Gene Page: HCK

Summary
GeneID  3055
Symbol  HCK
Synonyms  JTK9
Description  hemopoietic cell kinase
See related  HGNC:4840|MIM:142370|Ensembl:ENSG00000101336|HPRD:00796|
Locus tag  RP5-836N17.3
Gene type  protein-coding
Map location  20q11-q12
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.1626 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
NDUFA90.850.76
C20orf300.830.79
APOA1BP0.820.73
TSPAN310.820.65
TRUB20.820.71
SDHB0.820.72
CYC10.810.67
C1orf1020.800.73
ECHS10.800.75
METTL10.800.76
Top 10 negatively co-expressed genes
EIF5B-0.42-0.49
ANP32C-0.38-0.46
AF347015.18-0.36-0.28
AC010300.1-0.36-0.44
AC005921.3-0.33-0.49
MAP4K4-0.31-0.29
ZNF326-0.30-0.25
AC100783.1-0.30-0.26
ZC3H13-0.29-0.21
THOC2-0.29-0.28
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005515protein bindingIPI7859737 |12029088 
GO:0005524ATP bindingIEA-
GO:0004715non-membrane spanning protein tyrosine kinase activityIEA-
GO:0016740transferase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006468protein amino acid phosphorylationTAS3496523 
GO:0007498mesoderm developmentTAS3453117 
GO:0044419interspecies interaction between organismsIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmIEA-
GO:0016020membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABL1ABL | JTK7 | bcr/abl | c-ABL | p150 | v-ablc-abl oncogene 1, receptor tyrosine kinase-HPRD,BioGRID9407116 
ABL2ABLL | ARG | FLJ22224 | FLJ31718 | FLJ41441v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)-HPRD12748290 
ADAM15MDC15ADAM metallopeptidase domain 15-HPRD,BioGRID11741929 
BCAR1CAS | CAS1 | CASS1 | CRKAS | P130Casbreast cancer anti-estrogen resistance 1-HPRD,BioGRID9020138 
BCRALL | BCR-ABL1 | BCR1 | CML | D22S11 | D22S662 | FLJ16453 | PHLbreakpoint cluster regionAffinity Capture-WesternBioGRID10849448 |12592324 
BTKAGMX1 | AT | ATK | BPK | IMD1 | MGC126261 | MGC126262 | PSCTK1 | XLABruton agammaglobulinemia tyrosine kinase-HPRD,BioGRID8058772 
C14orf4EAP1 | IRF2BPL | KIAA1865chromosome 14 open reading frame 4-HPRD12029088 
CBLC-CBL | CBL2 | RNF55Cas-Br-M (murine) ecotropic retroviral transforming sequence-HPRD,BioGRID10092522 
CCR3CC-CKR-3 | CD193 | CKR3 | CMKBR3 | MGC102841chemokine (C-C motif) receptor 3-HPRD,BioGRID10527858 
CSF3RCD114 | GCSFRcolony stimulating factor 3 receptor (granulocyte)-HPRD,BioGRID9790917 
DOK1MGC117395 | MGC138860 | P62DOKdocking protein 1, 62kDa (downstream of tyrosine kinase 1)Reconstituted ComplexBioGRID11071635 
ELMO1CED-12 | CED12 | ELMO-1 | KIAA0281 | MGC126406engulfment and cell motility 1-HPRD,BioGRID12029088 
EVLRNB6Enah/Vasp-like-HPRD12029088 
FCGR1ACD64 | CD64A | FCRI | FLJ18345 | IGFR1Fc fragment of IgG, high affinity Ia, receptor (CD64)-HPRD,BioGRID8064233 
FCGR2ACD32 | CD32A | CDw32 | FCG2 | FCGR2 | FCGR2A1 | FcGR | IGFR2 | MGC23887 | MGC30032Fc fragment of IgG, low affinity IIa, receptor (CD32)-HPRD9268059 
GALNAC4S-6STBRAG | DKFZp781H1369 | KIAA0598 | MGC34346 | RP11-47G11.1B cell RAG associated protein-HPRD,BioGRID10749872 
IL6STCD130 | CDw130 | GP130 | GP130-RAPS | IL6R-betainterleukin 6 signal transducer (gp130, oncostatin M receptor)-HPRD,BioGRID11689697 
