Gene Page: FGF2

Summary
GeneID  2247
Symbol  FGF2
Synonyms  BFGF|FGFB|HBGF-2
Description  fibroblast growth factor 2 (basic)
See related  HGNC:3676|MIM:134920|Ensembl:ENSG00000138685|HPRD:00622|
Locus tag  -
Gene type  protein-coding
Map location  4q26-q27
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
GLUD10.910.88
SLC4A40.900.87
HTRA10.890.90
NT5E0.890.90
ATP13A40.890.89
ATP1A20.880.86
SUCLG20.870.84
SLC1A30.870.79
ADHFE10.870.90
MERTK0.860.89
Top 10 negatively co-expressed genes
DUSP12-0.58-0.68
MED19-0.58-0.67
ZNF821-0.58-0.67
BZW2-0.58-0.71
MLLT11-0.57-0.65
MPP3-0.57-0.67
RTF1-0.57-0.68
USF1-0.57-0.67
SPATS2-0.57-0.66
ZBTB8A-0.56-0.64
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI11075807 
GO:0008201heparin bindingIEA-
GO:0008083growth factor activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0010001glial cell differentiationIEAGlial (GO term level: 8)-
GO:0007399nervous system developmentTASneurite (GO term level: 5)9576942 
GO:0000186activation of MAPKK activityIEA-
GO:0000187activation of MAPK activityTAS9712850 
GO:0001759induction of an organIEA-
GO:0001934positive regulation of protein amino acid phosphorylationIEA-
GO:0007265Ras protein signal transductionTAS10848592 
GO:0009887organ morphogenesisTAS10903182 
GO:0007165signal transductionNAS9712850 
GO:0008285negative regulation of cell proliferationIEA-
GO:0008543fibroblast growth factor receptor signaling pathwayEXP17133345 
GO:0006935chemotaxisTAS10848592 
GO:0007275multicellular organismal developmentIEA-
GO:0021940positive regulation of granule cell precursor proliferationIEA-
GO:0030324lung developmentIEA-
GO:0045766positive regulation of angiogenesisIEA-
GO:0050679positive regulation of epithelial cell proliferationIEA-
GO:0045597positive regulation of cell differentiationIEA-
GO:0046668regulation of retinal cell programmed cell deathIEA-
GO:0060045positive regulation of cardiac muscle cell proliferationIDA9553078 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionEXP1697263 |8622701 |9139660 
|11294897 |16597617 
GO:0005576extracellular regionTAS10490103 
GO:0005615extracellular spaceTAS2435575 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
API5AAC-11 | AAC11 | API5L1apoptosis inhibitor 5-HPRD11075807 
CD44CDW44 | CSPG8 | ECMR-III | HCELL | IN | LHR | MC56 | MDU2 | MDU3 | MGC10468 | MIC4 | MUTCH-I | Pgp1CD44 molecule (Indian blood group)-HPRD7532176 
CEP57KIAA0092 | PIG8 | TSP57centrosomal protein 57kDa-HPRD12717444 
CSNK2A1CK2A1 | CKIIcasein kinase 2, alpha 1 polypeptide-HPRD,BioGRID12145206 
CSNK2A2CK2A2 | CSNK2A1 | FLJ43934casein kinase 2, alpha prime polypeptideReconstituted ComplexBioGRID12145206 
-HPRD7735329 
CSNK2BCK2B | CK2N | CSK2B | G5A | MGC138222 | MGC138224casein kinase 2, beta polypeptideReconstituted ComplexBioGRID12145206 
CXCL13ANGIE | ANGIE2 | BCA-1 | BCA1 | BLC | BLR1L | SCYB13chemokine (C-X-C motif) ligand 13-HPRD11708770 
FGFBP1FGFBP | HBP17fibroblast growth factor binding protein 1-HPRD,BioGRID11509569 
FGFR1BFGFR | CD331 | CEK | FGFBR | FLG | FLJ99988 | FLT2 | HBGFR | KAL2 | N-SAMfibroblast growth factor receptor 1-HPRD,BioGRID10950949 |11030354 
FGFR2BEK | BFR-1 | CD332 | CEK3 | CFD1 | ECT1 | FLJ98662 | JWS | K-SAM | KGFR | TK14 | TK25fibroblast growth factor receptor 2-HPRD10950949 
FGFR4CD334 | JTK2 | MGC20292 | TKFfibroblast growth factor receptor 4-HPRD8530375 
GPC3DGSX | OCI-5 | SDYS | SGB | SGBS | SGBS1glypican 3-HPRD,BioGRID12478660 
GPC4K-glypicanglypican 4-HPRD,BioGRID11066092 
HSPG2PLC | PRCAN | SJA | SJS | SJS1heparan sulfate proteoglycan 2-HPRD11847221 
