Gene Page: GTF2E2

Summary
GeneID  2961
Symbol  GTF2E2
Synonyms  FE|TF2E2|TFIIE-B
Description  general transcription factor IIE, polypeptide 2, beta 34kDa
See related  HGNC:4651|MIM:189964|Ensembl:ENSG00000197265|HPRD:01800|
Locus tag  -
Gene type  protein-coding
Map location  8p21-p12
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.00057 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.03086 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
SMARCD30.740.75
CDKN2D0.740.72
ETNK20.740.76
FKBP1B0.740.76
RNF70.720.74
VPS250.710.71
CHID10.700.73
C1orf590.690.71
CHCHD60.680.71
GNB20.680.73
Top 10 negatively co-expressed genes
AF347015.2-0.52-0.56
MT-CO2-0.50-0.53
AF347015.8-0.50-0.54
AF347015.26-0.50-0.56
AF347015.15-0.50-0.54
AF347015.33-0.49-0.54
MT-CYB-0.49-0.54
AF347015.27-0.48-0.54
AF347015.31-0.47-0.50
AF347015.9-0.46-0.53
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003677DNA bindingIEA-
GO:0003702RNA polymerase II transcription factor activityIEA-
GO:0005515protein bindingIDA9271120 
GO:0005515protein bindingIPI7926747 |8999876 |9271120 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006367transcription initiation from RNA polymerase II promoterEXP8946909 
GO:0006367transcription initiation from RNA polymerase II promoterTAS1956398 
GO:0006368RNA elongation from RNA polymerase II promoterEXP9405375 
GO:0006350transcriptionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005654nucleoplasmEXP1939271 |2449431 |8946909 
GO:0005673transcription factor TFIIE complexIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ATF7IPFLJ10139 | FLJ10688 | MCAF | p621activating transcription factor 7 interacting protein-HPRD10777215 
ERCC3BTF2 | GTF2H | RAD25 | TFIIH | XPBexcision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing)Reconstituted ComplexBioGRID7926747 
ERCC6ARMD5 | CKN2 | COFS | COFS1 | CSB | RAD26excision repair cross-complementing rodent repair deficiency, complementation group 6-HPRD8999876 
FOSAP-1 | C-FOSv-fos FBJ murine osteosarcoma viral oncogene homologReconstituted ComplexBioGRID8628277 
GTF2A1MGC129969 | MGC129970 | TF2A1 | TFIIAgeneral transcription factor IIA, 1, 19/37kDa-HPRD,BioGRID9618479 |11509574 
GTF2BTF2B | TFIIBgeneral transcription factor IIBAffinity Capture-Western
Reconstituted Complex		BioGRID11113176 |12665589 
GTF2E1FE | TF2E1 | TFIIE-Ageneral transcription factor IIE, polypeptide 1, alpha 56kDa-HPRD,BioGRID9677423 |11113176 
|12665589 
GTF2E2FE | TF2E2 | TFIIE-Bgeneral transcription factor IIE, polypeptide 2, beta 34kDaReconstituted ComplexBioGRID9677423 
GTF2F1BTF4 | RAP74 | TF2F1 | TFIIFgeneral transcription factor IIF, polypeptide 1, 74kDaReconstituted ComplexBioGRID9677423 |11113176 
GTF2F2BTF4 | RAP30 | TF2F2 | TFIIFgeneral transcription factor IIF, polypeptide 2, 30kDaReconstituted ComplexBioGRID11113176 
JUNAP-1 | AP1 | c-Junjun oncogeneReconstituted ComplexBioGRID8628277 
KLF5BTEB2 | CKLF | IKLFKruppel-like factor 5 (intestinal)-HPRD9089417 
MDM2HDMX | MGC71221 | hdm2Mdm2 p53 binding protein homolog (mouse)-HPRD9271120 
POLR2AMGC75453 | POLR2 | POLRA | RPB1 | RPBh1 | RPO2 | RPOL2 | RpIILS | hRPB220 | hsRPB1polymerase (RNA) II (DNA directed) polypeptide A, 220kDaAffinity Capture-WesternBioGRID12665589 
SND1TDRD11 | p100staphylococcal nuclease and tudor domain containing 1-HPRD,BioGRID7651391 
TBPGTF2D | GTF2D1 | MGC117320 | MGC126054 | MGC126055 | SCA17 | TFIIDTATA box binding protein-HPRD,BioGRID9677423 |11113176 
XPAXP1 | XPACxeroderma pigmentosum, complementation group AReconstituted ComplexBioGRID7876263 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_BASAL_TRANSCRIPTION_FACTORS 3624All SZGR genes in this pathway
REACTOME_RNA_POL_II_TRANSCRIPTION 10554All SZGR genes in this pathway
REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING 4121All SZGR genes in this pathway
REACTOME_TRANSCRIPTION 210127All SZGR genes in this pathway
REACTOME_RNA_POL_II_PRE_TRANSCRIPTION_EVENTS 6132All SZGR genes in this pathway
REACTOME_HIV_INFECTION 207122All SZGR genes in this pathway
REACTOME_HIV_LIFE_CYCLE 12569All SZGR genes in this pathway
REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE 10461All SZGR genes in this pathway
SILIGAN_TARGETS_OF_EWS_FLI1_FUSION_DN 189All SZGR genes in this pathway
DARWICHE_SKIN_TUMOR_PROMOTER_DN 185115All SZGR genes in this pathway
DARWICHE_PAPILLOMA_RISK_LOW_DN 165107All SZGR genes in this pathway
DARWICHE_PAPILLOMA_RISK_HIGH_DN 180110All SZGR genes in this pathway
DARWICHE_SQUAMOUS_CELL_CARCINOMA_DN 181107All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN 712443All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_CHEK2_PCC_NETWORK 779480All SZGR genes in this pathway
GOLUB_ALL_VS_AML_UP 2420All SZGR genes in this pathway
SMITH_TERT_TARGETS_UP 14591All SZGR genes in this pathway
BECKER_TAMOXIFEN_RESISTANCE_UP 5036All SZGR genes in this pathway
STEARMAN_LUNG_CANCER_EARLY_VS_LATE_UP 12589All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_3D_UP 210124All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_DN 540340All SZGR genes in this pathway
LINDSTEDT_DENDRITIC_CELL_MATURATION_C 6949All SZGR genes in this pathway
AGUIRRE_PANCREATIC_CANCER_COPY_NUMBER_DN 238145All SZGR genes in this pathway
YAGI_AML_WITH_11Q23_REARRANGED 351238All SZGR genes in this pathway
QI_HYPOXIA 14096All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_LATE 1137655All SZGR genes in this pathway
LEE_BMP2_TARGETS_DN 882538All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-30-5p1211271Ahsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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