Gene Page: LDLR

Summary
GeneID  3949
Symbol  LDLR
Synonyms  FH|FHC
Description  low density lipoprotein receptor
See related  HGNC:6547|MIM:606945|Ensembl:ENSG00000130164|HPRD:06091|
Locus tag  -
Gene type  protein-coding
Map location  19p13.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0288 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005041low-density lipoprotein receptor activityTAS2777800 
GO:0004888transmembrane receptor activityTAS6091915 
GO:0004872receptor activityIEA-
GO:0030229very-low-density lipoprotein receptor activityIEA-
GO:0005509calcium ion bindingIEA-
GO:0005319lipid transporter activityIEA-
GO:0008034lipoprotein bindingTAS6091915 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006493protein amino acid O-linked glycosylationTAS6091915 
GO:0008202steroid metabolic processIEA-
GO:0008203cholesterol metabolic processIEA-
GO:0006629lipid metabolic processTAS6299582 |10827173 
GO:0006869lipid transportIEA-
GO:0006897endocytosisTAS12671190 
GO:0034383low-density lipoprotein particle clearanceIMP17142622 
GO:0030301cholesterol transportIMP17142622 
GO:0030299cholesterol absorptionIMP17142622 
GO:0042632cholesterol homeostasisIEA-
GO:0044419interspecies interaction between organismsIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005768endosomeIEA-
GO:0005905coated pitIEA-
GO:0005886plasma membraneEXP221835 |8300609 
GO:0005886plasma membraneTAS2777800 
GO:0005887integral to plasma membraneTAS6327078 
GO:0010008endosome membraneEXP221835 
GO:0030669clathrin-coated endocytic vesicle membraneEXP221835 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AP1M2AP1-mu2 | HSMU1B | MU-1B | MU1B | mu2adaptor-related protein complex 1, mu 2 subunit-HPRD,BioGRID11157985 
APOBFLDBapolipoprotein B (including Ag(x) antigen)-HPRD12031600 
APOEAD2 | LPG | MGC1571 | apoproteinapolipoprotein E-HPRD12036962 
CD36CHDS7 | FAT | GP3B | GP4 | GPIV | PASIV | SCARB3CD36 molecule (thrombospondin receptor)Reconstituted ComplexBioGRID9555943 
DAB1-disabled homolog 1 (Drosophila)Reconstituted Complex
Two-hybrid		BioGRID9837937 |10827173 
-HPRD10380922 
DAB2DOC-2 | DOC2 | FLJ26626disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)Reconstituted ComplexBioGRID11247302 
HSPA5BIP | FLJ26106 | GRP78 | MIF2heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)-HPRD,BioGRID10906332 
LDLRAP1ARH | ARH1 | ARH2 | DKFZp586D0624 | FHCB1 | FHCB2 | MGC34705low density lipoprotein receptor adaptor protein 1-HPRD,BioGRID12221107 
LRPAP1A2MRAP | A2RAP | HBP44 | MGC138272 | MRAP | RAPlow density lipoprotein receptor-related protein associated protein 1-HPRD,BioGRID7822276 
PF4CXCL4 | MGC138298 | SCYB4platelet factor 4-HPRD,BioGRID11986215 
SNX17KIAA0064sorting nexin 17-HPRD,BioGRID12169628 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_ENDOCYTOSIS 183132All SZGR genes in this pathway
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 478302All SZGR genes in this pathway
REACTOME_LIPID_DIGESTION_MOBILIZATION_AND_TRANSPORT 4637All SZGR genes in this pathway
REACTOME_LIPOPROTEIN_METABOLISM 2824All SZGR genes in this pathway
REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT 1615All SZGR genes in this pathway
WINTER_HYPOXIA_UP 9257All SZGR genes in this pathway
WILCOX_RESPONSE_TO_PROGESTERONE_UP 15290All SZGR genes in this pathway
GARY_CD5_TARGETS_UP 473314All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP 485293All SZGR genes in this pathway
PUIFFE_INVASION_INHIBITED_BY_ASCITES_DN 14591All SZGR genes in this pathway
CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_DN 663425All SZGR genes in this pathway
GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_YELLOW_UP 3225All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_1_DN 12686All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_2_DN 7746All SZGR genes in this pathway
MULLIGHAN_NPM1_SIGNATURE_3_DN 162116All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_FIMA_UP 544308All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_FIMA_DN 284156All SZGR genes in this pathway
NAGASHIMA_NRG1_SIGNALING_UP 176123All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP 722443All SZGR genes in this pathway
MARKEY_RB1_ACUTE_LOF_UP 215137All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN 770415All SZGR genes in this pathway
KAN_RESPONSE_TO_ARSENIC_TRIOXIDE 12380All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN 712443All SZGR genes in this pathway
DAUER_STAT3_TARGETS_UP 4935All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN 483336All SZGR genes in this pathway
DAIRKEE_TERT_TARGETS_UP 380213All SZGR genes in this pathway
AMIT_EGF_RESPONSE_40_HELA 4229All SZGR genes in this pathway
AMIT_EGF_RESPONSE_60_HELA 4632All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_DN 357212All SZGR genes in this pathway
BROCKE_APOPTOSIS_REVERSED_BY_IL6 14498All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_DN 309206All SZGR genes in this pathway
