Gene Page: SOD1

Summary
GeneID  6647
Symbol  SOD1
Synonyms  ALS|ALS1|IPOA|SOD|homodimer
Description  superoxide dismutase 1, soluble
See related  HGNC:11179|MIM:147450|Ensembl:ENSG00000142168|HPRD:00937|
Locus tag  -
Gene type  protein-coding
Map location  21q22.1|21q22.11
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 5 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
GAK0.890.88
ARFGAP10.880.86
DNAJC110.860.83
CUL90.860.85
PLA2G60.860.83
ATG2A0.860.85
ZNF8390.860.82
C16orf580.850.81
DDX510.850.85
RAB11FIP30.850.85
Top 10 negatively co-expressed genes
AF347015.21-0.78-0.67
MT-CO2-0.70-0.60
AF347015.31-0.70-0.61
AF347015.8-0.67-0.58
C1orf54-0.67-0.62
MT-CYB-0.65-0.55
CLEC2B-0.65-0.60
AF347015.27-0.64-0.57
AF347015.33-0.64-0.53
NOSTRIN-0.63-0.50
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005507copper ion bindingIDA17008312 
GO:0004784superoxide dismutase activityIDA15544046 |17324120 
GO:0008270zinc ion bindingIDA17381088 
GO:0016209antioxidant activityIEA-
GO:0016491oxidoreductase activityIEA-
GO:0051087chaperone bindingIPI9726962 
GO:0042803protein homodimerization activityNAS9726962 |10837872 
GO:0030346protein phosphatase 2B bindingIDA17324120 
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0048678response to axon injuryISSaxon (GO term level: 5)-
GO:0019226transmission of nerve impulseISSneuron (GO term level: 5)-
GO:0043524negative regulation of neuron apoptosisISSneuron (GO term level: 9)-
GO:0000187activation of MAPK activityISS-
GO:0000303response to superoxideIDA16790527 
GO:0001541ovarian follicle developmentISS-
GO:0002262myeloid cell homeostasisISS-
GO:0001895retina homeostasisISS-
GO:0001890placenta developmentNAS12485882 
GO:0001819positive regulation of cytokine productionIDA15544046 
GO:0006302double-strand break repairISS-
GO:0006309DNA fragmentation during apoptosisISS-
GO:0008217regulation of blood pressureISS-
GO:0007283spermatogenesisISS-
GO:0009408response to heatISS-
GO:0007626locomotory behaviorISS-
GO:0007605sensory perception of soundISS-
GO:0007569cell agingIEP15377661 
GO:0007569cell agingIMP12871978 
GO:0007566embryo implantationISS-
GO:0007566embryo implantationNAS10920331 
GO:0006749glutathione metabolic processISS-
GO:0006879cellular iron ion homeostasisISS-
GO:0043065positive regulation of apoptosisIC16790527 
GO:0033081regulation of T cell differentiation in the thymusNAS16716898 
GO:0042493response to drugISS-
GO:0042554superoxide releaseIEA-
GO:0032287myelin maintenance in the peripheral nervous systemISS-
GO:0043085positive regulation of catalytic activityIDA17324120 
GO:0019430removal of superoxide radicalsISS-
GO:0042542response to hydrogen peroxideISS-
GO:0040014regulation of multicellular organism growthISS-
GO:0045541negative regulation of cholesterol biosynthetic processIDA15473258 
GO:0045859regulation of protein kinase activityIDA16254550 
GO:0050665hydrogen peroxide biosynthetic processIDA15544046 
GO:0050665hydrogen peroxide biosynthetic processISS-
GO:0046620regulation of organ growthNAS16716898 
GO:0046716muscle maintenanceISS-
GO:0048538thymus developmentNAS16716898 
GO:0060088auditory receptor cell stereocilium organizationISS-
GO:0060087relaxation of vascular smooth muscleISS-
GO:0045471response to ethanolISS-
GO:0055114oxidation reductionIEA-
GO:0060047heart contractionIDA9539776 
GO:0060052neurofilament cytoskeleton organizationISS-
GO:0051881regulation of mitochondrial membrane potentialIMP16790527 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0043025cell somaIDAaxon, dendrite (GO term level: 4)17324120 
GO:0032839dendrite cytoplasmIDAdendrite (GO term level: 9)17324120 
GO:0005829cytosolIDA16790527 
GO:0005615extracellular spaceIDA7172448 |9453566 
GO:0005634nucleusIDA9726962 |17504823 
GO:0005737cytoplasmIDA9726962 |11527942 |17077646 
|17504823 
GO:0005739mitochondrionIDA16790527 
GO:0005759mitochondrial matrixNAS17008312 
GO:0005777peroxisomeNAS15766328 
GO:0005886plasma membraneIDA17077646 |17324120 
GO:0031012extracellular matrixIDA9699963 
GO:0031410cytoplasmic vesicleIDA17077646 
GO:0043234protein complexIDA17324120 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BCL2Bcl-2B-cell CLL/lymphoma 2-HPRD,BioGRID15233914 
CCSMGC138260copper chaperone for superoxide dismutase-HPRD,BioGRID9726962 |10677207 
CCS interacts with SOD1.BIND11115513 
ESR1DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1estrogen receptor 1ER interacts with SOD-1 enhancer.BIND16009131 
HECW1KIAA0322 | NEDL1HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1Affinity Capture-WesternBioGRID14684739 
