Gene Page: FURIN

Summary
GeneID  5045
Symbol  FURIN
Synonyms  FUR|PACE|PCSK3|SPC1
Description  furin (paired basic amino acid cleaving enzyme)
See related  HGNC:8568|MIM:136950|Ensembl:ENSG00000140564|HPRD:00653|
Locus tag  -
Gene type  protein-coding
Map location  15q26.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.1637 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004252serine-type endopeptidase activityIEAglutamate (GO term level: 7)-
GO:0002020protease bindingIPI14744861 
GO:0004867serine-type endopeptidase inhibitor activityIDA10567353 
GO:0005509calcium ion bindingIEA-
GO:0005515protein bindingIEA-
GO:0008233peptidase activityIDA15082773 
GO:0042277peptide bindingIDA8940009 
GO:0048406nerve growth factor bindingIDA8615794 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006465signal peptide processingIDA16912035 
GO:0052548regulation of endopeptidase activityIDA14744861 
GO:0008283cell proliferationIMP15899807 
GO:0042176regulation of protein catabolic processIMP15899807 
GO:0051605protein maturation via proteolysisIDA9242664 |10567353 |14744861 
GO:0051605protein maturation via proteolysisIMP15899807 
GO:0019067viral assembly, maturation, egress, and releaseIEP8940009 
GO:0032804negative regulation of low-density lipoprotein receptor catabolic processIDA16912035 
GO:0032904negative regulation of nerve growth factor productionIDA10567353 
GO:0032911negative regulation of transforming growth factor-beta1 productionIMP15899807 
GO:0032940secretion by cellIDA8615794 
GO:0032455nerve growth factor processingEXP12787574 
GO:0043043peptide biosynthetic processIDA8262946 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000139Golgi membraneEXP8615794 
GO:0005794Golgi apparatusIEA-
GO:0005802trans-Golgi networkIDA14744861 
GO:0005615extracellular spaceIDA10567353 
GO:0016021integral to membraneIEA-
GO:0009986cell surfaceIDA16537537 
GO:0005886plasma membraneIEA-
GO:0030140trans-Golgi network transport vesicleIDA15078902 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ADAMTS4ADAMTS-2 | ADAMTS-4 | ADMP-1 | KIAA0688ADAM metallopeptidase with thrombospondin type 1 motif, 4Furin interacts with ADAMTS4.BIND14744861 
AP2M1AP50 | CLAPM1 | mu2adaptor-related protein complex 2, mu 1 subunit-HPRD,BioGRID10593987 
COL23A1DKFZp434K0621collagen, type XXIII, alpha 1-HPRD12644459 
FLNAABP-280 | ABPX | DKFZp434P031 | FLN | FLN1 | FMD | MNS | NHBP | OPD | OPD1 | OPD2filamin A, alpha (actin binding protein 280)-HPRD9412467 
FLNCABP-280 | ABP280A | ABPA | ABPL | FLJ10186 | FLN2filamin C, gamma (actin binding protein 280)-HPRD9412467 
LRP1A2MR | APOER | APR | CD91 | FLJ16451 | IGFBP3R | LRP | MGC88725 | TGFBR5low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)-HPRD8546712 
PACS1FLJ10209 | KIAA1175phosphofurin acidic cluster sorting protein 1-HPRD,BioGRID9695949 |11331585 
SERPINB8CAP2 | PI8serpin peptidase inhibitor, clade B (ovalbumin), member 8-HPRD,BioGRID9442015 
ZP4ZBP | ZP1 | ZPBzona pellucida glycoprotein 4-HPRD11804956 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_NOTCH_PATHWAY 5949All SZGR genes in this pathway
PID_P75_NTR_PATHWAY 6951All SZGR genes in this pathway
PID_HIF1_TFPATHWAY 6652All SZGR genes in this pathway
REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION 2717All SZGR genes in this pathway
REACTOME_SIGNALLING_BY_NGF 217167All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_SIGNALING_BY_NODAL 1811All SZGR genes in this pathway
REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS 118All SZGR genes in this pathway
REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX 2911All SZGR genes in this pathway
REACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING 4424All SZGR genes in this pathway
REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION 8742All SZGR genes in this pathway
REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI 1610All SZGR genes in this pathway
REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS 2616All SZGR genes in this pathway
REACTOME_SIGNALING_BY_PDGF 12293All SZGR genes in this pathway
REACTOME_METABOLISM_OF_PROTEINS 518242All SZGR genes in this pathway
REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION 188116All SZGR genes in this pathway
REACTOME_SIGNALING_BY_NOTCH 10364All SZGR genes in this pathway
REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX 6342All SZGR genes in this pathway
GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN 335193All SZGR genes in this pathway
GINESTIER_BREAST_CANCER_20Q13_AMPLIFICATION_DN 180101All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN 514330All SZGR genes in this pathway
GOTZMANN_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_UP 6955All SZGR genes in this pathway
SUNG_METASTASIS_STROMA_UP 11070All SZGR genes in this pathway
HSIAO_LIVER_SPECIFIC_GENES 244154All SZGR genes in this pathway
NEMETH_INFLAMMATORY_RESPONSE_LPS_UP 8864All SZGR genes in this pathway
MOREAUX_MULTIPLE_MYELOMA_BY_TACI_UP 412249All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_20HR_UP 240152All SZGR genes in this pathway
YAMAZAKI_TCEB3_TARGETS_UP 175116All SZGR genes in this pathway
SAFFORD_T_LYMPHOCYTE_ANERGY 8754All SZGR genes in this pathway
JOSEPH_RESPONSE_TO_SODIUM_BUTYRATE_UP 3121All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_DN 540340All SZGR genes in this pathway
LABBE_TGFB1_TARGETS_UP 10264All SZGR genes in this pathway
LABBE_TARGETS_OF_TGFB1_AND_WNT3A_UP 11170All SZGR genes in this pathway
WANG_TUMOR_INVASIVENESS_DN 210128All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_CTNNB1_DN 170105All SZGR genes in this pathway
YAGI_AML_WITH_T_8_21_TRANSLOCATION 368247All SZGR genes in this pathway
LI_INDUCED_T_TO_NATURAL_KILLER_UP 307182All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_MESENCHYMAL 216130All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_2_UP 14094All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3 824528All SZGR genes in this pathway
DELACROIX_RARG_BOUND_MEF 367231All SZGR genes in this pathway
KRIEG_KDM3A_TARGETS_NOT_HYPOXIA 208107All SZGR genes in this pathway
BOSCO_ALLERGEN_INDUCED_TH2_ASSOCIATED_MODULE 15186All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-103/107828834m8hsa-miR-103brainAGCAGCAUUGUACAGGGCUAUGA
hsa-miR-107brainAGCAGCAUUGUACAGGGCUAUCA
miR-124/50612871293m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-12812251231m8hsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-1373653721A,m8hsa-miR-137UAUUGCUUAAGAAUACGCGUAG
miR-15/16/195/424/497829835m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-153156715741A,m8hsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-17-5p/20/93.mr/106/519.d4248m8hsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
hsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
miR-1854314371Ahsa-miR-185brainUGGAGAGAAAGGCAGUUC
miR-219131213191A,m8hsa-miR-219brainUGAUUGUCCAAACGCAAUUCU
miR-22249255m8hsa-miR-22brainAAGCUGCCAGUUGAAGAACUGU
miR-24724730m8hsa-miR-24SZUGGCUCAGUUCAGCAGGAACAG
miR-33113871393m8hsa-miR-331brainGCCCCUGGGCCUAUCCUAGAA
miR-448156815741Ahsa-miR-448UUGCAUAUGUAGGAUGUCCCAU
miR-45215701576m8hsa-miR-452UGUUUGCAGAGGAAACUGAGAC
miR-543153215381Ahsa-miR-543AAACAUUCGCGGUGCACUUCU
miR-95662m8hsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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