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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Gene Page: DLG3

Summary

GeneID

1741

Symbol

DLG3

Synonyms

KIAA1232|MRX|MRX90|NE-Dlg|NEDLG|SAP102

Description

discs, large homolog 3 (neuroendocrine-dlg, Drosophila)

Locus tag

RP11-291O7.3

Gene type

protein-coding

Map location

Xq13.1

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 1.7558

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005515

protein binding

IEA

GO:0005515

protein binding

IPI

16192269 |17353931

GO:0004385

guanylate kinase activity

NAS

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0008285

negative regulation of cell proliferation

NAS

9188857

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005575

cellular_component

GO:0005634

nucleus

IDA

18029348

GO:0005730

nucleolus

IDA

18029348

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ANXA1	ANX1 \| LPC1	annexin A1	Affinity Capture-MS	BioGRID	17353931
APC	BTPS2 \| DP2 \| DP2.5 \| DP3 \| GS	adenomatous polyposis coli	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	9188857
ATP2B2	PMCA2 \| PMCA2a \| PMCA2i	ATPase, Ca++ transporting, plasma membrane 2	Affinity Capture-Western	BioGRID	11274188
ATP2B4	ATP2B2 \| DKFZp686G08106 \| DKFZp686M088 \| MXRA1 \| PMCA4 \| PMCA4b \| PMCA4x	ATPase, Ca++ transporting, plasma membrane 4	-	HPRD,BioGRID	11274188
ATP2B4		ATPase, Ca++ transporting, plasma membrane 4	PMCA4b interacts with SAP102. This interaction was modeled on a demonstrated interaction between human PMCA4b and SAP102 from rat and an unspecified source.	BIND	11274188
CAMK2A	CAMKA \| KIAA0968	calcium/calmodulin-dependent protein kinase II alpha	Affinity Capture-MS	BioGRID	17353931
CRIPT	HSPC139	cysteine-rich PDZ-binding protein	-	HPRD,BioGRID	11937501 \|12070168
CUL2	MGC131970	cullin 2	Affinity Capture-MS	BioGRID	17353931
DLG1	DKFZp761P0818 \| DKFZp781B0426 \| DLGH1 \| SAP97 \| dJ1061C18.1.1 \| hdlg	discs, large homolog 1 (Drosophila)	-	HPRD,BioGRID	12351654
DLG4	FLJ97752 \| FLJ98574 \| PSD95 \| SAP90	discs, large homolog 4 (Drosophila)	-	HPRD,BioGRID	10026200
DLGAP1	DAP-1 \| DAP-1-ALPHA \| DAP-1-BETA \| GKAP \| MGC88156 \| SAPAP1 \| hGKAP	discs, large (Drosophila) homolog-associated protein 1	Two-hybrid	BioGRID	9115257
DLGAP4	DAP4 \| KIAA0964 \| MGC131862 \| RP5-977B1.6 \| SAPAP4	discs, large (Drosophila) homolog-associated protein 4	-	HPRD	9115257
ERBB4	HER4 \| MGC138404 \| p180erbB4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	-	HPRD,BioGRID	10725395 \|12175853
ERBB4	HER4 \| MGC138404 \| p180erbB4		ErbB-4 interacts with SAP-102.	BIND	10725395
EXOC3	SEC6 \| SEC6L1 \| Sec6p	exocyst complex component 3	Affinity Capture-Western	BioGRID	12738960
EXOC4	MGC27170 \| REC8 \| SEC8 \| SEC8L1 \| Sec8p	exocyst complex component 4	-	HPRD,BioGRID	12738960
EXOC7	2-5-3p \| DKFZp686J04253 \| EX070 \| EXO70 \| EXOC1 \| Exo70p \| FLJ40965 \| FLJ46415 \| YJL085W	exocyst complex component 7	Reconstituted Complex	BioGRID	12738960
