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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: PRKCE

Summary

GeneID

5581

Symbol

PRKCE

Synonyms

MGC125656|MGC125657|PKCE|nPKC-epsilon

Description

protein kinase C, epsilon

Locus tag

Gene type

protein-coding

Map location

2p21

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 6.2183

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

MYT1

0.93

0.82

PHF21B

0.91

0.84

VANGL2

0.91

0.89

MED12

0.91

0.87

CTBP2

0.90

0.87

SERINC2

0.90

0.82

NUP188

0.90

0.89

PLAGL2

0.90

0.84

FANCC

0.89

0.85

ABL1

0.89

0.87

Top 10 negatively co-expressed genes

C5orf53

-0.58

-0.79

HLA-F

-0.55

-0.71

FBXO2

-0.55

-0.64

PTH1R

-0.54

-0.66

AIFM3

-0.54

-0.69

SLC16A11

-0.54

-0.61

LHPP

-0.54

-0.58

TNFSF12

-0.53

-0.61

ALDOC

-0.53

-0.63

TMEM54

-0.53

-0.57

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0000166

nucleotide binding

IEA

GO:0004871

signal transducer activity

TAS

1382605 |10438519

GO:0004699

calcium-independent protein kinase C activity

IEA

GO:0005515

protein binding

IPI

10801826 |17668322

GO:0005524

ATP binding

IEA

GO:0004674

protein serine/threonine kinase activity

IEA

GO:0016740

transferase activity

IEA

GO:0008270

zinc ion binding

IEA

GO:0019992

diacylglycerol binding

IEA

GO:0046872

metal ion binding

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006468

protein amino acid phosphorylation

IEA

GO:0006468

protein amino acid phosphorylation

TAS

1382605

GO:0007242

intracellular signaling cascade

IEA

GO:0006917

induction of apoptosis

TAS

10438519

GO:0050730

regulation of peptidyl-tyrosine phosphorylation

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005624

membrane fraction

TAS

7935319

GO:0005634

nucleus

IEA

GO:0005737

cytoplasm

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ACTA1	ACTA \| ASMA \| CFTD \| CFTD1 \| CFTDM \| MPFD \| NEM1 \| NEM2 \| NEM3	actin, alpha 1, skeletal muscle	Affinity Capture-MS Affinity Capture-Western	BioGRID	11897493
ACTC1	ACTC \| CMD1R \| CMH11	actin, alpha, cardiac muscle 1	-	HPRD	11968018
ADAP1	CENTA1 \| GCS1L \| p42IP4	ArfGAP with dual PH domains 1	Biochemical Activity	BioGRID	12893243
AFAP1	AFAP \| AFAP-110 \| FLJ56849	actin filament associated protein 1	-	HPRD,BioGRID	12134071
AKAP9	AKAP350 \| AKAP450 \| CG-NAP \| HYPERION \| KIAA0803 \| MU-RMS-40.16A \| PRKA9 \| YOTIAO	A kinase (PRKA) anchor protein (yotiao) 9	-	HPRD	10945988
CFTR	ABC35 \| ABCC7 \| CF \| CFTR/MRP \| MRP7 \| TNR-CFTR \| dJ760C5.1	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	-	HPRD,BioGRID	11956211
CNN1	SMCC \| Sm-Calp	calponin 1, basic, smooth muscle	-	HPRD	9312127
COPB1	COPB \| DKFZp761K102 \| FLJ10341	coatomer protein complex, subunit beta 1	-	HPRD	11897493
COPB2	beta'-COP	coatomer protein complex, subunit beta 2 (beta prime)	Affinity Capture-MS Affinity Capture-Western	BioGRID	11897493
COPB2	beta'-COP	coatomer protein complex, subunit beta 2 (beta prime)	-	HPRD	9360998
GAD1	FLJ45882 \| GAD \| SCP	glutamate decarboxylase 1 (brain, 67kDa)	Biochemical Activity	BioGRID	15147202
GAD2	GAD65 \| MGC161605 \| MGC161607	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	-	HPRD,BioGRID	15147202
