Gene Page: RARA

Summary
GeneID  5914
Symbol  RARA
Synonyms  NR1B1|RAR
Description  retinoic acid receptor, alpha
See related  HGNC:9864|MIM:180240|Ensembl:ENSG00000131759|HPRD:06769|
Locus tag  -
Gene type  protein-coding
Map location  17q21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityIEA-
GO:0003707steroid hormone receptor activityIEA-
GO:0003708retinoic acid receptor activityIEA-
GO:0003713transcription coactivator activityIDA2825025 
GO:0001972retinoic acid bindingIDA2825025 
GO:0005515protein bindingIPI10866662 |16432238 |17560333 
GO:0008270zinc ion bindingIEA-
GO:0046872metal ion bindingIEA-
GO:0043565sequence-specific DNA bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0030520estrogen receptor signaling pathwayIDA15831516 
GO:0006350transcriptionIEA-
GO:0007165signal transductionIDA2825025 
GO:0048384retinoic acid receptor signaling pathwayIMP17538076 
GO:0032689negative regulation of interferon-gamma productionIDA18416830 
GO:0032526response to retinoic acidIMP17538076 
GO:0032754positive regulation of interleukin-5 productionIDA18416830 
GO:0032753positive regulation of interleukin-4 productionIDA18416830 
GO:0032720negative regulation of tumor necrosis factor productionIDA18416830 
GO:0032736positive regulation of interleukin-13 productionIDA18416830 
GO:0032355response to estradiol stimulusIDA15831516 
GO:0045630positive regulation of T-helper 2 cell differentiationIDA18416830 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0009986cell surfaceIC2825025 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ANP32AC15orf1 | I1PP2A | LANP | MAPM | MGC119787 | MGC150373 | PHAP1 | PHAPI | PP32acidic (leucine-rich) nuclear phosphoprotein 32 family, member ARAR-alpha interacts with pp32.BIND15308690 
ARNTLBMAL1 | BMAL1c | JAP3 | MGC47515 | MOP3 | PASD3 | TIC | bHLHe5aryl hydrocarbon receptor nuclear translocator-likeReconstituted ComplexBioGRID11439184 
BAG1RAP46BCL2-associated athanogene-HPRD,BioGRID9642262 
BTG1-B-cell translocation gene 1, anti-proliferativeBTG1 interacts with RARA (RAR-alpha).BIND15674337 
CCND3-cyclin D3in vitro
in vivo
Two-hybrid		BioGRID12482873 
CDK7CAK1 | CDKN7 | MO15 | STK1 | p39MO15cyclin-dependent kinase 7RAR-alpha interacts with hMo15.BIND15249124 
CLOCKKAT13D | KIAA0334 | bHLHe8clock homolog (mouse)Reconstituted Complex
Two-hybrid		BioGRID11439184 
GADD45ADDIT1 | GADD45growth arrest and DNA-damage-inducible, alphaAffinity Capture-WesternBioGRID10872826 
GADD45GCR6 | DDIT2 | GADD45gamma | GRP17growth arrest and DNA-damage-inducible, gammaReconstituted ComplexBioGRID10872826 
GATA2MGC2306 | NFE1BGATA binding protein 2-HPRD10938104 
HDAC3HD3 | RPD3 | RPD3-2histone deacetylase 3Reconstituted ComplexBioGRID12943985 
HDAC4HA6116 | HD4 | HDAC-A | HDACA | KIAA0288histone deacetylase 4Reconstituted ComplexBioGRID12943985 
IRX4IRXA3 | MGC131996iroquois homeobox 4-HPRD,BioGRID11382777 
JARID1AKDM5A | RBBP2 | RBP2jumonji, AT rich interactive domain 1AReconstituted ComplexBioGRID11358960 
Rbp2 interacts with RAR.BIND11358960 
KAT2BCAF | P | P/CAF | PCAFK(lysine) acetyltransferase 2BAffinity Capture-WesternBioGRID14581481 
