Gene Page: BNIP3

Summary
GeneID  664
Symbol  BNIP3
Synonyms  NIP3
Description  BCL2/adenovirus E1B 19kDa interacting protein 3
See related  HGNC:1084|MIM:603293|Ensembl:ENSG00000176171|HPRD:04482|
Locus tag  -
Gene type  protein-coding
Map location  10q26.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.03487 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
SOX180.700.64
FOXQ10.680.62
TBX30.670.61
EPAS10.670.62
SEMA3G0.660.64
HSPA12B0.650.66
FOXF10.640.56
GPER0.640.57
GATA20.640.62
TBX20.640.60
Top 10 negatively co-expressed genes
ZNF32-0.43-0.48
COMMD3-0.42-0.45
FRG1-0.41-0.44
C12orf45-0.41-0.48
POLB-0.40-0.43
OXSM-0.39-0.42
RPL31-0.39-0.47
UBE2D2-0.39-0.35
PFDN5-0.39-0.47
C18orf21-0.38-0.38
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0042803protein homodimerization activityIDA9396766 |10381623 
GO:0046982protein heterodimerization activityIDA10381623 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0051402neuron apoptosisISSneuron, axon, dendrite (GO term level: 7)-
GO:0001666response to hypoxiaISS-
GO:0006309DNA fragmentation during apoptosisIDA10891486 
GO:0006338chromatin remodelingIDA10891486 
GO:0008219cell deathIDA10891486 
GO:0008219cell deathISS-
GO:0006917induction of apoptosisIDA9396766 |9973195 |10381623 
GO:0008634negative regulation of survival gene product expressionIDA9973195 
GO:0006800oxygen and reactive oxygen species metabolic processIDA10891486 
GO:0006916anti-apoptosisTAS7954800 
GO:0051607defense response to virusIDA9973195 
GO:0045837negative regulation of membrane potentialIDA10891486 
GO:0046902regulation of mitochondrial membrane permeabilityIDA10891486 
GO:0044419interspecies interaction between organismsIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0030425dendriteISSneuron, axon, dendrite (GO term level: 6)-
GO:0005634nucleusISS-
GO:0005635nuclear envelopeIDA7954800 
GO:0005654nucleoplasmISS-
GO:0005737cytoplasmISS-
GO:0005739mitochondrionIDA7954800 |9396766 
GO:0005739mitochondrionTAS9973195 
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0031307integral to mitochondrial outer membraneIDA10891486 
GO:0031966mitochondrial membraneIDA10891486 
GO:0031966mitochondrial membraneIMP9396766 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BCL2Bcl-2B-cell CLL/lymphoma 2-HPRD,BioGRID10625696 
BCL2L1BCL-XL/S | BCL2L | BCLX | Bcl-X | DKFZp781P2092 | bcl-xL | bcl-xSBCL2-like 1-HPRD,BioGRID10625696 
BNIP3NIP3BCL2/adenovirus E1B 19kDa interacting protein 3-HPRD,BioGRID9396766 
BNIP3LBNIP3a | NIXBCL2/adenovirus E1B 19kDa interacting protein 3-likeTwo-hybridBioGRID16189514 
CD47IAP | MER6 | OA3CD47 molecule-HPRD,BioGRID12690108 
NCBP1CBP80 | MGC2087 | NCBPnuclear cap binding protein subunit 1, 80kDa-HPRD,BioGRID7478990 
TMEM11C17orf35 | PM1 | PMItransmembrane protein 11Affinity Capture-Western
Two-hybrid		BioGRID16189514 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_MTOR_4PATHWAY 6955All SZGR genes in this pathway
PID_HIF1_TFPATHWAY 6652All SZGR genes in this pathway
WINTER_HYPOXIA_UP 9257All SZGR genes in this pathway
NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_DN 634384All SZGR genes in this pathway
LIU_SOX4_TARGETS_DN 309191All SZGR genes in this pathway
GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN 493298All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_DN 463290All SZGR genes in this pathway
PRAMOONJAGO_SOX4_TARGETS_UP 5238All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
GRABARCZYK_BCL11B_TARGETS_UP 8140All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_EARLY_DN 367220All SZGR genes in this pathway
OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_DN 275168All SZGR genes in this pathway
ELVIDGE_HYPOXIA_UP 171112All SZGR genes in this pathway
ELVIDGE_HYPOXIA_BY_DMOG_UP 13085All SZGR genes in this pathway
ELVIDGE_HIF1A_TARGETS_DN 9158All SZGR genes in this pathway
ELVIDGE_HIF1A_AND_HIF2A_TARGETS_DN 10472All SZGR genes in this pathway
WAMUNYOKOLI_OVARIAN_CANCER_GRADES_1_2_DN 6743All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_UP 293179All SZGR genes in this pathway
LAU_APOPTOSIS_CDKN2A_UP 5540All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_DN 234147All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
GALLUZZI_PERMEABILIZE_MITOCHONDRIA 4331All SZGR genes in this pathway
DUTTA_APOPTOSIS_VIA_NFKB 3325All SZGR genes in this pathway
