Gene Page: CTTN

Summary
GeneID  2017
Symbol  CTTN
Synonyms  EMS1|FLJ34459
Description  cortactin
See related  HGNC:3338|MIM:164765|Ensembl:ENSG00000085733|HPRD:01268|
Locus tag  -
Gene type  protein-coding
Map location  11q13
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0836 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIEA-
GO:0005515protein bindingISS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0001726ruffleISS-
GO:0005856cytoskeletonTAS9054437 
GO:0005625soluble fractionTAS9054437 
GO:0005737cytoplasmIEA-
GO:0005737cytoplasmISS-
GO:0030027lamellipodiumIEA-
GO:0030027lamellipodiumISS-
GO:0005938cell cortexIEA-
GO:0005938cell cortexISS-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACTR2ARP2ARP2 actin-related protein 2 homolog (yeast)Affinity Capture-MSBioGRID11018051 
ACTR3ARP3ARP3 actin-related protein 3 homolog (yeast)-HPRD,BioGRID12176742 
ARHGAP17DKFZp564A1363 | FLJ37567 | FLJ43368 | MGC87805 | MST066 | MST110 | MSTP038 | MSTP066 | MSTP110 | NADRIN | RICH1 | WBP15Rho GTPase activating protein 17Reconstituted ComplexBioGRID11431473 
ARHGAP8BPGAP1 | FLJ20185 | PP610Rho GTPase activating protein 8BPGAP1 interacts with Cortactin.BIND15064355 
ARPC2ARC34 | PNAS-139 | PRO2446 | p34-Arcactin related protein 2/3 complex, subunit 2, 34kDaAffinity Capture-MS
Affinity Capture-Western		BioGRID11018051 
ARPC3ARC21 | p21-Arcactin related protein 2/3 complex, subunit 3, 21kDaAffinity Capture-MSBioGRID11018051 
ARPC4ARC20 | MGC13544 | p20-Arcactin related protein 2/3 complex, subunit 4, 20kDaAffinity Capture-MSBioGRID11018051 
ASAP1AMAP1 | CENTB4 | DDEF1 | KIAA1249 | PAG2 | PAP | ZG14PArfGAP with SH3 domain, ankyrin repeat and PH domain 1DDEF1 (AMAP1) interacts with an unspecified isoform of CTTN (cortactin).BIND15719014 
CASP3CPP32 | CPP32B | SCA-1caspase 3, apoptosis-related cysteine peptidaseBiochemical ActivityBioGRID11689006 
CHD3Mi-2a | Mi2-ALPHA | ZFHchromodomain helicase DNA binding protein 3Two-hybridBioGRID16169070 
CRB2FLJ16786 | FLJ38464crumbs homolog 2 (Drosophila)Affinity Capture-WesternBioGRID11439336 
CTNND1CAS | CTNND | KIAA0384 | P120CAS | P120CTN | p120catenin (cadherin-associated protein), delta 1-HPRD,BioGRID12835311 
CTNND2GT24 | NPRAPcatenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)-HPRD12835311 
DNM1DNMdynamin 1-HPRD12419186 
DNM2CMTDI1 | CMTDIB | DI-CMTB | DYN2 | DYNIIdynamin 2-HPRD12419186 
FERTYK3fer (fps/fes related) tyrosine kinase-HPRD,BioGRID9722593 
FGD1AAS | FGDY | ZFYVE3FYVE, RhoGEF and PH domain containing 1-HPRD12913069 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2-HPRD11439336 
KCNA2HBK5 | HK4 | HUKIV | KV1.2 | MGC50217 | MK2 | NGK1 | RBK2potassium voltage-gated channel, shaker-related subfamily, member 2-HPRD,BioGRID12151401 
MYLKDKFZp686I10125 | FLJ12216 | KRP | MLCK | MLCK1 | MLCK108 | MLCK210 | MSTP083 | MYLK1 | smMLCKmyosin light chain kinase-HPRD,BioGRID12408982 
PXNFLJ16691paxillinPXN (Paxillin) interacts with an unspecified isoform of CTTN (cortactin).BIND15719014 
SDC3N-syndecan | SDCN | SYND3syndecan 3-HPRD,BioGRID9553134 
SHANK2CORTBP1 | CTTNBP1 | ProSAP1 | SHANK | SPANK-3SH3 and multiple ankyrin repeat domains 2-HPRD,BioGRID9742101 
SYKDKFZp313N1010 | FLJ25043 | FLJ37489spleen tyrosine kinase-HPRD,BioGRID8636079 
TJP1DKFZp686M05161 | MGC133289 | ZO-1tight junction protein 1 (zona occludens 1)-HPRD9792678|11018051 
WASLDKFZp779G0847 | MGC48327 | N-WASP | NWASPWiskott-Aldrich syndrome-like-HPRD,BioGRID11830518 
WIPF1MGC111041 | PRPL-2 | WASPIP | WIPWAS/WASL interacting protein family, member 1-HPRD,BioGRID12620186 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_TIGHT_JUNCTION 13486All SZGR genes in this pathway
KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION 5936All SZGR genes in this pathway
BIOCARTA_AGR_PATHWAY 3631All SZGR genes in this pathway
PID_ECADHERIN_NASCENT_AJ_PATHWAY 3933All SZGR genes in this pathway
PID_PDGFRB_PATHWAY 129103All SZGR genes in this pathway
PID_SYNDECAN_3_PATHWAY 1715All SZGR genes in this pathway
PID_NCADHERIN_PATHWAY 3332All SZGR genes in this pathway
PID_FGF_PATHWAY 5537All SZGR genes in this pathway
PYEON_HPV_POSITIVE_TUMORS_DN 105All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_UP 783507All SZGR genes in this pathway
BORCZUK_MALIGNANT_MESOTHELIOMA_DN 10459All SZGR genes in this pathway
