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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: RAB5A

Summary

GeneID

5868

Symbol

RAB5A

Synonyms

RAB5

Description

RAB5A, member RAS oncogene family

Locus tag

Gene type

protein-coding

Map location

3p24-p22

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GSMA_I

genome scan meta-analysis

Psr: 0.006

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.012

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

MAST2

0.95

0.93

ANKRD13B

0.93

0.94

ZNF446

0.93

0.94

AC145098.2

0.93

KIAA1602

0.93

SMPD4

0.93

0.95

GPR173

0.93

0.92

CCDC120

0.92

0.91

PPRC1

0.92

KIAA0895L

0.92

0.93

Top 10 negatively co-expressed genes

AF347015.31

-0.72

-0.83

AF347015.27

-0.71

-0.82

C5orf53

-0.70

-0.73

MT-CO2

-0.69

-0.82

COPZ2

-0.67

-0.75

AF347015.33

-0.67

-0.77

AF347015.8

-0.66

-0.81

IFI27

-0.66

-0.75

MT-CYB

-0.66

-0.78

S100B

-0.66

-0.74

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0000166

nucleotide binding

IEA

GO:0003924

GTPase activity

TAS

2501306

GO:0005515

protein binding

IPI

9697774 |15016378

GO:0005515

protein binding

NAS

14613930

GO:0005525

GTP binding

IEA

GO:0019001

guanyl nucleotide binding

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007264

small GTPase mediated signal transduction

IEA

GO:0006897

endocytosis

TAS

8521472

GO:0015031

protein transport

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0001726

ruffle

IEA

GO:0005886

plasma membrane

IEA

GO:0030139

endocytic vesicle

IEA

GO:0042470

melanosome

IEA

GO:0031901

early endosome membrane

IEA

GO:0045121

membrane raft

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AGTR1	AG2S \| AGTR1A \| AGTR1B \| AT1 \| AT1B \| AT1R \| AT2R1 \| AT2R1A \| AT2R1B \| HAT1R	angiotensin II receptor, type 1	-	HPRD,BioGRID	11682489
ALS2CL	DKFZp686P238 \| MGC129698 \| RN49018	ALS2 C-terminal like	-	HPRD,BioGRID	15388334
AP1G1	ADTG \| CLAPG1 \| MGC18255	adaptor-related protein complex 1, gamma 1 subunit	Two-hybrid	BioGRID	14665628
AP1G2	G2AD	adaptor-related protein complex 1, gamma 2 subunit	Two-hybrid	BioGRID	14665628
CHM	DXS540 \| FLJ38564 \| GGTA \| HSD-32 \| MGC102710 \| REP-1 \| TCD	choroideremia (Rab escort protein 1)	Reconstituted Complex	BioGRID	8294464
CHML	FLJ10071 \| FLJ13361 \| REP2	choroideremia-like (Rab escort protein 2)	-	HPRD,BioGRID	8294464 \|9730828
EEA1	MST105 \| MSTP105 \| ZFYVE2	early endosome antigen 1	Rab5 interacts with EEA.1.	BIND	15782196
			-	HPRD	10491193 \|14600265
			FRET Reconstituted Complex Two-hybrid	BioGRID	11493665 \|11718716 \|14600265
GDI2	FLJ16452 \| FLJ37352 \| RABGDIB	GDP dissociation inhibitor 2	-	HPRD,BioGRID	10512627
GGA1	-	golgi associated, gamma adaptin ear containing, ARF binding protein 1	Two-hybrid	BioGRID	14665628
GGA2	FLJ20966 \| KIAA1080 \| VEAR	golgi associated, gamma adaptin ear containing, ARF binding protein 2	Two-hybrid	BioGRID	14665628
GGA3	KIAA0154	golgi associated, gamma adaptin ear containing, ARF binding protein 3	Two-hybrid	BioGRID	14665628
KIF3B	HH0048 \| KIAA0359	kinesin family member 3B	Affinity Capture-Western	BioGRID	12832475
RAB37	FLJ30284 \| FLJ32507	RAB37, member RAS oncogene family	-	HPRD,BioGRID	10722846
RAB4A	HRES-1/RAB4 \| RAB4	RAB4A, member RAS oncogene family	Co-purification	BioGRID	9524117
RAB5A	RAB5	RAB5A, member RAS oncogene family	Rab5 interacts with a second Rab5 molecule.	BIND	15782196
RAB7A	FLJ20819 \| PRO2706 \| RAB7	RAB7A, member RAS oncogene family	Two-hybrid	BioGRID	10329441
RABAC1	PRA1 \| PRAF1 \| YIP3	Rab acceptor 1 (prenylated)	-	HPRD	10329441
RABEP1	RAB5EP \| RABPT5	rabaptin, RAB GTPase binding effector protein 1	Co-purification Reconstituted Complex Two-hybrid	BioGRID	8521472 \|9045618 \|9524117 \|11718716
RABEP1	RAB5EP \| RABPT5	rabaptin, RAB GTPase binding effector protein 1	-	HPRD	8521472\|9045618
RASA1	CM-AVM \| CMAVM \| DKFZp434N071 \| GAP \| PKWS \| RASA \| RASGAP \| p120GAP \| p120RASGAP	RAS p21 protein activator (GTPase activating protein) 1	-	HPRD	11536198
RIN1	-	Ras and Rab interactor 1	-	HPRD,BioGRID	11703925
RIN2	RASSF4	Ras and Rab interactor 2	-	HPRD	12972505
RIN2	RASSF4	Ras and Rab interactor 2	Two-hybrid	BioGRID	11733506
RIN3	DKFZp762H1613 \| FLJ11700 \| FLJ22439	Ras and Rab interactor 3	Two-hybrid	BioGRID	12972505
RIT2	RIBA \| RIN \| ROC2	Ras-like without CAAX 2	Biochemical Activity	BioGRID	11703925
SDCBP	MDA-9 \| ST1 \| SYCL \| TACIP18	syndecan binding protein (syntenin)	Affinity Capture-Western Two-hybrid	BioGRID	15014045
STX4	STX4A \| p35-2	syntaxin 4	-	HPRD,BioGRID	11884531
TBC1D3	TBC1D3A \| TRE17	TBC1 domain family, member 3	-	HPRD	12612085
TBC1D3C	FLJ78248 \| MGC44903	TBC1 domain family, member 3C	-	HPRD	12359748
TSC2	FLJ43106 \| LAM \| TSC4	tuberous sclerosis 2	-	HPRD	9045618
TSC2	FLJ43106 \| LAM \| TSC4	tuberous sclerosis 2	Co-purification	BioGRID	12147258
VPS45	H1 \| H1VPS45 \| VPS45A \| VPS45B \| VPS54A \| VSP45 \| VSP45A	vacuolar protein sorting 45 homolog (S. cerevisiae)	Affinity Capture-MS	BioGRID	11062261
ZFYVE20	FLJ34993 \| MGC126210 \| Rabenosyn-5	zinc finger, FYVE domain containing 20	-	HPRD,BioGRID	11062261

