Gene Page: PLCB4

Summary
GeneID  5332
Symbol  PLCB4
Synonyms  FLJ16169|PI-PLC
Description  phospholipase C, beta 4
See related  HGNC:9059|MIM:600810|Ensembl:ENSG00000101333|HPRD:02885|
Locus tag  RP4-811H13.1
Gene type  protein-coding
Map location  20p12
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.046 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
AL161668.20.820.84
KIAA01950.810.80
ARAP10.810.81
LTBP30.800.80
SLC27A10.800.84
ASAP30.780.78
GPR560.780.82
CASKIN20.770.77
GPT20.770.75
DNM20.770.76
Top 10 negatively co-expressed genes
PPEF1-0.49-0.49
THOC7-0.48-0.52
CALM2-0.48-0.50
BRP44-0.48-0.55
GLMN-0.47-0.54
GPR160-0.47-0.55
TCEAL7-0.47-0.51
TMEM70-0.46-0.53
USMG5-0.45-0.59
BEX5-0.45-0.47
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004871signal transducer activityIEA-
GO:0005509calcium ion bindingIEA-
GO:0005515protein bindingIEA-
GO:0005515protein bindingIPI16767099 
GO:0004435phosphoinositide phospholipase C activityIEA-
GO:0016787hydrolase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0016042lipid catabolic processIEA-
GO:0007242intracellular signaling cascadeIEA-
GO:0006629lipid metabolic processIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0014069postsynaptic densityIEASynap (GO term level: 10)-
GO:0030425dendriteIEAneuron, axon, dendrite (GO term level: 6)-
GO:0005792microsomeIEA-
GO:0005790smooth endoplasmic reticulumIEA-
GO:0005634nucleusIEA-
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_INOSITOL_PHOSPHATE_METABOLISM 5442All SZGR genes in this pathway
KEGG_CALCIUM_SIGNALING_PATHWAY 178134All SZGR genes in this pathway
KEGG_CHEMOKINE_SIGNALING_PATHWAY 190128All SZGR genes in this pathway
KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM 7656All SZGR genes in this pathway
KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION 11581All SZGR genes in this pathway
KEGG_WNT_SIGNALING_PATHWAY 151112All SZGR genes in this pathway
KEGG_GAP_JUNCTION 9068All SZGR genes in this pathway
KEGG_LONG_TERM_POTENTIATION 7057All SZGR genes in this pathway
KEGG_LONG_TERM_DEPRESSION 7053All SZGR genes in this pathway
KEGG_GNRH_SIGNALING_PATHWAY 10177All SZGR genes in this pathway
KEGG_MELANOGENESIS 10280All SZGR genes in this pathway
KEGG_ALZHEIMERS_DISEASE 169110All SZGR genes in this pathway
KEGG_HUNTINGTONS_DISEASE 185109All SZGR genes in this pathway
ST_G_ALPHA_I_PATHWAY 3529All SZGR genes in this pathway
REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK 205136All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_OPIOID_SIGNALLING 7856All SZGR genes in this pathway
REACTOME_PLC_BETA_MEDIATED_EVENTS 4332All SZGR genes in this pathway
REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS 184116All SZGR genes in this pathway
REACTOME_GPCR_DOWNSTREAM_SIGNALING 805368All SZGR genes in this pathway
DAVICIONI_TARGETS_OF_PAX_FOXO1_FUSIONS_DN 6849All SZGR genes in this pathway
BASAKI_YBX1_TARGETS_UP 290177All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_1_DN 12686All SZGR genes in this pathway
MULLIGHAN_NPM1_SIGNATURE_3_DN 162116All SZGR genes in this pathway
JAATINEN_HEMATOPOIETIC_STEM_CELL_UP 316190All SZGR genes in this pathway
ODONNELL_METASTASIS_UP 8258All SZGR genes in this pathway
STREICHER_LSM1_TARGETS_UP 4434All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_XPCS_DN 8871All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_HIGH_RECURRENCE 4931All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
DAWSON_METHYLATED_IN_LYMPHOMA_TCL1 5945All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_POORLY_UP 236139All SZGR genes in this pathway
RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_MODERATELY_UP 10969All SZGR genes in this pathway
RICKMAN_METASTASIS_UP 344180All SZGR genes in this pathway
RICKMAN_HEAD_AND_NECK_CANCER_A 10063All SZGR genes in this pathway
STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN 517309All SZGR genes in this pathway
ROZANOV_MMP14_TARGETS_UP 266171All SZGR genes in this pathway
HADDAD_T_LYMPHOCYTE_AND_NK_PROGENITOR_UP 7856All SZGR genes in this pathway
AFFAR_YY1_TARGETS_UP 214133All SZGR genes in this pathway
WANG_SMARCE1_TARGETS_DN 371218All SZGR genes in this pathway
ULE_SPLICING_VIA_NOVA2 4338All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_6HR_DN 160101All SZGR genes in this pathway
RIGGINS_TAMOXIFEN_RESISTANCE_DN 220147All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_DN 228114All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_UP 648398All SZGR genes in this pathway
GRADE_COLON_CANCER_UP 871505All SZGR genes in this pathway
GRADE_COLON_AND_RECTAL_CANCER_UP 285167All SZGR genes in this pathway
HUANG_DASATINIB_RESISTANCE_DN 6944All SZGR genes in this pathway
FIRESTEIN_PROLIFERATION 175125All SZGR genes in this pathway
SASAI_TARGETS_OF_CXCR6_AND_PTCH1_UP 139All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_C_D_DN 252155All SZGR genes in this pathway
GU_PDEF_TARGETS_UP 7149All SZGR genes in this pathway
MARIADASON_RESPONSE_TO_BUTYRATE_CURCUMIN_SULINDAC_TSA_1 107All SZGR genes in this pathway
NIELSEN_GIST 9866All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_1HR_DN 222147All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_PRONEURAL 177132All SZGR genes in this pathway
WIERENGA_PML_INTERACTOME 4223All SZGR genes in this pathway
TORCHIA_TARGETS_OF_EWSR1_FLI1_FUSION_DN 321200All SZGR genes in this pathway
IKEDA_MIR30_TARGETS_UP 11687All SZGR genes in this pathway
SERVITJA_ISLET_HNF1A_TARGETS_UP 163111All SZGR genes in this pathway
FORTSCHEGGER_PHF8_TARGETS_DN 784464All SZGR genes in this pathway
PHONG_TNF_RESPONSE_NOT_VIA_P38 337236All SZGR genes in this pathway
RAO_BOUND_BY_SALL4_ISOFORM_A 182108All SZGR genes in this pathway
ACEVEDO_FGFR1_TARGETS_IN_PROSTATE_CANCER_MODEL_DN 308187All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
let-7/984934991Ahsa-let-7abrainUGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrainUGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrainUGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrainAGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrainUGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrainUGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brainUGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZUGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrainUGAGGUAGUAGUUUGUGCUGU
miR-130/3013994051Ahsa-miR-130abrainCAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrainCAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3pUAGUGCAAUAUUGCUUAUAGGGUUU
miR-183507513m8hsa-miR-183UAUGGCACUGGUAGAAUUCACUG
miR-190112211281Ahsa-miR-190UGAUAUGUUUGAUAUAUUAGGU
miR-21412001206m8hsa-miR-214brainACAGCAGGCACAGACAGGCAG
miR-23752758m8hsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
miR-30-5p6516571Ahsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-3237527581Ahsa-miR-323brainGCACAUUACACGGUCGACCUCU
miR-36510311037m8hsa-miR-365UAAUGCCCCUAAAAAUCCUUAU
miR-378112611321Ahsa-miR-378CUCCUGACUCCAGGUCCUGUGU
miR-381134813541Ahsa-miR-381UAUACAAGGGCAAGCUCUCUGU
miR-965976041A,m8hsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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