KLF5BTEB2 | CKLF | IKLFKruppel-like factor 5 (intestinal)in vitro
in vivo		BioGRID12101409 
MECRCGI-63 | FASN2B | NRBF1mitochondrial trans-2-enoyl-CoA reductase-HPRD,BioGRID9795230 
MED6NY-REN-28mediator complex subunit 6Med6 interacts with RAR-alpha.BIND15808511 
NCOA1F-SRC-1 | KAT13A | MGC129719 | MGC129720 | NCoA-1 | RIP160 | SRC-1 | SRC1 | bHLHe42nuclear receptor coactivator 1RAR-alpha interacts with SRC-1.BIND15249124 
-HPRD12138096 
NCOA2GRIP1 | KAT13C | MGC138808 | NCoA-2 | TIF2nuclear receptor coactivator 2GRIP1 interacts with RAR. This interaction was modeled on a demonstrated interaction between mouse GRIP1 and human RAR.BIND9920895 
NCOA3ACTR | AIB-1 | AIB1 | CAGH16 | CTG26 | KAT13B | MGC141848 | RAC3 | SRC3 | TNRC14 | TNRC16 | TRAM-1 | pCIPnuclear receptor coactivator 3RAC3 interacts with RAR-alpha.BIND9238002 
NCOA6AIB3 | ANTP | ASC2 | HOX1.1 | HOXA7 | KIAA0181 | NRC | PRIP | RAP250 | TRBPnuclear receptor coactivator 6-HPRD,BioGRID10567404 
NCOR1KIAA1047 | MGC104216 | N-CoR | TRAC1 | hCIT529I10 | hN-CoRnuclear receptor co-repressor 1NCOR1 (N-CoR) interacts with p-RAR-alpha2 (RAR-alpha2 promoter).BIND15729358 
Reconstituted Complex
Two-hybrid		BioGRID9531570 |10336495 
NCOR2CTG26 | SMRT | SMRTE | SMRTE-tau | TNRC14 | TRAC-1 | TRAC1nuclear receptor co-repressor 2Affinity Capture-Western
Reconstituted Complex		BioGRID9256429 |11929748 
NCOR2 (SMRT) interacts with p-RAR-alpha2 (RAR-alpha2 promoter).BIND15729358 
NKX2-1BCH | BHC | NK-2 | NKX2.1 | NKX2A | TEBP | TITF1 | TTF-1 | TTF1NK2 homeobox 1-HPRD,BioGRID10617585 
NPAS2FLJ23138 | MGC71151 | MOP4 | PASD4 | bHLHe9neuronal PAS domain protein 2Reconstituted Complex
Two-hybrid		BioGRID11439184 
NR0B2FLJ17090 | SHP | SHP1nuclear receptor subfamily 0, group B, member 2-HPRD,BioGRID9773978 
NR1H3LXR-a | LXRA | RLD-1nuclear receptor subfamily 1, group H, member 3-HPRD10022764 
NR2E3ESCS | MGC49976 | PNR | RNR | RP37 | rd7nuclear receptor subfamily 2, group E, member 3-HPRD,BioGRID10611353 
NR4A2HZF-3 | NOT | NURR1 | RNR1 | TINURnuclear receptor subfamily 4, group A, member 2Reconstituted Complex
Two-hybrid		BioGRID7705655 
NRBF2COPR1 | COPR2 | DKFZp564C1664 | FLJ30395 | NRBF-2nuclear receptor binding factor 2-HPRD,BioGRID10786636 
NRIP1FLJ77253 | RIP140nuclear receptor interacting protein 1Affinity Capture-Western
Reconstituted Complex		BioGRID8887632 |12549917 
|14581481 
-HPRD12403842 |12549917 
NRIP2DKFZp761G1913nuclear receptor interacting protein 2-HPRD10860982 
NSD1ARA267 | DKFZp666C163 | FLJ10684 | FLJ22263 | FLJ44628 | KMT3B | SOTOS | STOnuclear receptor binding SET domain protein 1-HPRD9628876 
PARP1ADPRT | ADPRT1 | PARP | PARP-1 | PPOL | pADPRT-1poly (ADP-ribose) polymerase 1PARP-1 interacts with RAR-alpha.BIND15808511 
PMLMYL | PP8675 | RNF71 | TRIM19promyelocytic leukemia-HPRD12935927 
Reconstituted ComplexBioGRID10610177 
PNRC2FLJ20312 | MGC99541proline-rich nuclear receptor coactivator 2-HPRD11574675 
POU2F1OCT1 | OTF1POU class 2 homeobox 1Reconstituted ComplexBioGRID10480874 
PRMT2HRMT1L1 | MGC111373protein arginine methyltransferase 2PRMT2 interacts with RAR.BIND12039952 