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_ENDOCYTOSIS	183	132	All SZGR genes in this pathway
KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION	44	30	All SZGR genes in this pathway
KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS	53	43	All SZGR genes in this pathway
BIOCARTA_PTDINS_PATHWAY	23	16	All SZGR genes in this pathway
BIOCARTA_RAB_PATHWAY	12	8	All SZGR genes in this pathway
PID_MET_PATHWAY	80	60	All SZGR genes in this pathway
PID_AJDISS_2PATHWAY	48	38	All SZGR genes in this pathway
PID_ERBB1_DOWNSTREAM_PATHWAY	105	78	All SZGR genes in this pathway
PID_PDGFRB_PATHWAY	129	103	All SZGR genes in this pathway
PID_IL8_CXCR2_PATHWAY	34	26	All SZGR genes in this pathway
PID_ERBB1_INTERNALIZATION_PATHWAY	41	35	All SZGR genes in this pathway
PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY	38	29	All SZGR genes in this pathway
PID_IL8_CXCR1_PATHWAY	28	19	All SZGR genes in this pathway
REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION	132	101	All SZGR genes in this pathway
REACTOME_HEMOSTASIS	466	331	All SZGR genes in this pathway
THUM_SYSTOLIC_HEART_FAILURE_UP	423	283	All SZGR genes in this pathway
SENESE_HDAC2_TARGETS_UP	114	66	All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_DN	508	354	All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_UP	530	342	All SZGR genes in this pathway
LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN	800	473	All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN	712	443	All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP	811	508	All SZGR genes in this pathway
CAFFAREL_RESPONSE_TO_THC_UP	33	20	All SZGR genes in this pathway
CAFFAREL_RESPONSE_TO_THC_24HR_5_UP	34	23	All SZGR genes in this pathway
BENPORATH_NANOG_TARGETS	988	594	All SZGR genes in this pathway
BENPORATH_OCT4_TARGETS	290	172	All SZGR genes in this pathway
BENPORATH_SOX2_TARGETS	734	436	All SZGR genes in this pathway
BENPORATH_NOS_TARGETS	179	105	All SZGR genes in this pathway
PENG_GLUCOSE_DEPRIVATION_DN	169	112	All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_20HR_UP	240	152	All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_16HR_UP	225	139	All SZGR genes in this pathway
DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_UP	314	201	All SZGR genes in this pathway
LU_AGING_BRAIN_DN	153	120	All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_8HR_UP	105	73	All SZGR genes in this pathway
YIH_RESPONSE_TO_ARSENITE_C2	18	15	All SZGR genes in this pathway
MARTINEZ_RESPONSE_TO_TRABECTEDIN_DN	271	175	All SZGR genes in this pathway
ACEVEDO_NORMAL_TISSUE_ADJACENT_TO_LIVER_TUMOR_DN	354	216	All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_UP	245	159	All SZGR genes in this pathway
LINDSTEDT_DENDRITIC_CELL_MATURATION_A	67	52	All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_UP	518	299	All SZGR genes in this pathway
ROME_INSULIN_TARGETS_IN_MUSCLE_UP	442	263	All SZGR genes in this pathway
SASSON_RESPONSE_TO_GONADOTROPHINS_UP	91	59	All SZGR genes in this pathway
SASSON_RESPONSE_TO_FORSKOLIN_DN	88	68	All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN	1972	1213	All SZGR genes in this pathway
AZARE_NEOPLASTIC_TRANSFORMATION_BY_STAT3_UP	121	70	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-101	884	891	1A,m8	hsa-miR-101	UACAGUACUGUGAUAACUGAAG
miR-130/301	1162	1169	1A,m8	hsa-miR-130a^brain	CAGUGCAAUGUUAAAAGGGCAU
				hsa-miR-301	CAGUGCAAUAGUAUUGUCAAAGC
				hsa-miR-130b^brain	CAGUGCAAUGAUGAAAGGGCAU
				hsa-miR-454-3p	UAGUGCAAUAUUGCUUAUAGGGUUU
				hsa-miR-130a^brain	CAGUGCAAUGUUAAAAGGGCAU
				hsa-miR-301	CAGUGCAAUAGUAUUGUCAAAGC
				hsa-miR-130b^brain	CAGUGCAAUGAUGAAAGGGCAU
				hsa-miR-454-3p	UAGUGCAAUAUUGCUUAUAGGGUUU
miR-144	885	891	1A	hsa-miR-144	UACAGUAUAGAUGAUGUACUAG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.