Gene Page: MAPK1

Summary
GeneID  5594
Symbol  MAPK1
Synonyms  ERK|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk
Description  mitogen-activated protein kinase 1
See related  HGNC:6871|MIM:176948|Ensembl:ENSG00000100030|HPRD:01496|
Locus tag  -
Gene type  protein-coding
Map location  22q11.2|22q11.21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.031 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.1451 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0004707MAP kinase activityTAS10706854 
GO:0001784phosphotyrosine bindingIEA-
GO:0005515protein bindingIPI9632734 |16286470 |16291755 
GO:0005524ATP bindingIEA-
GO:0004674protein serine/threonine kinase activityEXP16626623 
GO:0004674protein serine/threonine kinase activityIEA-
GO:0016740transferase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007268synaptic transmissionTASneuron, Synap, Neurotransmitter (GO term level: 6)10051431 
GO:0000165MAPKKK cascadeIEA-
GO:0006468protein amino acid phosphorylationIEA-
GO:0007265Ras protein signal transductionEXP11520933 
GO:0006917induction of apoptosisTAS10958679 
GO:0009887organ morphogenesisIEA-
GO:0007049cell cycleIEA-
GO:0019858cytosine metabolic processIEA-
GO:0006974response to DNA damage stimulusIEA-
GO:0006935chemotaxisTAS10706854 
GO:0032496response to lipopolysaccharideIEA-
GO:0031663lipopolysaccharide-mediated signaling pathwayIEA-
GO:0043330response to exogenous dsRNAIEA-
GO:0044419interspecies interaction between organismsIEA-
GO:0045596negative regulation of cell differentiationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP10066798 |10878576 
GO:0005856cytoskeletonIDA18029348 
GO:0005634nucleusIEA-
GO:0005654nucleoplasmEXP9687510 |16456541 |16626623 
|17322878 
GO:0005730nucleolusIDA18029348 
GO:0005737cytoplasmIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ADAM17CD156b | MGC71942 | TACE | cSVPADAM metallopeptidase domain 17Affinity Capture-Western
Biochemical Activity
Reconstituted Complex		BioGRID12058067 
ARAIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFMandrogen receptorReconstituted ComplexBioGRID10318905 
ATF2CRE-BP1 | CREB2 | HB16 | MGC111558 | TREB7activating transcription factor 2Biochemical ActivityBioGRID7737129 
ATP1A1MGC3285 | MGC51750ATPase, Na+/K+ transporting, alpha 1 polypeptideBiochemical ActivityBioGRID15069082 
BCL2Bcl-2B-cell CLL/lymphoma 2-HPRD15225643 
C1QBPGC1QBP | HABP1 | SF2p32 | gC1Q-R | gC1qR | p32complement component 1, q subcomponent binding protein-HPRD,BioGRID11866440 
CALCOCO1Cocoa | KIAA1536 | PP13275 | calphoglincalcium binding and coiled-coil domain 1KIAA1536 is phosphorylated by MAPK1. This interaction was modeled on a demonstrated interaction between human KIAA1536 and MAPK1 from an unspecified species.BIND15489336 
CASP9APAF-3 | APAF3 | CASPASE-9c | ICE-LAP6 | MCH6caspase 9, apoptosis-related cysteine peptidase-HPRD,BioGRID12792650 
CEBPBC/EBP-beta | CRP2 | IL6DBP | LAP | MGC32080 | NF-IL6 | TCF5CCAAT/enhancer binding protein (C/EBP), betaBiochemical ActivityBioGRID11500490 
DAPK1DAPK | DKFZp781I035death-associated protein kinase 1DAPK interacts with Erk2.BIND15616583 
DUSP1CL100 | HVH1 | MKP-1 | MKP1 | PTPN10dual specificity phosphatase 1-HPRD,BioGRID11278799 
DUSP16KIAA1700 | MGC129701 | MGC129702 | MKP-7 | MKP7dual specificity phosphatase 16-HPRD,BioGRID11489891 
DUSP22JKAP | JSP1 | MKPX | VHXdual specificity phosphatase 22Affinity Capture-Western
Biochemical Activity		BioGRID11346645 
DUSP3VHRdual specificity phosphatase 3-HPRD,BioGRID10224087 
DUSP4HVH2 | MKP-2 | MKP2 | TYPdual specificity phosphatase 4-HPRD7535768 
DUSP6MKP3 | PYST1dual specificity phosphatase 6-HPRD,BioGRID9535927 
-HPRD9535927 |15269220 
DYRK1BMIRKdual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B-HPRD,BioGRID10910078 
