Gene Page: ELN

Summary
GeneID  2006
Symbol  ELN
Synonyms  FLJ38671|FLJ43523|SVAS|WBS|WS
Description  elastin
See related  HGNC:3327|MIM:130160|Ensembl:ENSG00000049540|HPRD:00556|
Locus tag  -
Gene type  protein-coding
Map location  7q11.23
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
C19orf250.870.89
SCAND10.870.87
C19orf200.850.87
YDJC0.850.86
EXOSC40.840.86
ANAPC110.840.85
NME30.840.83
COPE0.840.83
ZNHIT20.830.84
COMMD50.830.85
Top 10 negatively co-expressed genes
MT-ATP8-0.50-0.51
AF347015.26-0.49-0.49
AF347015.8-0.48-0.46
AF347015.27-0.48-0.47
AF347015.15-0.46-0.46
AF347015.18-0.46-0.48
AF347015.33-0.45-0.45
MT-CYB-0.44-0.45
Z83840.4-0.44-0.45
AF347015.2-0.44-0.43
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIEA-
GO:0005525GTP bindingIEA-
GO:0004519endonuclease activityIEA-
GO:0030023extracellular matrix constituent conferring elasticityNAS-
GO:0005201extracellular matrix structural constituentIEA-
GO:0008415acyltransferase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007519skeletal muscle developmentIEAneuron (GO term level: 8)-
GO:0006281DNA repairIEA-
GO:0009887organ morphogenesisTAS9580666 
GO:0008283cell proliferationTAS9607766 
GO:0008015blood circulationTAS8096434 |9873040 
GO:0007585respiratory gaseous exchangeTAS9873040 
GO:0043149stress fiber formationIEA-
GO:0030833regulation of actin filament polymerizationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005578proteinaceous extracellular matrixIEA-
GO:0005578proteinaceous extracellular matrixNAS-
GO:0005737cytoplasmIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ASS1ASS | CTLN1argininosuccinate synthetase 1-HPRD1372742 
BGNDSPG1 | PG-S1 | PGI | SLRR1Abiglycan-HPRD,BioGRID11723132 
DCNCSCD | DSPG2 | PG40 | PGII | PGS2 | SLRR1Bdecorin-HPRD,BioGRID11723132 
ELA2GE | HLE | HNE | NE | PMN-Eelastase 2, neutrophil-HPRD10471600 
FBLN1FBLNfibulin 1-HPRD,BioGRID10544250 
FBLN2-fibulin 2-HPRD,BioGRID10544250 
FBN1FBN | MASS | MFS1 | OCTD | SGS | WMSfibrillin 1-HPRD,BioGRID10825173 
FBN2CCA | DA9fibrillin 2-HPRD,BioGRID10825173 
FCN1FCNMficolin (collagen/fibrinogen domain containing) 1-HPRD,BioGRID8947836 
FKBP10FKBP6 | FKBP65 | FLJ20683 | FLJ22041 | FLJ23833 | hFKBP65FK506 binding protein 10, 65 kDa-HPRD11071917 
LGALS3CBP35 | GAL3 | GALBP | GALIG | LGALS2 | MAC2lectin, galactoside-binding, soluble, 3-HPRD,BioGRID10536372 
LOXMGC105112lysyl oxidase-HPRD6912069 
LYZLZMlysozyme (renal amyloidosis)-HPRD9745729 
MFAP2MAGP | MAGP-1 | MAGP1microfibrillar-associated protein 2-HPRD8761465 |11723132 
NID2-nidogen 2 (osteonidogen)Tropoelastin interacts with Nidogen-2.BIND10544250 
-HPRD,BioGRID10544250 
PRTN3ACPA | AGP7 | C-ANCA | MBT | P29 | PR-3proteinase 3-HPRD,BioGRID11867344 
SPINK1PCTT | PSTI | Spink3 | TATIserine peptidase inhibitor, Kazal type 1-HPRD2093478 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
GESERICK_TERT_TARGETS_DN 2116All SZGR genes in this pathway
CHIARADONNA_NEOPLASTIC_TRANSFORMATION_KRAS_DN 14295All SZGR genes in this pathway
CHIARADONNA_NEOPLASTIC_TRANSFORMATION_CDC25_DN 153100All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP 552347All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_UP 211136All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_2B 392251All SZGR genes in this pathway
