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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: ETF1

Summary

GeneID

2107

Symbol

ETF1

Synonyms

D5S1995|ERF|ERF1|MGC111066|RF1|SUP45L1|TB3-1

Description

eukaryotic translation termination factor 1

Locus tag

Gene type

protein-coding

Map location

5q31.1

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GSMA_I

genome scan meta-analysis

Psr: 0.0032

Expression

P value: 1.79

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.0278

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

MDS1

1.00

FLI1

0.82

0.80

ITGA1

0.81

0.82

COBLL1

0.77

0.78

OCLN

0.76

0.78

FGD5

0.75

0.78

ETS1

0.75

0.80

TEK

0.75

0.77

TGFBR2

0.73

0.79

CDH5

0.73

Top 10 negatively co-expressed genes

RPS21

-0.38

-0.45

FAM128A

-0.37

-0.35

MRPL52

-0.37

-0.38

SNHG12

-0.36

RPL31

-0.36

-0.43

C12orf45

-0.36

-0.37

ATP5E

-0.36

-0.41

BLOC1S1

-0.36

-0.35

ST20

-0.36

AC008763.1

-0.35

-0.40

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0003723

RNA binding

TAS

7990965

GO:0005515

protein binding

IPI

9620853 |9712840

GO:0016149

translation release factor activity, codon specific

IEA

GO:0043022

ribosome binding

TAS

12867083

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006449

regulation of translational termination

TAS

7990965

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005737

cytoplasm

TAS

7990965

Interactions

Shown by Network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
GSPT1	551G9.2 \| ETF3A \| FLJ38048 \| FLJ39067 \| GST1 \| eRF3a	G1 to S phase transition 1	-	HPRD,BioGRID	9712840
GSPT2	FLJ10441 \| GST2 \| eRF3b	G1 to S phase transition 2	-	HPRD,BioGRID	9712840
KEAP1	INrf2 \| KIAA0132 \| KLHL19 \| MGC10630 \| MGC1114 \| MGC20887 \| MGC4407 \| MGC9454	kelch-like ECH-associated protein 1	Two-hybrid	BioGRID	16189514
PABPC1	PAB1 \| PABP \| PABP1 \| PABPC2 \| PABPL1	poly(A) binding protein, cytoplasmic 1	Affinity Capture-Western	BioGRID	18056425
PAN3	-	PAN3 polyA specific ribonuclease subunit homolog (S. cerevisiae)	Reconstituted Complex	BioGRID	18056425
PPP2CA	PP2Ac \| PP2CA \| RP-C	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	Affinity Capture-Western Co-purification Two-hybrid	BioGRID	9003791

