Gene Page: DLG4

Summary
GeneID  1742
Symbol  DLG4
Synonyms  FLJ97752|FLJ98574|PSD95|SAP90
Description  discs, large homolog 4 (Drosophila)
See related  HGNC:2903|MIM:602887|HPRD:04199|
Locus tag  -
Gene type  protein-coding
Map location  17p13.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 7 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 7.5711 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIEA-
GO:0008022protein C-terminus bindingIPI7477295 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0016188synaptic vesicle maturationIEASynap (GO term level: 8)-
GO:0007268synaptic transmissionTASneuron, Synap, Neurotransmitter (GO term level: 6)9853749 
GO:0048169regulation of long-term neuronal synaptic plasticityIEAneuron, Synap (GO term level: 10)-
GO:0007399nervous system developmentTASneurite (GO term level: 5)9286702 
GO:0006461protein complex assemblyTAS7477295 
GO:0007165signal transductionTAS10364559 
GO:0007612learningTAS9853749 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0014069postsynaptic densityIEASynap (GO term level: 10)-
GO:0019717synaptosomeIEASynap, Brain (GO term level: 7)-
GO:0045211postsynaptic membraneIDASynap, Neurotransmitter (GO term level: 5)12151521 
GO:0045202synapseIEAneuron, Synap, Neurotransmitter, Glial (GO term level: 2)-
GO:0005737cytoplasmIEA-
GO:0005886plasma membraneIEA-
GO:0030054cell junctionIEA-
GO:0031234extrinsic to internal side of plasma membraneIEA-
GO:0030863cortical cytoskeletonIDA12151521 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACCN3ASIC3 | DRASIC | SLNAC1 | TNaC1amiloride-sensitive cation channel 3ASIC3 interacts with DLG4 (PSD-95). This interaction was modeled on a demonstrated interaction between mouse or rat ASIC3 and rat DLG4 (PSD-95).BIND15317815 
-HPRD,BioGRID15317815 
ACTN2CMD1AAactinin, alpha 2-HPRD,BioGRID12435606 
ADAM22MDC2 | MGC149832ADAM metallopeptidase domain 22Affinity Capture-MS
Affinity Capture-Western
BioGRID16990550 
ADRB1ADRB1R | B1AR | BETA1AR | RHRadrenergic, beta-1-, receptor-HPRD,BioGRID10995758 
AKAP5AKAP75 | AKAP79 | H21A kinase (PRKA) anchor protein 5-HPRD10939335 
ATP2B2PMCA2 | PMCA2a | PMCA2iATPase, Ca++ transporting, plasma membrane 2-HPRD11274188 
PMCA2b interacts with SAP90. This interaction was modeled on a demonstrated interaction between human PMCA2b and rat SAP90.BIND11274188 
ATP2B4ATP2B2 | DKFZp686G08106 | DKFZp686M088 | MXRA1 | PMCA4 | PMCA4b | PMCA4xATPase, Ca++ transporting, plasma membrane 4PMCA4b interacts with PSD-95.BIND9430700 
-HPRD11274188 
BAI1FLJ41988brain-specific angiogenesis inhibitor 1-HPRD,BioGRID11937501 
BEGAINKIAA1446brain-enriched guanylate kinase-associated homolog (rat)-HPRD9756850 
CACNG2MGC138502 | MGC138504calcium channel, voltage-dependent, gamma subunit 2-HPRD,BioGRID11805122 
CASKCAGH39 | CMG | FLJ22219 | FLJ31914 | LIN2 | MICPCH | TNRC8calcium/calmodulin-dependent serine protein kinase (MAGUK family)-HPRD,BioGRID12151521 
CD46MCP | MGC26544 | MIC10 | TLX | TRA2.10CD46 molecule, complement regulatory protein-HPRD,BioGRID11714708 
CITCRIK | KIAA0949 | STK21citron (rho-interacting, serine/threonine kinase 21)in vivo
Two-hybrid
BioGRID9870942 
CRIPTHSPC139cysteine-rich PDZ-binding protein-HPRD,BioGRID9581762 
