Gene Page: BAK1

Summary
GeneID  578
Symbol  BAK1
Synonyms  BAK|BAK-LIKE|BCL2L7|CDN1|MGC117255|MGC3887
Description  BCL2-antagonist/killer 1
See related  HGNC:949|MIM:600516|Ensembl:ENSG00000030110|HPRD:02744|
Locus tag  -
Gene type  protein-coding
Map location  6p21.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies1Link to SZGene
GSMA_Igenome scan meta-analysisPsr: 0.033 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ZNF4280.930.93
RALY0.910.91
NFKBIL10.910.89
CCDC940.910.92
SIRT60.900.92
AC011498.30.900.91
U2AF10.900.91
DNAJC170.900.92
NAGK0.890.92
PRPF310.890.91
Top 10 negatively co-expressed genes
AF347015.27-0.72-0.85
AF347015.31-0.71-0.83
AF347015.33-0.71-0.83
MT-CO2-0.70-0.82
MT-CYB-0.70-0.83
HLA-F-0.68-0.71
AF347015.8-0.67-0.82
AF347015.15-0.67-0.83
C5orf53-0.66-0.70
AF347015.2-0.65-0.83
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0042802identical protein bindingIPI15901672 
GO:0046982protein heterodimerization activityIPI10837489 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001836release of cytochrome c from mitochondriaIDA9843949 
GO:0006917induction of apoptosisTAS10381623 
GO:0008635caspase activation via cytochrome cIEA-
GO:0010046response to mycotoxinIEA-
GO:0009620response to fungusIEA-
GO:0010248establishment or maintenance of transmembrane electrochemical gradientIDA9843949 
GO:0008053mitochondrial fusionIEA-
GO:0042981regulation of apoptosisIEA-
GO:0043496regulation of protein homodimerization activityIDA9111042 
GO:0043497regulation of protein heterodimerization activityIDA9111042 
GO:0046902regulation of mitochondrial membrane permeabilityIDA9843949 
GO:0051881regulation of mitochondrial membrane potentialIDA9843949 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005739mitochondrionIDA9843949 
GO:0005741mitochondrial outer membraneEXP10950869 |12721291 
GO:0016020membraneIEA-
GO:0046930pore complexIDA9843949 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACTR2ARP2ARP2 actin-related protein 2 homolog (yeast)Affinity Capture-MSBioGRID17353931 
AKAP13AKAP-Lbc | BRX | FLJ11952 | FLJ43341 | HA-3 | Ht31 | LBC | PROTO-LB | PROTO-LBC | c-lbcA kinase (PRKA) anchor protein 13Affinity Capture-MSBioGRID17353931 
BAK1BAK | BAK-LIKE | BCL2L7 | CDN1 | MGC117255 | MGC3887BCL2-antagonist/killer 1Affinity Capture-WesternBioGRID15077116 
BAK1 (Bak) interacts with itself to form a dimer.BIND15846303 
BAXBCL2L4BCL2-associated X protein-HPRD,BioGRID11571294 
BCL2Bcl-2B-cell CLL/lymphoma 2-HPRD,BioGRID11728179 
BCL2A1ACC-1 | ACC-2 | BCL2L5 | BFL1 | GRS | HBPA1BCL2-related protein A1-HPRD10381646 
BCL2L1BCL-XL/S | BCL2L | BCLX | Bcl-X | DKFZp781P2092 | bcl-xL | bcl-xSBCL2-like 1-HPRD,BioGRID11175750 
BCL2L2BCL-W | BCLW | KIAA0271BCL2-like 2Affinity Capture-WesternBioGRID10381646 
BIDFP497 | MGC15319 | MGC42355BH3 interacting domain death agonist-HPRD10950869 
DFFADFF-45 | DFF1 | ICADDNA fragmentation factor, 45kDa, alpha polypeptideAffinity Capture-MSBioGRID17353931 
FBLFIB | FLRN | RNU3IP1fibrillarinAffinity Capture-MSBioGRID17353931 
FRYLDKFZp686E205 | FLJ16177 | KIAA0826FRY-likeAffinity Capture-MSBioGRID17353931 
HSPD1CPN60 | GROEL | HSP60 | HSP65 | HuCHA60 | SPG13heat shock 60kDa protein 1 (chaperonin)-HPRD,BioGRID12070120 
KRT31HA1 | Ha-1 | KRTHA1 | MGC138630 | hHa1keratin 31Affinity Capture-MSBioGRID17353931 
MCL1BCL2L3 | EAT | MCL1L | MCL1S | MGC104264 | MGC1839 | TMmyeloid cell leukemia sequence 1 (BCL2-related)-HPRD10579309 |10837489 
Affinity Capture-Western
Protein-peptide
Reconstituted Complex
Two-hybrid		BioGRID10837489 |15077116 
|15637055 |15901672 
MYCBP2DKFZp686M08244 | FLJ10106 | FLJ13826 | FLJ21597 | FLJ21646 | KIAA0916 | PAMMYC binding protein 2Affinity Capture-MSBioGRID17353931 
SRRM2300-KD | CWF21 | DKFZp686O15166 | FLJ21926 | FLJ22250 | KIAA0324 | MGC40295 | SRL300 | SRm300serine/arginine repetitive matrix 2Affinity Capture-MSBioGRID17353931 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53Mitochondrial p53-P72 interacts with Bak.BIND15077116 
Mitochondrial p53-R72 interacts with Bak.BIND15077116 
Affinity Capture-MS
Affinity Capture-Western
