Gene Page: FOXC1

Summary
GeneID  2296
Symbol  FOXC1
Synonyms  ARA|FKHL7|FREAC-3|FREAC3|IGDA|IHG1|IRID1
Description  forkhead box C1
See related  HGNC:3800|MIM:601090|Ensembl:ENSG00000054598|HPRD:03054|
Locus tag  -
Gene type  protein-coding
Map location  6p25
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0159 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
PLXNA10.880.87
ZNF7780.860.82
NAV10.860.85
CELSR30.860.81
CACNA1E0.850.81
KIAA15490.850.82
DLG50.850.85
ZNF6290.850.84
ANKS1A0.850.83
AMMECR1L0.840.84
Top 10 negatively co-expressed genes
C5orf53-0.57-0.66
COPZ2-0.55-0.66
AF347015.31-0.55-0.72
AF347015.27-0.54-0.70
S100B-0.54-0.68
MT-CO2-0.54-0.71
HLA-F-0.54-0.57
AIFM3-0.54-0.58
TSC22D4-0.53-0.62
FXYD1-0.53-0.69
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003705RNA polymerase II transcription factor activity, enhancer bindingIEA-
GO:0008301DNA bending activityIDA7957066 
GO:0008134transcription factor bindingIPI15684392 
GO:0016563transcription activator activityNAS8499623 
GO:0043565sequence-specific DNA bindingIDA7957066 |15277473 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007420brain developmentIEABrain (GO term level: 7)-
GO:0001568blood vessel developmentIEA-
GO:0001501skeletal system developmentIEA-
GO:0001503ossificationIEA-
GO:0001657ureteric bud developmentIEA-
GO:0001701in utero embryonic developmentIEA-
GO:0001541ovarian follicle developmentIEA-
GO:0003007heart morphogenesisIEA-
GO:0001822kidney developmentIEA-
GO:0001945lymph vessel developmentIEA-
GO:0001974blood vessel remodelingIEA-
GO:0055010ventricular cardiac muscle morphogenesisIEA-
GO:0006350transcriptionIEA-
GO:0007219Notch signaling pathwayIEA-
GO:0008354germ cell migrationIEA-
GO:0014032neural crest cell developmentIEA-
GO:0048010vascular endothelial growth factor receptor signaling pathwayIEA-
GO:0006916anti-apoptosisIEA-
GO:0030203glycosaminoglycan metabolic processIEA-
GO:0042475odontogenesis of dentine-containing toothIMP12614756 
GO:0030199collagen fibril organizationIEA-
GO:0043010camera-type eye developmentIEA-
GO:0035050embryonic heart tube developmentIEA-
GO:0032808lacrimal gland developmentIEA-
GO:0048341paraxial mesoderm formationIEA-
GO:0045930negative regulation of mitotic cell cycleIDA12408963 
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA-
GO:0050880regulation of blood vessel sizeIEA-
GO:0046620regulation of organ growthIEA-
GO:0048844artery morphogenesisIEA-
GO:0048762mesenchymal cell differentiationIEA-
GO:0060038cardiac muscle cell proliferationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIC7957066 
GO:0005634nucleusIDA15277473 |16449236 
GO:0005720nuclear heterochromatinIDA15684392 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_DN 634384All SZGR genes in this pathway
CHEMNITZ_RESPONSE_TO_PROSTAGLANDIN_E2_DN 391222All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN 460312All SZGR genes in this pathway
DOANE_BREAST_CANCER_CLASSES_DN 3426All SZGR genes in this pathway
DOANE_BREAST_CANCER_ESR1_DN 4828All SZGR genes in this pathway
GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_GREY_DN 7444All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_8D_UP 15791All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_UP 501327All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_DN 329219All SZGR genes in this pathway
KIM_WT1_TARGETS_UP 214155All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_UP 530342All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
TOMIDA_METASTASIS_DN 1811All SZGR genes in this pathway
WONG_ENDMETRIUM_CANCER_UP 2517All SZGR genes in this pathway
RIZ_ERYTHROID_DIFFERENTIATION_6HR 4023All SZGR genes in this pathway
PEREZ_TP53_TARGETS 1174695All SZGR genes in this pathway
FARMER_BREAST_CANCER_APOCRINE_VS_BASAL 330217All SZGR genes in this pathway
