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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Gene Page: STX1A

Summary

GeneID

6804

Symbol

STX1A

Synonyms

HPC-1|STX1|p35-1

Description

syntaxin 1A (brain)

Locus tag

Gene type

protein-coding

Map location

7q11.23

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Association

A combined odds ratio method (Sun et al. 2008), association studies

Link to SZGene

Literature

High-throughput literature-search

Co-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]

Click to show detail

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 2

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.0456

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

CALM3

0.92

0.91

SYP

0.89

0.93

MOAP1

0.88

ATP6V1G2

0.88

SPRYD3

0.88

0.90

ARF3

0.87

TPRG1L

0.87

0.90

SULT4A1

0.86

0.91

AC073610.6

0.86

AC005277.1

0.86

0.88

Top 10 negatively co-expressed genes

RAB13

-0.46

-0.53

BCL7C

-0.41

-0.47

RPS20

-0.39

-0.43

GRTP1

-0.39

-0.40

C9orf46

-0.39

-0.36

HYAL2

-0.39

-0.40

GPR125

-0.39

-0.38

CLIC1

-0.38

-0.53

RPL34

-0.38

-0.42

CDC42EP4

-0.38

-0.36

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0000149

SNARE binding

IEA

GO:0005484

SNAP receptor activity

IEA

GO:0005515

protein binding

IEA

GO:0019855

calcium channel inhibitor activity

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007268

synaptic transmission

IEA

neuron, Synap, Neurotransmitter (GO term level: 6)

GO:0006836

neurotransmitter transport

IEA

neuron, Neurotransmitter (GO term level: 5)