ELK1-ELK1, member of ETS oncogene familyMapk1 (p42Mapk) phosphorylates Elk1 at Ser383.BIND15782123 
-HPRD8208531 |8586671 
Biochemical Activity
Reconstituted Complex		BioGRID8586671 |12594221 
EPORMGC138358erythropoietin receptor-HPRD12538595 
ESR1DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1estrogen receptor 1-HPRD,BioGRID12093745 
FHL2AAG11 | DRAL | SLIM3four and a half LIM domains 2Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID14729955 
FHL3MGC19547 | MGC23614 | MGC8696 | SLIM2four and a half LIM domains 3-HPRD14729955 
GATA4MGC126629GATA binding protein 4Biochemical ActivityBioGRID11585926 
GMFBGMFglia maturation factor, beta-HPRD8639570 
HDAC4HA6116 | HD4 | HDAC-A | HDACA | KIAA0288histone deacetylase 4-HPRD,BioGRID11114188 
HMMRCD168 | IHABP | MGC119494 | MGC119495 | RHAMMhyaluronan-mediated motility receptor (RHAMM)Affinity Capture-WesternBioGRID11403955 
HSP90AA1FLJ31884 | HSP86 | HSP89A | HSP90A | HSP90N | HSPC1 | HSPCA | HSPCAL1 | HSPCAL4 | HSPN | Hsp89 | Hsp90 | LAP2heat shock protein 90kDa alpha (cytosolic), class A member 1-HPRD11748628 
IER3DIF-2 | DIF2 | GLY96 | IEX-1 | IEX-1L | IEX1 | PRG1immediate early response 3Biochemical ActivityBioGRID12356731 
IFNAR1AVP | IFN-alpha-REC | IFNAR | IFNBR | IFRCinterferon (alpha, beta and omega) receptor 1-HPRD9029147 
INSRCD220 | HHF5insulin receptorAffinity Capture-WesternBioGRID11409918 
KLF11FKLF | FKLF1 | MODY7 | TIEG2 | Tieg3Kruppel-like factor 11-HPRD12006497 
KSR2FLJ25965kinase suppressor of ras 2-HPRD12975377 
MAP2K1MAPKK1 | MEK1 | MKK1 | PRKMK1mitogen-activated protein kinase kinase 1MEK1 interacts with and phosphorylates ERK2. This interaction is modeled on a demonstrated interaction between human MEK1 and rat ERK2.BIND11134045 
Affinity Capture-Western
Biochemical Activity
Reconstituted Complex
Two-hybrid		BioGRID10757792 |11266467 
|11279118 |11352917 
|11823456 |12697810 
MAP2K2FLJ26075 | MAPKK2 | MEK2 | MKK2 | PRKMK2mitogen-activated protein kinase kinase 2MEK2 interacts with ERK2. This interaction is modeled on a demonstrated interaction between human MEK2 and rat ERK2.BIND11134045 
-HPRD,BioGRID11823456 
MAP3K1MAPKKK1 | MEKK | MEKK1mitogen-activated protein kinase kinase kinase 1Affinity Capture-WesternBioGRID10969079 
MEKK1 interacts with ERK2.BIND10969079 
MAPK14CSBP1 | CSBP2 | CSPB1 | EXIP | Mxi2 | PRKM14 | PRKM15 | RK | SAPK2A | p38 | p38ALPHAmitogen-activated protein kinase 14-HPRD,BioGRID12697810 
MAPKAPK2MK2mitogen-activated protein kinase-activated protein kinase 2Affinity Capture-WesternBioGRID15094067 
MAPKAPK5PRAKmitogen-activated protein kinase-activated protein kinase 5-HPRD9628874 
MAPKSP1MAP2K1IP1 | MAPBP | MP1MAPK scaffold protein 1-HPRD,BioGRID11266467 
MBPMGC99675myelin basic proteinMBP interacts with MAPK1. This interaction was modeled on a demonstrated interaction between MBP from an unspecified species, and monkey and mouse MAPK1.BIND9792705 
MKNK1MNK1MAP kinase interacting serine/threonine kinase 1Reconstituted Complex
Two-hybrid		BioGRID9155017 
MKNK2GPRK7 | MNK2MAP kinase interacting serine/threonine kinase 2-HPRD,BioGRID9155017 
MYCbHLHe39 | c-Mycv-myc myelocytomatosis viral oncogene homolog (avian)Biochemical Activity
Reconstituted Complex		BioGRID7957875 |9207092 
|15210690 
NEK2HsPK21 | NEK2A | NLK1NIMA (never in mitosis gene a)-related kinase 2-HPRD,BioGRID15358203 
PEA15HMAT1 | HUMMAT1H | MAT1 | MAT1H | PEA-15 | PEDphosphoprotein enriched in astrocytes 15-HPRD,BioGRID11702783 
PEBP1HCNP | PBP | PEBP | RKIPphosphatidylethanolamine binding protein 1-HPRD,BioGRID10757792 
PECAM1CD31 | PECAM-1platelet/endothelial cell adhesion moleculeAffinity Capture-WesternBioGRID10801826 
