Gene Page: PRODH

Summary
GeneID  5625
Symbol  PRODH
Synonyms  FLJ33744|HSPOX2|MGC148078|MGC148079|PIG6|POX|PRODH1|PRODH2|SCZD4|TP53I6
Description  proline dehydrogenase (oxidase) 1
See related  HGNC:9453|MIM:606810|Ensembl:ENSG00000100033|HPRD:08433|
Locus tag  -
Gene type  protein-coding
Map location  22q11.21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies2Link to SZGene
GSMA_Igenome scan meta-analysisPsr: 0.031 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenia, schizophrenias, schizotypy]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
MPO0.790.58
ELANE0.690.70
PRG20.670.08
SLC22A180.620.54
TNFSF90.550.53
S100A120.540.31
G6PC30.530.53
OLFM40.530.48
HYAL30.520.43
JAK30.510.64
Top 10 negatively co-expressed genes
ANP32C-0.26-0.37
ZRSR1-0.25-0.33
AC073528.1-0.24-0.27
EIF3S8-0.24-0.36
GTF2H2-0.24-0.29
SFRS12-0.24-0.37
ZNF326-0.23-0.41
EIF5B-0.23-0.38
C6orf204-0.23-0.28
ERC1-0.23-0.32
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003674molecular_functionND-
GO:0004657proline dehydrogenase activityTAS10192398 
GO:0016491oxidoreductase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006537glutamate biosynthetic processIEAglutamate (GO term level: 9)-
GO:0008631induction of apoptosis by oxidative stressNAS9305847 
GO:0006562proline catabolic processIEA-
GO:0055114oxidation reductionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005575cellular_componentND-
GO:0005739mitochondrionIEA-
GO:0005743mitochondrial inner membraneIEA-
GO:0005759mitochondrial matrixIEA-
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_ARGININE_AND_PROLINE_METABOLISM 5439All SZGR genes in this pathway
REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES 200136All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_UP 450256All SZGR genes in this pathway
HU_ANGIOGENESIS_UP 2116All SZGR genes in this pathway
GALLUZZI_PERMEABILIZE_MITOCHONDRIA 4331All SZGR genes in this pathway
JAZAG_TGFB1_SIGNALING_VIA_SMAD4_DN 6638All SZGR genes in this pathway
RICKMAN_METASTASIS_DN 261155All SZGR genes in this pathway
STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN 517309All SZGR genes in this pathway
STARK_HYPPOCAMPUS_22Q11_DELETION_DN 2019All SZGR genes in this pathway
ROSS_AML_WITH_PML_RARA_FUSION 7762All SZGR genes in this pathway
LEE_LIVER_CANCER_CIPROFIBRATE_DN 6643All SZGR genes in this pathway
LEE_LIVER_CANCER_ACOX1_DN 6539All SZGR genes in this pathway
LEE_LIVER_CANCER_DENA_DN 7445All SZGR genes in this pathway
PENG_GLUTAMINE_DEPRIVATION_DN 337230All SZGR genes in this pathway
CROMER_METASTASIS_DN 8158All SZGR genes in this pathway
VERHAAK_AML_WITH_NPM1_MUTATED_DN 246180All SZGR genes in this pathway
MURAKAMI_UV_RESPONSE_6HR_UP 3731All SZGR genes in this pathway
JIANG_HYPOXIA_NORMAL 311205All SZGR genes in this pathway
RIGGINS_TAMOXIFEN_RESISTANCE_UP 6644All SZGR genes in this pathway
MASSARWEH_TAMOXIFEN_RESISTANCE_UP 578341All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_UP 973570All SZGR genes in this pathway
ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_UP 863514All SZGR genes in this pathway
SMID_BREAST_CANCER_RELAPSE_IN_LUNG_DN 3722All SZGR genes in this pathway
SMID_BREAST_CANCER_ERBB2_UP 14783All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_D_CLUSTER_UP 2719All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_D_UP 8962All SZGR genes in this pathway
PIONTEK_PKD1_TARGETS_UP 3824All SZGR genes in this pathway
CHAUHAN_RESPONSE_TO_METHOXYESTRADIOL_UP 5132All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
VALK_AML_CLUSTER_12 3020All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_DN 267160All SZGR genes in this pathway
CHYLA_CBFA2T3_TARGETS_UP 387225All SZGR genes in this pathway


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.