Gene Page: ERBB2

Summary
GeneID  2064
Symbol  ERBB2
Synonyms  CD340|HER-2|HER-2/neu|HER2|NEU|NGL|TKR1
Description  v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
See related  HGNC:3430|MIM:164870|Ensembl:ENSG00000141736|HPRD:01281|
Locus tag  -
Gene type  protein-coding
Map location  17q11.2-q12|17q21.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 6 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 5.3826 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
PSMA20.930.92
DIABLO0.930.92
IFT520.920.94
POLB0.920.93
ALKBH20.920.92
PHF5A0.910.90
CCT70.910.88
BTF30.910.91
TSG1010.910.93
C14orf1660.910.89
Top 10 negatively co-expressed genes
AF347015.27-0.68-0.79
AF347015.15-0.67-0.80
AF347015.33-0.67-0.78
AF347015.8-0.67-0.78
MT-CYB-0.66-0.78
MT-CO2-0.65-0.74
AF347015.26-0.65-0.81
TINAGL1-0.65-0.75
HLA-F-0.65-0.72
AF347015.2-0.64-0.79
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004714transmembrane receptor protein tyrosine kinase activityIEAneurite (GO term level: 8)-
GO:0000166nucleotide bindingIEA-
GO:0005006epidermal growth factor receptor activityNAS15504738 
GO:0004888transmembrane receptor activityIDA7514177 
GO:0004716receptor signaling protein tyrosine kinase activityTAS10851066 
GO:0005509calcium ion bindingIEA-
GO:0005524ATP bindingIEA-
GO:0004713protein tyrosine kinase activityIEA-
GO:0004715non-membrane spanning protein tyrosine kinase activityIDA10485918 
GO:0016740transferase activityIEA-
GO:0019838growth factor bindingIDA7514177 
GO:0042802identical protein bindingIPI16843263 
GO:0043125ErbB-3 class receptor bindingTAS9590694 
GO:0046982protein heterodimerization activityIDA10572067 
GO:0046982protein heterodimerization activityNAS15504738 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0008045motor axon guidanceIEAneuron, axon (GO term level: 14)-
GO:0042552myelinationIEAneuron, axon, Brain, oligodendrocyte (GO term level: 13)-
GO:0007528neuromuscular junction developmentIEASynap (GO term level: 10)-
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayIDA10485918 
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayNAS15609325 
GO:0006468protein amino acid phosphorylationIEA-
GO:0008283cell proliferationTAS10851066 
GO:0007507heart developmentIEA-
GO:0007507heart developmentTAS15504738 
GO:0007422peripheral nervous system developmentIEA-
GO:0048015phosphoinositide-mediated signalingNAS15504738 
GO:0014065phosphoinositide 3-kinase cascadeIDA7556068 
GO:0042060wound healingIDA12646923 
GO:0033088negative regulation of immature T cell proliferation in the thymusIEA-
GO:0030879mammary gland developmentTAS15504738 
GO:0043406positive regulation of MAP kinase activityIDA10572067 
GO:0045785positive regulation of cell adhesionIDA7556068 
GO:0045765regulation of angiogenesisNAS15609325 
GO:0050679positive regulation of epithelial cell proliferationIDA10572067 
GO:0046777protein amino acid autophosphorylationIDA7556068 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0043235receptor complexIDANeurotransmitter (GO term level: 4)7514177 
GO:0043235receptor complexTASNeurotransmitter (GO term level: 4)7556068 
GO:0005576extracellular regionIDA10485918 
GO:0005737cytoplasmIEA-
GO:0016020membraneIEA-
GO:0016021integral to membraneNAS15609325 
GO:0005886plasma membraneNAS12000754 
GO:0016323basolateral plasma membraneIDA12646923 
GO:0016324apical plasma membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AGTR2AT2 | ATGR2 | MRX88angiotensin II receptor, type 2-HPRD10710290 
BTC-betacellulin-HPRD9662041 
CAV1CAV | MSTP085 | VIP21caveolin 1, caveolae protein, 22kDa-HPRD9685399 
CD44CDW44 | CSPG8 | ECMR-III | HCELL | IN | LHR | MC56 | MDU2 | MDU3 | MGC10468 | MIC4 | MUTCH-I | Pgp1CD44 molecule (Indian blood group)Affinity Capture-WesternBioGRID12093135 