PLATDKFZp686I03148 | T-PA | TPAplasminogen activator, tissue-HPRD15861134 
PRKCEMGC125656 | MGC125657 | PKCE | nPKC-epsilonprotein kinase C, epsilonAffinity Capture-WesternBioGRID11350735 
PTPN5FLJ14427 | PTPSTEP | STEPprotein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)Reconstituted ComplexBioGRID9857190 
PTPN7BPTP-4 | HEPTP | LC-PTP | LPTP | PTPNIprotein tyrosine phosphatase, non-receptor type 7-HPRD,BioGRID10206983 |10702794 
PTPRHFLJ39938 | MGC133058 | MGC133059 | SAP-1protein tyrosine phosphatase, receptor type, H-HPRD11278335 
PTPRRDKFZp781C1038 | EC-PTP | FLJ34328 | MGC131968 | MGC148170 | PCPTP1 | PTP-SL | PTPBR7 | PTPRQprotein tyrosine phosphatase, receptor type, R-HPRD,BioGRID9857190 
RAF1CRAF | NS5 | Raf-1 | c-Rafv-raf-1 murine leukemia viral oncogene homolog 1Affinity Capture-WesternBioGRID11409918 
Raf-1 interacts with ERK2. This interaction was modelled on a demonstrated interaction between human Raf-1 and ERK2 from an unspecified species.BIND15664191 
RB1OSRC | RB | p105-Rb | pRb | pp110retinoblastoma 1RB1 is phosphorylated by MAPK1. This interaction was modeled on a demonstrated interaction between human KIAA1536 and MAPK1 from an unspecified species.BIND15489336 
RPS6KA1HU-1 | MAPKAPK1A | RSK | RSK1ribosomal protein S6 kinase, 90kDa, polypeptide 1-HPRD,BioGRID9915826 |12594221 
|12832467 
RPS6KA2HU-2 | MAPKAPK1C | RSK | RSK3 | S6K-alpha | S6K-alpha2 | p90-RSK3 | pp90RSK3ribosomal protein S6 kinase, 90kDa, polypeptide 2Rsk3 interacts with ERK2. This interaction was modelled on a demonstrated interaction between human Rsk3 and monkey ERK2.BIND9915826 
-HPRD,BioGRID8939914 
RPS6KA3CLS | HU-3 | ISPK-1 | MAPKAPK1B | MRX19 | RSK | RSK2 | S6K-alpha3 | p90-RSK2 | pp90RSK2ribosomal protein S6 kinase, 90kDa, polypeptide 3Affinity Capture-WesternBioGRID8939914 |9915826 
-HPRD12832467 
RPS6KA4MSK2 | RSK-Bribosomal protein S6 kinase, 90kDa, polypeptide 4-HPRD9687510 
RPS6KA5MGC1911 | MSK1 | MSPK1 | RLPKribosomal protein S6 kinase, 90kDa, polypeptide 5Phenotypic EnhancementBioGRID9687510 
SHC1FLJ26504 | SHC | SHCASHC (Src homology 2 domain containing) transforming protein 1-HPRD,BioGRID10996427 
SNCAMGC110988 | NACP | PARK1 | PARK4 | PD1synuclein, alpha (non A4 component of amyloid precursor)Affinity Capture-WesternBioGRID12121974 
-HPRD11279280 
SNCGBCSG1 | SRsynuclein, gamma (breast cancer-specific protein 1)Affinity Capture-WesternBioGRID12121974 
SORBS3SCAM-1 | SCAM1 | SH3D4 | VINEXINsorbin and SH3 domain containing 3Affinity Capture-Western
Biochemical Activity		BioGRID15184391 
SREBF1SREBP-1c | SREBP1 | bHLHd1sterol regulatory element binding transcription factor 1Biochemical ActivityBioGRID10627507 
SREBF2SREBP2 | bHLHd2sterol regulatory element binding transcription factor 2-HPRD,BioGRID10627507 
STAT5AMGF | STAT5signal transducer and activator of transcription 5A-HPRD,BioGRID10194762 |10996427 
STAT5BSTAT5signal transducer and activator of transcription 5B-HPRD10996427 
THTYHtyrosine hydroxylaseBiochemical ActivityBioGRID1347949 
TNFSF11CD254 | ODF | OPGL | OPTB2 | RANKL | TRANCE | hRANKL2 | sOdftumor necrosis factor (ligand) superfamily, member 11-HPRD10635328 
TNIP1ABIN-1 | KIAA0113 | NAF1 | VANTNFAIP3 interacting protein 1Naf1-alpha interacts with ERK2.BIND12220502 
Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID12220502 
TNKS2PARP-5b | PARP-5c | PARP5B | PARP5C | TANK2 | TNKLtankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2Biochemical ActivityBioGRID10988299 
TOB1APRO6 | MGC104792 | MGC34446 | PIG49 | TOB | TROB | TROB1transducer of ERBB2, 1-HPRD,BioGRID12151396 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53Affinity Capture-WesternBioGRID10958792 
TPR-translocated promoter region (to activated MET oncogene)-HPRD,BioGRID12594221 