GJA1	CX43 \| DFNB38 \| GJAL \| ODDD	gap junction protein, alpha 1, 43kDa	-	HPRD,BioGRID	10679481
GNA12	MGC104623 \| MGC99644 \| NNX3 \| RMP \| gep	guanine nucleotide binding protein (G protein) alpha 12	Biochemical Activity	BioGRID	8824244
GNA13	G13 \| MGC46138	guanine nucleotide binding protein (G protein), alpha 13	-	HPRD,BioGRID	8824244
GNB2L1	Gnb2-rs1 \| H12.3 \| HLC-7 \| PIG21 \| RACK1	guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1	Affinity Capture-Western Far Western Reconstituted Complex	BioGRID	11956211
GRIN1	NMDA1 \| NMDAR1 \| NR1	glutamate receptor, ionotropic, N-methyl D-aspartate 1	-	HPRD	10862698
HK2	DKFZp686M1669 \| HKII \| HXK2	hexokinase 2	Affinity Capture-Western	BioGRID	12663490
KRT1	CK1 \| EHK1 \| K1 \| KRT1A	keratin 1	-	HPRD,BioGRID	11897493
KRT18	CYK18 \| K18	keratin 18	-	HPRD,BioGRID	1374067
MAPK1	ERK \| ERK2 \| ERT1 \| MAPK2 \| P42MAPK \| PRKM1 \| PRKM2 \| p38 \| p40 \| p41 \| p41mapk	mitogen-activated protein kinase 1	Affinity Capture-Western	BioGRID	11350735
MYH2	MYH2A \| MYHSA2 \| MYHas8 \| MyHC-2A \| MyHC-IIa	myosin, heavy chain 2, skeletal muscle, adult	-	HPRD	11897493
MYH9	DFNA17 \| EPSTS \| FTNS \| MGC104539 \| MHA \| NMHC-II-A \| NMMHCA	myosin, heavy chain 9, non-muscle	Affinity Capture-MS Affinity Capture-Western	BioGRID	11897493
PDLIM5	ENH \| ENH1 \| L9 \| LIM	PDZ and LIM domain 5	-	HPRD,BioGRID	8940095
PDPK1	MGC20087 \| MGC35290 \| PDK1 \| PRO0461	3-phosphoinositide dependent protein kinase-1	An unspecified isoform of PDPK1 (PDK1) phosphorylates PRKCE (PKC-epsilon). This interaction was modeled on a demonstrated interaction between PDPK1 from an unspecified species and PRKCE from an unspecified species.	BIND	12223477
PIK3CB	DKFZp779K1237 \| MGC133043 \| PI3K \| PI3KCB \| PI3Kbeta \| PIK3C1 \| p110-BETA	phosphoinositide-3-kinase, catalytic, beta polypeptide	-	HPRD,BioGRID	9822674
PPP1R14A	CPI-17 \| CPI17 \| PPP1INL	protein phosphatase 1, regulatory (inhibitor) subunit 14A	-	HPRD	15003508
PRKCE	MGC125656 \| MGC125657 \| PKCE \| nPKC-epsilon	protein kinase C, epsilon	PRKCE (PKC-epsilon) autophosphorylates. This interaction was modeled on a demonstrated interaction using PRKCE from an unspecified species.	BIND	12223477
PRKD1	PKC-MU \| PKCM \| PKD \| PRKCM	protein kinase D1	PRKCE (PKC-epsilon) phosphorylates PRKD1 (PKC-mu). This interaction was modeled on a demonstrated interaction between PRKCE from an unspecified species and human PRKD1.	BIND	12223477
RAF1	CRAF \| NS5 \| Raf-1 \| c-Raf	v-raf-1 murine leukemia viral oncogene homolog 1	-	HPRD,BioGRID	11350735
RASGRP3	GRP3 \| KIAA0846	RAS guanyl releasing protein 3 (calcium and DAG-regulated)	Biochemical Activity	BioGRID	15213298
SLC25A4	AAC1 \| ANT \| ANT1 \| PEO2 \| PEO3 \| T1	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4	Affinity Capture-Western	BioGRID	12663490
SNCA	MGC110988 \| NACP \| PARK1 \| PARK4 \| PD1	synuclein, alpha (non A4 component of amyloid precursor)	-	HPRD	10407019
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	-	HPRD	11834516
TIAM1	FLJ36302	T-cell lymphoma invasion and metastasis 1	-	HPRD,BioGRID	10212259
VDAC1	MGC111064 \| PORIN \| PORIN-31-HL	voltage-dependent anion channel 1	-	HPRD,BioGRID	12663490
YWHAZ	KCIP-1 \| MGC111427 \| MGC126532 \| MGC138156	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	Affinity Capture-Western	BioGRID	11950841