CD824F9 | C33 | GR15 | IA4 | KAI1 | R2 | SAR2 | ST6 | TSPAN27CD82 molecule-HPRD,BioGRID14576349 
CDC37P50CDC37cell division cycle 37 homolog (S. cerevisiae)An unspecified isoform of ERBB2 interacts with P50CDC37. This interaction was modelled on a demonstrated interaction between human ERBB2 and monkey P50CDC37.BIND15643424 
CTNNB1CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923catenin (cadherin-associated protein), beta 1, 88kDa-HPRD,BioGRID7702605 
DDX10HRH-J8DEAD (Asp-Glu-Ala-Asp) box polypeptide 10ErbB-2 interacts with the DDX10 locus.BIND15380516 
DLG4FLJ97752 | FLJ98574 | PSD95 | SAP90discs, large homolog 4 (Drosophila)-HPRD,BioGRID10839362 
EGFHOMG4 | URGepidermal growth factor (beta-urogastrone)-HPRD,BioGRID12093292 
EGFRERBB | ERBB1 | HER1 | PIG61 | mENAepidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)-HPRD11500850 
EGFR interacts with ErbB2.BIND15652750 
ERBB2CD340 | HER-2 | HER-2/neu | HER2 | NEU | NGL | TKR1v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)Affinity Capture-WesternBioGRID14576349 
ERBB2IPERBIN | LAP2erbb2 interacting protein-HPRD,BioGRID10878805 |11278603 
ERBB3ErbB-3 | HER3 | LCCS2 | MDA-BF-1 | MGC88033 | c-erbB-3 | c-erbB3 | erbB3-S | p180-ErbB3 | p45-sErbB3 | p85-sErbB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)-HPRD7538656 |10799311 
-HPRD7538656 
ERBB4HER4 | MGC138404 | p180erbB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)Affinity Capture-WesternBioGRID10839362 
ERRFI1GENE-33 | MIG-6 | MIG6 | RALTERBB receptor feedback inhibitor 1RALT interacts with an unspecified isoform of ERBB2. This interaction was modeled on a demonstrated interaction between RALT from an unspecified species and human ERBB2.BIND15856022 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2-HPRD11173924 |11606575|11606575 
-HPRD,BioGRID11606575 
GRB7-growth factor receptor-bound protein 7-HPRD,BioGRID9079677 
H3F3AH3.3A | H3F3 | MGC87782 | MGC87783H3 histone, family 3AHistone H3 interacts with erbB2 promoter.BIND15311210 
HLA-AHLAAmajor histocompatibility complex, class I, A-HPRD,BioGRID10593938 
HSP90AA1FLJ31884 | HSP86 | HSP89A | HSP90A | HSP90N | HSPC1 | HSPCA | HSPCAL1 | HSPCAL4 | HSPN | Hsp89 | Hsp90 | LAP2heat shock protein 90kDa alpha (cytosolic), class A member 1ERBB2 interacts with HSP90. This interaction was modelled on a demonstrated interaction between human ERBB2 and monkey HSP90.BIND15643424 
-HPRD,BioGRID11071886 
HSP90B1ECGP | GP96 | GRP94 | TRA1heat shock protein 90kDa beta (Grp94), member 1-HPRD,BioGRID8617772 
IL6STCD130 | CDw130 | GP130 | GP130-RAPS | IL6R-betainterleukin 6 signal transducer (gp130, oncostatin M receptor)-HPRD,BioGRID11821958 
ITGB4CD104integrin, beta 4-HPRD11375975 
JAK2JTK10Janus kinase 2 (a protein tyrosine kinase)-HPRD,BioGRID11940572 
JUPARVD12 | CTNNG | DP3 | DPIII | PDGB | PKGBjunction plakoglobin-HPRD,BioGRID7702605 
MATKCHK | CTK | DKFZp434N1212 | HHYLTK | HYL | HYLTK | Lsk | MGC1708 | MGC2101megakaryocyte-associated tyrosine kinase-HPRD12122014 
MMP16MMP-X2 | MT-MMP2 | MT-MMP3 | MT3-MMPmatrix metallopeptidase 16 (membrane-inserted)ErbB-2 interacts with the MMP16 locus.BIND15380516 
MUC1CD227 | EMA | H23AG | MAM6 | PEM | PEMT | PUMmucin 1, cell surface associated-HPRD,BioGRID11278868 
MUC4HSA276359mucin 4, cell surface associated-HPRD11598901 |11687512 
|12434309 
NCOA3ACTR | AIB-1 | AIB1 | CAGH16 | CTG26 | KAT13B | MGC141848 | RAC3 | SRC3 | TNRC14 | TNRC16 | TRAM-1 | pCIPnuclear receptor coactivator 3NCOA3 (AIB1) interacts with the ERBB2 (HER2) promoter.BIND15788656 
NCOR1KIAA1047 | MGC104216 | N-CoR | TRAC1 | hCIT529I10 | hN-CoRnuclear receptor co-repressor 1NCOR1 (NCoR) interacts with the ERBB2 (HER2) promoter.BIND15788656 