TSC2FLJ43106 | LAM | TSC4tuberous sclerosis 2Affinity Capture-Western
Reconstituted Complex		BioGRID15851026 
Erk2 interacts with TSC2. This interaction was modelled on a demonstrated interaction between Erk2 from an unspecified species and human TSC2.BIND15851026 
UBR5DD5 | EDD | EDD1 | FLJ11310 | HYD | KIAA0896 | MGC57263ubiquitin protein ligase E3 component n-recognin 5-HPRD,BioGRID12594221 
VAV1VAVvav 1 guanine nucleotide exchange factor-HPRD,BioGRID8900182 |9013873 
Vav interacts with ERK2.BIND9013873 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MAPK_SIGNALING_PATHWAY 267205All SZGR genes in this pathway
KEGG_ERBB_SIGNALING_PATHWAY 8771All SZGR genes in this pathway
KEGG_CHEMOKINE_SIGNALING_PATHWAY 190128All SZGR genes in this pathway
KEGG_OOCYTE_MEIOSIS 11479All SZGR genes in this pathway
KEGG_MTOR_SIGNALING_PATHWAY 5240All SZGR genes in this pathway
KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION 11581All SZGR genes in this pathway
KEGG_DORSO_VENTRAL_AXIS_FORMATION 2521All SZGR genes in this pathway
KEGG_TGF_BETA_SIGNALING_PATHWAY 8664All SZGR genes in this pathway
KEGG_AXON_GUIDANCE 129103All SZGR genes in this pathway
KEGG_VEGF_SIGNALING_PATHWAY 7653All SZGR genes in this pathway
KEGG_FOCAL_ADHESION 201138All SZGR genes in this pathway
KEGG_ADHERENS_JUNCTION 7553All SZGR genes in this pathway
KEGG_GAP_JUNCTION 9068All SZGR genes in this pathway
KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY 10288All SZGR genes in this pathway
KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY 6247All SZGR genes in this pathway
KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY 13792All SZGR genes in this pathway
KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY 10889All SZGR genes in this pathway
KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY 7556All SZGR genes in this pathway
KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY 7958All SZGR genes in this pathway
KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS 9771All SZGR genes in this pathway
KEGG_LONG_TERM_POTENTIATION 7057All SZGR genes in this pathway
KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 126103All SZGR genes in this pathway
KEGG_LONG_TERM_DEPRESSION 7053All SZGR genes in this pathway
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 216144All SZGR genes in this pathway
KEGG_INSULIN_SIGNALING_PATHWAY 137103All SZGR genes in this pathway
KEGG_GNRH_SIGNALING_PATHWAY 10177All SZGR genes in this pathway
KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION 8659All SZGR genes in this pathway
KEGG_MELANOGENESIS 10280All SZGR genes in this pathway
KEGG_TYPE_II_DIABETES_MELLITUS 4741All SZGR genes in this pathway
KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION 4229All SZGR genes in this pathway
KEGG_ALZHEIMERS_DISEASE 169110All SZGR genes in this pathway
KEGG_PRION_DISEASES 3528All SZGR genes in this pathway
KEGG_LEISHMANIA_INFECTION 7256All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_COLORECTAL_CANCER 6247All SZGR genes in this pathway
KEGG_RENAL_CELL_CARCINOMA 7060All SZGR genes in this pathway
KEGG_PANCREATIC_CANCER 7056All SZGR genes in this pathway
KEGG_ENDOMETRIAL_CANCER 5245All SZGR genes in this pathway
KEGG_GLIOMA 6556All SZGR genes in this pathway
KEGG_PROSTATE_CANCER 8975All SZGR genes in this pathway
KEGG_THYROID_CANCER 2926All SZGR genes in this pathway
KEGG_MELANOMA 7157All SZGR genes in this pathway
KEGG_BLADDER_CANCER 4233All SZGR genes in this pathway
KEGG_CHRONIC_MYELOID_LEUKEMIA 7359All SZGR genes in this pathway
KEGG_ACUTE_MYELOID_LEUKEMIA 6047All SZGR genes in this pathway
KEGG_NON_SMALL_CELL_LUNG_CANCER 5447All SZGR genes in this pathway
BIOCARTA_AGR_PATHWAY 3631All SZGR genes in this pathway