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION	115	81	All SZGR genes in this pathway
KEGG_TIGHT_JUNCTION	134	86	All SZGR genes in this pathway
KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY	79	58	All SZGR genes in this pathway
KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS	97	71	All SZGR genes in this pathway
KEGG_TYPE_II_DIABETES_MELLITUS	47	41	All SZGR genes in this pathway
BIOCARTA_KERATINOCYTE_PATHWAY	46	38	All SZGR genes in this pathway
BIOCARTA_PTDINS_PATHWAY	23	16	All SZGR genes in this pathway
BIOCARTA_AKAPCENTROSOME_PATHWAY	15	14	All SZGR genes in this pathway
PID_ENDOTHELIN_PATHWAY	63	52	All SZGR genes in this pathway
PID_LYSOPHOSPHOLIPID_PATHWAY	66	53	All SZGR genes in this pathway
PID_TCR_PATHWAY	66	51	All SZGR genes in this pathway
PID_LPA4_PATHWAY	15	10	All SZGR genes in this pathway
PID_CDC42_PATHWAY	70	51	All SZGR genes in this pathway
PID_CD8_TCR_PATHWAY	53	42	All SZGR genes in this pathway
PID_TXA2PATHWAY	57	43	All SZGR genes in this pathway
PID_NFAT_3PATHWAY	54	47	All SZGR genes in this pathway
PID_IL2_1PATHWAY	55	43	All SZGR genes in this pathway
PID_PDGFRB_PATHWAY	129	103	All SZGR genes in this pathway
PID_IL8_CXCR1_PATHWAY	28	19	All SZGR genes in this pathway
PID_RAS_PATHWAY	30	22	All SZGR genes in this pathway
PID_CD8_TCR_DOWNSTREAM_PATHWAY	65	56	All SZGR genes in this pathway
REACTOME_SIGNALLING_BY_NGF	217	167	All SZGR genes in this pathway
REACTOME_DAG_AND_IP3_SIGNALING	32	25	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ERBB2	101	78	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_EGFR_IN_CANCER	109	80	All SZGR genes in this pathway
REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE	137	105	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR_IN_DISEASE	127	88	All SZGR genes in this pathway
REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK	205	136	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR	920	449	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_PDGF	122	93	All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION	95	76	All SZGR genes in this pathway
REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS	184	116	All SZGR genes in this pathway
REACTOME_GPCR_DOWNSTREAM_SIGNALING	805	368	All SZGR genes in this pathway
REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS	44	29	All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR	100	74	All SZGR genes in this pathway
REACTOME_PHOSPHOLIPASE_C_MEDIATED_CASCADE	54	40	All SZGR genes in this pathway
REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS	25	17	All SZGR genes in this pathway
REACTOME_HEMOSTASIS	466	331	All SZGR genes in this pathway
REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION	208	138	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR	112	80	All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_3_4WK_UP	214	144	All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_4_5WK_DN	196	131	All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP	1037	673	All SZGR genes in this pathway
MANTOVANI_NFKB_TARGETS_UP	43	33	All SZGR genes in this pathway
MANTOVANI_VIRAL_GPCR_SIGNALING_UP	86	54	All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS	1038	678	All SZGR genes in this pathway
