Gene Page: RAB27A

Summary
GeneID  5873
Symbol  RAB27A
Synonyms  GS2|HsT18676|MGC117246|RAB27|RAM
Description  RAB27A, member RAS oncogene family
See related  HGNC:9766|MIM:603868|Ensembl:ENSG00000069974|HPRD:04845|
Locus tag  -
Gene type  protein-coding
Map location  15q15-q21.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
PNPLA60.900.88
DCTN10.900.89
ABCF30.900.88
OTUD50.890.89
CACNB10.880.87
ENO20.880.88
MAPK8IP30.880.86
C17orf280.880.85
APLP10.880.88
ADRBK10.880.87
Top 10 negatively co-expressed genes
AF347015.21-0.68-0.52
AF347015.31-0.59-0.47
MT-CO2-0.59-0.46
GNG11-0.59-0.49
AF347015.8-0.58-0.45
C1orf54-0.58-0.51
AP002478.3-0.57-0.50
NOSTRIN-0.56-0.44
AF347015.2-0.56-0.39
AF347015.18-0.56-0.42
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0003924GTPase activityTAS9066979 
GO:0005515protein bindingIEA-
GO:0005525GTP bindingIEA-
GO:0031489myosin V bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007596blood coagulationIEA-
GO:0007264small GTPase mediated signal transductionIEA-
GO:0006605protein targetingIEA-
GO:0016192vesicle-mediated transportIEA-
GO:0015031protein transportIEA-
GO:0043473pigmentationIEA-
GO:0032402melanosome transportIEA-
GO:0032400melanosome localizationIEA-
GO:0030318melanocyte differentiationIEA-
GO:0043320natural killer cell degranulationIEA-
GO:0043316cytotoxic T cell degranulationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0030425dendriteIDAneuron, axon, dendrite (GO term level: 6)11266474 
GO:0001750photoreceptor outer segmentIEA-
GO:0005794Golgi apparatusIEA-
GO:0005737cytoplasmIDA18029348 
GO:0016020membraneIEA-
GO:0042470melanosomeIDA11266474 
GO:0030141secretory granuleIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
C14orf1ERG28 | NET51chromosome 14 open reading frame 1Two-hybridBioGRID16169070 
C1orf103FLJ11269 | RIF1 | RP11-96K19.1chromosome 1 open reading frame 103Two-hybridBioGRID16169070 
C7orf64DKFZP564O0523 | DKFZp686D1651 | HSPC304chromosome 7 open reading frame 64Two-hybridBioGRID16169070 
COPS6CSN6 | MOV34-34KDCOP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis)Two-hybridBioGRID16169070 
EEF1A1CCS-3 | CCS3 | EEF-1 | EEF1A | EF-Tu | EF1A | FLJ25721 | GRAF-1EF | HNGC:16303 | LENG7 | MGC102687 | MGC131894 | MGC16224 | PTI1 | eEF1A-1eukaryotic translation elongation factor 1 alpha 1Two-hybridBioGRID16169070 
EXPH5DKFZp781H0795 | KIAA0624 | MGC133291 | MGC134967 | SLAC2-Bexophilin 5Affinity Capture-WesternBioGRID11773082 
GDF9-growth differentiation factor 9Two-hybridBioGRID16169070 
GZMBCCPI | CGL-1 | CGL1 | CSP-B | CSPB | CTLA1 | CTSGL1 | HLP | SECTgranzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)-HPRD11266473 
KIAA1377-KIAA1377Two-hybridBioGRID16169070 
MLPHMGC2771 | MGC59733 | SLAC2-Amelanophilin-HPRD11773082 |11856727 
|11980908 |12062444 
|15059972 
Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID11773082 |11980908 
|12062444 |15059972 
MYO5AGS1 | MYH12 | MYO5 | MYR12myosin VA (heavy chain 12, myoxin)-HPRD,BioGRID12006666 
MYRIPDKFZp586F1018 | FLJ44025 | MGC130034 | MGC130035 | SLAC2-C | SLAC2Cmyosin VIIA and Rab interacting protein-HPRD,BioGRID12590134 
RPH3AKIAA0985rabphilin 3A homolog (mouse)Affinity Capture-WesternBioGRID12578829 
RPH3ALNOC2rabphilin 3A-like (without C2 domains)-HPRD,BioGRID12578829 
STX1AHPC-1 | STX1 | p35-1syntaxin 1A (brain)-HPRD12101244 
SYTL1FLJ14996 | JFC1 | SLP1synaptotagmin-like 1-HPRD,BioGRID11980908 
-HPRD12590134 
SYTL2CHR11SYT | KIAA1597 | MGC102768 | SGA72M | SLP2synaptotagmin-like 2-HPRD11773082 |12590134 
-HPRD,BioGRID11773082 
SYTL3MGC105130 | MGC118883 | MGC118884 | MGC118885 | SLP3synaptotagmin-like 3-HPRD,BioGRID11773082 |12590134 
SYTL4DKFZp451P0116 | FLJ40960 | SLP4synaptotagmin-like 4-HPRD11773082|11865063 
Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID11773082 |11865063 
|12101244 |12176990 
|12590134 
SYTL5slp5synaptotagmin-like 5-HPRD,BioGRID12051743 
UNC13DFHL3 | HLH3 | HPLH3 | Munc13-4unc-13 homolog D (C. elegans)Reconstituted ComplexBioGRID14699162 
ZBTB16PLZF | ZNF145zinc finger and BTB domain containing 16Two-hybridBioGRID16169070 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