NRP1BDCA4 | CD304 | DKFZp686A03134 | DKFZp781F1414 | NP1 | NRP | VEGF165Rneuropilin 1NRP1 (Npn-1) interacts with FGF2. This interaction was modeled on a demonstrated interaction between rat NRP1 and human FGF2.BIND15695515 
PF4CXCL4 | MGC138298 | SCYB4platelet factor 4-HPRD9558385 
RPL6SHUJUN-2 | TAXREB107 | TXREB1ribosomal protein L6-HPRD,BioGRID9826564 
RPS19DBAribosomal protein S19-HPRD,BioGRID11716516 
SDC1CD138 | SDC | SYND1 | syndecansyndecan 1Co-purificationBioGRID16982797 
SDC2HSPG | HSPG1 | SYND2syndecan 2Co-purificationBioGRID16982797 
SDC3N-syndecan | SDCN | SYND3syndecan 3-HPRD,BioGRID8344959 
SDC4MGC22217 | SYND4syndecan 4Co-purificationBioGRID16982797 
VTNV75 | VN | VNTvitronectin-HPRD,BioGRID11796824 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MAPK_SIGNALING_PATHWAY 267205All SZGR genes in this pathway
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 216144All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_MELANOMA 7157All SZGR genes in this pathway
BIOCARTA_NFAT_PATHWAY 5645All SZGR genes in this pathway
PID_GLYPICAN_1PATHWAY 2720All SZGR genes in this pathway
PID_ANGIOPOIETIN_RECEPTOR_PATHWAY 5041All SZGR genes in this pathway
PID_AVB3_INTEGRIN_PATHWAY 7553All SZGR genes in this pathway
PID_SYNDECAN_4_PATHWAY 3225All SZGR genes in this pathway
PID_FGF_PATHWAY 5537All SZGR genes in this pathway
REACTOME_NEGATIVE_REGULATION_OF_FGFR_SIGNALING 3724All SZGR genes in this pathway
REACTOME_INSULIN_RECEPTOR_SIGNALLING_CASCADE 8764All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR_IN_DISEASE 12788All SZGR genes in this pathway
REACTOME_ACTIVATED_POINT_MUTANTS_OF_FGFR2 1611All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR1_MUTANTS 3020All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ACTIVATED_POINT_MUTANTS_OF_FGFR1 118All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR3_MUTANTS 119All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR_MUTANTS 4429All SZGR genes in this pathway
REACTOME_FRS2_MEDIATED_CASCADE 3627All SZGR genes in this pathway
REACTOME_PI_3K_CASCADE 5639All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR 10074All SZGR genes in this pathway
REACTOME_PHOSPHOLIPASE_C_MEDIATED_CASCADE 5440All SZGR genes in this pathway
REACTOME_SHC_MEDIATED_CASCADE 2819All SZGR genes in this pathway
REACTOME_SIGNALING_BY_INSULIN_RECEPTOR 10872All SZGR genes in this pathway
REACTOME_FGFR_LIGAND_BINDING_AND_ACTIVATION 2215All SZGR genes in this pathway
REACTOME_FGFR2C_LIGAND_BINDING_AND_ACTIVATION 129All SZGR genes in this pathway
REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION 128All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR 11280All SZGR genes in this pathway
REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION 149All SZGR genes in this pathway
REACTOME_PI3K_CASCADE 7151All SZGR genes in this pathway
PARENT_MTOR_SIGNALING_DN 4629All SZGR genes in this pathway
SENGUPTA_NASOPHARYNGEAL_CARCINOMA_UP 294178All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN 455304All SZGR genes in this pathway
BASAKI_YBX1_TARGETS_UP 290177All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_48HR_DN 6439All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_96HR_UP 11784All SZGR genes in this pathway
STREICHER_LSM1_TARGETS_DN 1913All SZGR genes in this pathway
BAKER_HEMATOPOESIS_STAT1_TARGETS 109All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN 483336All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP 811508All SZGR genes in this pathway
