Gene Page: CTNNA1

Summary
GeneID  1495
Symbol  CTNNA1
Synonyms  CAP102|FLJ36832
Description  catenin (cadherin-associated protein), alpha 1, 102kDa
See related  HGNC:2509|MIM:116805|Ensembl:ENSG00000044115|HPRD:00285|
Locus tag  -
Gene type  protein-coding
Map location  5q31
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0032 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ADAMTS100.880.79
CNKSR10.880.80
LPAR20.880.76
HGFAC0.880.78
MAMDC40.880.77
VWCE0.870.78
ATAD3B0.870.78
JMJD7-PLA2G4B0.870.80
MICAL10.870.80
CCDC570.860.76
Top 10 negatively co-expressed genes
ABCG2-0.54-0.58
ITM2B-0.53-0.56
ACOT13-0.52-0.57
PLA2G4A-0.52-0.59
AF347015.31-0.51-0.61
AF347015.27-0.51-0.61
FAM162A-0.51-0.55
C5orf53-0.50-0.55
HLA-C-0.50-0.47
ALDOC-0.50-0.49
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI12477722 
GO:0005198structural molecule activityIEA-
GO:0051015actin filament bindingIEA-
GO:0017166vinculin bindingIPI9700171 
GO:0045296cadherin bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007406negative regulation of neuroblast proliferationIEAneurogenesis (GO term level: 10)-
GO:0007155cell adhesionNAS8323564 
GO:0007163establishment or maintenance of cell polarityIEA-
GO:0043066negative regulation of apoptosisIEA-
GO:0043297apical junction assemblyNAS9700171 
GO:0045880positive regulation of smoothened signaling pathwayIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmIEA-
GO:0030027lamellipodiumIEA-
GO:0005915zonula adherensIEA-
GO:0005912adherens junctionIEA-
GO:0005886plasma membraneIEA-
GO:0015629actin cytoskeletonIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACTN1FLJ40884actinin, alpha 1-HPRD,BioGRID7790378 
APCBTPS2 | DP2 | DP2.5 | DP3 | GSadenomatous polyposis coliAffinity Capture-WesternBioGRID7651399 |8259519 
CA9CAIX | MNcarbonic anhydrase IXAffinity Capture-WesternBioGRID14567991 
CDH1Arc-1 | CD324 | CDHE | ECAD | LCAM | UVOcadherin 1, type 1, E-cadherin (epithelial)Affinity Capture-WesternBioGRID7542250 |8227214 
|9233779 |10381631 
|11960376 
CDH2CD325 | CDHN | CDw325 | NCADcadherin 2, type 1, N-cadherin (neuronal)Affinity Capture-MS
Affinity Capture-Western		BioGRID12604612 |14625392 
CDH3CDHP | HJMD | PCADcadherin 3, type 1, P-cadherin (placental)Affinity Capture-Western
Co-purification		BioGRID10381631 |10910767 
CDH57B4 | CD144 | FLJ17376cadherin 5, type 2 (vascular endothelium)-HPRD,BioGRID12003790 
CTNNA1CAP102 | FLJ36832catenin (cadherin-associated protein), alpha 1, 102kDaAffinity Capture-WesternBioGRID9762469 
CTNNB1CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923catenin (cadherin-associated protein), beta 1, 88kDa-HPRD,BioGRID7706414 
Beta-catenin interacts with alpha-catenin. This interaction was modelled on a demonstrated interaction between human beta-catenin and mouse alpha-catenin.BIND15294866 
CTNND1CAS | CTNND | KIAA0384 | P120CAS | P120CTN | p120catenin (cadherin-associated protein), delta 1Affinity Capture-WesternBioGRID7651399 
DLG1DKFZp761P0818 | DKFZp781B0426 | DLGH1 | SAP97 | dJ1061C18.1.1 | hdlgdiscs, large homolog 1 (Drosophila)-HPRD,BioGRID9512503 
FAM84BBCMP101 | NSE2family with sequence similarity 84, member B-HPRD,BioGRID12477722 