POLR2AMGC75453 | POLR2 | POLRA | RPB1 | RPBh1 | RPO2 | RPOL2 | RpIILS | hRPB220 | hsRPB1polymerase (RNA) II (DNA directed) polypeptide A, 220kDaPol II interacts with SOD-1 enhancer.BIND16009131 
PPP3CACALN | CALNA | CALNA1 | CCN1 | CNA1 | PPP2Bprotein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform-HPRD11513882 
SSR4TRAPDsignal sequence receptor, delta (translocon-associated protein delta)Affinity Capture-WesternBioGRID14684739 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_PEROXISOME 7847All SZGR genes in this pathway
KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS 5343All SZGR genes in this pathway
KEGG_HUNTINGTONS_DISEASE 185109All SZGR genes in this pathway
KEGG_PRION_DISEASES 3528All SZGR genes in this pathway
BIOCARTA_FREE_PATHWAY 107All SZGR genes in this pathway
BIOCARTA_LONGEVITY_PATHWAY 1513All SZGR genes in this pathway
PID_ERA_GENOMIC_PATHWAY 6537All SZGR genes in this pathway
PID_HNF3A_PATHWAY 4429All SZGR genes in this pathway
REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ 8956All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 208138All SZGR genes in this pathway
CHANDRAN_METASTASIS_TOP50_UP 3827All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
PROVENZANI_METASTASIS_DN 13694All SZGR genes in this pathway
DARWICHE_SKIN_TUMOR_PROMOTER_UP 14296All SZGR genes in this pathway
DARWICHE_PAPILLOMA_RISK_LOW_DN 165107All SZGR genes in this pathway
DARWICHE_PAPILLOMA_RISK_HIGH_DN 180110All SZGR genes in this pathway
DARWICHE_SQUAMOUS_CELL_CARCINOMA_UP 146104All SZGR genes in this pathway
HU_ANGIOGENESIS_DN 3725All SZGR genes in this pathway
AMUNDSON_RESPONSE_TO_ARSENITE 217143All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_UP 358245All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
FRIDMAN_SENESCENCE_UP 7760All SZGR genes in this pathway
GOTZMANN_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_DN 206136All SZGR genes in this pathway
BENPORATH_MYC_MAX_TARGETS 775494All SZGR genes in this pathway
HOUSTIS_ROS 3629All SZGR genes in this pathway
ROSS_AML_OF_FAB_M7_TYPE 6844All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN 546351All SZGR genes in this pathway
HSIAO_LIVER_SPECIFIC_GENES 244154All SZGR genes in this pathway
BROWN_MYELOID_CELL_DEVELOPMENT_DN 12986All SZGR genes in this pathway
NADLER_OBESITY_DN 4834All SZGR genes in this pathway
FAELT_B_CLL_WITH_VH_REARRANGEMENTS_DN 4826All SZGR genes in this pathway
TAKAO_RESPONSE_TO_UVB_RADIATION_UP 8655All SZGR genes in this pathway
MARTINEZ_RESPONSE_TO_TRABECTEDIN_UP 7149All SZGR genes in this pathway
NATSUME_RESPONSE_TO_INTERFERON_BETA_DN 5233All SZGR genes in this pathway
ZHANG_PROLIFERATING_VS_QUIESCENT 5141All SZGR genes in this pathway
HEDENFALK_BREAST_CANCER_BRCA1_VS_BRCA2 163113All SZGR genes in this pathway
WHITESIDE_CISPLATIN_RESISTANCE_DN 139All SZGR genes in this pathway
XU_GH1_AUTOCRINE_TARGETS_UP 268157All SZGR genes in this pathway
VISALA_RESPONSE_TO_HEAT_SHOCK_AND_AGING_DN 1412All SZGR genes in this pathway
JIANG_AGING_HYPOTHALAMUS_UP 4731All SZGR genes in this pathway
HILLION_HMGA1_TARGETS 9071All SZGR genes in this pathway
HILLION_HMGA1B_TARGETS 9268All SZGR genes in this pathway
KYNG_ENVIRONMENTAL_STRESS_RESPONSE_NOT_BY_GAMMA_IN_WS 3322All SZGR genes in this pathway
KYNG_ENVIRONMENTAL_STRESS_RESPONSE_NOT_BY_UV_IN_WS 129All SZGR genes in this pathway
KYNG_DNA_DAMAGE_DN 195135All SZGR genes in this pathway
KYNG_ENVIRONMENTAL_STRESS_RESPONSE_UP 5641All SZGR genes in this pathway
LEE_METASTASIS_AND_ALTERNATIVE_SPLICING_DN 4531All SZGR genes in this pathway
IWANAGA_CARCINOGENESIS_BY_KRAS_PTEN_DN 353226All SZGR genes in this pathway
ACEVEDO_NORMAL_TISSUE_ADJACENT_TO_LIVER_TUMOR_DN 354216All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_DN 540340All SZGR genes in this pathway
MATZUK_PREOVULATORY_FOLLICLE 108All SZGR genes in this pathway
CHUNG_BLISTER_CYTOTOXICITY_UP 13484All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
HINATA_NFKB_TARGETS_KERATINOCYTE_UP 9163All SZGR genes in this pathway
HINATA_NFKB_TARGETS_FIBROBLAST_UP 8460All SZGR genes in this pathway
HSIAO_HOUSEKEEPING_GENES 389245All SZGR genes in this pathway
YAMASHITA_LIVER_CANCER_STEM_CELL_DN 7651All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S3 266180All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP 756494All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP 682440All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D 658397All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-377107113m8hsa-miR-377AUCACACAAAGGCAACUUUUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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