DAPMGC99796death-associated protein-HPRD9286858 
DLG1DKFZp761P0818 | DKFZp781B0426 | DLGH1 | SAP97 | dJ1061C18.1.1 | hdlgdiscs, large homolog 1 (Drosophila)Affinity Capture-WesternBioGRID9286858 
DLG2DKFZp781D1854 | DKFZp781E0954 | FLJ37266 | MGC131811 | PSD-93discs, large homolog 2, chapsyn-110 (Drosophila)-HPRD,BioGRID9182804 
DLG3KIAA1232 | MRX | MRX90 | NE-Dlg | NEDLG | SAP102discs, large homolog 3 (neuroendocrine-dlg, Drosophila)-HPRD,BioGRID10026200 
DLG4FLJ97752 | FLJ98574 | PSD95 | SAP90discs, large homolog 4 (Drosophila)Affinity Capture-WesternBioGRID9182804 
DLGAP1DAP-1 | DAP-1-ALPHA | DAP-1-BETA | GKAP | MGC88156 | SAPAP1 | hGKAPdiscs, large (Drosophila) homolog-associated protein 1Affinity Capture-Western
Co-fractionation
Far Western
Reconstituted Complex
Two-hybrid
BioGRID9024696 |9115257 
|9286858 |10527873 
|10844022 |11060025 
-HPRD9024696 |9286858 
PSD-95 interacts with DAP-1alpha.BIND9286858 
DLGAP2DAP2 | SAPAP2discs, large (Drosophila) homolog-associated protein 2-HPRD9286858 
Reconstituted Complex
Two-hybrid
BioGRID9115257 
DLGAP3DAP3 | SAPAP3discs, large (Drosophila) homolog-associated protein 3Two-hybridBioGRID9115257 
DLGAP4DAP4 | KIAA0964 | MGC131862 | RP5-977B1.6 | SAPAP4discs, large (Drosophila) homolog-associated protein 4Two-hybridBioGRID9115257 
DYNLL1DLC1 | DLC8 | DNCL1 | DNCLC1 | LC8 | LC8a | MGC126137 | MGC126138 | PIN | hdlc1dynein, light chain, LC8-type 1Affinity Capture-Western
Reconstituted Complex
BioGRID10844022 
-HPRD14760703 
DYNLL2DNCL1B | Dlc2 | MGC17810dynein, light chain, LC8-type 2-HPRD,BioGRID10844022 
ERBB2CD340 | HER-2 | HER-2/neu | HER2 | NEU | NGL | TKR1v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)-HPRD,BioGRID10839362 
ERBB2IPERBIN | LAP2erbb2 interacting protein-HPRD,BioGRID11279080 
ERBB4HER4 | MGC138404 | p180erbB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)-HPRD,BioGRID10725395 
ErbB-4 interacts with PSD-95.BIND10725395 
EXOC4MGC27170 | REC8 | SEC8 | SEC8L1 | Sec8pexocyst complex component 4Affinity Capture-Western
Reconstituted Complex
BioGRID12675619 |12738960 
FYNMGC45350 | SLK | SYNFYN oncogene related to SRC, FGR, YES-HPRD,BioGRID12419528 
FZD1DKFZp564G072frizzled homolog 1 (Drosophila)-HPRD,BioGRID12067714 
FZD2-frizzled homolog 2 (Drosophila)Two-hybridBioGRID12067714 
FZD4CD344 | EVR1 | FEVR | FZD4S | Fz-4 | FzE4 | GPCR | MGC34390frizzled homolog 4 (Drosophila)-HPRD,BioGRID12067714 
FZD7FzE3frizzled homolog 7 (Drosophila)Affinity Capture-Western
Two-hybrid
BioGRID12067714 
GDACYPIN | GUANASE | KIAA1258 | MGC9982 | NEDASINguanine deaminase-HPRD10595517 
GRIA2GLUR2 | GLURB | GluR-K2 | HBGR2glutamate receptor, ionotropic, AMPA 2Affinity Capture-MSBioGRID16990550 
GRIA3GLUR-C | GLUR-K3 | GLUR3 | GLURC | MRX94glutamate receptor, ionotrophic, AMPA 3Affinity Capture-MSBioGRID16990550 
GRIK1EAA3 | EEA3 | GLR5 | GLUR5glutamate receptor, ionotropic, kainate 1-HPRD,BioGRID12597860 
GRIK2EAA4 | GLR6 | GLUK6 | GLUR6 | MGC74427 | MRT6glutamate receptor, ionotropic, kainate 2-HPRD9808460 |11276111 
|12597860 
Affinity Capture-Western
Reconstituted Complex
BioGRID9808460 |11279111 
|12597860 
