Gene Page: ATXN2

Summary
GeneID  6311
Symbol  ATXN2
Synonyms  ATX2|FLJ46772|SCA2|TNRC13
Description  ataxin 2
See related  HGNC:10555|MIM:601517|Ensembl:ENSG00000204842|HPRD:03307|
Locus tag  -
Gene type  protein-coding
Map location  12q24.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.02 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003723RNA bindingNAS10814712 
GO:0008022protein C-terminus bindingIPI15663938 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006417regulation of translationNAS16835262 
GO:0016070RNA metabolic processNAS15663938 
GO:0008219cell deathIEA-
GO:0034063stress granule assemblyIMP17392519 
GO:0033962cytoplasmic mRNA processing body assemblyIMP17392519 
GO:0050658RNA transportNAS10814712 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005794Golgi apparatusIDA12812977 |17097639 
GO:0005802trans-Golgi networkIDA10814712 
GO:0005844polysomeIDA16835262 
GO:0005737cytoplasmIDA10814712 |17392519 
GO:0010494stress granuleIDA17392519 
GO:0048471perinuclear region of cytoplasmIDA17097639 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
A2BP1FOX1 | HRNBP1ataxin 2-binding protein 1-HPRD11471052 
CD247CD3-ZETA | CD3H | CD3Q | CD3Z | T3Z | TCRZCD247 moleculeAffinity Capture-WesternBioGRID9575182 
CHGBSCG1chromogranin B (secretogranin 1)Two-hybridBioGRID16169070 
VHLHRCA1 | RCA1 | VHL1von Hippel-Lindau tumor suppressorAffinity Capture-MSBioGRID17353931 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
ENK_UV_RESPONSE_KERATINOCYTE_DN 485334All SZGR genes in this pathway
BERENJENO_ROCK_SIGNALING_NOT_VIA_RHOA_DN 4834All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN 483336All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN 514319All SZGR genes in this pathway
UEDA_PERIFERAL_CLOCK 169111All SZGR genes in this pathway
GUO_HEX_TARGETS_UP 8154All SZGR genes in this pathway
TAKAO_RESPONSE_TO_UVB_RADIATION_DN 9867All SZGR genes in this pathway
STEARMAN_LUNG_CANCER_EARLY_VS_LATE_UP 12589All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_DN 540340All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_GOOD_SURVIVAL_A4 196124All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_SCP2_QTL_TRANS 2513All SZGR genes in this pathway
CHANDRAN_METASTASIS_UP 221135All SZGR genes in this pathway
GUO_TARGETS_OF_IRS1_AND_IRS2 9867All SZGR genes in this pathway
PLASARI_TGFB1_SIGNALING_VIA_NFIC_1HR_DN 10677All SZGR genes in this pathway
DELACROIX_RARG_BOUND_MEF 367231All SZGR genes in this pathway
DELACROIX_RAR_BOUND_ES 462273All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1452652721A,m8hsa-miR-145GUCCAGUUUUCCCAGGAAUCCCUU
miR-15/16/195/424/4973463531A,m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-204/2115165221Ahsa-miR-204brainUUCCCUUUGUCAUCCUAUGCCU
hsa-miR-211UUCCCUUUGUCAUCCUUCGCCU
miR-2186470m8hsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
miR-433-3p3023081Ahsa-miR-433brainAUCAUGAUGGGCUCCUCGGUGU
miR-5033473531Ahsa-miR-503UAGCAGCGGGAACAGUUCUGCAG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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