KHDRBS1FLJ34027 | Sam68 | p62KH domain containing, RNA binding, signal transduction associated 1Hck interacts with Sam68.BIND11278465 
PECAM1CD31 | PECAM-1platelet/endothelial cell adhesion molecule-HPRD,BioGRID10858437 
PLAURCD87 | UPAR | URKRplasminogen activator, urokinase receptor-HPRD,BioGRID11097855 
PLCG1PLC-II | PLC1 | PLC148 | PLCgamma1phospholipase C, gamma 1-HPRD10586033 
RAPGEF1C3G | DKFZp781P1719 | GRF2Rap guanine nucleotide exchange factor (GEF) 1-HPRD,BioGRID14551197 
RASA1CM-AVM | CMAVM | DKFZp434N071 | GAP | PKWS | RASA | RASGAP | p120GAP | p120RASGAPRAS p21 protein activator (GTPase activating protein) 1-HPRD,BioGRID7782336 
RASA3GAP1IP4BP | GAPIII | MGC46517 | MGC47588RAS p21 protein activator 3-HPRD,BioGRID7782336 
RPL10DKFZp686J1851 | DXS648 | DXS648E | FLJ23544 | FLJ27072 | NOV | QMribosomal protein L10Reconstituted ComplexBioGRID12138090 
SH3BP1-SH3-domain binding protein 1-HPRD12029088 
SKAP2MGC10411 | MGC33304 | PRAP | RA70 | SAPS | SCAP2 | SKAP-HOM | SKAP55Rsrc kinase associated phosphoprotein 2-HPRD,BioGRID9837776 
TRPV4OTRPC4 | TRP12 | VR-OAC | VRL-2 | VRL2 | VROACtransient receptor potential cation channel, subfamily V, member 4-HPRD,BioGRID12538589 
UNC119HRG4unc-119 homolog (C. elegans)-HPRD,BioGRID12496276 
WASIMD2 | THC | WASPWiskott-Aldrich syndrome (eczema-thrombocytopenia)Reconstituted ComplexBioGRID12029088 
WIPF1MGC111041 | PRPL-2 | WASPIP | WIPWAS/WASL interacting protein family, member 1-HPRD,BioGRID12029088 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CHEMOKINE_SIGNALING_PATHWAY 190128All SZGR genes in this pathway
KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS 9771All SZGR genes in this pathway
BIOCARTA_BARRESTIN_SRC_PATHWAY 1514All SZGR genes in this pathway
PID_GLYPICAN_1PATHWAY 2720All SZGR genes in this pathway
PID_PTP1B_PATHWAY 5240All SZGR genes in this pathway
PID_P38_ALPHA_BETA_PATHWAY 3125All SZGR genes in this pathway
PID_TXA2PATHWAY 5743All SZGR genes in this pathway
PID_CXCR4_PATHWAY 10278All SZGR genes in this pathway
PID_PI3KCI_PATHWAY 4940All SZGR genes in this pathway
PID_AMB2_NEUTROPHILS_PATHWAY 4132All SZGR genes in this pathway
PID_EPHA_FWDPATHWAY 3429All SZGR genes in this pathway
PID_IL6_7_PATHWAY 4740All SZGR genes in this pathway
PID_PDGFRB_PATHWAY 129103All SZGR genes in this pathway
PID_IL8_CXCR2_PATHWAY 3426All SZGR genes in this pathway
PID_IL8_CXCR1_PATHWAY 2819All SZGR genes in this pathway
PID_EPHRINB_REV_PATHWAY 3025All SZGR genes in this pathway
PID_ALPHA_SYNUCLEIN_PATHWAY 3325All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ILS 10786All SZGR genes in this pathway
REACTOME_REGULATION_OF_SIGNALING_BY_CBL 1816All SZGR genes in this pathway
REACTOME_IL_3_5_AND_GM_CSF_SIGNALING 4334All SZGR genes in this pathway
REACTOME_HIV_INFECTION 207122All SZGR genes in this pathway
REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS 13281All SZGR genes in this pathway
REACTOME_THE_ROLE_OF_NEF_IN_HIV1_REPLICATION_AND_DISEASE_PATHOGENESIS 2819All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 270204All SZGR genes in this pathway