GRIK5EAA2 | GRIK2 | KA2glutamate receptor, ionotropic, kainate 5-HPRD,BioGRID9808460 |11279111 
GRIN1NMDA1 | NMDAR1 | NR1glutamate receptor, ionotropic, N-methyl D-aspartate 1-HPRD9009191 |9502803 
|11506858 |12068077 
|14732708 |15030493 
GRIN2ANMDAR2A | NR2Aglutamate receptor, ionotropic, N-methyl D-aspartate 2A-HPRD7569905 |11937501 
|12419528 
Affinity Capture-Western
in vitro
in vivo
Reconstituted Complex
Two-hybrid
BioGRID7569905 |9278515 
|9286858 |10648730 
|11937501 |12419528 
GRIN2BMGC142178 | MGC142180 | NMDAR2B | NR2B | hNR3glutamate receptor, ionotropic, N-methyl D-aspartate 2BAffinity Capture-Western
in vitro
in vivo
Reconstituted Complex
Two-hybrid
BioGRID7569905 |9278515 
|9581762 |11937501 
|11997254 |12738960 
-HPRD7569905 |9581762|11937501 
GRIN2CNMDAR2C | NR2Cglutamate receptor, ionotropic, N-methyl D-aspartate 2C-HPRD,BioGRID7569905 |11937501 
GRIN2DEB11 | NMDAR2Dglutamate receptor, ionotropic, N-methyl D-aspartate 2D-HPRD,BioGRID7569905 
GRIN3AFLJ45414 | NMDAR-L | NR3Aglutamate receptor, ionotropic, N-methyl-D-aspartate 3Ain vitro
in vivo
Two-hybrid
BioGRID7569905 
GRIN3BNR3Bglutamate receptor, ionotropic, N-methyl-D-aspartate 3Bin vitro
in vivo
Two-hybrid
BioGRID7569905 
GUCY1A2GC-SA2 | GUC1A2guanylate cyclase 1, soluble, alpha 2-HPRD,BioGRID11572861 
HGSHRS | ZFYVE8hepatocyte growth factor-regulated tyrosine kinase substrate-HPRD,BioGRID12151521 
HTR2A5-HT2A | HTR25-hydroxytryptamine (serotonin) receptor 2A-HPRD,BioGRID12682061 
HTR2C5-HT2C | 5-HTR2C | HTR1C5-hydroxytryptamine (serotonin) receptor 2C-HPRD,BioGRID12006486 
HTTHD | IT15huntingtinHuntingtin interacts with PSD-95.BIND11319238 
IL13RA1CD213A1 | IL-13Ra | NR4interleukin 13 receptor, alpha 1in vitro
in vivo
Two-hybrid
BioGRID7569905 
KCNA1AEMK | EA1 | HBK1 | HUK1 | KV1.1 | MBK1 | MGC126782 | MGC138385 | MK1 | RBK1potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)Reconstituted Complex
Two-hybrid
BioGRID12435606 
KCNA2HBK5 | HK4 | HUKIV | KV1.2 | MGC50217 | MK2 | NGK1 | RBK2potassium voltage-gated channel, shaker-related subfamily, member 2-HPRD,BioGRID8938729 |12435606 
KCNA4HBK4 | HK1 | HPCN2 | HUKII | KCNA4L | KCNA8 | KV1.4 | PCN2potassium voltage-gated channel, shaker-related subfamily, member 4-HPRD8938729 |9581762 
|12435606 
Affinity Capture-Western
Reconstituted Complex
Two-hybrid
BioGRID8938729 |9581762 
|11997254 |12435606 
KCNA5ATFB7 | HCK1 | HK2 | HPCN1 | KV1.5 | MGC117058 | MGC117059 | PCN1potassium voltage-gated channel, shaker-related subfamily, member 5Affinity Capture-Western
Reconstituted Complex
Two-hybrid
BioGRID12435606 |12860415 
KCND2KIAA1044 | KV4.2 | MGC119702 | MGC119703 | RK5potassium voltage-gated channel, Shal-related subfamily, member 2Two-hybridBioGRID12435606 
KCNJ10BIRK-10 | KCNJ13-PEN | KIR1.2 | KIR4.1potassium inwardly-rectifying channel, subfamily J, member 10-HPRD9148889 
KCNJ12FLJ14167 | IRK2 | KCNJN1 | Kir2.2 | Kir2.2v | hIRK | hIRK1 | hkir2.2x | kcnj12xpotassium inwardly-rectifying channel, subfamily J, member 12-HPRD,BioGRID15024025 
KCNJ2HHBIRK1 | HHIRK1 | IRK1 | KIR2.1 | LQT7 | SQT3potassium inwardly-rectifying channel, subfamily J, member 2-HPRD,BioGRID10627592 