NF2ACN | BANF | SCHneurofibromin 2 (merlin)-HPRD12118253 
NRG1ARIA | GGF | GGF2 | HGL | HRG | HRG1 | HRGA | NDF | SMDFneuregulin 1Reconstituted ComplexBioGRID7592681 
-HPRD9168114 
OSMRMGC150626 | MGC150627 | MGC75127 | OSMRBoncostatin M receptorAffinity Capture-WesternBioGRID11821958 
PAK1MGC130000 | MGC130001 | PAKalphap21 protein (Cdc42/Rac)-activated kinase 1-HPRD,BioGRID9774445 
PICK1MGC15204 | PICK | PRKCABPprotein interacting with PRKCA 1-HPRD,BioGRID11278603 
PIK3R1GRB1 | p85 | p85-ALPHAphosphoinositide-3-kinase, regulatory subunit 1 (alpha)-HPRD1351056 
PIK3R2P85B | p85 | p85-BETAphosphoinositide-3-kinase, regulatory subunit 2 (beta)-HPRD,BioGRID1334406 
PLCG1PLC-II | PLC1 | PLC148 | PLCgamma1phospholipase C, gamma 1-HPRD,BioGRID1676673 |1683701 
PTK2FADK | FAK | FAK1 | pp125FAKPTK2 protein tyrosine kinase 2-HPRD11807823 
PTK2BCADTK | CAKB | FADK2 | FAK2 | FRNK | PKB | PTK | PYK2 | RAFTKPTK2B protein tyrosine kinase 2 beta-HPRD,BioGRID10713673 
PTPN11BPTP3 | CFC | MGC14433 | NS1 | PTP-1D | PTP2C | SH-PTP2 | SH-PTP3 | SHP2protein tyrosine phosphatase, non-receptor type 11Affinity Capture-MSBioGRID16729043 
SERPINA3AACT | ACT | GIG24 | GIG25 | MGC88254serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3-HPRD10829039 
SH3BGRLMGC117402 | SH3BGRSH3 domain binding glutamic acid-rich protein likeAffinity Capture-MSBioGRID16729043 
SHC1FLJ26504 | SHC | SHCASHC (Src homology 2 domain containing) transforming protein 1-HPRD,BioGRID9710588 
SOS1GF1 | GGF1 | GINGF | HGF | NS4son of sevenless homolog 1 (Drosophila)-HPRD11173924 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)-HPRD7542762 
Reconstituted ComplexBioGRID11940572 
SRC (SRC-1) interacts with the ERBB2 (HER2) promoter.BIND15788656 
STAT3APRF | FLJ20882 | HIES | MGC16063signal transducer and activator of transcription 3 (acute-phase response factor)Affinity Capture-WesternBioGRID11940572 
TOB1APRO6 | MGC104792 | MGC34446 | PIG49 | TOB | TROB | TROB1transducer of ERBB2, 1-HPRD8632892 
TP53RKBUD32 | C20orf64 | Nori-2 | Nori-2p | PRPK | dJ101A2TP53 regulating kinaseErbB-2 interacts with the PRPK promoter.BIND15380516 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_ERBB_SIGNALING_PATHWAY 8771All SZGR genes in this pathway
KEGG_CALCIUM_SIGNALING_PATHWAY 178134All SZGR genes in this pathway
KEGG_FOCAL_ADHESION 201138All SZGR genes in this pathway
KEGG_ADHERENS_JUNCTION 7553All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_PANCREATIC_CANCER 7056All SZGR genes in this pathway
KEGG_ENDOMETRIAL_CANCER 5245All SZGR genes in this pathway
KEGG_PROSTATE_CANCER 8975All SZGR genes in this pathway
KEGG_BLADDER_CANCER 4233All SZGR genes in this pathway
KEGG_NON_SMALL_CELL_LUNG_CANCER 5447All SZGR genes in this pathway
PID_ERBB4_PATHWAY 3832All SZGR genes in this pathway
PID_ERBB2_ERBB3_PATHWAY 4435All SZGR genes in this pathway
PID_ERBB_NETWORK_PATHWAY 1513All SZGR genes in this pathway
PID_A6B1_A6B4_INTEGRIN_PATHWAY 4635All SZGR genes in this pathway
PID_MYC_REPRESS_PATHWAY 6352All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING 129All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ERBB2 10178All SZGR genes in this pathway
REACTOME_GRB2_EVENTS_IN_ERBB2_SIGNALING 2220All SZGR genes in this pathway
REACTOME_PI3K_EVENTS_IN_ERBB2_SIGNALING 4434All SZGR genes in this pathway
REACTOME_AXON_GUIDANCE 251188All SZGR genes in this pathway
REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING 3222All SZGR genes in this pathway
REACTOME_SEMAPHORIN_INTERACTIONS 6853All SZGR genes in this pathway
REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE 2721All SZGR genes in this pathway