GINESTIER_BREAST_CANCER_20Q13_AMPLIFICATION_UP 11966All SZGR genes in this pathway
SENESE_HDAC1_TARGETS_UP 457269All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_UP 501327All SZGR genes in this pathway
NAGASHIMA_NRG1_SIGNALING_UP 176123All SZGR genes in this pathway
JAATINEN_HEMATOPOIETIC_STEM_CELL_DN 226132All SZGR genes in this pathway
DELYS_THYROID_CANCER_UP 443294All SZGR genes in this pathway
CHIN_BREAST_CANCER_COPY_NUMBER_UP 2718All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN 770415All SZGR genes in this pathway
MAHADEVAN_RESPONSE_TO_MP470_DN 1911All SZGR genes in this pathway
SNIJDERS_AMPLIFIED_IN_HEAD_AND_NECK_TUMORS 3727All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN 514319All SZGR genes in this pathway
MURATA_VIRULENCE_OF_H_PILORI 2416All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM1 229137All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_UP 479299All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
NAKAYAMA_FRA2_TARGETS 4327All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
LIU_NASOPHARYNGEAL_CARCINOMA 7038All SZGR genes in this pathway
WEI_MYCN_TARGETS_WITH_E_BOX 795478All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_11Q12_Q14_AMPLICON 15893All SZGR genes in this pathway
DING_LUNG_CANCER_EXPRESSION_BY_COPY_NUMBER 10062All SZGR genes in this pathway
ONDER_CDH1_TARGETS_1_UP 14085All SZGR genes in this pathway
PENG_GLUCOSE_DEPRIVATION_UP 4826All SZGR genes in this pathway
PENG_RAPAMYCIN_RESPONSE_UP 203130All SZGR genes in this pathway
STONER_ESOPHAGEAL_CARCINOGENESIS_UP 3925All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_LB_UP 4828All SZGR genes in this pathway
MENSE_HYPOXIA_UP 9871All SZGR genes in this pathway
REN_ALVEOLAR_RHABDOMYOSARCOMA_DN 408274All SZGR genes in this pathway
KAAB_FAILED_HEART_ATRIUM_DN 14199All SZGR genes in this pathway
RAMALHO_STEMNESS_UP 206118All SZGR genes in this pathway
SIMBULAN_PARP1_TARGETS_UP 3123All SZGR genes in this pathway
WEIGEL_OXIDATIVE_STRESS_BY_HNE_AND_TBH 6042All SZGR genes in this pathway
BURTON_ADIPOGENESIS_7 5134All SZGR genes in this pathway
RAMPON_ENRICHED_LEARNING_ENVIRONMENT_LATE_UP 2216All SZGR genes in this pathway
JI_RESPONSE_TO_FSH_UP 7456All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_UP 953554All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_UP 783442All SZGR genes in this pathway
GAVIN_FOXP3_TARGETS_CLUSTER_P4 10062All SZGR genes in this pathway
FOSTER_TOLERANT_MACROPHAGE_UP 15692All SZGR genes in this pathway
HELLER_HDAC_TARGETS_UP 317208All SZGR genes in this pathway
AMUNDSON_POOR_SURVIVAL_AFTER_GAMMA_RADIATION_2G 17196All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_DN 543317All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_UP 602364All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_UP 601369All SZGR genes in this pathway
SAGIV_CD24_TARGETS_DN 4626All SZGR genes in this pathway
GRADE_COLON_CANCER_UP 871505All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_DN 546362All SZGR genes in this pathway
CLIMENT_BREAST_CANCER_COPY_NUMBER_UP 2320All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_C_D_DN 252155All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_DN 366257All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_GOOD_SURVIVAL_A12 317177All SZGR genes in this pathway
FONTAINE_PAPILLARY_THYROID_CARCINOMA_UP 6638All SZGR genes in this pathway
RAGHAVACHARI_PLATELET_SPECIFIC_GENES 7046All SZGR genes in this pathway
PILON_KLF1_TARGETS_UP 504321All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_UP 430288All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_DN 918550All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_UP 682433All SZGR genes in this pathway
TORCHIA_TARGETS_OF_EWSR1_FLI1_FUSION_UP 271165All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_NOT_SATB1_DN 448282All SZGR genes in this pathway
PEDERSEN_METASTASIS_BY_ERBB2_ISOFORM_7 403240All SZGR genes in this pathway
DELACROIX_RARG_BOUND_MEF 367231All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-221/222134813541Ahsa-miR-221brainAGCUACAUUGUCUGCUGGGUUUC
hsa-miR-222brainAGCUACAUCUGGCUACUGGGUCUC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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