FARMER_BREAST_CANCER_BASAL_VS_LULMINAL 330215All SZGR genes in this pathway
LIEN_BREAST_CARCINOMA_METAPLASTIC_VS_DUCTAL_UP 8351All SZGR genes in this pathway
DAWSON_METHYLATED_IN_LYMPHOMA_TCL1 5945All SZGR genes in this pathway
YANG_BREAST_CANCER_ESR1_LASER_DN 5038All SZGR genes in this pathway
LIU_NASOPHARYNGEAL_CARCINOMA 7038All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
BENPORATH_ES_CORE_NINE_CORRELATED 10068All SZGR genes in this pathway
AMIT_EGF_RESPONSE_60_HELA 4632All SZGR genes in this pathway
OKUMURA_INFLAMMATORY_RESPONSE_LPS 183115All SZGR genes in this pathway
ALCALAY_AML_BY_NPM1_LOCALIZATION_UP 14083All SZGR genes in this pathway
VERHAAK_AML_WITH_NPM1_MUTATED_UP 183111All SZGR genes in this pathway
ZHENG_RESPONSE_TO_ARSENITE_DN 1815All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN 830547All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_NHEK_UP 244151All SZGR genes in this pathway
BAELDE_DIABETIC_NEPHROPATHY_DN 434302All SZGR genes in this pathway
STEIN_ESRRA_TARGETS_UP 388234All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP 673430All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_DN 593372All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_DN 591366All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_UP 973570All SZGR genes in this pathway
ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_UP 863514All SZGR genes in this pathway
SMID_BREAST_CANCER_RELAPSE_IN_BONE_DN 315197All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_DN 564326All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_UP 648398All SZGR genes in this pathway
BRUECKNER_TARGETS_OF_MIRLET7A3_UP 11169All SZGR genes in this pathway
GU_PDEF_TARGETS_DN 3920All SZGR genes in this pathway
VANTVEER_BREAST_CANCER_ESR1_DN 240153All SZGR genes in this pathway
COLINA_TARGETS_OF_4EBP1_AND_4EBP2 356214All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
VALK_AML_CLUSTER_6 3322All SZGR genes in this pathway
YAGI_AML_WITH_11Q23_REARRANGED 351238All SZGR genes in this pathway
STEIN_ESRRA_TARGETS 535325All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_4HR_DN 254158All SZGR genes in this pathway
BHAT_ESR1_TARGETS_NOT_VIA_AKT1_UP 211131All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A 898516All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_AND_SATB1_UP 8752All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_NOT_SATB1_DN 448282All SZGR genes in this pathway
SCHMIDT_POR_TARGETS_IN_LIMB_BUD_UP 2621All SZGR genes in this pathway
KATSANOU_ELAVL1_TARGETS_UP 169105All SZGR genes in this pathway
PLASARI_TGFB1_TARGETS_10HR_DN 244157All SZGR genes in this pathway
WANG_MLL_TARGETS 289188All SZGR genes in this pathway
PHONG_TNF_RESPONSE_VIA_P38_COMPLETE 227151All SZGR genes in this pathway
ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF 516308All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-103/107175517611Ahsa-miR-103brainAGCAGCAUUGUACAGGGCUAUGA
hsa-miR-107brainAGCAGCAUUGUACAGGGCUAUCA
miR-1335385441Ahsa-miR-133aUUGGUCCCCUUCAACCAGCUGU
hsa-miR-133bUUGGUCCCCUUCAACCAGCUA
miR-137139814051A,m8hsa-miR-137UAUUGCUUAAGAAUACGCGUAG
miR-1381601671A,m8hsa-miR-138brainAGCUGGUGUUGUGAAUC
hsa-miR-138brainAGCUGGUGUUGUGAAUC
miR-204/2116196261A,m8hsa-miR-204brainUUCCCUUUGUCAUCCUAUGCCU
hsa-miR-211UUCCCUUUGUCAUCCUUCGCCU
miR-24116611721Ahsa-miR-24SZUGGCUCAGUUCAGCAGGAACAG
miR-28168116871Ahsa-miR-28brainAAGGAGCUCACAGUCUAUUGAG
miR-3207467521Ahsa-miR-320AAAAGCUGGGUUGAGAGGGCGAA
miR-3309289351A,m8hsa-miR-330brainGCAAAGCACACGGCCUGCAGAGA
miR-3746126181Ahsa-miR-374UUAUAAUACAACCUGAUAAGUG
miR-495682688m8hsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
hsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
miR-4964884941Ahsa-miR-496AUUACAUGGCCAAUCUC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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