FARMER_BREAST_CANCER_APOCRINE_VS_LUMINAL 326213All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_NEUROEPITHELIUM_UP 176111All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_FETAL_LIVER_UP 227137All SZGR genes in this pathway
MAINA_VHL_TARGETS_DN 1814All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_DN 203134All SZGR genes in this pathway
WANG_RESPONSE_TO_BEXAROTENE_UP 3417All SZGR genes in this pathway
GROSS_ELK3_TARGETS_DN 3217All SZGR genes in this pathway
GROSS_HIF1A_TARGETS_DN 2515All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_HIF1A_DN 11078All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_AND_HIF1A_UP 142104All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_UP 769437All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
CAFFAREL_RESPONSE_TO_THC_8HR_5_UP 167All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_12HR_UP 11679All SZGR genes in this pathway
IIZUKA_LIVER_CANCER_PROGRESSION_G2_G3_UP 2814All SZGR genes in this pathway
UEDA_PERIFERAL_CLOCK 169111All SZGR genes in this pathway
VANTVEER_BREAST_CANCER_METASTASIS_DN 12165All SZGR genes in this pathway
SMITH_LIVER_CANCER 4527All SZGR genes in this pathway
MANALO_HYPOXIA_UP 207145All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN 546351All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 555346All SZGR genes in this pathway
KANG_IMMORTALIZED_BY_TERT_UP 8961All SZGR genes in this pathway
JAIN_NFKB_SIGNALING 7544All SZGR genes in this pathway
MENSE_HYPOXIA_UP 9871All SZGR genes in this pathway
BRUNO_HEMATOPOIESIS 6648All SZGR genes in this pathway
KIM_HYPOXIA 2521All SZGR genes in this pathway
WEIGEL_OXIDATIVE_STRESS_RESPONSE 3528All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
HARRIS_HYPOXIA 8164All SZGR genes in this pathway
WANG_SMARCE1_TARGETS_DN 371218All SZGR genes in this pathway
SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_2 5034All SZGR genes in this pathway
LEONARD_HYPOXIA 4735All SZGR genes in this pathway
SATO_SILENCED_EPIGENETICALLY_IN_PANCREATIC_CANCER 4930All SZGR genes in this pathway
KAAB_HEART_ATRIUM_VS_VENTRICLE_DN 261183All SZGR genes in this pathway
WELCSH_BRCA1_TARGETS_UP 198132All SZGR genes in this pathway
SESTO_RESPONSE_TO_UV_C1 7245All SZGR genes in this pathway
GEISS_RESPONSE_TO_DSRNA_UP 3829All SZGR genes in this pathway
JIANG_HYPOXIA_NORMAL 311205All SZGR genes in this pathway
SEMENZA_HIF1_TARGETS 3632All SZGR genes in this pathway
SAFFORD_T_LYMPHOCYTE_ANERGY 8754All SZGR genes in this pathway
SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1 419273All SZGR genes in this pathway
BURTON_ADIPOGENESIS_6 189112All SZGR genes in this pathway
MONNIER_POSTRADIATION_TUMOR_ESCAPE_DN 373196All SZGR genes in this pathway
COATES_MACROPHAGE_M1_VS_M2_DN 7844All SZGR genes in this pathway
LEE_METASTASIS_AND_ALTERNATIVE_SPLICING_UP 7451All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP 673430All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_UP 602364All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_UP 601369All SZGR genes in this pathway
BOCHKIS_FOXA2_TARGETS 425261All SZGR genes in this pathway
WINTER_HYPOXIA_METAGENE 242168All SZGR genes in this pathway
MOOTHA_HUMAN_MITODB_6_2002 429260All SZGR genes in this pathway
MELLMAN_TUT1_TARGETS_DN 4729All SZGR genes in this pathway
HAN_SATB1_TARGETS_DN 442275All SZGR genes in this pathway
FONTAINE_FOLLICULAR_THYROID_ADENOMA_DN 6845All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_0 7654All SZGR genes in this pathway
KYNG_RESPONSE_TO_H2O2_VIA_ERCC6_DN 4631All SZGR genes in this pathway
BAE_BRCA1_TARGETS_UP 7547All SZGR genes in this pathway
KIM_ALL_DISORDERS_CALB1_CORR_UP 548370All SZGR genes in this pathway
HIRSCH_CELLULAR_TRANSFORMATION_SIGNATURE_UP 242159All SZGR genes in this pathway
QI_HYPOXIA 14096All SZGR genes in this pathway
SUBTIL_PROGESTIN_TARGETS 3625All SZGR genes in this pathway
PILON_KLF1_TARGETS_UP 504321All SZGR genes in this pathway
MIYAGAWA_TARGETS_OF_EWSR1_ETS_FUSIONS_DN 229135All SZGR genes in this pathway
VANDESLUIS_COMMD1_TARGETS_GROUP_2_UP 1512All SZGR genes in this pathway
FARDIN_HYPOXIA_9 76All SZGR genes in this pathway
FARDIN_HYPOXIA_11 3229All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
KRIEG_HYPOXIA_NOT_VIA_KDM3A 770480All SZGR genes in this pathway
SMIRNOV_RESPONSE_TO_IR_6HR_DN 11469All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1457968031A,m8hsa-miR-145GUCCAGUUUUCCCAGGAAUCCCUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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