KCNJ4HIR | HIRK2 | HRK1 | IRK3 | Kir2.3 | MGC142066 | MGC142068potassium inwardly-rectifying channel, subfamily J, member 4Affinity Capture-Western
Two-hybrid
BioGRID10627592 |11997254 
|14960569 
KIF13BGAKIN | KIAA0639kinesin family member 13B-HPRD,BioGRID10859302 
KIF1BCMT2 | CMT2A | CMT2A1 | FLJ23699 | HMSNII | KIAA0591 | KIAA1448 | KLP | MGC134844kinesin family member 1B-HPRD12097473 
LGI1EPITEMPIN | EPT | ETL1 | IB1099leucine-rich, glioma inactivated 1Affinity Capture-MS
Affinity Capture-Western
BioGRID16990550 
LIN7ALIN-7A | LIN7 | MALS-1 | MGC148143 | TIP-33 | VELI1lin-7 homolog A (C. elegans)-HPRD,BioGRID10341223 
LIN7BLIN-7B | MALS-2 | MALS2 | VELI2lin-7 homolog B (C. elegans)in vivoBioGRID10341223 
LRP1A2MR | APOER | APR | CD91 | FLJ16451 | IGFBP3R | LRP | MGC88725 | TGFBR5low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)-HPRD,BioGRID10827173 
LRP2DBS | gp330low density lipoprotein-related protein 2-HPRD,BioGRID12713445 
LRP8APOER2 | HSZ75190 | MCI1low density lipoprotein receptor-related protein 8, apolipoprotein e receptorTwo-hybridBioGRID10827173 
LRRC1FLJ10775 | FLJ11834 | LANO | dJ523E19.1leucine rich repeat containing 1-HPRD,BioGRID11440998 
LRRC7DKFZp686I1147 | KIAA1365 | MGC144918leucine rich repeat containing 7Affinity Capture-WesternBioGRID12390249 
LYNFLJ26625 | JTK8v-yes-1 Yamaguchi sarcoma viral related oncogene homolog-HPRD9892651 
MAP1AFLJ77111 | MAP1L | MTAP1Amicrotubule-associated protein 1A-HPRD,BioGRID9786987 |11925566 
MAP3K10MLK2 | MSTmitogen-activated protein kinase kinase kinase 10-HPRD,BioGRID11152698 
MAP3K11MGC17114 | MLK-3 | MLK3 | PTK1 | SPRKmitogen-activated protein kinase kinase kinase 11Affinity Capture-WesternBioGRID11152698 
NDOR1MGC138148 | NR1 | bA350O14.9NADPH dependent diflavin oxidoreductase 1-HPRD,BioGRID7569905 
NLGN1KIAA1070 | MGC45115neuroligin 1Reconstituted Complex
Two-hybrid
BioGRID9278515 
NLGN2KIAA1366neuroligin 2Two-hybridBioGRID9278515 
NLGN3ASPGX1 | AUTSX1 | HNL3 | KIAA1480neuroligin 3-HPRD,BioGRID9278515 
NLGN4XASPGX2 | AUTSX2 | HLNX | HNLX | KIAA1260 | MGC22376 | NLGN | NLGN4neuroligin 4, X-linked-HPRD,BioGRID11368788 
NOS1IHPS1 | NOS | nNOSnitric oxide synthase 1 (neuronal)-HPRD,BioGRID8625413 
NRG1ARIA | GGF | GGF2 | HGL | HRG | HRG1 | HRGA | NDF | SMDFneuregulin 1Nrg-1 interacts with PSD-95 promoter. This interaction was modeled on a demonstrated interaction between Nrg-1 from an unspecified species and human PSD-95 promoter.BIND15494726 
PARK2AR-JP | LPRS2 | PDJ | PRKNParkinson disease (autosomal recessive, juvenile) 2, parkinAffinity Capture-WesternBioGRID11679592 
PRKCAAAG6 | MGC129900 | MGC129901 | PKC-alpha | PKCA | PRKACAprotein kinase C, alpha-HPRD,BioGRID11937501 
PTK2BCADTK | CAKB | FADK2 | FAK2 | FRNK | PKB | PTK | PYK2 | RAFTKPTK2B protein tyrosine kinase 2 beta-HPRD,BioGRID12576483 
PTPRGHPTPG | PTPG | R-PTP-GAMMA | RPTPGprotein tyrosine phosphatase, receptor type, G-HPRD,BioGRID10521598 
RICSGC-GAP | GRIT | KIAA0712 | MGC1892 | p200RhoGAP | p250GAPRho GTPase-activating protein-HPRD12531901 
SEMA4CFLJ20369 | KIAA1739 | M-SEMA-F | MGC126382 | MGC126383 | SEMACL1 | SEMAF | SEMAIsema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C-HPRD,BioGRID11134026 
