Gene Page: ILK

Summary
GeneID  3611
Symbol  ILK
Synonyms  DKFZp686F1765|P59
Description  integrin-linked kinase
See related  HGNC:6040|MIM:602366|Ensembl:ENSG00000166333|HPRD:03842|
Locus tag  -
Gene type  protein-coding
Map location  11p15.5-p15.4
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.2113 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
NOTCH30.860.84
LRIG10.840.86
BMP70.810.82
ASAP30.800.77
SYDE10.790.80
LAMB20.790.85
NRARP0.790.75
CTDSP10.790.79
LTBP30.780.79
ZFP36L20.770.79
Top 10 negatively co-expressed genes
NDUFAF2-0.46-0.58
VPS29-0.45-0.52
PFDN4-0.45-0.60
C20orf7-0.44-0.52
PSMA6-0.43-0.57
GPR22-0.42-0.45
MRPL1-0.41-0.52
PPP2R3C-0.41-0.54
FAM92A1-0.41-0.50
TAF9-0.41-0.50
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005515protein bindingIPI16936772 |17353931 |18339839 
GO:0005524ATP bindingNAS-
GO:0004674protein serine/threonine kinase activityIDA10871859 
GO:0004713protein tyrosine kinase activityIEA-
GO:0016740transferase activityIEA-
GO:0016301kinase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001658ureteric bud branchingIEA-
GO:0007160cell-matrix adhesionNAS-
GO:0006468protein amino acid phosphorylationIDA10871859 
GO:0007229integrin-mediated signaling pathwayIEA-
GO:0007229integrin-mediated signaling pathwayNAS-
GO:0008284positive regulation of cell proliferationIEA-
GO:0045197establishment or maintenance of epithelial cell apical/basal polarityIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmNAS-
GO:0005925focal adhesionIEA-
GO:0005886plasma membraneIEA-
GO:0030054cell junctionIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACP6ACPL1 | LPAP | PACPL1acid phosphatase 6, lysophosphatidicAffinity Capture-MSBioGRID17353931 
AKT1AKT | MGC99656 | PKB | PKB-ALPHA | PRKBA | RAC | RAC-ALPHAv-akt murine thymoma viral oncogene homolog 1-HPRD,BioGRID9736715 
AUP1-ancient ubiquitous protein 1Affinity Capture-MSBioGRID17353931 
CAV1CAV | MSTP085 | VIP21caveolin 1, caveolae protein, 22kDaILK1 interacts with caveolin-1.BIND15722199 
COPB2beta'-COPcoatomer protein complex, subunit beta 2 (beta prime)Affinity Capture-MSBioGRID17353931 
COPGCOPG1 | FLJ21068coatomer protein complex, subunit gammaAffinity Capture-MSBioGRID17353931 
DDX3XDBX | DDX14 | DDX3 | HLP2DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linkedAffinity Capture-MSBioGRID17353931 
DHX36DDX36 | G4R1 | KIAA1488 | MLEL1 | RHAUDEAH (Asp-Glu-Ala-His) box polypeptide 36Affinity Capture-MSBioGRID17353931 
ERHDROER | FLJ27340enhancer of rudimentary homolog (Drosophila)Affinity Capture-MSBioGRID17353931 
EWSR1EWSEwing sarcoma breakpoint region 1Affinity Capture-MSBioGRID17353931 
FANCIFLJ10719 | KIAA1794Fanconi anemia, complementation group IAffinity Capture-MSBioGRID17353931 
GEMIN4DKFZp434B131 | DKFZp434D174 | HC56 | HCAP1 | HHRF-1 | p97gem (nuclear organelle) associated protein 4Affinity Capture-MSBioGRID17353931 
GSK3B-glycogen synthase kinase 3 beta-HPRD9736715 
HEATR1BAP28 | FLJ10359 | MGC72083HEAT repeat containing 1Affinity Capture-MSBioGRID17353931 
HEATR2FLJ20397 | FLJ25564 | FLJ31671 | FLJ39381HEAT repeat containing 2Affinity Capture-MSBioGRID17353931 
HSPB1CMT2F | DKFZp586P1322 | HMN2B | HS.76067 | HSP27 | HSP28 | Hsp25 | SRP27heat shock 27kDa protein 1Affinity Capture-MSBioGRID17353931 
IGF2BP1CRD-BP | CRDBP | IMP-1 | IMP1 | VICKZ1 | ZBP1insulin-like growth factor 2 mRNA binding protein 1Affinity Capture-MSBioGRID17353931 
ILKDKFZp686F1765 | P59integrin-linked kinaseBiochemical ActivityBioGRID8538749 
ILKAPDKFZp434J2031 | FLJ10181 | MGC4846 | PP2C-DELTAintegrin-linked kinase-associated serine/threonine phosphatase 2C-HPRD,BioGRID11331582 
ITGA5CD49e | FNRA | VLA5Aintegrin, alpha 5 (fibronectin receptor, alpha polypeptide)Affinity Capture-WesternBioGRID8538749 
ITGB1CD29 | FNRB | GPIIA | MDF2 | MSK12 | VLA-BETA | VLABintegrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)Integrin-beta-1 interacts with ILK.BIND8538749 
-HPRD,BioGRID8538749 |9736715 
ITGB2CD18 | LAD | LCAMB | LFA-1 | MAC-1 | MF17 | MFI7integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)-HPRD9736715 
ITGB3CD61 | GP3A | GPIIIaintegrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)-HPRD,BioGRID12372433 
Integrin-beta-3 interacts with ILK.BIND12372433 