BIOCARTA_AT1R_PATHWAY 3628All SZGR genes in this pathway
BIOCARTA_SPPA_PATHWAY 2218All SZGR genes in this pathway
BIOCARTA_BIOPEPTIDES_PATHWAY 4535All SZGR genes in this pathway
BIOCARTA_CDMAC_PATHWAY 1615All SZGR genes in this pathway
BIOCARTA_CCR3_PATHWAY 2321All SZGR genes in this pathway
BIOCARTA_CERAMIDE_PATHWAY 2216All SZGR genes in this pathway
BIOCARTA_CXCR4_PATHWAY 2422All SZGR genes in this pathway
BIOCARTA_ECM_PATHWAY 2417All SZGR genes in this pathway
BIOCARTA_ERK_PATHWAY 2822All SZGR genes in this pathway
BIOCARTA_FCER1_PATHWAY 4130All SZGR genes in this pathway
BIOCARTA_FMLP_PATHWAY 3929All SZGR genes in this pathway
BIOCARTA_GH_PATHWAY 2822All SZGR genes in this pathway
BIOCARTA_MPR_PATHWAY 3428All SZGR genes in this pathway
BIOCARTA_HCMV_PATHWAY 1716All SZGR genes in this pathway
BIOCARTA_IL2RB_PATHWAY 3826All SZGR genes in this pathway
BIOCARTA_RACCYCD_PATHWAY 2623All SZGR genes in this pathway
BIOCARTA_INTEGRIN_PATHWAY 3829All SZGR genes in this pathway
BIOCARTA_KERATINOCYTE_PATHWAY 4638All SZGR genes in this pathway
BIOCARTA_PYK2_PATHWAY 3124All SZGR genes in this pathway
BIOCARTA_MAPK_PATHWAY 8768All SZGR genes in this pathway
BIOCARTA_MCALPAIN_PATHWAY 2516All SZGR genes in this pathway
BIOCARTA_PPARA_PATHWAY 5843All SZGR genes in this pathway
BIOCARTA_IGF1R_PATHWAY 2320All SZGR genes in this pathway
BIOCARTA_NFAT_PATHWAY 5645All SZGR genes in this pathway
BIOCARTA_ARENRF2_PATHWAY 139All SZGR genes in this pathway
BIOCARTA_EDG1_PATHWAY 2724All SZGR genes in this pathway
BIOCARTA_CDK5_PATHWAY 1111All SZGR genes in this pathway
BIOCARTA_PTEN_PATHWAY 1814All SZGR genes in this pathway
BIOCARTA_BAD_PATHWAY 2623All SZGR genes in this pathway
BIOCARTA_EIF4_PATHWAY 2419All SZGR genes in this pathway
BIOCARTA_HER2_PATHWAY 2217All SZGR genes in this pathway
BIOCARTA_ERK5_PATHWAY 1815All SZGR genes in this pathway
BIOCARTA_MAL_PATHWAY 1917All SZGR genes in this pathway
BIOCARTA_BARR_MAPK_PATHWAY 1211All SZGR genes in this pathway
BIOCARTA_BARRESTIN_SRC_PATHWAY 1514All SZGR genes in this pathway
BIOCARTA_MET_PATHWAY 3730All SZGR genes in this pathway
BIOCARTA_SPRY_PATHWAY 1815All SZGR genes in this pathway
BIOCARTA_CREB_PATHWAY 2725All SZGR genes in this pathway
BIOCARTA_TFF_PATHWAY 2115All SZGR genes in this pathway
ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS 4535All SZGR genes in this pathway
SA_B_CELL_RECEPTOR_COMPLEXES 2420All SZGR genes in this pathway
ST_ERK1_ERK2_MAPK_PATHWAY 3225All SZGR genes in this pathway
SIG_CD40PATHWAYMAP 3428All SZGR genes in this pathway
ST_GA12_PATHWAY 2316All SZGR genes in this pathway
ST_G_ALPHA_S_PATHWAY 1611All SZGR genes in this pathway
ST_G_ALPHA_I_PATHWAY 3529All SZGR genes in this pathway
ST_P38_MAPK_PATHWAY 3728All SZGR genes in this pathway
SIG_IL4RECEPTOR_IN_B_LYPHOCYTES 2723All SZGR genes in this pathway
ST_GRANULE_CELL_SURVIVAL_PATHWAY 2723All SZGR genes in this pathway
ST_ADRENERGIC 3629All SZGR genes in this pathway
ST_INTEGRIN_SIGNALING_PATHWAY 8262All SZGR genes in this pathway
SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES 5141All SZGR genes in this pathway
ST_T_CELL_SIGNAL_TRANSDUCTION 4533All SZGR genes in this pathway
SIG_BCR_SIGNALING_PATHWAY 4638All SZGR genes in this pathway
ST_B_CELL_ANTIGEN_RECEPTOR 4032All SZGR genes in this pathway
ST_FAS_SIGNALING_PATHWAY 6554All SZGR genes in this pathway
ST_MYOCYTE_AD_PATHWAY 2725All SZGR genes in this pathway
SA_PTEN_PATHWAY 1714All SZGR genes in this pathway
PID_FCER1_PATHWAY 6243All SZGR genes in this pathway
PID_ENDOTHELIN_PATHWAY 6352All SZGR genes in this pathway
PID_BCR_5PATHWAY 6550All SZGR genes in this pathway
PID_PRL_SIGNALING_EVENTS_PATHWAY 2317All SZGR genes in this pathway
PID_ERBB4_PATHWAY 3832All SZGR genes in this pathway