FERREIRA_EWINGS_SARCOMA_UNSTABLE_VS_STABLE_DN 9859All SZGR genes in this pathway
WU_CELL_MIGRATION 184114All SZGR genes in this pathway
BENPORATH_ES_1 379235All SZGR genes in this pathway
BENPORATH_NANOG_TARGETS 988594All SZGR genes in this pathway
BENPORATH_OCT4_TARGETS 290172All SZGR genes in this pathway
BENPORATH_SOX2_TARGETS 734436All SZGR genes in this pathway
BENPORATH_NOS_TARGETS 179105All SZGR genes in this pathway
AMIT_EGF_RESPONSE_240_HELA 6043All SZGR genes in this pathway
GEORGES_CELL_CYCLE_MIR192_TARGETS 6246All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215 893528All SZGR genes in this pathway
STANELLE_E2F1_TARGETS 2920All SZGR genes in this pathway
SMITH_TERT_TARGETS_UP 14591All SZGR genes in this pathway
KANG_IMMORTALIZED_BY_TERT_UP 8961All SZGR genes in this pathway
REN_ALVEOLAR_RHABDOMYOSARCOMA_DN 408274All SZGR genes in this pathway
DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_UP 314201All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_16HR_DN 8662All SZGR genes in this pathway
WANG_SMARCE1_TARGETS_DN 371218All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_14HR_DN 298200All SZGR genes in this pathway
JI_RESPONSE_TO_FSH_DN 5843All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_20HR_DN 10170All SZGR genes in this pathway
LU_AGING_BRAIN_UP 262186All SZGR genes in this pathway
MA_PITUITARY_FETAL_VS_ADULT_UP 2921All SZGR genes in this pathway
SATO_SILENCED_EPIGENETICALLY_IN_PANCREATIC_CANCER 4930All SZGR genes in this pathway
GEISS_RESPONSE_TO_DSRNA_UP 3829All SZGR genes in this pathway
ZHANG_ANTIVIRAL_RESPONSE_TO_RIBAVIRIN_DN 5132All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_6HR_DN 160101All SZGR genes in this pathway
KYNG_DNA_DAMAGE_BY_4NQO_OR_GAMMA_RADIATION 1513All SZGR genes in this pathway
KYNG_DNA_DAMAGE_DN 195135All SZGR genes in this pathway
SARRIO_EPITHELIAL_MESENCHYMAL_TRANSITION_UP 180114All SZGR genes in this pathway
MARZEC_IL2_SIGNALING_UP 11580All SZGR genes in this pathway
BASSO_HAIRY_CELL_LEUKEMIA_DN 8066All SZGR genes in this pathway
BONCI_TARGETS_OF_MIR15A_AND_MIR16_1 9175All SZGR genes in this pathway
BOQUEST_STEM_CELL_CULTURED_VS_FRESH_UP 425298All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_DN 13892All SZGR genes in this pathway
JU_AGING_TERC_TARGETS_UP 106All SZGR genes in this pathway
MIZUKAMI_HYPOXIA_UP 1212All SZGR genes in this pathway
MIZUKAMI_HYPOXIA_DN 65All SZGR genes in this pathway
HINATA_NFKB_TARGETS_FIBROBLAST_UP 8460All SZGR genes in this pathway
POOLA_INVASIVE_BREAST_CANCER_DN 13483All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME2 491319All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_PR_DN 4434All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_RXRA_BOUND_8D 882506All SZGR genes in this pathway
PLASARI_TGFB1_TARGETS_10HR_UP 199143All SZGR genes in this pathway
SMIRNOV_RESPONSE_TO_IR_6HR_UP 16697All SZGR genes in this pathway
GHANDHI_DIRECT_IRRADIATION_UP 11068All SZGR genes in this pathway
GHANDHI_BYSTANDER_IRRADIATION_UP 8654All SZGR genes in this pathway
NABA_SECRETED_FACTORS 344197All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-103/10756395645m8hsa-miR-103brainAGCAGCAUUGUACAGGGCUAUGA
hsa-miR-107brainAGCAGCAUUGUACAGGGCUAUCA
miR-140377437801Ahsa-miR-140brainAGUGGUUUUACCCUAUGGUAG
miR-15/16/195/424/497564056471A,m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-503560056061Ahsa-miR-503UAGCAGCGGGAACAGUUCUGCAG
hsa-miR-503UAGCAGCGGGAACAGUUCUGCAG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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