JUBAjuba | MGC15563jub, ajuba homolog (Xenopus laevis)-HPRD12417594 
JUPARVD12 | CTNNG | DP3 | DPIII | PDGB | PKGBjunction plakoglobin-HPRD,BioGRID7650039 |9110993 
MLLT4AF-6 | AF6 | AFADIN | FLJ34371 | RP3-431P23.3myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4-HPRD,BioGRID11907041 
MYO7ADFNA11 | DFNB2 | MYOVIIA | MYU7A | NSRD2 | USH1Bmyosin VIIAAffinity Capture-WesternBioGRID11080149 
PSEN1AD3 | FAD | PS1 | S182presenilin 1Affinity Capture-WesternBioGRID10635315 
PTPN14MGC126803 | PEZ | PTP36protein tyrosine phosphatase, non-receptor type 14Affinity Capture-MSBioGRID12808048 
SPTAN1(ALPHA)II-SPECTRIN | FLJ44613 | NEASspectrin, alpha, non-erythrocytic 1 (alpha-fodrin)-HPRD11069925 
SPTBN1ELF | SPTB2 | betaSpIIspectrin, beta, non-erythrocytic 1Reconstituted ComplexBioGRID11069925 
TJP2MGC26306 | X104 | ZO-2 | ZO2tight junction protein 2 (zona occludens 2)-HPRD,BioGRID10026224 
VCLCMD1W | MVCLvinculin-HPRD,BioGRID9700171 
VEZTDKFZp761C241 | VEZATINvezatin, adherens junctions transmembrane protein-HPRD,BioGRID11080149 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_ADHERENS_JUNCTION 7553All SZGR genes in this pathway
KEGG_TIGHT_JUNCTION 13486All SZGR genes in this pathway
KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 11878All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_ENDOMETRIAL_CANCER 5245All SZGR genes in this pathway
KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC 7659All SZGR genes in this pathway
BIOCARTA_CELL2CELL_PATHWAY 1411All SZGR genes in this pathway
PID_MET_PATHWAY 8060All SZGR genes in this pathway
PID_ARF6_TRAFFICKING_PATHWAY 4934All SZGR genes in this pathway
PID_NECTIN_PATHWAY 3020All SZGR genes in this pathway
PID_CDC42_PATHWAY 7051All SZGR genes in this pathway
PID_AJDISS_2PATHWAY 4838All SZGR genes in this pathway
PID_ECADHERIN_NASCENT_AJ_PATHWAY 3933All SZGR genes in this pathway
PID_ECADHERIN_KERATINOCYTE_PATHWAY 2119All SZGR genes in this pathway
PID_ECADHERIN_STABILIZATION_PATHWAY 4234All SZGR genes in this pathway
PID_VEGFR1_2_PATHWAY 6957All SZGR genes in this pathway
PID_NCADHERIN_PATHWAY 3332All SZGR genes in this pathway
PID_RAC1_PATHWAY 5437All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_CELL_CELL_COMMUNICATION 12077All SZGR genes in this pathway
REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS 2720All SZGR genes in this pathway
REACTOME_CELL_CELL_JUNCTION_ORGANIZATION 5631All SZGR genes in this pathway
REACTOME_CELL_JUNCTION_ORGANIZATION 7843All SZGR genes in this pathway
REACTOME_MYOGENESIS 2820All SZGR genes in this pathway
HOLLMANN_APOPTOSIS_VIA_CD40_DN 267178All SZGR genes in this pathway
GARY_CD5_TARGETS_UP 473314All SZGR genes in this pathway
THUM_SYSTOLIC_HEART_FAILURE_UP 423283All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_UP 368234All SZGR genes in this pathway
WANG_CLIM2_TARGETS_UP 269146All SZGR genes in this pathway
AKL_HTLV1_INFECTION_UP 2716All SZGR genes in this pathway
SENESE_HDAC1_TARGETS_UP 457269All SZGR genes in this pathway
SENESE_HDAC1_AND_HDAC2_TARGETS_UP 238144All SZGR genes in this pathway
KIM_WT1_TARGETS_12HR_DN 209122All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_UP 1821933All SZGR genes in this pathway