KLEIN_PRIMARY_EFFUSION_LYMPHOMA_UP 5129All SZGR genes in this pathway
HASLINGER_B_CLL_WITH_13Q14_DELETION 2418All SZGR genes in this pathway
AFFAR_YY1_TARGETS_DN 234137All SZGR genes in this pathway
ABE_VEGFA_TARGETS_2HR 3421All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_14HR_DN 298200All SZGR genes in this pathway
KANG_FLUOROURACIL_RESISTANCE_DN 1610All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
ZHU_CMV_8_HR_DN 5340All SZGR genes in this pathway
ZHU_CMV_24_HR_DN 9164All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_18HR_UP 178111All SZGR genes in this pathway
ZHU_CMV_ALL_DN 12893All SZGR genes in this pathway
DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_DN 287208All SZGR genes in this pathway
JACKSON_DNMT1_TARGETS_DN 2521All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_NHEK_DN 318220All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_12HR_UP 11168All SZGR genes in this pathway
TSENG_IRS1_TARGETS_UP 11371All SZGR genes in this pathway
WANG_CISPLATIN_RESPONSE_AND_XPC_UP 202115All SZGR genes in this pathway
SESTO_RESPONSE_TO_UV_C5 4636All SZGR genes in this pathway
GENTILE_UV_RESPONSE_CLUSTER_D8 4029All SZGR genes in this pathway
BILD_HRAS_ONCOGENIC_SIGNATURE 261166All SZGR genes in this pathway
LEIN_MEDULLA_MARKERS 8148All SZGR genes in this pathway
ZHANG_GATA6_TARGETS_DN 6446All SZGR genes in this pathway
HELLER_SILENCED_BY_METHYLATION_UP 282183All SZGR genes in this pathway
IWANAGA_CARCINOGENESIS_BY_KRAS_UP 170107All SZGR genes in this pathway
ACEVEDO_NORMAL_TISSUE_ADJACENT_TO_LIVER_TUMOR_DN 354216All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_DN 540340All SZGR genes in this pathway
MITSIADES_RESPONSE_TO_APLIDIN_UP 439257All SZGR genes in this pathway
SMID_BREAST_CANCER_ERBB2_UP 14783All SZGR genes in this pathway
BOCHKIS_FOXA2_TARGETS 425261All SZGR genes in this pathway
LABBE_TARGETS_OF_TGFB1_AND_WNT3A_DN 10868All SZGR genes in this pathway
NAKAMURA_METASTASIS_MODEL_DN 4328All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_DN 366257All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_UP 338225All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_UP 418282All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_DN 245150All SZGR genes in this pathway
CHANG_CORE_SERUM_RESPONSE_DN 209137All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_GOOD_SURVIVAL_A12 317177All SZGR genes in this pathway
SHAFFER_IRF4_TARGETS_IN_MYELOMA_VS_MATURE_B_LYMPHOCYTE 10176All SZGR genes in this pathway
SHAFFER_IRF4_TARGETS_IN_PLASMA_CELL_VS_MATURE_B_LYMPHOCYTE 6751All SZGR genes in this pathway
SHAFFER_IRF4_TARGETS_IN_ACTIVATED_B_LYMPHOCYTE 8166All SZGR genes in this pathway
MILI_PSEUDOPODIA_CHEMOTAXIS_DN 457302All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_DN 668419All SZGR genes in this pathway
BOYAULT_LIVER_CANCER_SUBCLASS_G6_DN 1913All SZGR genes in this pathway
COULOUARN_TEMPORAL_TGFB1_SIGNATURE_DN 13899All SZGR genes in this pathway
WOO_LIVER_CANCER_RECURRENCE_DN 8054All SZGR genes in this pathway
FOURNIER_ACINAR_DEVELOPMENT_LATE_2 277172All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_4 1511All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_1HR_UP 6144All SZGR genes in this pathway
WANG_RESPONSE_TO_GSK3_INHIBITOR_SB216763_DN 374217All SZGR genes in this pathway
PANGAS_TUMOR_SUPPRESSION_BY_SMAD1_AND_SMAD5_DN 157106All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_UP 430288All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_LATE 1137655All SZGR genes in this pathway
LEE_BMP2_TARGETS_DN 882538All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP 570339All SZGR genes in this pathway
SCHMIDT_POR_TARGETS_IN_LIMB_BUD_UP 2621All SZGR genes in this pathway
PEDERSEN_METASTASIS_BY_ERBB2_ISOFORM_7 403240All SZGR genes in this pathway
ROLEF_GLIS3_TARGETS 3729All SZGR genes in this pathway
PHONG_TNF_TARGETS_UP 6343All SZGR genes in this pathway
PHONG_TNF_RESPONSE_VIA_P38_PARTIAL 160106All SZGR genes in this pathway
PHONG_TNF_RESPONSE_NOT_VIA_P38 337236All SZGR genes in this pathway
VANOEVELEN_MYOGENESIS_SIN3A_TARGETS 220133All SZGR genes in this pathway
SMIRNOV_RESPONSE_TO_IR_6HR_DN 11469All SZGR genes in this pathway
ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF 516308All SZGR genes in this pathway
HORTON_SREBF_TARGETS 2520All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-130/301871877m8hsa-miR-130abrainCAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrainCAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3pUAGUGCAAUAUUGCUUAUAGGGUUU
miR-148/152872878m8hsa-miR-148aUCAGUGCACUACAGAACUUUGU
hsa-miR-152brainUCAGUGCAUGACAGAACUUGGG
hsa-miR-148bUCAGUGCAUCACAGAACUUUGU
miR-17-5p/20/93.mr/106/519.d815821m8hsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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