Gene Page: PLXNB1

Summary
GeneID  5364
Symbol  PLXNB1
Synonyms  KIAA0407|MGC149167|PLEXIN-B1|PLXN5|SEP
Description  plexin B1
See related  HGNC:9103|MIM:601053|Ensembl:ENSG00000164050|HPRD:03032|
Locus tag  -
Gene type  protein-coding
Map location  3p21.31
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenia, schizophrenias]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
CCND10.800.81
TGFBR30.760.85
TEK0.760.80
CTSO0.750.79
NEBL0.750.76
PTPRB0.750.81
EPB41L20.750.79
MAP3K50.750.78
SASH10.750.79
SLC20A20.740.80
Top 10 negatively co-expressed genes
EXOSC8-0.52-0.60
RP9-0.52-0.56
NR2C2AP-0.51-0.52
CYP2R1-0.50-0.54
SNHG12-0.50-0.59
ZNF311-0.50-0.41
TRNAU1AP-0.50-0.49
PLEKHO1-0.49-0.49
ARL9-0.49-0.48
ALKBH2-0.49-0.53
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIEA-
GO:0017154semaphorin receptor activityTAS10520995 
GO:0030215semaphorin receptor bindingTAS10520995 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0050772positive regulation of axonogenesisIEAaxon, neurogenesis (GO term level: 14)-
GO:0007242intracellular signaling cascadeNAS10520995 
GO:0007275multicellular organismal developmentIEA-
GO:0016477cell migrationNAS10520995 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005622intracellularIEA-
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneNAS10520995 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARHGEF11DKFZp667F1223 | GTRAP48 | KIAA0380 | PDZ-RHOGEFRho guanine nucleotide exchange factor (GEF) 11-HPRD,BioGRID12183458 
ARHGEF12DKFZp686O2372 | KIAA0382 | LARG | PRO2792Rho guanine nucleotide exchange factor (GEF) 12-HPRD,BioGRID12220504 
MLLALL-1 | CXXC7 | FLJ11783 | HRX | HTRX1 | KMT2A | MLL/GAS7 | MLL1A | TET1-MLL | TRX1myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)-HPRD12123608 
PLXNA1NOV | NOVP | PLEXIN-A1 | PLXN1plexin A1-HPRD12559962 
RAC1MGC111543 | MIG5 | TC-25 | p21-Rac1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-HPRD12123608 
Plexin-B1 interacts with Rac1. This interaction was modelled on a demonstrated interaction between human Plexin-B1 and Rac1 from an unspecified species.BIND15642257 
RND1ARHS | FLJ42294 | RHO6 | RHOSRho family GTPase 1Plexin-B1 interacts with Rnd1.BIND15297673 
-HPRD,BioGRID12730235 
RND2ARHN | RHO7 | RhoNRho family GTPase 2Reconstituted ComplexBioGRID12730235 
RND3ARHE | Rho8 | RhoE | memBRho family GTPase 3Reconstituted ComplexBioGRID12730235 
SEMA4BKIAA1745 | MGC131831 | SEMAC | SemCsema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B-HPRD12123608 
SEMA4DC9orf164 | CD100 | FLJ33485 | FLJ34282 | FLJ39737 | FLJ46484 | M-sema-G | MGC169138 | MGC169141 | SEMAJ | coll-4sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D-HPRD,BioGRID11937491 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_AXON_GUIDANCE 129103All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_AXON_GUIDANCE 251188All SZGR genes in this pathway
REACTOME_G_ALPHA1213_SIGNALLING_EVENTS 7456All SZGR genes in this pathway
REACTOME_GPCR_DOWNSTREAM_SIGNALING 805368All SZGR genes in this pathway
REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING 3222All SZGR genes in this pathway
REACTOME_SEMAPHORIN_INTERACTIONS 6853All SZGR genes in this pathway
REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE 2721All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_UP 450256All SZGR genes in this pathway
BORCZUK_MALIGNANT_MESOTHELIOMA_DN 10459All SZGR genes in this pathway
WATANABE_ULCERATIVE_COLITIS_WITH_CANCER_UP 1810All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_UP 1821933All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_UP 293179All SZGR genes in this pathway
DELYS_THYROID_CANCER_UP 443294All SZGR genes in this pathway
ONDER_CDH1_TARGETS_2_DN 464276All SZGR genes in this pathway
KAYO_AGING_MUSCLE_UP 244165All SZGR genes in this pathway
KIM_GASTRIC_CANCER_CHEMOSENSITIVITY 10364All SZGR genes in this pathway
LU_AGING_BRAIN_UP 262186All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_18HR_DN 178121All SZGR genes in this pathway
SARRIO_EPITHELIAL_MESENCHYMAL_TRANSITION_DN 154101All SZGR genes in this pathway
IWANAGA_CARCINOGENESIS_BY_KRAS_DN 12081All SZGR genes in this pathway
ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_DN 274165All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_DN 701446All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_OPTIMAL_DEBULKING 246152All SZGR genes in this pathway
CHANG_CORE_SERUM_RESPONSE_DN 209137All SZGR genes in this pathway
VALK_AML_CLUSTER_6 3322All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S2 11574All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY 1839928All SZGR genes in this pathway
NABA_ECM_AFFILIATED 17189All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-101314320m8hsa-miR-101UACAGUACUGUGAUAACUGAAG
miR-3626166221Ahsa-miR-362AAUCCUUGGAACCUAGGUGUGAGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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