Gene Page: RAB3A

Summary
GeneID  5864
Symbol  RAB3A
Synonyms  -
Description  RAB3A, member RAS oncogene family
See related  HGNC:9777|MIM:179490|Ensembl:ENSG00000105649|HPRD:01535|
Locus tag  -
Gene type  protein-coding
Map location  19p13.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 7 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
CXorf390.530.58
DNAJC60.520.60
UBE3C0.510.59
USH2A0.500.37
MEF2A0.500.60
PLEKHB20.500.57
ARID5B0.490.60
SOD20.490.56
AC010896.10.490.55
DDHD20.490.56
Top 10 negatively co-expressed genes
C1orf61-0.32-0.41
IL32-0.30-0.35
RAB34-0.29-0.31
GNG5-0.29-0.32
AC098691.2-0.28-0.29
RPS27L-0.27-0.31
METRN-0.27-0.29
IRF7-0.27-0.27
RFXANK-0.27-0.23
AL022328.1-0.27-0.26
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0003924GTPase activityIMP10859313 
GO:0005515protein bindingIPI10859313 
GO:0005515protein bindingISS-
GO:0005525GTP bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007409axonogenesisIEAneuron, axon, neurite (GO term level: 12)-
GO:0016188synaptic vesicle maturationIEASynap (GO term level: 8)-
GO:0031630regulation of synaptic vesicle fusion to presynaptic membraneIEASynap, Neurotransmitter (GO term level: 11)-
GO:0007274neuromuscular synaptic transmissionIEAneuron, Synap (GO term level: 7)-
GO:0016079synaptic vesicle exocytosisIEAneuron, Synap, Neurotransmitter (GO term level: 9)-
GO:0048790maintenance of presynaptic active zone structureIEAneuron, Synap, Neurotransmitter (GO term level: 9)-
GO:0003016respiratory system processIEA-
GO:0009791post-embryonic developmentIEA-
GO:0007005mitochondrion organizationIEA-
GO:0007264small GTPase mediated signal transductionIEA-
GO:0015031protein transportIEA-
GO:0050975sensory perception of touchIEA-
GO:0051602response to electrical stimulusIEA-
GO:0030324lung developmentIEA-
GO:0017157regulation of exocytosisIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0008021synaptic vesicleTASSynap, Neurotransmitter (GO term level: 12)9194562 
GO:0005737cytoplasmIDA18029348 
GO:0005886plasma membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BSNZNF231bassoon (presynaptic cytomatrix protein)Affinity Capture-WesternBioGRID14734538 
CASKCAGH39 | CMG | FLJ22219 | FLJ31914 | LIN2 | MICPCH | TNRC8calcium/calmodulin-dependent serine protein kinase (MAGUK family)-HPRD11377421 
CHMDXS540 | FLJ38564 | GGTA | HSD-32 | MGC102710 | REP-1 | TCDchoroideremia (Rab escort protein 1)-HPRD,BioGRID12535645 
CHMLFLJ10071 | FLJ13361 | REP2choroideremia-like (Rab escort protein 2)-HPRD,BioGRID12535645 
DMXL2FLJ26672 | KIAA0856 | RC3Dmx-like 2-HPRD11809763 
RAB3IL1GRABRAB3A interacting protein (rabin3)-like 1-HPRD11516400 
RAB3IPFLJ14660 | FLJ22548 | MGC71495 | RABIN3RAB3A interacting protein (rabin3)-HPRD7532276 
RABAC1PRA1 | PRAF1 | YIP3Rab acceptor 1 (prenylated)-HPRD,BioGRID9341137 
RABGGTBGGTBRab geranylgeranyltransferase, beta subunit-HPRD,BioGRID8706741 
RABIFMSS4 | RASGFR3 | RASGRF3RAB interacting factor-HPRD,BioGRID9013620 
RIMS1CORD7 | KIAA0340 | MGC167823 | MGC176677 | RAB3IP2 | RIM | RIM1regulating synaptic membrane exocytosis 1Affinity Capture-Western
Reconstituted Complex
BioGRID11343654 |12578829 
RIMS2DKFZp781A0653 | KIAA0751 | OBOE | RAB3IP3 | RIM2regulating synaptic membrane exocytosis 2-HPRD,BioGRID12578829 
RPH3AKIAA0985rabphilin 3A homolog (mouse)-HPRD10025402 |12937130 
Affinity Capture-Western
Co-crystal Structure
Reconstituted Complex
BioGRID8636125 |10025402 
|12578829 
RPH3ALNOC2rabphilin 3A-like (without C2 domains)-HPRD,BioGRID11134008|12578829 
SYTL4DKFZp451P0116 | FLJ40960 | SLP4synaptotagmin-like 4-HPRD,BioGRID11773082 
SYTL5slp5synaptotagmin-like 5-HPRD,BioGRID12051743 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
BIOCARTA_RAB_PATHWAY 128All SZGR genes in this pathway
REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE 1513All SZGR genes in this pathway
REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 186155All SZGR genes in this pathway
REACTOME_NEURONAL_SYSTEM 279221All SZGR genes in this pathway
REACTOME_NEUROTRANSMITTER_RELEASE_CYCLE 3430All SZGR genes in this pathway
REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE 1111All SZGR genes in this pathway
REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE 109All SZGR genes in this pathway
REACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE 1010All SZGR genes in this pathway
REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION 1716All SZGR genes in this pathway
DOANE_RESPONSE_TO_ANDROGEN_UP 184125All SZGR genes in this pathway
WATTEL_AUTONOMOUS_THYROID_ADENOMA_UP 7347All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM4 261153All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
BENPORATH_MYC_MAX_TARGETS 775494All SZGR genes in this pathway
BENPORATH_CYCLING_GENES 648385All SZGR genes in this pathway
LEE_TARGETS_OF_PTCH1_AND_SUFU_DN 8369All SZGR genes in this pathway
MODY_HIPPOCAMPUS_POSTNATAL 6350All SZGR genes in this pathway
LU_AGING_BRAIN_DN 153120All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
YIH_RESPONSE_TO_ARSENITE_C4 1812All SZGR genes in this pathway
WANG_LSD1_TARGETS_DN 3930All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
NIELSEN_GIST 9866All SZGR genes in this pathway
WHITFIELD_CELL_CYCLE_M_G1 14895All SZGR genes in this pathway
ACOSTA_PROLIFERATION_INDEPENDENT_MYC_TARGETS_UP 8451All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A 898516All SZGR genes in this pathway
ROESSLER_LIVER_CANCER_METASTASIS_UP 10772All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 1725838All SZGR genes in this pathway


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