GDA	CYPIN \| GUANASE \| KIAA1258 \| MGC9982 \| NEDASIN	guanine deaminase	-	HPRD,BioGRID	10542258 \|10595517
GRIK2	EAA4 \| GLR6 \| GLUK6 \| GLUR6 \| MGC74427 \| MRT6	glutamate receptor, ionotropic, kainate 2	-	HPRD	12070168
GRIK2	EAA4 \| GLR6 \| GLUK6 \| GLUR6 \| MGC74427 \| MRT6	glutamate receptor, ionotropic, kainate 2	Affinity Capture-Western	BioGRID	9808460
GRIK5	EAA2 \| GRIK2 \| KA2	glutamate receptor, ionotropic, kainate 5	Affinity Capture-Western	BioGRID	9808460
GRIN1	NMDA1 \| NMDAR1 \| NR1	glutamate receptor, ionotropic, N-methyl D-aspartate 1	-	HPRD	10862698
GRIN2A	NMDAR2A \| NR2A	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	in vitro in vivo Two-hybrid	BioGRID	9278515 \|11937501
GRIN2A	NMDAR2A \| NR2A	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	-	HPRD	11937501 \|12070168
GRIN2B	MGC142178 \| MGC142180 \| NMDAR2B \| NR2B \| hNR3	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	-	HPRD,BioGRID	11937501
GRIN2C	NMDAR2C \| NR2C	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	-	HPRD,BioGRID	11937501
GUCY1A2	GC-SA2 \| GUC1A2	guanylate cyclase 1, soluble, alpha 2	-	HPRD,BioGRID	11572861
HIST1H2BC	H2B.1 \| H2B/l \| H2BFL \| MGC104246 \| dJ221C16.3	histone cluster 1, H2bc	Affinity Capture-MS	BioGRID	17353931
KCNJ12	FLJ14167 \| IRK2 \| KCNJN1 \| Kir2.2 \| Kir2.2v \| hIRK \| hIRK1 \| hkir2.2x \| kcnj12x	potassium inwardly-rectifying channel, subfamily J, member 12	-	HPRD,BioGRID	15024025
KLHDC3	PEAS \| RP1-20C7.3 \| dJ20C7.3 \| hPEAS	kelch domain containing 3	Affinity Capture-MS	BioGRID	17353931
KRT31	HA1 \| Ha-1 \| KRTHA1 \| MGC138630 \| hHa1	keratin 31	Affinity Capture-MS	BioGRID	17353931
KRT34	HA4 \| Ha-4 \| KRTHA4 \| hHa4	keratin 34	Affinity Capture-MS	BioGRID	17353931
KRT35	HA5 \| Ha-5 \| KRTHA5 \| hHa5	keratin 35	Affinity Capture-MS	BioGRID	17353931
KRT82	HB2 \| Hb-2 \| KRTHB2	keratin 82	Affinity Capture-MS	BioGRID	17353931
KRT85	HB5 \| Hb-5 \| KRTHB5 \| hHb5	keratin 85	Affinity Capture-MS	BioGRID	17353931
LIN7A	LIN-7A \| LIN7 \| MALS-1 \| MGC148143 \| TIP-33 \| VELI1	lin-7 homolog A (C. elegans)	-	HPRD,BioGRID	9753324
LRP2	DBS \| gp330	low density lipoprotein-related protein 2	-	HPRD,BioGRID	12713445
NLGN1	KIAA1070 \| MGC45115	neuroligin 1	Two-hybrid	BioGRID	9278515
NLGN2	KIAA1366	neuroligin 2	Two-hybrid	BioGRID	9278515
NLGN3	ASPGX1 \| AUTSX1 \| HNL3 \| KIAA1480	neuroligin 3	-	HPRD,BioGRID	9278515
PTK2B	CADTK \| CAKB \| FADK2 \| FAK2 \| FRNK \| PKB \| PTK \| PYK2 \| RAFTK	PTK2B protein tyrosine kinase 2 beta	-	HPRD,BioGRID	12576483
S100A3	S100E	S100 calcium binding protein A3	Affinity Capture-MS	BioGRID	17353931
SEMA4C	FLJ20369 \| KIAA1739 \| M-SEMA-F \| MGC126382 \| MGC126383 \| SEMACL1 \| SEMAF \| SEMAI	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C	-	HPRD,BioGRID	11134026
SYNGAP1	DKFZp761G1421 \| KIAA1938 \| RASA1 \| RASA5 \| SYNGAP	synaptic Ras GTPase activating protein 1 homolog (rat)	-	HPRD,BioGRID	9581761