RARANR1B1 | RARretinoic acid receptor, alphaReconstituted ComplexBioGRID14521715 
RBP2CRABP-II | CRBP2 | CRBPII | RBPC2retinol binding protein 2, cellular-HPRD11358960 
RXRAFLJ00280 | FLJ00318 | FLJ16020 | FLJ16733 | MGC102720 | NR2B1retinoid X receptor, alphaCo-purification
Reconstituted Complex		BioGRID1314167 |12052862 
RXRBDAUDI6 | H-2RIIBP | MGC1831 | NR2B2 | RCoR-1retinoid X receptor, betaTwo-hybridBioGRID16189514 
RXRGNR2B3 | RXRCretinoid X receptor, gammaTwo-hybridBioGRID16189514 
SP1-Sp1 transcription factorReconstituted ComplexBioGRID10361124 
SPENKIAA0929 | MINT | RP1-134O19.1 | SHARPspen homolog, transcriptional regulator (Drosophila)-HPRD11331609 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)Reconstituted ComplexBioGRID10454579 
TADA3LADA3 | FLJ20221 | FLJ21329 | hADA3transcriptional adaptor 3 (NGG1 homolog, yeast)-like-HPRD,BioGRID12235159 
TDG-thymine-DNA glycosylaseReconstituted ComplexBioGRID12874288 
TNFRSF10BCD262 | DR5 | KILLER | KILLER/DR5 | TRAIL-R2 | TRAILR2 | TRICK2 | TRICK2A | TRICK2B | TRICKB | ZTNFR9tumor necrosis factor receptor superfamily, member 10bRARA (RAR-alpha) interacts with TNFRSF10B (DR5) RARE.BIND12805378 
TRIM24PTC6 | RNF82 | TF1A | TIF1 | TIF1A | TIF1ALPHA | hTIF1tripartite motif-containing 24Reconstituted ComplexBioGRID9115274 
TRIP4HsT17391thyroid hormone receptor interactor 4-HPRD,BioGRID10454579 
ZBTB16PLZF | ZNF145zinc finger and BTB domain containing 16-HPRD,BioGRID14521715 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_ACUTE_MYELOID_LEUKEMIA 6047All SZGR genes in this pathway
BIOCARTA_EGFR_SMRTE_PATHWAY 1111All SZGR genes in this pathway
BIOCARTA_RARRXR_PATHWAY 159All SZGR genes in this pathway
BIOCARTA_NUCLEARRS_PATHWAY 1512All SZGR genes in this pathway
BIOCARTA_PML_PATHWAY 1712All SZGR genes in this pathway
BIOCARTA_CARM1_PATHWAY 1311All SZGR genes in this pathway
PID_RXR_VDR_PATHWAY 2624All SZGR genes in this pathway
PID_RETINOIC_ACID_PATHWAY 3023All SZGR genes in this pathway
REACTOME_GENERIC_TRANSCRIPTION_PATHWAY 352181All SZGR genes in this pathway
REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY 4936All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_DN 463290All SZGR genes in this pathway
THUM_SYSTOLIC_HEART_FAILURE_UP 423283All SZGR genes in this pathway
SMIRNOV_CIRCULATING_ENDOTHELIOCYTES_IN_CANCER_UP 158103All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_6HR_DN 4129All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_1_DN 12686All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_2_DN 7746All SZGR genes in this pathway
MULLIGHAN_NPM1_SIGNATURE_3_DN 162116All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_HSC_DN 187115All SZGR genes in this pathway
UDAYAKUMAR_MED1_TARGETS_DN 240171All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_24HR_DN 214133All SZGR genes in this pathway
NAGASHIMA_NRG1_SIGNALING_UP 176123All SZGR genes in this pathway
KIM_WT1_TARGETS_UP 214155All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_DN 781465All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_1_UP 12171All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_DN 394258All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_WITH_LOH_IN_CHR9Q 11671All SZGR genes in this pathway
