Gene Page: GLI3

Summary
GeneID  2737
Symbol  GLI3
Synonyms  ACLS|GCPS|PAP-A|PAPA|PAPA1|PAPB|PHS|PPDIV
Description  GLI-Kruppel family member GLI3
See related  HGNC:4319|MIM:165240|Ensembl:ENSG00000106571|HPRD:01313|
Locus tag  -
Gene type  protein-coding
Map location  7p13
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 6 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003682chromatin bindingIEA-
GO:0003700transcription factor activityTAS9054938 |10077605 
GO:0005515protein bindingIPI10564661 |10806483 |11238441 
GO:0008270zinc ion bindingIEA-
GO:0046872metal ion bindingIEA-
GO:0043565sequence-specific DNA bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0048663neuron fate commitmentIEAneuron (GO term level: 9)-
GO:0021631optic nerve morphogenesisIEABrain (GO term level: 9)-
GO:0030900forebrain developmentIEABrain (GO term level: 8)-
GO:0021915neural tube developmentIEABrain (GO term level: 7)-
GO:0021776smoothened signaling pathway involved in spinal cord motor neuron cell fate specificationIEAneuron (GO term level: 12)-
GO:0021775smoothened signaling pathway involved in ventral spinal cord interneuron specificationIEAneuron (GO term level: 12)-
GO:0000060protein import into nucleus, translocationTAS10077605 
GO:0001658ureteric bud branchingIEA-
GO:0001656metanephros developmentIEA-
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0009954proximal/distal pattern formationIEA-
GO:0007224smoothened signaling pathwayIEA-
GO:0009952anterior/posterior pattern formationIEA-
GO:0007165signal transductionTAS10077605 
GO:0008285negative regulation of cell proliferationIEA-
GO:0007507heart developmentIEA-
GO:0007442hindgut morphogenesisIEA-
GO:0007389pattern specification processIEA-
GO:0016481negative regulation of transcriptionIEA-
GO:0042475odontogenesis of dentine-containing toothIEA-
GO:0030879mammary gland developmentIEA-
GO:0030326embryonic limb morphogenesisIEA-
GO:0030324lung developmentIEA-
GO:0035295tube developmentIEA-
GO:0021513spinal cord dorsal/ventral patterningIEA-
GO:0045596negative regulation of cell differentiationIEA-
GO:0048558embryonic gut morphogenesisIEA-
GO:0048589developmental growthIEA-
GO:0048593camera-type eye morphogenesisIEA-
GO:0048598embryonic morphogenesisIEA-
GO:0048646anatomical structure formationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005622intracellularIEA-
GO:0005634nucleusTAS10077605 
GO:0005730nucleolusIDA18029348 
GO:0005737cytoplasmTAS10077605 
GO:0017053transcriptional repressor complexIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CREBBPCBP | KAT3A | RSTSCREB binding proteinAffinity Capture-Western
Reconstituted Complex		BioGRID10075717 
SMAD1BSP1 | JV4-1 | JV41 | MADH1 | MADR1SMAD family member 1-HPRD9843199 
SMAD2JV18 | JV18-1 | MADH2 | MADR2 | MGC22139 | MGC34440 | hMAD-2 | hSMAD2SMAD family member 2-HPRD9843199 
SMAD3DKFZp586N0721 | DKFZp686J10186 | HSPC193 | HsT17436 | JV15-2 | MADH3 | MGC60396SMAD family member 3-HPRD9843199 
SMAD4DPC4 | JIP | MADH4SMAD family member 4-HPRD9843199 
STK36DKFZp434N0223 | FU | KIAA1278serine/threonine kinase 36, fused homolog (Drosophila)-HPRD,BioGRID10806483 
SUFUPRO1280 | SUFUH | SUFUXLsuppressor of fused homolog (Drosophila)-HPRD,BioGRID10564661 
TWIST1ACS3 | BPES2 | BPES3 | SCS | TWIST | bHLHa38twist homolog 1 (Drosophila)-HPRD12142027 
ZIC1ZIC | ZNF201Zic family member 1 (odd-paired homolog, Drosophila)-HPRD,BioGRID11238441 
ZIC2HPE5Zic family member 2 (odd-paired homolog, Drosophila)Affinity Capture-Western
Reconstituted Complex		BioGRID11238441 
ZIC3HTX | HTX1 | ZNF203Zic family member 3 (odd-paired homolog, Drosophila)Reconstituted ComplexBioGRID11238441 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_HEDGEHOG_SIGNALING_PATHWAY 5642All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_BASAL_CELL_CARCINOMA 5544All SZGR genes in this pathway
BIOCARTA_SHH_PATHWAY 1615All SZGR genes in this pathway
PID_HEDGEHOG_GLI_PATHWAY 4835All SZGR genes in this pathway
WAMUNYOKOLI_OVARIAN_CANCER_LMP_DN 199124All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_3_DN 229142All SZGR genes in this pathway
OUELLET_CULTURED_OVARIAN_CANCER_INVASIVE_VS_LMP_DN 3520All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN 514319All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN 848527All SZGR genes in this pathway
LEE_AGING_NEOCORTEX_DN 8049All SZGR genes in this pathway
KAYO_CALORIE_RESTRICTION_MUSCLE_DN 8759All SZGR genes in this pathway
MARIADASON_REGULATED_BY_HISTONE_ACETYLATION_UP 8349All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_18HR_DN 178121All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_UP 428266All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_12HR_DN 10164All SZGR genes in this pathway
DOUGLAS_BMI1_TARGETS_UP 566371All SZGR genes in this pathway
NAKAMURA_METASTASIS_MODEL_DN 4328All SZGR genes in this pathway
VANTVEER_BREAST_CANCER_ESR1_UP 16799All SZGR genes in this pathway
VANTVEER_BREAST_CANCER_BRCA1_DN 4428All SZGR genes in this pathway
LI_WILMS_TUMOR 2712All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
CHANDRAN_METASTASIS_DN 306191All SZGR genes in this pathway
PASINI_SUZ12_TARGETS_DN 315215All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124.128592865m8hsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-124/506285828651A,m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-1431071141A,m8hsa-miR-143brainUGAGAUGAAGCACUGUAGCUCA
miR-200bc/429217223m8hsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
miR-203.12012071Ahsa-miR-203UGAAAUGUUUAGGACCACUAG
miR-24282628321Ahsa-miR-24SZUGGCUCAGUUCAGCAGGAACAG
miR-49433333339m8hsa-miR-494brainUGAAACAUACACGGGAAACCUCUU
miR-496314931561A,m8hsa-miR-496AUUACAUGGCCAAUCUC
miR-71952021A,m8hsa-miR-7SZUGGAAGACUAGUGAUUUUGUUG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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