SMIRNOV_CIRCULATING_ENDOTHELIOCYTES_IN_CANCER_UP 158103All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_2_UP 418263All SZGR genes in this pathway
JAATINEN_HEMATOPOIETIC_STEM_CELL_DN 226132All SZGR genes in this pathway
MARKEY_RB1_ACUTE_LOF_UP 215137All SZGR genes in this pathway
LI_LUNG_CANCER 4130All SZGR genes in this pathway
KHETCHOUMIAN_TRIM24_TARGETS_UP 4738All SZGR genes in this pathway
GROSS_ELK3_TARGETS_UP 2716All SZGR genes in this pathway
MORI_IMMATURE_B_LYMPHOCYTE_UP 5335All SZGR genes in this pathway
BROCKE_APOPTOSIS_REVERSED_BY_IL6 14498All SZGR genes in this pathway
SHIPP_DLBCL_VS_FOLLICULAR_LYMPHOMA_UP 4530All SZGR genes in this pathway
BROWN_MYELOID_CELL_DEVELOPMENT_UP 165100All SZGR genes in this pathway
NEMETH_INFLAMMATORY_RESPONSE_LPS_UP 8864All SZGR genes in this pathway
HESS_TARGETS_OF_HOXA9_AND_MEIS1_DN 7748All SZGR genes in this pathway
VERHAAK_AML_WITH_NPM1_MUTATED_UP 183111All SZGR genes in this pathway
HADDAD_T_LYMPHOCYTE_AND_NK_PROGENITOR_DN 6341All SZGR genes in this pathway
NOUZOVA_TRETINOIN_AND_H4_ACETYLATION 14385All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_LATE_PROGENITOR 544307All SZGR genes in this pathway
MCLACHLAN_DENTAL_CARIES_DN 245144All SZGR genes in this pathway
MCLACHLAN_DENTAL_CARIES_UP 253147All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_UP 953554All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_UP 783442All SZGR genes in this pathway
HELLER_SILENCED_BY_METHYLATION_UP 282183All SZGR genes in this pathway
FINETTI_BREAST_CANCER_KINOME_GREEN 1614All SZGR genes in this pathway
ZHANG_BREAST_CANCER_PROGENITORS_DN 14593All SZGR genes in this pathway
BHATI_G2M_ARREST_BY_2METHOXYESTRADIOL_UP 12568All SZGR genes in this pathway
QI_PLASMACYTOMA_UP 259185All SZGR genes in this pathway
FIRESTEIN_PROLIFERATION 175125All SZGR genes in this pathway
BOHN_PRIMARY_IMMUNODEFICIENCY_SYNDROM_DN 4031All SZGR genes in this pathway
ICHIBA_GRAFT_VERSUS_HOST_DISEASE_D7_UP 10767All SZGR genes in this pathway
ICHIBA_GRAFT_VERSUS_HOST_DISEASE_35D_UP 13179All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_DN 435289All SZGR genes in this pathway
HOFFMANN_LARGE_TO_SMALL_PRE_BII_LYMPHOCYTE_DN 7247All SZGR genes in this pathway
HOFFMANN_IMMATURE_TO_MATURE_B_LYMPHOCYTE_DN 5036All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K27ME3 7959All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME2_AND_H3K27ME3 5935All SZGR genes in this pathway
GUTIERREZ_WALDENSTROEMS_MACROGLOBULINEMIA_1_DN 97All SZGR genes in this pathway
MIKKELSEN_NPC_HCP_WITH_H3K27ME3 341243All SZGR genes in this pathway
NAKAMURA_ADIPOGENESIS_EARLY_DN 3827All SZGR genes in this pathway
NAKAMURA_ADIPOGENESIS_LATE_DN 3825All SZGR genes in this pathway
MARTENS_BOUND_BY_PML_RARA_FUSION 456287All SZGR genes in this pathway
BHAT_ESR1_TARGETS_NOT_VIA_AKT1_UP 211131All SZGR genes in this pathway
BHAT_ESR1_TARGETS_VIA_AKT1_UP 281183All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_UP 682433All SZGR genes in this pathway
MADAN_DPPA4_TARGETS 4626All SZGR genes in this pathway
PLASARI_TGFB1_TARGETS_10HR_UP 199143All SZGR genes in this pathway


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