Gene Page: GAD1

Summary
GeneID  2571
Symbol  GAD1
Synonyms  FLJ45882|GAD|SCP
Description  glutamate decarboxylase 1 (brain, 67kDa)
See related  HGNC:4092|MIM:605363|Ensembl:ENSG00000128683|HPRD:12011|
Locus tag  -
Gene type  protein-coding
Map location  2q31
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies2Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenia, schizophrenias]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 4 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 31 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
FUT10.810.68
FIGN0.790.57
OPRM10.760.66
RNF2200.750.40
TCF7L20.740.55
COL23A10.740.60
EPHA10.730.24
LHX90.730.01
MAST40.720.52
GBX20.720.35
Top 10 negatively co-expressed genes
SLA-0.29-0.28
NEUROD6-0.28-0.36
NEUROD2-0.27-0.32
AC087491.1-0.27-0.44
UXT-0.27-0.51
CSRP2-0.27-0.53
KLHL1-0.27-0.23
RPL37-0.27-0.59
TMEM108-0.26-0.23
TTC28-0.26-0.22
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004351glutamate decarboxylase activityIDAglutamate (GO term level: 6)10671565 
GO:0005515protein bindingIPI10671565 
GO:0016829lyase activityIEA-
GO:0016831carboxy-lyase activityIEA-
GO:0030170pyridoxal phosphate bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007268synaptic transmissionTASneuron, Synap, Neurotransmitter (GO term level: 6)8954991 
GO:0006540glutamate decarboxylation to succinateTASGABA, glutamate, Brain, Neurotransmitter (GO term level: 10)1549570 
GO:0042136neurotransmitter biosynthetic processIEAneuron, axon, Synap, Neurotransmitter (GO term level: 9)-
GO:0018352protein-pyridoxal-5-phosphate linkageTAS10671565 
GO:0019752carboxylic acid metabolic processIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0012506vesicle membraneNAS10671565 
GO:0005622intracellularIDA10671565 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
GAD2GAD65 | MGC161605 | MGC161607glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)-HPRD,BioGRID7836456 
HAAO3-HAO | HAO3-hydroxyanthranilate 3,4-dioxygenaseTwo-hybridBioGRID16189514 
PRKACAMGC102831 | MGC48865 | PKACAprotein kinase, cAMP-dependent, catalytic, alphaBiochemical ActivityBioGRID15147202 
PRKCEMGC125656 | MGC125657 | PKCE | nPKC-epsilonprotein kinase C, epsilonBiochemical ActivityBioGRID15147202 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM 3226All SZGR genes in this pathway
KEGG_BETA_ALANINE_METABOLISM 2216All SZGR genes in this pathway
KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM 107All SZGR genes in this pathway
KEGG_BUTANOATE_METABOLISM 3420All SZGR genes in this pathway
KEGG_TYPE_I_DIABETES_MELLITUS 4438All SZGR genes in this pathway
BIOCARTA_NEUROTRANSMITTERS_PATHWAY 65All SZGR genes in this pathway
REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 186155All SZGR genes in this pathway
REACTOME_NEURONAL_SYSTEM 279221All SZGR genes in this pathway
REACTOME_NEUROTRANSMITTER_RELEASE_CYCLE 3430All SZGR genes in this pathway
REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION 1716All SZGR genes in this pathway
SENGUPTA_NASOPHARYNGEAL_CARCINOMA_UP 294178All SZGR genes in this pathway
WATANABE_COLON_CANCER_MSI_VS_MSS_UP 2918All SZGR genes in this pathway
DAVICIONI_TARGETS_OF_PAX_FOXO1_FUSIONS_UP 255177All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_EARLY_UP 430232All SZGR genes in this pathway
OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP 233161All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_8D_UP 15791All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_1_DN 12686All SZGR genes in this pathway
MULLIGHAN_NPM1_SIGNATURE_3_DN 162116All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP 722443All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_DN 781465All SZGR genes in this pathway
PEREZ_TP53_TARGETS 1174695All SZGR genes in this pathway
APPIERTO_RESPONSE_TO_FENRETINIDE_UP 3826All SZGR genes in this pathway
SEITZ_NEOPLASTIC_TRANSFORMATION_BY_8P_DELETION_DN 3025All SZGR genes in this pathway
MOHANKUMAR_TLX1_TARGETS_DN 193112All SZGR genes in this pathway
WANG_HCP_PROSTATE_CANCER 11169All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_UP 769437All SZGR genes in this pathway
BENPORATH_ES_1 379235All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
LEE_TARGETS_OF_PTCH1_AND_SUFU_DN 8369All SZGR genes in this pathway
ROZANOV_MMP14_TARGETS_DN 3522All SZGR genes in this pathway
CHESLER_BRAIN_D6MIT150_QTL_TRANS 97All SZGR genes in this pathway
YU_MYC_TARGETS_DN 5538All SZGR genes in this pathway
YAGI_AML_FAB_MARKERS 191131All SZGR genes in this pathway
LU_AGING_BRAIN_DN 153120All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_NO_BLOOD_DN 15093All SZGR genes in this pathway
MCCLUNG_COCAINE_REWARD_5D 7962All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_DN 14588All SZGR genes in this pathway
LOPES_METHYLATED_IN_COLON_CANCER_UP 2720All SZGR genes in this pathway
MITSIADES_RESPONSE_TO_APLIDIN_UP 439257All SZGR genes in this pathway
GRADE_COLON_CANCER_UP 871505All SZGR genes in this pathway
CHEN_HOXA5_TARGETS_9HR_UP 223132All SZGR genes in this pathway
HUPER_BREAST_BASAL_VS_LUMINAL_DN 5944All SZGR genes in this pathway
HUNSBERGER_EXERCISE_REGULATED_GENES 3126All SZGR genes in this pathway
HOFFMANN_IMMATURE_TO_MATURE_B_LYMPHOCYTE_UP 4334All SZGR genes in this pathway
HAN_SATB1_TARGETS_UP 395249All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3 142103All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
MIKKELSEN_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3 210148All SZGR genes in this pathway
MIKKELSEN_MEF_HCP_WITH_H3K27ME3 590403All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP 756494All SZGR genes in this pathway
LU_EZH2_TARGETS_DN 414237All SZGR genes in this pathway
HOELZEL_NF1_TARGETS_UP 13993All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3 824528All SZGR genes in this pathway
MADAN_DPPA4_TARGETS 4626All SZGR genes in this pathway
RAO_BOUND_BY_SALL4_ISOFORM_B 517302All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY 1839928All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-12811971203m8hsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-146101610221Ahsa-miR-146aUGAGAACUGAAUUCCAUGGGUU
hsa-miR-146bbrainUGAGAACUGAAUUCCAUAGGCU
miR-191921981Ahsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
miR-248248301Ahsa-miR-24SZUGGCUCAGUUCAGCAGGAACAG
miR-381739745m8hsa-miR-381UAUACAAGGGCAAGCUCUCUGU
miR-4107737791Ahsa-miR-410AAUAUAACACAGAUGGCCUGU
miR-493-5p216222m8hsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
miR-98288341Ahsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.