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
REACTOME_TRANSLATION	222	75	All SZGR genes in this pathway
REACTOME_METABOLISM_OF_PROTEINS	518	242	All SZGR genes in this pathway
REACTOME_METABOLISM_OF_MRNA	284	128	All SZGR genes in this pathway
REACTOME_METABOLISM_OF_RNA	330	155	All SZGR genes in this pathway
REACTOME_NONSENSE_MEDIATED_DECAY_ENHANCED_BY_THE_EXON_JUNCTION_COMPLEX	176	57	All SZGR genes in this pathway
GARY_CD5_TARGETS_DN	431	263	All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP	1382	904	All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN	455	304	All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_6HR_DN	167	100	All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_24HR_UP	557	331	All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP	1278	748	All SZGR genes in this pathway
ELVIDGE_HYPOXIA_DN	146	94	All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP	552	347	All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN	1781	1082	All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN	770	415	All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_UP	536	340	All SZGR genes in this pathway
SCHLOSSER_MYC_TARGETS_REPRESSED_BY_SERUM	159	93	All SZGR genes in this pathway
DIRMEIER_LMP1_RESPONSE_LATE_UP	57	41	All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN	584	395	All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK	1652	1023	All SZGR genes in this pathway
WEI_MYCN_TARGETS_WITH_E_BOX	795	478	All SZGR genes in this pathway
SCIAN_INVERSED_TARGETS_OF_TP53_AND_TP73_DN	31	23	All SZGR genes in this pathway
BENPORATH_MYC_MAX_TARGETS	775	494	All SZGR genes in this pathway
SHEPARD_CRUSH_AND_BURN_MUTANT_UP	197	110	All SZGR genes in this pathway
PENG_LEUCINE_DEPRIVATION_DN	187	122	All SZGR genes in this pathway
BYSTROEM_CORRELATED_WITH_IL5_UP	51	30	All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_DN	309	206	All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS	882	572	All SZGR genes in this pathway
PENG_RAPAMYCIN_RESPONSE_DN	245	154	All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP	555	346	All SZGR genes in this pathway
NEMETH_INFLAMMATORY_RESPONSE_LPS_UP	88	64	All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_LATE_PROGENITOR	544	307	All SZGR genes in this pathway
SESTO_RESPONSE_TO_UV_C1	72	45	All SZGR genes in this pathway
MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP	393	244	All SZGR genes in this pathway
HOWLIN_CITED1_TARGETS_2_DN	17	11	All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_STIMULATED	1022	619	All SZGR genes in this pathway
FOSTER_TOLERANT_MACROPHAGE_UP	156	92	All SZGR genes in this pathway
ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_UP	863	514	All SZGR genes in this pathway
YAGI_AML_WITH_INV_16_TRANSLOCATION	422	277	All SZGR genes in this pathway
MARSON_FOXP3_TARGETS_DN	54	38	All SZGR genes in this pathway
GUTIERREZ_MULTIPLE_MYELOMA_UP	35	24	All SZGR genes in this pathway
DANG_BOUND_BY_MYC	1103	714	All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_7	76	46	All SZGR genes in this pathway
THILLAINADESAN_ZNF217_TARGETS_UP	44	22	All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_C	92	60	All SZGR genes in this pathway
LEE_BMP2_TARGETS_DN	882	538	All SZGR genes in this pathway
HUANG_GATA2_TARGETS_DN	72	52	All SZGR genes in this pathway
RAO_BOUND_BY_SALL4_ISOFORM_B	517	302	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-124.1	88	94	m8	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-124/506	88	94	1A	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	88	94	1A	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-134	1481	1487	m8	hsa-miR-134^brain	UGUGACUGGUUGACCAGAGGG
miR-136	2177	2184	1A,m8	hsa-miR-136	ACUCCAUUUGUUUUGAUGAUGGA
miR-150	832	839	1A,m8	hsa-miR-150	UCUCCCAACCCUUGUACCAGUG
miR-17-5p/20/93.mr/106/519.d	1442	1448	1A	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-181	962	968	m8	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-182	1966	1972	1A	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-186	1982	1988	1A	hsa-miR-186	CAAAGAAUUCUCCUUUUGGGCUU
miR-200bc/429	2187	2193	1A	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
miR-205	1349	1355	1A	hsa-miR-205	UCCUUCAUUCCACCGGAGUCUG
miR-205	1349	1355	1A	hsa-miR-205	UCCUUCAUUCCACCGGAGUCUG
miR-216	952	959	1A,m8	hsa-miR-216	UAAUCUCAGCUGGCAACUGUG
miR-23	959	965	1A	hsa-miR-23a^brain	AUCACAUUGCCAGGGAUUUCC
miR-23	959	965	1A	hsa-miR-23b^brain	AUCACAUUGCCAGGGAUUACC
miR-26	1564	1570	1A	hsa-miR-26a^brain	UUCAAGUAAUCCAGGAUAGGC
miR-26	1564	1570	1A	hsa-miR-26b^SZ	UUCAAGUAAUUCAGGAUAGGUU
miR-299-5p	2192	2198	1A	hsa-miR-299-5p	UGGUUUACCGUCCCACAUACAU
miR-299-5p	2192	2198	1A	hsa-miR-299-5p	UGGUUUACCGUCCCACAUACAU
miR-320	1492	1498	1A	hsa-miR-320	AAAAGCUGGGUUGAGAGGGCGAA
miR-324-3p	447	453	1A	hsa-miR-324-3p	CCACUGCCCCAGGUGCUGCUGG
miR-326	1849	1855	1A	hsa-miR-326	CCUCUGGGCCCUUCCUCCAG
miR-329	2034	2040	1A	hsa-miR-329^brain	AACACACCUGGUUAACCUCUUU
miR-330	1733	1739	m8	hsa-miR-330^brain	GCAAAGCACACGGCCUGCAGAGA
miR-335	292	298	m8	hsa-miR-335^brain	UCAAGAGCAAUAACGAAAAAUGU
miR-34b	1536	1542	1A	hsa-miR-34b	UAGGCAGUGUCAUUAGCUGAUUG
miR-381	295	301	m8	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-410	2022	2028	1A	hsa-miR-410	AAUAUAACACAGAUGGCCUGU
miR-490	1523	1530	1A,m8	hsa-miR-490	CAACCUGGAGGACUCCAUGCUG
miR-493-5p	2168	2174	m8	hsa-miR-493-5p	UUGUACAUGGUAGGCUUUCAUU
miR-496	1590	1596	1A	hsa-miR-496	AUUACAUGGCCAAUCUC
miR-496	1590	1596	1A	hsa-miR-496	AUUACAUGGCCAAUCUC
miR-505	545	551	1A	hsa-miR-505	GUCAACACUUGCUGGUUUCCUC
miR-543	963	969	m8	hsa-miR-543	AAACAUUCGCGGUGCACUUCU
miR-544	1756	1762	m8	hsa-miR-544	AUUCUGCAUUUUUAGCAAGU
miR-96	1966	1972	1A	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.