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
REACTOME_DEVELOPMENTAL_BIOLOGY	396	292	All SZGR genes in this pathway
REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES	186	155	All SZGR genes in this pathway
REACTOME_NEURONAL_SYSTEM	279	221	All SZGR genes in this pathway
REACTOME_NEUROTRANSMITTER_RECEPTOR_BINDING_AND_DOWNSTREAM_TRANSMISSION_IN_THE_POSTSYNAPTIC_CELL	137	110	All SZGR genes in this pathway
REACTOME_AXON_GUIDANCE	251	188	All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_KAINATE_RECEPTORS_UPON_GLUTAMATE_BINDING	31	23	All SZGR genes in this pathway
REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS	11	11	All SZGR genes in this pathway
REACTOME_L1CAM_INTERACTIONS	86	62	All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_UP	380	215	All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_UP	450	256	All SZGR genes in this pathway
GAL_LEUKEMIC_STEM_CELL_UP	133	78	All SZGR genes in this pathway
ODONNELL_METASTASIS_DN	24	13	All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_UP	487	286	All SZGR genes in this pathway
KOYAMA_SEMA3B_TARGETS_UP	292	168	All SZGR genes in this pathway
BENPORATH_ES_1	379	235	All SZGR genes in this pathway
ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_DN	103	64	All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS	882	572	All SZGR genes in this pathway
SASAKI_ADULT_T_CELL_LEUKEMIA	176	122	All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_16HR_UP	225	139	All SZGR genes in this pathway
RAMASWAMY_METASTASIS_DN	61	47	All SZGR genes in this pathway
KAYO_AGING_MUSCLE_UP	244	165	All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_AND_PROGENITOR	681	420	All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_DN	701	446	All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_SUBOPTIMAL_DEBULKING	510	309	All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK	1210	725	All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_UP	518	299	All SZGR genes in this pathway
CAIRO_LIVER_DEVELOPMENT_UP	166	105	All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE	721	492	All SZGR genes in this pathway
KIM_ALL_DISORDERS_CALB1_CORR_UP	548	370	All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_EARLY_LATE	317	190	All SZGR genes in this pathway
CHANGOLKAR_H2AFY_TARGETS_UP	48	28	All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_UP	682	433	All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_DN	428	246	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-136	604	610	1A	hsa-miR-136	ACUCCAUUUGUUUUGAUGAUGGA
miR-138	1781	1787	1A	hsa-miR-138^brain	AGCUGGUGUUGUGAAUC
miR-141/200a	2021	2027	m8	hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
miR-141/200a	2021	2027	m8	hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
miR-143	208	214	1A	hsa-miR-143^brain	UGAGAUGAAGCACUGUAGCUCA
miR-24	2708	2715	1A,m8	hsa-miR-24^SZ	UGGCUCAGUUCAGCAGGAACAG
miR-299-5p	984	990	1A	hsa-miR-299-5p	UGGUUUACCGUCCCACAUACAU
miR-326	1490	1496	m8	hsa-miR-326	CCUCUGGGCCCUUCCUCCAG
miR-363	270	276	1A	hsa-miR-363	AUUGCACGGUAUCCAUCUGUAA
miR-369-3p	534	540	1A	hsa-miR-369-3p	AAUAAUACAUGGUUGAUCUUU
miR-369-3p	534	540	1A	hsa-miR-369-3p	AAUAAUACAUGGUUGAUCUUU
miR-374	534	540	m8	hsa-miR-374	UUAUAAUACAACCUGAUAAGUG
miR-374	534	540	m8	hsa-miR-374	UUAUAAUACAACCUGAUAAGUG
miR-375	86	92	1A	hsa-miR-375	UUUGUUCGUUCGGCUCGCGUGA
miR-410	536	542	1A	hsa-miR-410	AAUAUAACACAGAUGGCCUGU
				hsa-miR-410	AAUAUAACACAGAUGGCCUGU
				hsa-miR-410	AAUAUAACACAGAUGGCCUGU
miR-421	1790	1796	m8	hsa-miR-421	GGCCUCAUUAAAUGUUUGUUG
miR-500	268	275	1A,m8	hsa-miR-500	AUGCACCUGGGCAAGGAUUCUG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.