PID_GMCSF_PATHWAY 3731All SZGR genes in this pathway
PID_MET_PATHWAY 8060All SZGR genes in this pathway
PID_S1P_S1P3_PATHWAY 2924All SZGR genes in this pathway
PID_EPHB_FWD_PATHWAY 4038All SZGR genes in this pathway
PID_AVB3_OPN_PATHWAY 3129All SZGR genes in this pathway
PID_S1P_S1P4_PATHWAY 1411All SZGR genes in this pathway
PID_PS1_PATHWAY 4639All SZGR genes in this pathway
PID_TRAIL_PATHWAY 2820All SZGR genes in this pathway
PID_CDC42_PATHWAY 7051All SZGR genes in this pathway
PID_RET_PATHWAY 3929All SZGR genes in this pathway
PID_ANGIOPOIETIN_RECEPTOR_PATHWAY 5041All SZGR genes in this pathway
PID_S1P_S1P1_PATHWAY 2118All SZGR genes in this pathway
PID_TELOMERASE_PATHWAY 6848All SZGR genes in this pathway
PID_NETRIN_PATHWAY 3227All SZGR genes in this pathway
PID_REG_GR_PATHWAY 8260All SZGR genes in this pathway
PID_ARF6_DOWNSTREAM_PATHWAY 1514All SZGR genes in this pathway
PID_MTOR_4PATHWAY 6955All SZGR genes in this pathway
PID_IL2_1PATHWAY 5543All SZGR genes in this pathway
PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY 3529All SZGR genes in this pathway
PID_TCR_RAS_PATHWAY 1414All SZGR genes in this pathway
PID_CERAMIDE_PATHWAY 4837All SZGR genes in this pathway
PID_AVB3_INTEGRIN_PATHWAY 7553All SZGR genes in this pathway
PID_IFNG_PATHWAY 4034All SZGR genes in this pathway
PID_ERBB1_DOWNSTREAM_PATHWAY 10578All SZGR genes in this pathway
PID_ATF2_PATHWAY 5943All SZGR genes in this pathway
PID_ERBB2_ERBB3_PATHWAY 4435All SZGR genes in this pathway
PID_BMP_PATHWAY 4231All SZGR genes in this pathway
PID_ALK1_PATHWAY 2621All SZGR genes in this pathway
PID_PDGFRB_PATHWAY 129103All SZGR genes in this pathway
PID_TRKR_PATHWAY 6248All SZGR genes in this pathway
PID_SYNDECAN_1_PATHWAY 4629All SZGR genes in this pathway
PID_RETINOIC_ACID_PATHWAY 3023All SZGR genes in this pathway
PID_AR_NONGENOMIC_PATHWAY 3127All SZGR genes in this pathway
PID_CXCR3_PATHWAY 4334All SZGR genes in this pathway
PID_VEGFR1_PATHWAY 2623All SZGR genes in this pathway
PID_SMAD2_3PATHWAY 1713All SZGR genes in this pathway
PID_VEGFR1_2_PATHWAY 6957All SZGR genes in this pathway
PID_SYNDECAN_2_PATHWAY 3327All SZGR genes in this pathway
PID_ANTHRAX_PATHWAY 1715All SZGR genes in this pathway
PID_S1P_S1P2_PATHWAY 2419All SZGR genes in this pathway
PID_MAPK_TRK_PATHWAY 3431All SZGR genes in this pathway
PID_CD8_TCR_DOWNSTREAM_PATHWAY 6556All SZGR genes in this pathway
PID_LYMPH_ANGIOGENESIS_PATHWAY 2516All SZGR genes in this pathway
PID_ALPHA_SYNUCLEIN_PATHWAY 3325All SZGR genes in this pathway
PID_FGF_PATHWAY 5537All SZGR genes in this pathway
PID_FAK_PATHWAY 5945All SZGR genes in this pathway
REACTOME_SIGNALLING_BY_NGF 217167All SZGR genes in this pathway
REACTOME_SIGNALING_BY_SCF_KIT 7859All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING 149All SZGR genes in this pathway
REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING 2419All SZGR genes in this pathway
REACTOME_TRIF_MEDIATED_TLR3_SIGNALING 7454All SZGR genes in this pathway
REACTOME_NEGATIVE_REGULATION_OF_FGFR_SIGNALING 3724All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ERBB4 9067All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ERBB2 10178All SZGR genes in this pathway
REACTOME_GRB2_EVENTS_IN_ERBB2_SIGNALING 2220All SZGR genes in this pathway
REACTOME_SIGNALING_BY_EGFR_IN_CANCER 10980All SZGR genes in this pathway
REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING 2017All SZGR genes in this pathway
REACTOME_INSULIN_RECEPTOR_SIGNALLING_CASCADE 8764All SZGR genes in this pathway
REACTOME_ARMS_MEDIATED_ACTIVATION 1717All SZGR genes in this pathway
REACTOME_PROLONGED_ERK_ACTIVATION_EVENTS 1918All SZGR genes in this pathway
REACTOME_SIGNALLING_TO_RAS 2723All SZGR genes in this pathway
REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE 137105All SZGR genes in this pathway
REACTOME_SIGNALLING_TO_ERKS 3630All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR_IN_DISEASE 12788All SZGR genes in this pathway
REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN 1514All SZGR genes in this pathway
REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK 205136All SZGR genes in this pathway
REACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION 2420All SZGR genes in this pathway
REACTOME_ERKS_ARE_INACTIVATED 129All SZGR genes in this pathway
REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING 1513All SZGR genes in this pathway
REACTOME_ERK_MAPK_TARGETS 2117All SZGR genes in this pathway
REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 186155All SZGR genes in this pathway
REACTOME_NEURONAL_SYSTEM 279221All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_OPIOID_SIGNALLING 7856All SZGR genes in this pathway
REACTOME_CA_DEPENDENT_EVENTS 3023All SZGR genes in this pathway
REACTOME_NEUROTRANSMITTER_RECEPTOR_BINDING_AND_DOWNSTREAM_TRANSMISSION_IN_THE_POSTSYNAPTIC_CELL 137110All SZGR genes in this pathway
REACTOME_PLC_BETA_MEDIATED_EVENTS 4332All SZGR genes in this pathway
REACTOME_SIGNALING_BY_PDGF 12293All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION 9576All SZGR genes in this pathway
REACTOME_AXON_GUIDANCE 251188All SZGR genes in this pathway
REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH 6449All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_NMDA_RECEPTOR_UPON_GLUTAMATE_BINDING_AND_POSTSYNAPTIC_EVENTS 3732All SZGR genes in this pathway
REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_RAS 2723All SZGR genes in this pathway
REACTOME_POST_NMDA_RECEPTOR_ACTIVATION_EVENTS 3328All SZGR genes in this pathway
REACTOME_FRS2_MEDIATED_CASCADE 3627All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR 10074All SZGR genes in this pathway
REACTOME_MAP_KINASE_ACTIVATION_IN_TLR_CASCADE 5037All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS 108All SZGR genes in this pathway
REACTOME_MAPK_TARGETS_NUCLEAR_EVENTS_MEDIATED_BY_MAP_KINASES 3024All SZGR genes in this pathway
REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS 3220All SZGR genes in this pathway
REACTOME_L1CAM_INTERACTIONS 8662All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ILS 10786All SZGR genes in this pathway
REACTOME_SIGNAL_TRANSDUCTION_BY_L1 3425All SZGR genes in this pathway
REACTOME_RECYCLING_PATHWAY_OF_L1 2715All SZGR genes in this pathway
REACTOME_TRAF6_MEDIATED_INDUCTION_OF_NFKB_AND_MAP_KINASES_UPON_TLR7_8_OR_9_ACTIVATION 7757All SZGR genes in this pathway
REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING 1311All SZGR genes in this pathway
REACTOME_NFKB_AND_MAP_KINASES_ACTIVATION_MEDIATED_BY_TLR4_SIGNALING_REPERTOIRE 7253All SZGR genes in this pathway
REACTOME_IL_2_SIGNALING 4134All SZGR genes in this pathway
REACTOME_SIGNALING_BY_INSULIN_RECEPTOR 10872All SZGR genes in this pathway
REACTOME_SOS_MEDIATED_SIGNALLING 1413All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
REACTOME_RAF_MAP_KINASE_CASCADE 1010All SZGR genes in this pathway
REACTOME_SHC_MEDIATED_SIGNALLING 1512All SZGR genes in this pathway
REACTOME_MYD88_MAL_CASCADE_INITIATED_ON_PLASMA_MEMBRANE 8363All SZGR genes in this pathway
REACTOME_INNATE_IMMUNE_SYSTEM 279178All SZGR genes in this pathway
REACTOME_ACTIVATED_TLR4_SIGNALLING 9369All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_TOLL_RECEPTOR_CASCADES 11884All SZGR genes in this pathway
REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 270204All SZGR genes in this pathway
REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 208138All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR 11280All SZGR genes in this pathway