Reconstituted Complex		BioGRID15077116 
VDAC2FLJ23841voltage-dependent anion channel 2-HPRD,BioGRID12881569 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
BIOCARTA_MITOCHONDRIA_PATHWAY 2115All SZGR genes in this pathway
SA_PROGRAMMED_CELL_DEATH 129All SZGR genes in this pathway
ST_FAS_SIGNALING_PATHWAY 6554All SZGR genes in this pathway
PID_P73PATHWAY 7959All SZGR genes in this pathway
PID_P53_DOWNSTREAM_PATHWAY 13794All SZGR genes in this pathway
REACTOME_APOPTOSIS 14894All SZGR genes in this pathway
REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS 3021All SZGR genes in this pathway
KIM_WT1_TARGETS_12HR_UP 162116All SZGR genes in this pathway
ELVIDGE_HYPOXIA_DN 14694All SZGR genes in this pathway
CONCANNON_APOPTOSIS_BY_EPOXOMICIN_UP 239157All SZGR genes in this pathway
WANG_ESOPHAGUS_CANCER_VS_NORMAL_UP 12172All SZGR genes in this pathway
MARKS_HDAC_TARGETS_UP 2315All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_TTD_UP 6439All SZGR genes in this pathway
GALLUZZI_PERMEABILIZE_MITOCHONDRIA 4331All SZGR genes in this pathway
GALLUZZI_PREVENT_MITOCHONDIAL_PERMEABILIZATION 2216All SZGR genes in this pathway
PATIL_LIVER_CANCER 747453All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_UP 309199All SZGR genes in this pathway
RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_POORLY_DN 382224All SZGR genes in this pathway
RICKMAN_METASTASIS_DN 261155All SZGR genes in this pathway
ZEILSTRA_CD44_TARGETS_DN 75All SZGR genes in this pathway
STANELLE_E2F1_TARGETS 2920All SZGR genes in this pathway
KANNAN_TP53_TARGETS_UP 5840All SZGR genes in this pathway
FRASOR_RESPONSE_TO_ESTRADIOL_DN 8252All SZGR genes in this pathway
TENEDINI_MEGAKARYOCYTE_MARKERS 6648All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_DN 309206All SZGR genes in this pathway
DER_IFN_GAMMA_RESPONSE_UP 7145All SZGR genes in this pathway
AFFAR_YY1_TARGETS_UP 214133All SZGR genes in this pathway
WEIGEL_OXIDATIVE_STRESS_BY_TBH_AND_H2O2 3624All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_20HR_UP 240152All SZGR genes in this pathway
TAKAO_RESPONSE_TO_UVB_RADIATION_UP 8655All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_16HR_UP 225139All SZGR genes in this pathway
KAYO_CALORIE_RESTRICTION_MUSCLE_DN 8759All SZGR genes in this pathway
MACLACHLAN_BRCA1_TARGETS_DN 1612All SZGR genes in this pathway
MOREIRA_RESPONSE_TO_TSA_UP 2823All SZGR genes in this pathway
BRACHAT_RESPONSE_TO_CAMPTOTHECIN_DN 4631All SZGR genes in this pathway
MAHAJAN_RESPONSE_TO_IL1A_UP 8152All SZGR genes in this pathway
FOSTER_TOLERANT_MACROPHAGE_UP 15692All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_UP 245159All SZGR genes in this pathway
MUELLER_PLURINET 299189All SZGR genes in this pathway
MOOTHA_HUMAN_MITODB_6_2002 429260All SZGR genes in this pathway
MOOTHA_MITOCHONDRIA 447277All SZGR genes in this pathway
ZHANG_TLX_TARGETS_36HR_UP 221150All SZGR genes in this pathway
YAMASHITA_LIVER_CANCER_STEM_CELL_UP 4738All SZGR genes in this pathway
FONTAINE_PAPILLARY_THYROID_CARCINOMA_DN 8053All SZGR genes in this pathway
WORSCHECH_TUMOR_EVASION_AND_TOLEROGENICITY_DN 1411All SZGR genes in this pathway
MIKKELSEN_ES_ICP_WITH_H3K4ME3 718401All SZGR genes in this pathway
MIKKELSEN_NPC_ICP_WITH_H3K4ME3 445257All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_6HR_DN 9156All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN 505328All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_NOT_SATB1_DN 448282All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
FORTSCHEGGER_PHF8_TARGETS_DN 784464All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY 1839928All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-125/3516306371A,m8hsa-miR-125bbrainUCCCUGAGACCCUAACUUGUGA
hsa-miR-125abrainUCCCUGAGACCCUUUAACCUGUG
miR-26103210391A,m8hsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
miR-291881951A,m8hsa-miR-29aSZUAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZUAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZUAGCACCAUUUGAAAUCGGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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