Gene Page: ATF4

Summary
GeneID  468
Symbol  ATF4
Synonyms  CREB-2|CREB2|TAXREB67|TXREB
Description  activating transcription factor 4 (tax-responsive enhancer element B67)
See related  HGNC:786|MIM:604064|Ensembl:ENSG00000128272|HPRD:06817|
Locus tag  -
Gene type  protein-coding
Map location  22q13.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenia, schizophrenias]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
SND10.870.84
RPN10.870.86
PSMD20.870.84
C22orf280.870.86
DAP30.870.85
CCT70.860.84
PRMT50.860.82
MTCH20.860.86
ZNF2070.860.84
FAF10.860.85
Top 10 negatively co-expressed genes
MT-CO2-0.74-0.71
AF347015.8-0.73-0.72
AF347015.21-0.73-0.72
AF347015.31-0.72-0.71
AF347015.2-0.71-0.73
AF347015.33-0.70-0.71
AF347015.27-0.69-0.70
MT-CYB-0.69-0.69
AF347015.15-0.68-0.70
AF347015.26-0.68-0.69
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityTAS12689582 
GO:0003704specific RNA polymerase II transcription factor activityISS-
GO:0016563transcription activator activityIMP11960987 
GO:0016563transcription activator activityISS-
GO:0016563transcription activator activityNAS9190894 
GO:0043565sequence-specific DNA bindingIEA-
GO:0046983protein dimerization activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006355regulation of transcription, DNA-dependentISS-
GO:0006350transcriptionIEA-
GO:0006520amino acid metabolic processTAS12689582 
GO:0006094gluconeogenesisISS-
GO:0006950response to stressIEP15314157 
GO:0045944positive regulation of transcription from RNA polymerase II promoterIMP15788408 
GO:0045944positive regulation of transcription from RNA polymerase II promoterISS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusISS-
GO:0005737cytoplasmISS-
GO:0005886plasma membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CCDC106HSU79303 | ZNF581coiled-coil domain containing 106Two-hybridBioGRID16169070 
CEBPBC/EBP-beta | CRP2 | IL6DBP | LAP | MGC32080 | NF-IL6 | TCF5CCAAT/enhancer binding protein (C/EBP), beta-HPRD11018027 
CEBPGGPE1BP | IG/EBP-1CCAAT/enhancer binding protein (C/EBP), gamma-HPRD,BioGRID1371974 
CREBBPCBP | KAT3A | RSTSCREB binding proteinReconstituted ComplexBioGRID9295363 
DAPK3FLJ36473 | ZIP | ZIPKdeath-associated protein kinase 3-HPRD9488481 
DISC1C1orf136 | FLJ13381 | FLJ21640 | FLJ25311 | FLJ41105 | KIAA0457 | SCZD9disrupted in schizophrenia 1-HPRD,BioGRID12812986 
An unspecified isoform of DISC1 interacts with ATF4.BIND14623284 
DISC-1 interacts with ATF4.BIND12812986 
EIF2ACDA02 | EIF-2A | MST089 | MSTP004 | MSTP089eukaryotic translation initiation factor 2A, 65kDaAffinity Capture-WesternBioGRID15475356 
GABBR2FLJ36928 | GABABR2 | GPR51 | GPRC3B | HG20 | HRIHFB2099gamma-aminobutyric acid (GABA) B receptor, 2-HPRD,BioGRID11087824 
GPS2AMF-1 | MGC104294 | MGC119287 | MGC119288 | MGC119289G protein pathway suppressor 2Two-hybridBioGRID16189514 
GTF2BTF2B | TFIIBgeneral transcription factor IIBReconstituted ComplexBioGRID9295363 
GTF2F2BTF4 | RAP30 | TF2F2 | TFIIFgeneral transcription factor IIF, polypeptide 2, 30kDa-HPRD,BioGRID9295363 
JUNAP-1 | AP1 | c-Junjun oncogene-HPRD,BioGRID1827203 
LDOC1BCUR1 | Mar7 | Mart7leucine zipper, down-regulated in cancer 1Two-hybridBioGRID16189514 
NFE2L1FLJ00380 | LCR-F1 | NRF1 | TCF11nuclear factor (erythroid-derived 2)-like 1-HPRD11025215 
NFE2L2NRF2nuclear factor (erythroid-derived 2)-like 2-HPRD11274184 
POLR2CRPB3 | RPB31 | hRPB33 | hsRPB3polymerase (RNA) II (DNA directed) polypeptide C, 33kDa-HPRD,BioGRID12860379 
PTCD3DKFZp666K071 | FLJ20758Pentatricopeptide repeat domain 3Two-hybridBioGRID16189514 
TBPGTF2D | GTF2D1 | MGC117320 | MGC126054 | MGC126055 | SCA17 | TFIIDTATA box binding proteinReconstituted ComplexBioGRID9295363 
TREX2-three prime repair exonuclease 2Two-hybridBioGRID16189514 
TRIB3C20orf97 | NIPK | SINK | SKIP3 | TRB3tribbles homolog 3 (Drosophila)-HPRD,BioGRID12743605 
SKIP3 interacts with ATF4.BIND12743605 
TTRHsT2651 | PALB | TBPAtransthyretinTwo-hybridBioGRID16189514 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MAPK_SIGNALING_PATHWAY 267205All SZGR genes in this pathway
KEGG_LONG_TERM_POTENTIATION 7057All SZGR genes in this pathway
KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 126103All SZGR genes in this pathway
KEGG_GNRH_SIGNALING_PATHWAY 10177All SZGR genes in this pathway
KEGG_PROSTATE_CANCER 8975All SZGR genes in this pathway
PID_FRA_PATHWAY 3728All SZGR genes in this pathway
REACTOME_DIABETES_PATHWAYS 13391All SZGR genes in this pathway
