Gene Page: ERC1

Summary
GeneID  23085
Symbol  ERC1
Synonyms  Cast2|ELKS|KIAA1081|MGC12974|RAB6IP2
Description  ELKS/RAB6-interacting/CAST family member 1
See related  HGNC:17072|MIM:607127|Ensembl:ENSG00000082805|HPRD:06181|
Locus tag  -
Gene type  protein-coding
Map location  12p13.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI12391317 |12923177 
GO:0043522leucine zipper domain bindingNAS15218148 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006355regulation of transcription, DNA-dependentNAS15218148 
GO:0007252I-kappaB phosphorylationIDA15218148 
GO:0007275multicellular organismal developmentNAS15218148 
GO:0051092positive regulation of NF-kappaB transcription factor activityTAS15218148 
GO:0015031protein transportIEA-
GO:0045768positive regulation of anti-apoptosisTAS15218148 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0042734presynaptic membraneTASneuron, axon, Synap (GO term level: 5)12391317 
GO:0000139Golgi membraneIEA-
GO:0005794Golgi apparatusIEA-
GO:0005737cytoplasmTAS15218148 
GO:0008385IkappaB kinase complexIDA15218148 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
NFKBIAIKBA | MAD-3 | NFKBInuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alphaELKS interacts with I-kappa-B-alpha.BIND15218148 
PPFIA1FLJ41337 | FLJ42630 | FLJ43474 | LIP.1 | LIP1 | LIPRIN | MGC26800protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1-HPRD12923177 
RAB6ARAB6 | RAB6A' | RAB6BRAB6A, member RAS oncogene family-HPRD,BioGRID11929610 
Rab6A (Rab6A') interacts with an unspecified isoform of RAB6IP2. This interaction was modeled on a demonstrated interaction between RAB6A' from an unspecified species and mouse RAB6IP2.BIND11929610 
RAB6B-RAB6B, member RAS oncogene family-HPRD,BioGRID11929610 
RIMS1CORD7 | KIAA0340 | MGC167823 | MGC176677 | RAB3IP2 | RIM | RIM1regulating synaptic membrane exocytosis 1-HPRD12391317 
TWF2A6RP | A6r | MSTP011 | PTK9Ltwinfilin, actin-binding protein, homolog 2 (Drosophila)Affinity Capture-MSBioGRID17353931 
YWHAG14-3-3GAMMAtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide-HPRD15324660 
Affinity Capture-MSBioGRID17353931 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_NFKAPPAB_CANONICAL_PATHWAY 2320All SZGR genes in this pathway
PID_IL1_PATHWAY 3428All SZGR genes in this pathway
KORKOLA_SEMINOMA_UP 4427All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_DN 526357All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_FIMA_UP 544308All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN 770415All SZGR genes in this pathway
SCHEIDEREIT_IKK_INTERACTING_PROTEINS 5845All SZGR genes in this pathway
SILIGAN_BOUND_BY_EWS_FLT1_FUSION 4734All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN 848527All SZGR genes in this pathway
LIU_COMMON_CANCER_GENES 7947All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_DN 428306All SZGR genes in this pathway
GENTILE_UV_LOW_DOSE_DN 6746All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1 528324All SZGR genes in this pathway
LEIN_CEREBELLUM_MARKERS 8547All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP 673430All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_DN 593372All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_DN 591366All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP 323240All SZGR genes in this pathway
TERAO_AOX4_TARGETS_SKIN_UP 3827All SZGR genes in this pathway
FORTSCHEGGER_PHF8_TARGETS_DN 784464All SZGR genes in this pathway


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