Gene Page: VAMP2

Summary
GeneID  6844
Symbol  VAMP2
Synonyms  FLJ11460|SYB2|VAMP-2
Description  vesicle-associated membrane protein 2 (synaptobrevin 2)
See related  HGNC:12643|MIM:185881|Ensembl:ENSG00000179036|HPRD:01717|
Locus tag  -
Gene type  protein-coding
Map location  17p13.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
DNAJC280.740.69
FBXO90.730.64
TTC350.690.67
C2orf740.690.61
KRT222P0.680.58
NMNAT10.680.70
C13orf10.680.59
C1D0.670.60
SGTB0.660.56
TYW30.660.57
Top 10 negatively co-expressed genes
HYAL2-0.44-0.44
OLFM2-0.41-0.38
SEMA4B-0.40-0.35
SH3BP2-0.39-0.39
AC006276.1-0.39-0.34
NAPRT1-0.39-0.33
SH2B2-0.39-0.41
SPNS1-0.38-0.32
SLC38A5-0.38-0.40
WDR86-0.38-0.37
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI9920726 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0016192vesicle-mediated transportIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0019717synaptosomeIEASynap, Brain (GO term level: 7)-
GO:0045202synapseIEAneuron, Synap, Neurotransmitter, Glial (GO term level: 2)-
GO:0016020membraneIEA-
GO:0005887integral to plasma membraneTAS1976629 
GO:0030054cell junctionIEA-
GO:0031410cytoplasmic vesicleIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BCAP316C6-AG | BAP31 | CDM | DXS1357EB-cell receptor-associated protein 31Reconstituted ComplexBioGRID9396746 
CPLX1CPX-I | CPX1complexin 1-HPRD,BioGRID11832227 
DNAJC5CSP | DKFZp434N1429 | DKFZp761N1221 | DNAJC5A | FLJ00118 | FLJ13070DnaJ (Hsp40) homolog, subfamily C, member 5Csp1 interacts with VAMP2. This interaction was modeled on a demonstrated interaction between cow Csp1, and human VAMP2.BIND15610015 
NAPASNAPAN-ethylmaleimide-sensitive factor attachment protein, alphaReconstituted ComplexBioGRID7622514 
RABAC1PRA1 | PRAF1 | YIP3Rab acceptor 1 (prenylated)-HPRD,BioGRID9341137 
SNAP23HsT17016 | SNAP23A | SNAP23Bsynaptosomal-associated protein, 23kDaSNAP23 interacts with VAMP2.BIND15610015 
-HPRD,BioGRID10713150 
SNAP25FLJ23079 | RIC-4 | RIC4 | SEC9 | SNAP | SNAP-25 | bA416N4.2 | dJ1068F16.2synaptosomal-associated protein, 25kDa-HPRD7961655 
Affinity Capture-Western
Co-crystal Structure
Far Western
Reconstituted Complex
Two-hybrid		BioGRID9030619 |11524423 
|11832227 
STX11FHL4 | HLH4 | HPLH4syntaxin 11-HPRD,BioGRID10036234 
STX1AHPC-1 | STX1 | p35-1syntaxin 1A (brain)Affinity Capture-Western
Co-crystal Structure
Far Western
Reconstituted Complex
Two-hybrid		BioGRID7553862 |9030619 
|10100611 |10449403 
|11832227 |12093152 
STX1BSTX1B1 | STX1B2syntaxin 1B-HPRD,BioGRID12093152 
STX2EPIM | EPM | MGC51014 | STX2A | STX2B | STX2Csyntaxin 2Two-hybridBioGRID12828989 
STX3STX3Asyntaxin 3Two-hybridBioGRID12828989 
STX4STX4A | p35-2syntaxin 4Affinity Capture-Western
Two-hybrid		BioGRID8760387 |10194441 
|10820264 |12517971 
-HPRD8760387 |12417022 
|12517971|8770861 
STXBP2Hunc18b | MUNC18-2 | UNC18-2 | UNC18B | pp10122syntaxin binding protein 2-HPRD12773094 
STXBP3MUNC18-3 | MUNC18C | PSP | UNC-18Csyntaxin binding protein 3Reconstituted ComplexBioGRID12832401 
SYPL1H-SP1 | SYPLsynaptophysin-like 1-HPRD10370136 
TRPC3TRP3transient receptor potential cation channel, subfamily C, member 3-HPRD15327778 
TRPC3 interacts with VAMP2.BIND15327778 
UNC13BMGC133279 | MGC133280 | MUNC13 | UNC13 | Unc13h2 | hmunc13unc-13 homolog B (C. elegans)Co-fractionationBioGRID8999968 
VAMP3CEBvesicle-associated membrane protein 3 (cellubrevin)Reconstituted ComplexBioGRID12130530 
VAMP8EDBvesicle-associated membrane protein 8 (endobrevin)Reconstituted ComplexBioGRID12130530 
VAPAMGC3745 | VAP-33 | VAP-A | VAP33 | hVAP-33VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa-HPRD,BioGRID9657962 
VAPBALS8 | VAMP-B | VAMP-C | VAP-B | VAP-CVAMP (vesicle-associated membrane protein)-associated protein B and C-HPRD,BioGRID9920726 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT 3825All SZGR genes in this pathway
KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION 4430All SZGR genes in this pathway
PID_INSULIN_GLUCOSE_PATHWAY 2624All SZGR genes in this pathway
REACTOME_MEMBRANE_TRAFFICKING 12974All SZGR genes in this pathway
REACTOME_BOTULINUM_NEUROTOXICITY 1914All SZGR genes in this pathway
REACTOME_TRANS_GOLGI_NETWORK_VESICLE_BUDDING 6031All SZGR genes in this pathway
REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS 1712All SZGR genes in this pathway
REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE 1513All SZGR genes in this pathway
REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 186155All SZGR genes in this pathway