GO:0006886

intracellular protein transport

IEA

GO:0016192

vesicle-mediated transport

IEA

GO:0017156

calcium ion-dependent exocytosis

IEA

GO:0050796

regulation of insulin secretion

TAS

15537656

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005576

extracellular region

IEA

GO:0016020

membrane

IEA

GO:0016021

integral to membrane

IEA

GO:0005886

plasma membrane

EXP

8611567

GO:0005886

plasma membrane

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
APBA1	D9S411E \| MINT1 \| X11 \| X11A \| X11ALPHA	amyloid beta (A4) precursor protein-binding, family A, member 1	-	HPRD	9395480
ATP6V1B1	ATP6B1 \| MGC32642 \| RTA1B \| VATB \| VMA2 \| VPP3	ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1	Reconstituted Complex	BioGRID	12651853
CACNA1D	CACH3 \| CACN4 \| CACNL1A2 \| CCHL1A2 \| Cav1.3	calcium channel, voltage-dependent, L type, alpha 1D subunit	-	HPRD	10468580
CDK5	PSSALRE	cyclin-dependent kinase 5	-	HPRD,BioGRID	9478941
CFTR	ABC35 \| ABCC7 \| CF \| CFTR/MRP \| MRP7 \| TNR-CFTR \| dJ760C5.1	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	Syntaxin 1A interacts with CFTR.	BIND	9384384 \|12446681
CFTR	ABC35 \| ABCC7 \| CF \| CFTR/MRP \| MRP7 \| TNR-CFTR \| dJ760C5.1		-	HPRD,BioGRID	9384384
CPLX1	CPX-I \| CPX1	complexin 1	Affinity Capture-Western Co-crystal Structure Reconstituted Complex	BioGRID	10449403 \|11832227 \|12200427
CPLX1	CPX-I \| CPX1	complexin 1	-	HPRD	7553862
CPLX2	921-L \| CPX-2 \| CPX2 \| Hfb1 \| MGC138492	complexin 2	Affinity Capture-Western	BioGRID	10449403
KCNB1	DRK1 \| KV2.1 \| h-DRK1	potassium voltage-gated channel, Shab-related subfamily, member 1	-	HPRD	12403834
KIAA1128	FLJ14262 \| FLJ25809 \| Gcap14 \| bA486O22.1	KIAA1128	Two-hybrid	BioGRID	16169070
NAPA	SNAPA	N-ethylmaleimide-sensitive factor attachment protein, alpha	Affinity Capture-Western Reconstituted Complex	BioGRID	7553862 \|7622514
NSF	SKD2	N-ethylmaleimide-sensitive factor	-	HPRD	7622514
PSEN1	AD3 \| FAD \| PS1 \| S182	presenilin 1	PS1 interacts with syntaxin 1A.	BIND	10891589
RAB27A	GS2 \| HsT18676 \| MGC117246 \| RAB27 \| RAM	RAB27A, member RAS oncogene family	-	HPRD	12101244
RNF40	BRE1B \| DKFZp686K191 \| KIAA0661 \| MGC13051 \| RBP95 \| STARING	ring finger protein 40	Affinity Capture-Western Reconstituted Complex	BioGRID	12121982
SCNN1A	ENaCa \| ENaCalpha \| FLJ21883 \| SCNEA \| SCNN1	sodium channel, nonvoltage-gated 1 alpha	Affinity Capture-Western	BioGRID	14996668
SCNN1B	ENaCb \| ENaCbeta \| SCNEB	sodium channel, nonvoltage-gated 1, beta	Affinity Capture-Western	BioGRID	14996668
SCNN1B	ENaCb \| ENaCbeta \| SCNEB	sodium channel, nonvoltage-gated 1, beta	-	HPRD	11845306
SCNN1G	ENaCg \| ENaCgamma \| PHA1 \| SCNEG	sodium channel, nonvoltage-gated 1, gamma	-	HPRD,BioGRID	14996668
SEPT2	DIFF6 \| KIAA0158 \| NEDD5 \| Pnutl3 \| hNedd5	septin 2	-	HPRD	10321247
SEPT5	CDCREL \| CDCREL-1 \| CDCREL1 \| H5 \| PNUTL1	septin 5	-	HPRD	10321247
SLC6A1	GABATHG \| GABATR \| GAT1	solute carrier family 6 (neurotransmitter transporter, GABA), member 1	-	HPRD,BioGRID	9698305 \|11017172 \|11960023
SLC6A3	DAT \| DAT1	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	DAT interacts with Syn1A.	BIND	15202772
SLC6A4	5-HTT \| 5HTT \| HTT \| OCD1 \| SERT \| hSERT	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	-	HPRD,BioGRID	12175857
SLC6A5	GLYT2 \| NET1	solute carrier family 6 (neurotransmitter transporter, glycine), member 5	Affinity Capture-Western	BioGRID	10722844
SLC6A9	DKFZp547A1118 \| GLYT1	solute carrier family 6 (neurotransmitter transporter, glycine), member 9	-	HPRD,BioGRID	10722844
SNAP23	HsT17016 \| SNAP23A \| SNAP23B	synaptosomal-associated protein, 23kDa	-	HPRD	12209004\|12651853