BIOCARTA_RAB_PATHWAY 128All SZGR genes in this pathway
REACTOME_DIABETES_PATHWAYS 13391All SZGR genes in this pathway
REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING 2115All SZGR genes in this pathway
GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN 493298All SZGR genes in this pathway
TURASHVILI_BREAST_DUCTAL_CARCINOMA_VS_DUCTAL_NORMAL_DN 198110All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_UP 579346All SZGR genes in this pathway
SAMOLS_TARGETS_OF_KHSV_MIRNAS_DN 6235All SZGR genes in this pathway
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_DN 320184All SZGR genes in this pathway
GRABARCZYK_BCL11B_TARGETS_UP 8140All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_EARLY_DN 367220All SZGR genes in this pathway
OSMAN_BLADDER_CANCER_UP 404246All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_1_UP 380236All SZGR genes in this pathway
DELYS_THYROID_CANCER_UP 443294All SZGR genes in this pathway
BARRIER_CANCER_RELAPSE_NORMAL_SAMPLE_UP 3221All SZGR genes in this pathway
HAMAI_APOPTOSIS_VIA_TRAIL_UP 584356All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN 584395All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN 848527All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN 637377All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215 893528All SZGR genes in this pathway
WANG_PROSTATE_CANCER_ANDROGEN_INDEPENDENT 6637All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_UP 8758All SZGR genes in this pathway
WIELAND_UP_BY_HBV_INFECTION 10166All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_DN 309206All SZGR genes in this pathway
HALMOS_CEBPA_TARGETS_UP 5234All SZGR genes in this pathway
AFFAR_YY1_TARGETS_DN 234137All SZGR genes in this pathway
VERNELL_RETINOBLASTOMA_PATHWAY_UP 7047All SZGR genes in this pathway
BASSO_CD40_SIGNALING_UP 10176All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_18HR_UP 178111All SZGR genes in this pathway
SONG_TARGETS_OF_IE86_CMV_PROTEIN 6042All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_24HR_UP 14896All SZGR genes in this pathway
WANG_SMARCE1_TARGETS_UP 280183All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_UP 953554All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_UP 783442All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3 720440All SZGR genes in this pathway
ZHANG_GATA6_TARGETS_DN 6446All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP 673430All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_UP 602364All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_UP 601369All SZGR genes in this pathway
BHATI_G2M_ARREST_BY_2METHOXYESTRADIOL_UP 12568All SZGR genes in this pathway
PARK_APL_PATHOGENESIS_DN 5035All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_GOOD_SURVIVAL_A4 196124All SZGR genes in this pathway
BOYAULT_LIVER_CANCER_SUBCLASS_G6_DN 1913All SZGR genes in this pathway
BOYAULT_LIVER_CANCER_SUBCLASS_G56_DN 179All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_CTNNB1_DN 170105All SZGR genes in this pathway
SETLUR_PROSTATE_CANCER_TMPRSS2_ERG_FUSION_DN 2012All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_DN 267160All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
SASSON_RESPONSE_TO_GONADOTROPHINS_UP 9159All SZGR genes in this pathway
SASSON_RESPONSE_TO_FORSKOLIN_UP 9058All SZGR genes in this pathway
KAMIKUBO_MYELOID_MN1_NETWORK 1914All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_MESENCHYMAL 216130All SZGR genes in this pathway
CHICAS_RB1_TARGETS_SENESCENT 572352All SZGR genes in this pathway
CHICAS_RB1_TARGETS_LOW_SERUM 10051All SZGR genes in this pathway
OHGUCHI_LIVER_HNF4A_TARGETS_UP 4430All SZGR genes in this pathway
CHYLA_CBFA2T3_TARGETS_UP 387225All SZGR genes in this pathway
MIYAGAWA_TARGETS_OF_EWSR1_ETS_FUSIONS_DN 229135All SZGR genes in this pathway
SERVITJA_LIVER_HNF1A_TARGETS_UP 13596All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124.13383451A,m8hsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-124/5063383441Ahsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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