Gene Page: GPX3

Summary
GeneID  2878
Symbol  GPX3
Synonyms  GPx-P|GSHPx-3|GSHPx-P
Description  glutathione peroxidase 3 (plasma)
See related  HGNC:4555|MIM:138321|Ensembl:ENSG00000211445|HPRD:11750|
Locus tag  -
Gene type  protein-coding
Map location  5q23
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0032 
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.01718 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00459 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
FNDC3A0.740.84
KCTD30.730.78
AGL0.730.81
WDR440.720.81
BRWD20.710.78
SH3GLB10.710.76
ASCC30.710.81
SEMA6D0.710.77
ZMYND110.710.80
HMGCS10.700.77
Top 10 negatively co-expressed genes
MT-CO2-0.55-0.66
FXYD1-0.54-0.64
MYL3-0.54-0.66
AF347015.31-0.52-0.62
COPZ2-0.51-0.58
AF347015.33-0.51-0.60
AF347015.8-0.51-0.62
AF347015.21-0.50-0.62
AF347015.27-0.49-0.60
HIGD1B-0.49-0.63
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004602glutathione peroxidase activityIDA1897960 |3693360 
GO:0008430selenium bindingIDA2491950 |3693360 
GO:0008134transcription factor bindingTAS8056346 
GO:0016491oxidoreductase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006982response to lipid hydroperoxideTAS2491950 
GO:0006979response to oxidative stressIEA-
GO:0051289protein homotetramerizationIDA3693360 
GO:0042744hydrogen peroxide catabolic processTAS2491950 
GO:0055114oxidation reductionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005615extracellular spaceIDA1897960 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_GLUTATHIONE_METABOLISM 5034All SZGR genes in this pathway
KEGG_ARACHIDONIC_ACID_METABOLISM 5836All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_DN 463290All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_DN 11679All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_EARLY_DN 367220All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_DN 536332All SZGR genes in this pathway
SABATES_COLORECTAL_ADENOMA_DN 291176All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN 805505All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_DN 537339All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_48HR_UP 12895All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_96HR_UP 11784All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_1_DN 378231All SZGR genes in this pathway
LANDIS_ERBB2_BREAST_TUMORS_65_DN 3722All SZGR genes in this pathway
LANDIS_ERBB2_BREAST_PRENEOPLASTIC_DN 5533All SZGR genes in this pathway
CONCANNON_APOPTOSIS_BY_EPOXOMICIN_UP 239157All SZGR genes in this pathway
LANDIS_ERBB2_BREAST_TUMORS_324_DN 14993All SZGR genes in this pathway
WANG_BARRETTS_ESOPHAGUS_AND_ESOPHAGUS_CANCER_DN 3722All SZGR genes in this pathway
WANG_ESOPHAGUS_CANCER_VS_NORMAL_DN 10166All SZGR genes in this pathway
HUMMERICH_SKIN_CANCER_PROGRESSION_DN 10064All SZGR genes in this pathway
XU_HGF_TARGETS_REPRESSED_BY_AKT1_DN 9558All SZGR genes in this pathway
WEINMANN_ADAPTATION_TO_HYPOXIA_UP 2924All SZGR genes in this pathway
DAIRKEE_TERT_TARGETS_DN 12479All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_DN 203134All SZGR genes in this pathway
ONDER_CDH1_TARGETS_1_UP 14085All SZGR genes in this pathway
HOUSTIS_ROS 3629All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_UP 398262All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN 546351All SZGR genes in this pathway
ABBUD_LIF_SIGNALING_1_UP 4629All SZGR genes in this pathway
KUMAR_TARGETS_OF_MLL_AF9_FUSION 405264All SZGR genes in this pathway
LEE_AGING_NEOCORTEX_DN 8049All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_16HR_UP 225139All SZGR genes in this pathway
KAAB_HEART_ATRIUM_VS_VENTRICLE_UP 249170All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_8HR_UP 10573All SZGR genes in this pathway
SIMBULAN_PARP1_TARGETS_UP 3123All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
KEEN_RESPONSE_TO_ROSIGLITAZONE_DN 10668All SZGR genes in this pathway
WANG_CISPLATIN_RESPONSE_AND_XPC_UP 202115All SZGR genes in this pathway
HILLION_HMGA1_TARGETS 9071All SZGR genes in this pathway
FUJII_YBX1_TARGETS_DN 202132All SZGR genes in this pathway
RIGGI_EWING_SARCOMA_PROGENITOR_UP 430288All SZGR genes in this pathway
BOQUEST_STEM_CELL_CULTURED_VS_FRESH_UP 425298All SZGR genes in this pathway
ICHIBA_GRAFT_VERSUS_HOST_DISEASE_35D_UP 13179All SZGR genes in this pathway
VANASSE_BCL2_TARGETS_DN 7450All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_DN 435289All SZGR genes in this pathway
COLINA_TARGETS_OF_4EBP1_AND_4EBP2 356214All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3_UNMETHYLATED 536296All SZGR genes in this pathway
LIU_VAV3_PROSTATE_CARCINOGENESIS_UP 8961All SZGR genes in this pathway
JISON_SICKLE_CELL_DISEASE_DN 18197All SZGR genes in this pathway
SAKAI_CHRONIC_HEPATITIS_VS_LIVER_CANCER_UP 8363All SZGR genes in this pathway
KOBAYASHI_EGFR_SIGNALING_24HR_UP 10165All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S3 266180All SZGR genes in this pathway
NAKAYAMA_SOFT_TISSUE_TUMORS_PCA2_DN 8051All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_30MIN_UP 5638All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_UP 857456All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_EARLY_LATE 317190All SZGR genes in this pathway
AZARE_NEOPLASTIC_TRANSFORMATION_BY_STAT3_UP 12170All SZGR genes in this pathway
KATSANOU_ELAVL1_TARGETS_UP 169105All SZGR genes in this pathway
PEDERSEN_METASTASIS_BY_ERBB2_ISOFORM_7 403240All SZGR genes in this pathway
PEDERSEN_TARGETS_OF_611CTF_ISOFORM_OF_ERBB2 7645All SZGR genes in this pathway
ACEVEDO_FGFR1_TARGETS_IN_PROSTATE_CANCER_MODEL_DN 308187All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-24703709m8hsa-miR-24SZUGGCUCAGUUCAGCAGGAACAG
miR-37849551Ahsa-miR-378CUCCUGACUCCAGGUCCUGUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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