REACTOME_PERK_REGULATED_GENE_EXPRESSION 2914All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_CHAPERONES_BY_ATF6_ALPHA 139All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_GENES_BY_ATF4 2612All SZGR genes in this pathway
REACTOME_UNFOLDED_PROTEIN_RESPONSE 8051All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA 118All SZGR genes in this pathway
IGARASHI_ATF4_TARGETS_DN 9065All SZGR genes in this pathway
GARY_CD5_TARGETS_UP 473314All SZGR genes in this pathway
GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_RED_UP 1713All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_UP 530342All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_3_DN 229142All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP 552347All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN 770415All SZGR genes in this pathway
BARIS_THYROID_CANCER_UP 239All SZGR genes in this pathway
MARTIN_INTERACT_WITH_HDAC 4431All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN 712443All SZGR genes in this pathway
HEIDENBLAD_AMPLICON_8Q24_DN 4628All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM1 229137All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_DN 156106All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_ONLY_UP 3318All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP 811508All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
BENPORATH_NANOG_TARGETS 988594All SZGR genes in this pathway
BENPORATH_SOX2_TARGETS 734436All SZGR genes in this pathway
BENPORATH_MYC_TARGETS_WITH_EBOX 230156All SZGR genes in this pathway
BENPORATH_MYC_MAX_TARGETS 775494All SZGR genes in this pathway
BENPORATH_ES_CORE_NINE_CORRELATED 10068All SZGR genes in this pathway
PENG_LEUCINE_DEPRIVATION_UP 14293All SZGR genes in this pathway
FERNANDEZ_BOUND_BY_MYC 182116All SZGR genes in this pathway
LEE_AGING_NEOCORTEX_DN 8049All SZGR genes in this pathway
SESTO_RESPONSE_TO_UV_C6 3927All SZGR genes in this pathway
HU_GENOTOXIC_DAMAGE_24HR 3522All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_NHEK_UP 244151All SZGR genes in this pathway
ZHOU_TNF_SIGNALING_30MIN 5436All SZGR genes in this pathway
MARIADASON_RESPONSE_TO_CURCUMIN_SULINDAC_5 2317All SZGR genes in this pathway
VARELA_ZMPSTE24_TARGETS_UP 4030All SZGR genes in this pathway
DAZARD_UV_RESPONSE_CLUSTER_G2 3018All SZGR genes in this pathway
PELLICCIOTTA_HDAC_IN_ANTIGEN_PRESENTATION_DN 4938All SZGR genes in this pathway
HELLER_SILENCED_BY_METHYLATION_DN 10567All SZGR genes in this pathway
HELLER_HDAC_TARGETS_DN 292189All SZGR genes in this pathway
HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_DN 281179All SZGR genes in this pathway
DAIRKEE_CANCER_PRONE_RESPONSE_BPA_E2 11865All SZGR genes in this pathway
BOCHKIS_FOXA2_TARGETS 425261All SZGR genes in this pathway
GRADE_COLON_CANCER_UP 871505All SZGR genes in this pathway
LABBE_TARGETS_OF_TGFB1_AND_WNT3A_DN 10868All SZGR genes in this pathway
CHO_NR4A1_TARGETS 3322All SZGR genes in this pathway
BHATI_G2M_ARREST_BY_2METHOXYESTRADIOL_DN 12775All SZGR genes in this pathway
PODAR_RESPONSE_TO_ADAPHOSTIN_UP 14798All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_UP 245159All SZGR genes in this pathway
WANG_TUMOR_INVASIVENESS_DN 210128All SZGR genes in this pathway
BOHN_PRIMARY_IMMUNODEFICIENCY_SYNDROM_UP 4730All SZGR genes in this pathway
ZAIDI_OSTEOBLAST_TRANSCRIPTION_FACTORS 1412All SZGR genes in this pathway
CHAUHAN_RESPONSE_TO_METHOXYESTRADIOL_UP 5132All SZGR genes in this pathway
AGUIRRE_PANCREATIC_CANCER_COPY_NUMBER_DN 238145All SZGR genes in this pathway
SHAFFER_IRF4_TARGETS_IN_MYELOMA_VS_MATURE_B_LYMPHOCYTE 10176All SZGR genes in this pathway
SHAFFER_IRF4_TARGETS_IN_PLASMA_CELL_VS_MATURE_B_LYMPHOCYTE 6751All SZGR genes in this pathway
HSIAO_HOUSEKEEPING_GENES 389245All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
DORN_ADENOVIRUS_INFECTION_12HR_UP 2918All SZGR genes in this pathway
DORN_ADENOVIRUS_INFECTION_24HR_UP 126All SZGR genes in this pathway
DORN_ADENOVIRUS_INFECTION_32HR_UP 117All SZGR genes in this pathway
DORN_ADENOVIRUS_INFECTION_48HR_UP 149All SZGR genes in this pathway
BAE_BRCA1_TARGETS_UP 7547All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_DN 841431All SZGR genes in this pathway
PLASARI_TGFB1_SIGNALING_VIA_NFIC_1HR_UP 3325All SZGR genes in this pathway
FORTSCHEGGER_PHF8_TARGETS_UP 279155All SZGR genes in this pathway


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