PROVENZANI_METASTASIS_DN 13694All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_DN 485334All SZGR genes in this pathway
OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_UP 11785All SZGR genes in this pathway
BARIS_THYROID_CANCER_DN 5945All SZGR genes in this pathway
WANG_METHYLATED_IN_BREAST_CANCER 3525All SZGR genes in this pathway
KIM_MYC_AMPLIFICATION_TARGETS_DN 9751All SZGR genes in this pathway
FALVELLA_SMOKERS_WITH_LUNG_CANCER 8052All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_UP 424268All SZGR genes in this pathway
BASSO_B_LYMPHOCYTE_NETWORK 14396All SZGR genes in this pathway
IIZUKA_LIVER_CANCER_PROGRESSION_L0_L1_DN 2114All SZGR genes in this pathway
PENG_GLUCOSE_DEPRIVATION_DN 169112All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN 546351All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 555346All SZGR genes in this pathway
ALCALAY_AML_BY_NPM1_LOCALIZATION_UP 14083All SZGR genes in this pathway
FAELT_B_CLL_WITH_VH3_21_DN 4929All SZGR genes in this pathway
SESTO_RESPONSE_TO_UV_C8 7256All SZGR genes in this pathway
WEIGEL_OXIDATIVE_STRESS_BY_TBH_AND_H2O2 3624All SZGR genes in this pathway
KAAB_FAILED_HEART_ATRIUM_DN 14199All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
LEE_CALORIE_RESTRICTION_MUSCLE_UP 4333All SZGR genes in this pathway
VERRECCHIA_RESPONSE_TO_TGFB1_C5 2111All SZGR genes in this pathway
VERRECCHIA_DELAYED_RESPONSE_TO_TGFB1 3926All SZGR genes in this pathway
LEE_CALORIE_RESTRICTION_NEOCORTEX_DN 8858All SZGR genes in this pathway
HEDENFALK_BREAST_CANCER_BRCA1_VS_BRCA2 163113All SZGR genes in this pathway
BAELDE_DIABETIC_NEPHROPATHY_DN 434302All SZGR genes in this pathway
MITSIADES_RESPONSE_TO_APLIDIN_DN 249165All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_D_CLUSTER_DN 4026All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_D_DN 7834All SZGR genes in this pathway
GOLDRATH_ANTIGEN_RESPONSE 346192All SZGR genes in this pathway
LINDSTEDT_DENDRITIC_CELL_MATURATION_C 6949All SZGR genes in this pathway
RAY_TARGETS_OF_P210_BCR_ABL_FUSION_UP 1813All SZGR genes in this pathway
MILI_PSEUDOPODIA_CHEMOTAXIS_DN 457302All SZGR genes in this pathway
VALK_AML_CLUSTER_4 3117All SZGR genes in this pathway
VALK_AML_CLUSTER_15 3119All SZGR genes in this pathway
VALK_AML_WITH_CEBPA 3727All SZGR genes in this pathway
FONTAINE_THYROID_TUMOR_UNCERTAIN_MALIGNANCY_UP 3623All SZGR genes in this pathway
FONTAINE_PAPILLARY_THYROID_CARCINOMA_UP 6638All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_PCA3_DN 6938All SZGR genes in this pathway
WONG_EMBRYONIC_STEM_CELL_CORE 335193All SZGR genes in this pathway
WHITFIELD_CELL_CYCLE_G2_M 216124All SZGR genes in this pathway
LI_INDUCED_T_TO_NATURAL_KILLER_UP 307182All SZGR genes in this pathway
LU_EZH2_TARGETS_DN 414237All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_NOT_SATB1_UP 344215All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-141/200a717723m8hsa-miR-141UAACACUGUCUGGUAAAGAUGG
hsa-miR-200aUAACACUGUCUGGUAACGAUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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