SNAP23	HsT17016 \| SNAP23A \| SNAP23B	synaptosomal-associated protein, 23kDa	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	8663154 \|9168999 \|9852078 \|12651853 \|12828989
SNAP25	FLJ23079 \| RIC-4 \| RIC4 \| SEC9 \| SNAP \| SNAP-25 \| bA416N4.2 \| dJ1068F16.2	synaptosomal-associated protein, 25kDa	-	HPRD	7622514 \|7768895 \|9556632 \|10373452 \|11509230\|10954418
			-	HPRD	7622514 \|9556632\|10954418
			Affinity Capture-Western Co-crystal Structure Reconstituted Complex Two-hybrid	BioGRID	7553862 \|7768895 \|7961655 \|8663154 \|9852078 \|10195194 \|10449403 \|10954418 \|11524423 \|11832227 \|16169070
SNAP29	CEDNIK \| FLJ21051 \| SNAP-29	synaptosomal-associated protein, 29kDa	-	HPRD,BioGRID	9852078
STX1A	HPC-1 \| STX1 \| p35-1	syntaxin 1A (brain)	Reconstituted Complex	BioGRID	10100611
STX8	CARB	syntaxin 8	-	HPRD	11101518
STXBP1	EIEE4 \| MUNC18-1 \| UNC18 \| hUNC18 \| rbSec1	syntaxin binding protein 1	Affinity Capture-Western Reconstituted Complex	BioGRID	7553862 \|7768895 \|10449403 \|12093152 \|12963086
STXBP1	EIEE4 \| MUNC18-1 \| UNC18 \| hUNC18 \| rbSec1	syntaxin binding protein 1	-	HPRD	9045631
STXBP2	Hunc18b \| MUNC18-2 \| UNC18-2 \| UNC18B \| pp10122	syntaxin binding protein 2	-	HPRD,BioGRID	7768895 \|9045631
STXBP5	FLJ30922 \| LGL3 \| LLGL3 \| MGC141942 \| MGC141968 \| Nbla04300	syntaxin binding protein 5 (tomosyn)	-	HPRD,BioGRID	9620695
STXBP6	FLJ39638 \| HSPC156 \| amisyn	syntaxin binding protein 6 (amisyn)	-	HPRD	12145319
SYP	-	synaptophysin	Affinity Capture-Western	BioGRID	7553862
SYT1	DKFZp781D2042 \| P65 \| SVP65 \| SYT	synaptotagmin I	-	HPRD,BioGRID	9010211
SYT4	HsT1192 \| KIAA1342	synaptotagmin IV	-	HPRD	10397765
SYT7	IPCA-7 \| MGC150517 \| PCANAP7 \| SYT-VII	synaptotagmin VII	-	HPRD	7791877
SYTL4	DKFZp451P0116 \| FLJ40960 \| SLP4	synaptotagmin-like 4	-	HPRD,BioGRID	12101244
TRDMT1	DNMT2 \| M.HsaIIP \| PuMet \| RNMT1	tRNA aspartic acid methyltransferase 1	Two-hybrid	BioGRID	16169070
TXLNA	DKFZp451J0118 \| IL14 \| MGC118870 \| MGC118871 \| RP4-622L5.4 \| TXLN	taxilin alpha	Reconstituted Complex	BioGRID	12558796
TXLNB	C6orf198 \| DKFZp451A175 \| LST001 \| MDP77 \| dJ522B19.2	taxilin beta	-	HPRD,BioGRID	15184072
UNC13B	MGC133279 \| MGC133280 \| MUNC13 \| UNC13 \| Unc13h2 \| hmunc13	unc-13 homolog B (C. elegans)	-	HPRD,BioGRID	8999968
VAMP1	DKFZp686H12131 \| SYB1 \| VAMP-1	vesicle-associated membrane protein 1 (synaptobrevin 1)	Two-hybrid	BioGRID	12093152
VAMP2	FLJ11460 \| SYB2 \| VAMP-2	vesicle-associated membrane protein 2 (synaptobrevin 2)	Affinity Capture-Western Co-crystal Structure Far Western Reconstituted Complex Two-hybrid	BioGRID	7553862 \|9030619 \|10100611 \|10449403 \|11832227 \|12093152
VAMP7	SYBL1 \| TI-VAMP \| VAMP-7	vesicle-associated membrane protein 7	-	HPRD,BioGRID	12853575
VAMP8	EDB	vesicle-associated membrane protein 8 (endobrevin)	-	HPRD,BioGRID	11112705
VAPB	ALS8 \| VAMP-B \| VAMP-C \| VAP-B \| VAP-C	VAMP (vesicle-associated membrane protein)-associated protein B and C	Reconstituted Complex	BioGRID	12651853
VIM	FLJ36605	vimentin	Two-hybrid	BioGRID	16169070
VPS11	END1 \| PEP5 \| RNF108 \| hVPS11	vacuolar protein sorting 11 homolog (S. cerevisiae)	VPS11 interacts with STX1A (Syntaxin-1). This interaction was modeled on a demonstrated interaction between human VPS11 and STX1A (Syntaxin-1) from an unspecified species.	BIND	14623309
VPS18	KIAA1475 \| PEP3	vacuolar protein sorting 18 homolog (S. cerevisiae)	VPS18 interacts with STX1A (Syntaxin-1). This interaction was modeled on a demonstrated interaction between human VPS18 and STX1A (Syntaxin-1) from an unspecified species.	BIND	14623309