BENPORATH_EED_TARGETS	1062	725	All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3	1118	744	All SZGR genes in this pathway
BENPORATH_PRC2_TARGETS	652	441	All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_AND_BRAIN_QTL_CIS	65	38	All SZGR genes in this pathway
CHESLER_BRAIN_HIGHEST_EXPRESSION	40	29	All SZGR genes in this pathway
GOLDRATH_IMMUNE_MEMORY	65	42	All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_14HR_DN	298	200	All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL	254	164	All SZGR genes in this pathway
BURTON_ADIPOGENESIS_2	72	52	All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_AND_PROGENITOR	681	420	All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_DN	543	317	All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_UP	602	364	All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_UP	601	369	All SZGR genes in this pathway
IWANAGA_CARCINOGENESIS_BY_KRAS_DN	120	81	All SZGR genes in this pathway
YAUCH_HEDGEHOG_SIGNALING_PARACRINE_DN	264	159	All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_DN	435	289	All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE	721	492	All SZGR genes in this pathway
TORCHIA_TARGETS_OF_EWSR1_FLI1_FUSION_UP	271	165	All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D	658	397	All SZGR genes in this pathway
PEDRIOLI_MIR31_TARGETS_UP	221	120	All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY	1839	928	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-101	3040	3047	1A,m8	hsa-miR-101	UACAGUACUGUGAUAACUGAAG
miR-103/107	1564	1570	1A	hsa-miR-103^brain	AGCAGCAUUGUACAGGGCUAUGA
miR-103/107	1564	1570	1A	hsa-miR-107^brain	AGCAGCAUUGUACAGGGCUAUCA
miR-141/200a	1289	1296	1A,m8	hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
miR-141/200a	1289	1296	1A,m8	hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
miR-143	2180	2187	1A,m8	hsa-miR-143^brain	UGAGAUGAAGCACUGUAGCUCA
miR-144	3041	3047	1A	hsa-miR-144	UACAGUAUAGAUGAUGUACUAG
miR-181	3060	3066	m8	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-182	3032	3038	1A	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-182	3032	3038	1A	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-205	2732	2739	1A,m8	hsa-miR-205	UCCUUCAUUCCACCGGAGUCUG
miR-216	1495	1501	m8	hsa-miR-216	UAAUCUCAGCUGGCAACUGUG
miR-218	2153	2159	m8	hsa-miR-218^brain	UUGUGCUUGAUCUAACCAUGU
miR-23	3057	3063	1A	hsa-miR-23a^brain	AUCACAUUGCCAGGGAUUUCC
miR-23	3057	3063	1A	hsa-miR-23b^brain	AUCACAUUGCCAGGGAUUACC
miR-25/32/92/363/367	1628	1635	1A,m8	hsa-miR-25^brain	CAUUGCACUUGUCUCGGUCUGA
				hsa-miR-32	UAUUGCACAUUACUAAGUUGC
				hsa-miR-92	UAUUGCACUUGUCCCGGCCUG
				hsa-miR-367	AAUUGCACUUUAGCAAUGGUGA
				hsa-miR-92b^SZ	UAUUGCACUCGUCCCGGCCUC
miR-362	2735	2741	1A	hsa-miR-362	AAUCCUUGGAACCUAGGUGUGAGU
miR-363	2879	2885	1A	hsa-miR-363	AUUGCACGGUAUCCAUCUGUAA
miR-381	1503	1509	1A	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-500	1626	1633	1A,m8	hsa-miR-500	AUGCACCUGGGCAAGGAUUCUG
miR-543	1838	1844	m8	hsa-miR-543	AAACAUUCGCGGUGCACUUCU
miR-96	614	620	1A	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC
miR-96	614	620	1A	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.