KORKOLA_TERATOMA 3925All SZGR genes in this pathway
BERTUCCI_INVASIVE_CARCINOMA_DUCTAL_VS_LOBULAR_DN 4634All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_DN 428306All SZGR genes in this pathway
POMEROY_MEDULLOBLASTOMA_PROGNOSIS_UP 4730All SZGR genes in this pathway
YAO_HOXA10_TARGETS_VIA_PROGESTERONE_UP 7958All SZGR genes in this pathway
KANG_IMMORTALIZED_BY_TERT_UP 8961All SZGR genes in this pathway
IGLESIAS_E2F_TARGETS_UP 151103All SZGR genes in this pathway
KUMAR_TARGETS_OF_MLL_AF9_FUSION 405264All SZGR genes in this pathway
WESTON_VEGFA_TARGETS_6HR 5938All SZGR genes in this pathway
MCDOWELL_ACUTE_LUNG_INJURY_UP 4529All SZGR genes in this pathway
MCCLUNG_COCAINE_REWARD_5D 7962All SZGR genes in this pathway
WESTON_VEGFA_TARGETS_12HR 3523All SZGR genes in this pathway
SIMBULAN_PARP1_TARGETS_UP 3123All SZGR genes in this pathway
LINDVALL_IMMORTALIZED_BY_TERT_DN 8056All SZGR genes in this pathway
WESTON_VEGFA_TARGETS 10871All SZGR genes in this pathway
KEEN_RESPONSE_TO_ROSIGLITAZONE_DN 10668All SZGR genes in this pathway
WESTON_VEGFA_TARGETS_3HR 7447All SZGR genes in this pathway
DOUGLAS_BMI1_TARGETS_UP 566371All SZGR genes in this pathway
LEE_METASTASIS_AND_ALTERNATIVE_SPLICING_UP 7451All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_DN 543317All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_DN 593372All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_DN 591366All SZGR genes in this pathway
SMID_BREAST_CANCER_RELAPSE_IN_BONE_DN 315197All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_DN 564326All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_UP 648398All SZGR genes in this pathway
THUM_MIR21_TARGETS_HEART_DISEASE_UP 177All SZGR genes in this pathway
WU_ALZHEIMER_DISEASE_DN 1912All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_2 8650All SZGR genes in this pathway
MIYAGAWA_TARGETS_OF_EWSR1_ETS_FUSIONS_UP 259159All SZGR genes in this pathway
PLASARI_TGFB1_TARGETS_10HR_UP 199143All SZGR genes in this pathway
NABA_ECM_GLYCOPROTEINS 19699All SZGR genes in this pathway
NABA_CORE_MATRISOME 275148All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1018558621A,m8hsa-miR-101UACAGUACUGUGAUAACUGAAG
miR-1448568621Ahsa-miR-144UACAGUAUAGAUGAUGUACUAG
miR-18158641Ahsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-1846616681A,m8hsa-miR-184UGGACGGAGAACUGAUAAGGGU
miR-2178508571A,m8hsa-miR-217UACUGCAUCAGGAACUGAUUGGAU
miR-29310316m8hsa-miR-29aSZUAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZUAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZUAGCACCAUUUGAAAUCGGU
hsa-miR-29aSZUAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZUAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZUAGCACCAUUUGAAAUCGGU
hsa-miR-29aSZUAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZUAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZUAGCACCAUUUGAAAUCGGU
miR-299-5p6268m8hsa-miR-299-5pUGGUUUACCGUCCCACAUACAU
miR-49660661Ahsa-miR-496AUUACAUGGCCAAUCUC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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