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	38	25	All SZGR genes in this pathway
REACTOME_BOTULINUM_NEUROTOXICITY	19	14	All SZGR genes in this pathway
REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS	17	12	All SZGR genes in this pathway
REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE	15	13	All SZGR genes in this pathway
REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES	186	155	All SZGR genes in this pathway
REACTOME_NEURONAL_SYSTEM	279	221	All SZGR genes in this pathway
REACTOME_NEUROTRANSMITTER_RELEASE_CYCLE	34	30	All SZGR genes in this pathway
REACTOME_INTEGRATION_OF_ENERGY_METABOLISM	120	84	All SZGR genes in this pathway
REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE	11	11	All SZGR genes in this pathway
REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE	10	9	All SZGR genes in this pathway
REACTOME_DIABETES_PATHWAYS	133	91	All SZGR genes in this pathway
REACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE	10	10	All SZGR genes in this pathway
REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING	21	15	All SZGR genes in this pathway
REACTOME_REGULATION_OF_INSULIN_SECRETION	93	65	All SZGR genes in this pathway
REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION	17	16	All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_UP	501	327	All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP	811	508	All SZGR genes in this pathway
FERREIRA_EWINGS_SARCOMA_UNSTABLE_VS_STABLE_UP	167	92	All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3	1118	744	All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_UP	398	262	All SZGR genes in this pathway
VANTVEER_BREAST_CANCER_METASTASIS_DN	121	65	All SZGR genes in this pathway
HOEGERKORP_CD44_TARGETS_DIRECT_UP	27	21	All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN	1237	837	All SZGR genes in this pathway
KAYO_AGING_MUSCLE_UP	244	165	All SZGR genes in this pathway
MCCLUNG_CREB1_TARGETS_UP	100	72	All SZGR genes in this pathway
BILD_HRAS_ONCOGENIC_SIGNATURE	261	166	All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_UNSTIMULATED	1229	713	All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP	1305	895	All SZGR genes in this pathway
HOFFMANN_SMALL_PRE_BII_TO_IMMATURE_B_LYMPHOCYTE_DN	50	33	All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP	756	494	All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP	682	440	All SZGR genes in this pathway
KIM_ALL_DISORDERS_CALB1_CORR_UP	548	370	All SZGR genes in this pathway
WIERENGA_STAT5A_TARGETS_DN	213	127	All SZGR genes in this pathway
BHAT_ESR1_TARGETS_VIA_AKT1_UP	281	183	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-133	421	427	m8	hsa-miR-133a	UUGGUCCCCUUCAACCAGCUGU
miR-133	421	427	m8	hsa-miR-133b	UUGGUCCCCUUCAACCAGCUA
miR-15/16/195/424/497	441	447	m8	hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
miR-200bc/429	879	885	m8	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
miR-217	876	883	1A,m8	hsa-miR-217	UACUGCAUCAGGAACUGAUUGGAU
miR-29	438	444	m8	hsa-miR-29a^SZ	UAGCACCAUCUGAAAUCGGUU
				hsa-miR-29b^SZ	UAGCACCAUUUGAAAUCAGUGUU
				hsa-miR-29c^SZ	UAGCACCAUUUGAAAUCGGU
miR-490	451	457	1A	hsa-miR-490	CAACCUGGAGGACUCCAUGCUG
miR-9	1127	1133	m8	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.