LIMS1PINCH | PINCH1LIM and senescent cell antigen-like domains 1PINCH interacts with ILK.BIND15565145 
-HPRD,BioGRID10022929 
LIMS2FLJ10044 | PINCH-2LIM and senescent cell antigen-like domains 2-HPRD,BioGRID12167643 
MARSFLJ35667 | METRS | MTRNSmethionyl-tRNA synthetaseAffinity Capture-MSBioGRID17353931 
MMS19FLJ34167 | FLJ95146 | MET18 | MGC99604 | MMS19L | hMMS19MMS19 nucleotide excision repair homolog (S. cerevisiae)Affinity Capture-MSBioGRID17353931 
MYO1DKIAA0727 | myr4myosin IDAffinity Capture-MSBioGRID17353931 
NCK2GRB4 | NCKbetaNCK adaptor protein 2-HPRD,BioGRID10022929 
NOC2LDKFZp564C186 | FLJ35172 | NIRnucleolar complex associated 2 homolog (S. cerevisiae)Affinity Capture-MSBioGRID17353931 
OTUD4DKFZp434I0721 | DUBA6 | HIN1 | HSHIN1 | KIAA1046OTU domain containing 4Affinity Capture-MSBioGRID17353931 
PARVAFLJ10793 | FLJ12254 | MXRA2parvin, alphaTwo-hybridBioGRID16189514 
-HPRD11331308 |15284246 
-HPRD11331308 
-HPRD11694518 
PARVBCGI-56parvin, betaAffinity Capture-MSBioGRID17353931 
-HPRD15467740 
-HPRD11402068 
An unspecified isoform of affixin interacts with ILK.BIND12372433 
PDK1-pyruvate dehydrogenase kinase, isozyme 1-HPRD,BioGRID11313365 
PRPSAP1PAP39phosphoribosyl pyrophosphate synthetase-associated protein 1Affinity Capture-MSBioGRID17353931 
PUF60FIR | FLJ31379 | RoBPI | SIAHBP1poly-U binding splicing factor 60KDaAffinity Capture-MSBioGRID17353931 
PXNFLJ16691paxillin-HPRD,BioGRID11304546 |11694518 
RSU1FLJ31034 | RSP-1Ras suppressor protein 1Affinity Capture-MSBioGRID17353931 
S100A960B8AG | CAGB | CFAG | CGLB | L1AG | LIAG | MAC387 | MIF | MRP14 | NIF | P14S100 calcium binding protein A9Affinity Capture-MSBioGRID17353931 
TMSB4XFX | PTMB4 | TB4X | TMSB4thymosin beta 4, X-linkedILK interacts with Thymosin Beta-4.BIND15565145 
VTNR-vitronectin receptorAffinity Capture-WesternBioGRID8538749 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_PPAR_SIGNALING_PATHWAY 6947All SZGR genes in this pathway
KEGG_FOCAL_ADHESION 201138All SZGR genes in this pathway
KEGG_ENDOMETRIAL_CANCER 5245All SZGR genes in this pathway
BIOCARTA_PTEN_PATHWAY 1814All SZGR genes in this pathway
ST_INTEGRIN_SIGNALING_PATHWAY 8262All SZGR genes in this pathway
SA_PTEN_PATHWAY 1714All SZGR genes in this pathway
PID_AVB3_OPN_PATHWAY 3129All SZGR genes in this pathway
PID_ILK_PATHWAY 4532All SZGR genes in this pathway
PID_AVB3_INTEGRIN_PATHWAY 7553All SZGR genes in this pathway
REACTOME_CELL_CELL_COMMUNICATION 12077All SZGR genes in this pathway
REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS 1410All SZGR genes in this pathway
REACTOME_CELL_JUNCTION_ORGANIZATION 7843All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
HWANG_PROSTATE_CANCER_MARKERS 2819All SZGR genes in this pathway
HUMMERICH_SKIN_CANCER_PROGRESSION_DN 10064All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN 584395All SZGR genes in this pathway
BENPORATH_MYC_MAX_TARGETS 775494All SZGR genes in this pathway
PENG_GLUCOSE_DEPRIVATION_DN 169112All SZGR genes in this pathway
VERRECCHIA_RESPONSE_TO_TGFB1_C5 2111All SZGR genes in this pathway
VERRECCHIA_DELAYED_RESPONSE_TO_TGFB1 3926All SZGR genes in this pathway
KONDO_PROSTATE_CANCER_HCP_WITH_H3K27ME3 9772All SZGR genes in this pathway
TOOKER_GEMCITABINE_RESISTANCE_UP 7940All SZGR genes in this pathway
HSIAO_HOUSEKEEPING_GENES 389245All SZGR genes in this pathway
DANG_REGULATED_BY_MYC_DN 253192All SZGR genes in this pathway
DANG_MYC_TARGETS_DN 3125All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
SASSON_RESPONSE_TO_GONADOTROPHINS_DN 8766All SZGR genes in this pathway
SASSON_RESPONSE_TO_FORSKOLIN_DN 8868All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP 756494All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_CLASSICAL 162122All SZGR genes in this pathway
WIERENGA_STAT5A_TARGETS_DN 213127All SZGR genes in this pathway
PASINI_SUZ12_TARGETS_DN 315215All SZGR genes in this pathway
FORTSCHEGGER_PHF8_TARGETS_DN 784464All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-311901961Ahsa-miR-31AGGCAAGAUGCUGGCAUAGCUG
miR-542-3p2332401A,m8hsa-miR-542-3pUGUGACAGAUUGAUAACUGAAA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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