SEMA4FM-SEMA | PRO2353 | SEMAM | SEMAW | m-Sema-Msema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F-HPRD,BioGRID11483650 
SHANK1SPANK-1 | SSTRIP | synamonSH3 and multiple ankyrin repeat domains 1-HPRD,BioGRID10433268 
SHANK2CORTBP1 | CTTNBP1 | ProSAP1 | SHANK | SPANK-3SH3 and multiple ankyrin repeat domains 2-HPRD,BioGRID10527873 
SIPA1L1DKFZp686G1344 | E6TP1 | KIAA0440signal-induced proliferation-associated 1 like 1-HPRD,BioGRID11502259 
SYNGAP1DKFZp761G1421 | KIAA1938 | RASA1 | RASA5 | SYNGAPsynaptic Ras GTPase activating protein 1 homolog (rat)Two-hybridBioGRID9581761 
TANC1KIAA1728 | ROLSB | TANCtetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1-HPRD15673434 
YES1HsT441 | P61-YES | Yes | c-yesv-yes-1 Yamaguchi sarcoma viral oncogene homolog 1-HPRD9892651 
ZDHHC17HIP14 | HIP3 | HSPC294 | HYPH | KIAA0946zinc finger, DHHC-type containing 17HIP14 catalyzes palmitoylation of PSD-95. This interaction was modeled on a demonstrated interaction between human HIP14 and PSD-95 from an unspecified species.BIND15603740 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_HUNTINGTONS_DISEASE 185109All SZGR genes in this pathway
BIOCARTA_NOS1_PATHWAY 2421All SZGR genes in this pathway
ST_GA12_PATHWAY 2316All SZGR genes in this pathway
ST_GA13_PATHWAY 3732All SZGR genes in this pathway
ST_MYOCYTE_AD_PATHWAY 2725All SZGR genes in this pathway
PID_ERBB4_PATHWAY 3832All SZGR genes in this pathway
PEREZ_TP63_TARGETS 355243All SZGR genes in this pathway
WATTEL_AUTONOMOUS_THYROID_ADENOMA_UP 7347All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM2 153102All SZGR genes in this pathway
STARK_PREFRONTAL_CORTEX_22Q11_DELETION_UP 195138All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_UP 398262All SZGR genes in this pathway
JIANG_AGING_HYPOTHALAMUS_DN 4031All SZGR genes in this pathway
MCCLUNG_COCAINE_REWARD_5D 7962All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_18HR_UP 178111All SZGR genes in this pathway
RAMPON_ENRICHED_LEARNING_ENVIRONMENT_LATE_UP 2216All SZGR genes in this pathway
DOUGLAS_BMI1_TARGETS_UP 566371All SZGR genes in this pathway
LEIN_LOCALIZED_TO_DISTAL_AND_PROXIMAL_DENDRITES 1712All SZGR genes in this pathway
ZHANG_TLX_TARGETS_60HR_DN 277166All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_GOOD_SURVIVAL_A12 317177All SZGR genes in this pathway
MIKKELSEN_ES_ICP_WITH_H3K4ME3 718401All SZGR genes in this pathway
MIKKELSEN_NPC_ICP_WITH_H3K4ME3 445257All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_1HR_DN 222147All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_RXRA_BOUND_36HR 15288All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_RXRA_BOUND_8D 882506All SZGR genes in this pathway
ABDELMOHSEN_ELAVL4_TARGETS 1613All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1/2063393461A,m8hsa-miR-1UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZUGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613AGGAAUGUUCCUUCUUUGCC
miR-103/107747753m8hsa-miR-103brainAGCAGCAUUGUACAGGGCUAUGA
hsa-miR-107brainAGCAGCAUUGUACAGGGCUAUCA
miR-122154160m8hsa-miR-122aUGGAGUGUGACAAUGGUGUUUGU
miR-149728734m8hsa-miR-149brainUCUGGCUCCGUGUCUUCACUCC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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