNALING_BY_EGFR_IN_CANCER 10980All SZGR genes in this pathway
REACTOME_PI3K_EVENTS_IN_ERBB4_SIGNALING 3828All SZGR genes in this pathway
REACTOME_PI3K_EVENTS_IN_ERBB2_SIGNALING 4434All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNALING_EVENTS_OF_B_CELL_RECEPTOR_BCR 9766All SZGR genes in this pathway
REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR 12690All SZGR genes in this pathway
REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE 137105All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR_IN_DISEASE 12788All SZGR genes in this pathway
REACTOME_PI3K_AKT_ACTIVATION 3829All SZGR genes in this pathway
REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL 1210All SZGR genes in this pathway
REACTOME_GAB1_SIGNALOSOME 3829All SZGR genes in this pathway
REACTOME_CELL_CYCLE_MITOTIC 325185All SZGR genes in this pathway
REACTOME_CELL_CYCLE_CHECKPOINTS 12470All SZGR genes in this pathway
REACTOME_CYCLIN_E_ASSOCIATED_EVENTS_DURING_G1_S_TRANSITION_ 6540All SZGR genes in this pathway
REACTOME_G1_PHASE 3823All SZGR genes in this pathway
REACTOME_P53_DEPENDENT_G1_DNA_DAMAGE_RESPONSE 5735All SZGR genes in this pathway
REACTOME_SIGNALING_BY_PDGF 12293All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION 9576All SZGR genes in this pathway
REACTOME_G1_S_TRANSITION 11263All SZGR genes in this pathway
REACTOME_SYNTHESIS_OF_DNA 9253All SZGR genes in this pathway
REACTOME_MITOTIC_G1_G1_S_PHASES 13779All SZGR genes in this pathway
REACTOME_PI_3K_CASCADE 5639All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR 10074All SZGR genes in this pathway
REACTOME_DNA_REPLICATION 192110All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
REACTOME_PIP3_ACTIVATES_AKT_SIGNALING 2920All SZGR genes in this pathway
REACTOME_S_PHASE 10966All SZGR genes in this pathway
REACTOME_SCFSKP2_MEDIATED_DEGRADATION_OF_P27_P21 5634All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR 11280All SZGR genes in this pathway
HOLLMANN_APOPTOSIS_VIA_CD40_DN 267178All SZGR genes in this pathway
KIM_WT1_TARGETS_DN 459276All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_48HR_UP 12895All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_96HR_UP 11784All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_DN 485334All SZGR genes in this pathway
LAU_APOPTOSIS_CDKN2A_UP 5540All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
CAIRO_PML_TARGETS_BOUND_BY_MYC_DN 1412All SZGR genes in this pathway
PEREZ_TP53_TARGETS 1174695All SZGR genes in this pathway
FARMER_BREAST_CANCER_APOCRINE_VS_LUMINAL 326213All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
CAFFAREL_RESPONSE_TO_THC_UP 3320All SZGR genes in this pathway
CAFFAREL_RESPONSE_TO_THC_8HR_5_UP 167All SZGR genes in this pathway
BENPORATH_MYC_MAX_TARGETS 775494All SZGR genes in this pathway
BENPORATH_CYCLING_GENES 648385All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_UP 424268All SZGR genes in this pathway
ONDER_CDH1_TARGETS_1_UP 14085All SZGR genes in this pathway
RADAEVA_RESPONSE_TO_IFNA1_UP 5240All SZGR genes in this pathway
TENEDINI_MEGAKARYOCYTE_MARKERS 6648All SZGR genes in this pathway
FLECHNER_PBL_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN 5135All SZGR genes in this pathway
HADDAD_B_LYMPHOCYTE_PROGENITOR 293193All SZGR genes in this pathway
ABRAHAM_ALPC_VS_MULTIPLE_MYELOMA_UP 2622All SZGR genes in this pathway
FAELT_B_CLL_WITH_VH3_21_DN 4929All SZGR genes in this pathway
HARRIS_HYPOXIA 8164All SZGR genes in this pathway
CUI_TCF21_TARGETS_UP 3727All SZGR genes in this pathway
LEONARD_HYPOXIA 4735All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_UP 428266All SZGR genes in this pathway
SARTIPY_BLUNTED_BY_INSULIN_RESISTANCE_DN 1814All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_6HR_DN 160101All SZGR genes in this pathway
ZHENG_BOUND_BY_FOXP3 491310All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_STIMULATED 1022619All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_UNSTIMULATED 1229713All SZGR genes in this pathway
HELLER_HDAC_TARGETS_DN 292189All SZGR genes in this pathway
HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_DN 281179All SZGR genes in this pathway
MARZEC_IL2_SIGNALING_DN 3624All SZGR genes in this pathway
MATZUK_LUTEAL_GENES 85All SZGR genes in this pathway
LIN_NPAS4_TARGETS_UP 163100All SZGR genes in this pathway
WINTER_HYPOXIA_METAGENE 242168All SZGR genes in this pathway
BOHN_PRIMARY_IMMUNODEFICIENCY_SYNDROM_UP 4730All SZGR genes in this pathway
SCHRAETS_MLL_TARGETS_DN 3324All SZGR genes in this pathway
SHAFFER_IRF4_MULTIPLE_MYELOMA_PROGRAM 3625All SZGR genes in this pathway
SCHOEN_NFKB_SIGNALING 3426All SZGR genes in this pathway
DANG_REGULATED_BY_MYC_DN 253192All SZGR genes in this pathway
DANG_MYC_TARGETS_DN 3125All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_1HR_DN 222147All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_2HR_DN 4933All SZGR genes in this pathway
WHITFIELD_CELL_CYCLE_G2 182102All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_PRONEURAL 177132All SZGR genes in this pathway
BAKKER_FOXO3_TARGETS_UP 6141All SZGR genes in this pathway
HUANG_GATA2_TARGETS_UP 14996All SZGR genes in this pathway
PHONG_TNF_RESPONSE_NOT_VIA_P38 337236All SZGR genes in this pathway
ZWANG_DOWN_BY_2ND_EGF_PULSE 293119All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-148/1521281341Ahsa-miR-148aUCAGUGCACUACAGAACUUUGU
hsa-miR-152brainUCAGUGCAUGACAGAACUUGGG
hsa-miR-148bUCAGUGCAUCACAGAACUUUGU
miR-1864274331Ahsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
miR-1909096m8hsa-miR-190UGAUAUGUUUGAUAUAUUAGGU
miR-194130113071Ahsa-miR-194UGUAACAGCAACUCCAUGUGGA
miR-196245251m8hsa-miR-196aUAGGUAGUUUCAUGUUGUUGG
hsa-miR-196bUAGGUAGUUUCCUGUUGUUGG
miR-221/2222012081A,m8hsa-miR-221brainAGCUACAUUGUCUGCUGGGUUUC
hsa-miR-222brainAGCUACAUCUGGCUACUGGGUCUC
hsa-miR-221brainAGCUACAUUGUCUGCUGGGUUUC
hsa-miR-222brainAGCUACAUCUGGCUACUGGGUCUC
miR-24125312601A,m8hsa-miR-24SZUGGCUCAGUUCAGCAGGAACAG
miR-32312751281m8hsa-miR-323brainGCACAUUACACGGUCGACCUCU
miR-377127812851A,m8hsa-miR-377AUCACACAAAGGCAACUUUUGU
miR-4552792851Ahsa-miR-455UAUGUGCCUUUGGACUACAUCG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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