FARMER_BREAST_CANCER_BASAL_VS_LULMINAL 330215All SZGR genes in this pathway
YORDY_RECIPROCAL_REGULATION_BY_ETS1_AND_SP100_UP 2511All SZGR genes in this pathway
SCHLESINGER_METHYLATED_DE_NOVO_IN_CANCER 8864All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_17Q11_Q21_AMPLICON 13378All SZGR genes in this pathway
BYSTROEM_CORRELATED_WITH_IL5_DN 6447All SZGR genes in this pathway
JECHLINGER_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_DN 6647All SZGR genes in this pathway
FERNANDEZ_BOUND_BY_MYC 182116All SZGR genes in this pathway
HOFMANN_CELL_LYMPHOMA_DN 3929All SZGR genes in this pathway
ABRAHAM_ALPC_VS_MULTIPLE_MYELOMA_UP 2622All SZGR genes in this pathway
THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_DN 225163All SZGR genes in this pathway
EHRLICH_ICF_SYNDROM_UP 138All SZGR genes in this pathway
MOREIRA_RESPONSE_TO_TSA_UP 2823All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_UP 953554All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_UP 783442All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_WITH_H3K9ME3_UP 14175All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_DN 701446All SZGR genes in this pathway
BERNARD_PPAPDC1B_TARGETS_DN 5839All SZGR genes in this pathway
MATZUK_SPERMATOCYTE 7255All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_DN 546362All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP 323240All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
VANTVEER_BREAST_CANCER_ESR1_UP 16799All SZGR genes in this pathway
TAVAZOIE_METASTASIS 10868All SZGR genes in this pathway
MILI_PSEUDOPODIA_CHEMOTAXIS_DN 457302All SZGR genes in this pathway
DANG_REGULATED_BY_MYC_DN 253192All SZGR genes in this pathway
DANG_MYC_TARGETS_DN 3125All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
MARTENS_BOUND_BY_PML_RARA_FUSION 456287All SZGR genes in this pathway
GREGORY_SYNTHETIC_LETHAL_WITH_IMATINIB 14583All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_6HR_UP 229149All SZGR genes in this pathway
BHAT_ESR1_TARGETS_NOT_VIA_AKT1_UP 211131All SZGR genes in this pathway
BHAT_ESR1_TARGETS_VIA_AKT1_UP 281183All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_D 280158All SZGR genes in this pathway
KASLER_HDAC7_TARGETS_1_UP 194133All SZGR genes in this pathway
DUAN_PRDM5_TARGETS 7952All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_AND_SATB1_UP 8752All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D 658397All SZGR genes in this pathway
VANOEVELEN_MYOGENESIS_SIN3A_TARGETS 220133All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1287397451Ahsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-135374380m8hsa-miR-135aUAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135bUAUGGCUUUUCAUUCCUAUGUG
miR-1383293361A,m8hsa-miR-138brainAGCUGGUGUUGUGAAUC
hsa-miR-138brainAGCUGGUGUUGUGAAUC
miR-2055785841Ahsa-miR-205UCCUUCAUUCCACCGGAGUCUG
miR-218564570m8hsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
miR-277397461A,m8hsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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