DAVICIONI_MOLECULAR_ARMS_VS_ERMS_DN 182111All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_UP 450256All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_UP 1821933All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN 805505All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_48HR_UP 12895All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_96HR_UP 11784All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_1_DN 378231All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_3_UP 329196All SZGR genes in this pathway
CHIN_BREAST_CANCER_COPY_NUMBER_UP 2718All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN 770415All SZGR genes in this pathway
BARIS_THYROID_CANCER_DN 5945All SZGR genes in this pathway
HAMAI_APOPTOSIS_VIA_TRAIL_DN 186107All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_TTD_UP 6439All SZGR genes in this pathway
BREUHAHN_GROWTH_FACTOR_SIGNALING_IN_LIVER_CANCER 2219All SZGR genes in this pathway
LI_AMPLIFIED_IN_LUNG_CANCER 178108All SZGR genes in this pathway
MYLLYKANGAS_AMPLIFICATION_HOT_SPOT_12 118All SZGR genes in this pathway
FARMER_BREAST_CANCER_CLUSTER_8 77All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_UP 309199All SZGR genes in this pathway
LIEN_BREAST_CARCINOMA_METAPLASTIC_VS_DUCTAL_DN 11458All SZGR genes in this pathway
LI_WILMS_TUMOR_VS_FETAL_KIDNEY_2_DN 5142All SZGR genes in this pathway
BERTUCCI_INVASIVE_CARCINOMA_DUCTAL_VS_LOBULAR_UP 2517All SZGR genes in this pathway
BENPORATH_ES_1 379235All SZGR genes in this pathway
BENPORATH_NANOG_TARGETS 988594All SZGR genes in this pathway
BENPORATH_SOX2_TARGETS 734436All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_17Q11_Q21_AMPLICON 13378All SZGR genes in this pathway
FRASOR_RESPONSE_TO_ESTRADIOL_DN 8252All SZGR genes in this pathway
WEIGEL_OXIDATIVE_STRESS_BY_HNE_AND_H2O2 3929All SZGR genes in this pathway
KAAB_HEART_ATRIUM_VS_VENTRICLE_UP 249170All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_14HR_DN 298200All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_DN 504323All SZGR genes in this pathway
HEDENFALK_BREAST_CANCER_BRCA1_VS_BRCA2 163113All SZGR genes in this pathway
DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_DN 287208All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_5 482296All SZGR genes in this pathway
HILLION_HMGA1_TARGETS 9071All SZGR genes in this pathway
HILLION_HMGA1B_TARGETS 9268All SZGR genes in this pathway
KYNG_DNA_DAMAGE_BY_GAMMA_RADIATION 8159All SZGR genes in this pathway
KYNG_DNA_DAMAGE_UP 226164All SZGR genes in this pathway
MASSARWEH_TAMOXIFEN_RESISTANCE_UP 578341All SZGR genes in this pathway
SMID_BREAST_CANCER_ERBB2_UP 14783All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_DN 701446All SZGR genes in this pathway
CLIMENT_BREAST_CANCER_COPY_NUMBER_UP 2320All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP 323240All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_UP 165118All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_DN 13892All SZGR genes in this pathway
MOOTHA_MITOCHONDRIA 447277All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_GOOD_SURVIVAL_A4 196124All SZGR genes in this pathway
HAN_SATB1_TARGETS_UP 395249All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_DN 668419All SZGR genes in this pathway
TCGA_GLIOBLASTOMA_MUTATED 88All SZGR genes in this pathway
DANG_REGULATED_BY_MYC_DN 253192All SZGR genes in this pathway
DANG_MYC_TARGETS_DN 3125All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
CHANDRAN_METASTASIS_DN 306191All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_6HR_DN 9156All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN 505328All SZGR genes in this pathway
PEDRIOLI_MIR31_TARGETS_UP 221120All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_DN 428246All SZGR genes in this pathway


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.