REACTOME_SHC_RELATED_EVENTS 1713All SZGR genes in this pathway
GAZDA_DIAMOND_BLACKFAN_ANEMIA_MYELOID_DN 3825All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_DN 536332All SZGR genes in this pathway
ELVIDGE_HYPOXIA_DN 14694All SZGR genes in this pathway
BIDUS_METASTASIS_UP 214134All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP 633376All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP 722443All SZGR genes in this pathway
MARTIN_INTERACT_WITH_HDAC 4431All SZGR genes in this pathway
RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_POORLY_DN 382224All SZGR genes in this pathway
AMIT_EGF_RESPONSE_480_MCF10A 4326All SZGR genes in this pathway
SUNG_METASTASIS_STROMA_UP 11070All SZGR genes in this pathway
CHESLER_BRAIN_D6MIT150_QTL_TRANS 97All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_DN 309206All SZGR genes in this pathway
MOREAUX_MULTIPLE_MYELOMA_BY_TACI_UP 412249All SZGR genes in this pathway
MOREAUX_B_LYMPHOCYTE_MATURATION_BY_TACI_UP 9258All SZGR genes in this pathway
NATSUME_RESPONSE_TO_INTERFERON_BETA_UP 7149All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_LATE_PROGENITOR 544307All SZGR genes in this pathway
LU_AGING_BRAIN_DN 153120All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
HENDRICKS_SMARCA4_TARGETS_DN 5334All SZGR genes in this pathway
HEDENFALK_BREAST_CANCER_BRCA1_VS_BRCA2 163113All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_UP 953554All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_UP 783442All SZGR genes in this pathway
GAZIN_EPIGENETIC_SILENCING_BY_KRAS 2616All SZGR genes in this pathway
STEARMAN_LUNG_CANCER_EARLY_VS_LATE_UP 12589All SZGR genes in this pathway
OUILLETTE_CLL_13Q14_DELETION_UP 7440All SZGR genes in this pathway
BHATI_G2M_ARREST_BY_2METHOXYESTRADIOL_UP 12568All SZGR genes in this pathway
HUNSBERGER_EXERCISE_REGULATED_GENES 3126All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_UP 491316All SZGR genes in this pathway
SWEET_KRAS_ONCOGENIC_SIGNATURE 8956All SZGR genes in this pathway
BOYAULT_LIVER_CANCER_SUBCLASS_G23_UP 5235All SZGR genes in this pathway
LI_INDUCED_T_TO_NATURAL_KILLER_DN 11683All SZGR genes in this pathway
KIM_ALL_DISORDERS_CALB1_CORR_UP 548370All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_EARLY_LATE 317190All SZGR genes in this pathway
IVANOVSKA_MIR106B_TARGETS 9056All SZGR genes in this pathway
LINSLEY_MIR16_TARGETS 206127All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_NOT_SATB1_DN 448282All SZGR genes in this pathway
KRIEG_HYPOXIA_NOT_VIA_KDM3A 770480All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-129-5p388238881Ahsa-miR-129brainCUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5pCUUUUUGCGGUCUGGGCUUGCU
miR-132/212137913861A,m8hsa-miR-212SZUAACAGUCUCCAGUCACGGCC
hsa-miR-132brainUAACAGUCUACAGCCAUGGUCG
miR-18138423848m8hsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-18637983804m8hsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
miR-204/211325932651Ahsa-miR-204brainUUCCCUUUGUCAUCCUAUGCCU
hsa-miR-211UUCCCUUUGUCAUCCUUCGCCU
miR-214116811741Ahsa-miR-214brainACAGCAGGCACAGACAGGCAG
miR-217305311m8hsa-miR-217UACUGCAUCAGGAACUGAUUGGAU
miR-320652658m8hsa-miR-320AAAAGCUGGGUUGAGAGGGCGAA
miR-3261841901Ahsa-miR-326CCUCUGGGCCCUUCCUCCAG
miR-33031943200m8hsa-miR-330brainGCAAAGCACACGGCCUGCAGAGA
miR-34b15941600m8hsa-miR-34bUAGGCAGUGUCAUUAGCUGAUUG
miR-409-5p9649701Ahsa-miR-409-5pAGGUUACCCGAGCAACUUUGCA
miR-493-5p16421648m8hsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
miR-539153015371A,m8hsa-miR-539GGAGAAAUUAUCCUUGGUGUGU
miR-54338433849m8hsa-miR-543AAACAUUCGCGGUGCACUUCU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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