Gene Page: MASP1

Summary
GeneID  5648
Symbol  MASP1
Synonyms  CRARF|CRARF1|DKFZp686I01199|FLJ26383|MASP|MGC126283|MGC126284|PRSS5|RaRF
Description  mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
See related  HGNC:6901|MIM:600521|Ensembl:ENSG00000127241|HPRD:02749|
Locus tag  -
Gene type  protein-coding
Map location  3q27-q28
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004252serine-type endopeptidase activityIEAglutamate (GO term level: 7)-
GO:0004252serine-type endopeptidase activityTASglutamate (GO term level: 7)8018603 
GO:0003824catalytic activityIEA-
GO:0005529sugar bindingIEA-
GO:0005509calcium ion bindingIEA-
GO:0008233peptidase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001867complement activation, lectin pathwayEXP11532276 
GO:0006508proteolysisIEA-
GO:0006958complement activation, classical pathwayIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionEXP10639434 |10925294 
GO:0043231intracellular membrane-bounded organelleIDA18029348 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
C2CO2 | DKFZp779M0311complement component 2-HPRD10946292 
C3ARMD9 | ASP | CPAMD1complement component 3-HPRD9719152 
FCN2EBP-37 | FCNL | P35 | ficolin-2ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)-HPRD,BioGRID12421953 
MASP2MAP19 | MASP-2 | sMAPmannan-binding lectin serine peptidase 2Affinity Capture-WesternBioGRID10878362 
MBL2COLEC1 | HSMBPC | MBL | MBP | MBP1 | MGC116832 | MGC116833mannose-binding lectin (protein C) 2, soluble (opsonic defect)-HPRD,BioGRID10878362 
SERPING1C1IN | C1INH | C1NH | HAE1 | HAE2serpin peptidase inhibitor, clade G (C1 inhibitor), member 1-HPRD,BioGRID10946292 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_COMPLEMENT_AND_COAGULATION_CASCADES 6949All SZGR genes in this pathway
BIOCARTA_COMP_PATHWAY 1915All SZGR genes in this pathway
BIOCARTA_LECTIN_PATHWAY 1210All SZGR genes in this pathway
REACTOME_INNATE_IMMUNE_SYSTEM 279178All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_COMPLEMENT_CASCADE 3222All SZGR genes in this pathway
REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS 105All SZGR genes in this pathway
REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT 1610All SZGR genes in this pathway
LIU_PROSTATE_CANCER_DN 481290All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_DN 526357All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_UP 1821933All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_DN 781465All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_DN 234147All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP 612367All SZGR genes in this pathway
WONG_ENDMETRIUM_CANCER_DN 8253All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM4 261153All SZGR genes in this pathway
WOTTON_RUNX_TARGETS_UP 2114All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_UP 487286All SZGR genes in this pathway
LEE_TARGETS_OF_PTCH1_AND_SUFU_DN 8369All SZGR genes in this pathway
LEE_LIVER_CANCER_ACOX1_DN 6539All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_UP 6446All SZGR genes in this pathway
URS_ADIPOCYTE_DIFFERENTIATION_UP 7451All SZGR genes in this pathway
LEE_AGING_NEOCORTEX_DN 8049All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_DN 504323All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP 673430All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_DN 593372All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_DN 591366All SZGR genes in this pathway
LABBE_TGFB1_TARGETS_DN 10864All SZGR genes in this pathway
YAUCH_HEDGEHOG_SIGNALING_PARACRINE_UP 14985All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
BOYAULT_LIVER_CANCER_SUBCLASS_G3_DN 5132All SZGR genes in this pathway
YAMASHITA_LIVER_CANCER_STEM_CELL_DN 7651All SZGR genes in this pathway
MIKKELSEN_MEF_LCP_WITH_H3K4ME3 12868All SZGR genes in this pathway
MIKKELSEN_NPC_LCP_WITH_H3K4ME3 5834All SZGR genes in this pathway
PANGAS_TUMOR_SUPPRESSION_BY_SMAD1_AND_SMAD5_DN 157106All SZGR genes in this pathway
OHGUCHI_LIVER_HNF4A_TARGETS_DN 14985All SZGR genes in this pathway
PILON_KLF1_TARGETS_UP 504321All SZGR genes in this pathway
CHANGOLKAR_H2AFY_TARGETS_DN 4026All SZGR genes in this pathway
YANG_BCL3_TARGETS_UP 364236All SZGR genes in this pathway
NABA_ECM_REGULATORS 238125All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
let-7/98304310m8hsa-let-7abrainUGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrainUGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrainUGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrainAGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrainUGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrainUGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brainUGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZUGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrainUGAGGUAGUAGUUUGUGCUGU
miR-125/351150115081A,m8hsa-miR-125bbrainUCCCUGAGACCCUAACUUGUGA
hsa-miR-125abrainUCCCUGAGACCCUUUAACCUGUG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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