REACTOME_NEURONAL_SYSTEM 279221All SZGR genes in this pathway
REACTOME_NEUROTRANSMITTER_RELEASE_CYCLE 3430All SZGR genes in this pathway
REACTOME_INTEGRATION_OF_ENERGY_METABOLISM 12084All SZGR genes in this pathway
REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE 1111All SZGR genes in this pathway
REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE 109All SZGR genes in this pathway
REACTOME_DIABETES_PATHWAYS 13391All SZGR genes in this pathway
REACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE 1010All SZGR genes in this pathway
REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING 2115All SZGR genes in this pathway
REACTOME_REGULATION_OF_INSULIN_SECRETION 9365All SZGR genes in this pathway
REACTOME_LYSOSOME_VESICLE_BIOGENESIS 2311All SZGR genes in this pathway
REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS 5327All SZGR genes in this pathway
REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION 1716All SZGR genes in this pathway
GARY_CD5_TARGETS_UP 473314All SZGR genes in this pathway
HUTTMANN_B_CLL_POOR_SURVIVAL_UP 276187All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_5 14789All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_UP 479299All SZGR genes in this pathway
BENPORATH_MYC_TARGETS_WITH_EBOX 230156All SZGR genes in this pathway
STARK_HYPPOCAMPUS_22Q11_DELETION_UP 5340All SZGR genes in this pathway
LEE_TARGETS_OF_PTCH1_AND_SUFU_DN 8369All SZGR genes in this pathway
FERNANDEZ_BOUND_BY_MYC 182116All SZGR genes in this pathway
MODY_HIPPOCAMPUS_POSTNATAL 6350All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
MCCLUNG_COCAINE_REWARD_5D 7962All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL 254164All SZGR genes in this pathway
RAMPON_ENRICHED_LEARNING_ENVIRONMENT_EARLY_UP 1512All SZGR genes in this pathway
AMBROSINI_FLAVOPIRIDOL_TREATMENT_TP53 10963All SZGR genes in this pathway
MITSIADES_RESPONSE_TO_APLIDIN_UP 439257All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_DN 546362All SZGR genes in this pathway
CHAUHAN_RESPONSE_TO_METHOXYESTRADIOL_DN 10265All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_UP 491316All SZGR genes in this pathway
ZHANG_TLX_TARGETS_36HR_UP 221150All SZGR genes in this pathway
STEIN_ESR1_TARGETS 8555All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
ZEMBUTSU_SENSITIVITY_TO_DOXORUBICIN 1710All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A 898516All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_NOT_SATB1_DN 448282All SZGR genes in this pathway
RATTENBACHER_BOUND_BY_CELF1 467251All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1/206946952m8hsa-miR-1UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZUGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613AGGAAUGUUCCUUCUUUGCC
hsa-miR-1UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZUGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613AGGAAUGUUCCUUCUUUGCC
miR-12798104m8hsa-miR-127brainUCGGAUCCGUCUGAGCUUGGCU
miR-1339129181Ahsa-miR-133aUUGGUCCCCUUCAACCAGCUGU
hsa-miR-133bUUGGUCCCCUUCAACCAGCUA
miR-13570761Ahsa-miR-135aUAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135bUAUGGCUUUUCAUUCCUAUGUG
miR-150522528m8hsa-miR-150UCUCCCAACCCUUGUACCAGUG
miR-1533253321A,m8hsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-25/32/92/363/3673283341Ahsa-miR-25brainCAUUGCACUUGUCUCGGUCUGA
hsa-miR-32UAUUGCACAUUACUAAGUUGC
hsa-miR-92UAUUGCACUUGUCCCGGCCUG
hsa-miR-367AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZUAUUGCACUCGUCCCGGCCUC
miR-2812341240m8hsa-miR-28brainAAGGAGCUCACAGUCUAUUGAG
miR-30-3p118511921A,m8hsa-miR-30a-3pCUUUCAGUCGGAUGUUUGCAGC
hsa-miR-30e-3pCUUUCAGUCGGAUGUUUACAGC
miR-3252022081Ahsa-miR-325CCUAGUAGGUGUCCAGUAAGUGU
miR-338155315601A,m8hsa-miR-338brainUCCAGCAUCAGUGAUUUUGUUGA
hsa-miR-338brainUCCAGCAUCAGUGAUUUUGUUGA
miR-34/44912261232m8hsa-miR-34abrainUGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34cAGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449bAGGCAGUGUAUUGUUAGCUGGC
hsa-miR-34abrainUGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34cAGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449bAGGCAGUGUAUUGUUAGCUGGC
hsa-miR-34abrainUGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34cAGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449bAGGCAGUGUAUUGUUAGCUGGC
miR-34b11001106m8hsa-miR-34bUAGGCAGUGUCAUUAGCUGAUUG
miR-369-3p1691751Ahsa-miR-369-3pAAUAAUACAUGGUUGAUCUUU
miR-374169175m8hsa-miR-374UUAUAAUACAACCUGAUAAGUG
miR-377153415401Ahsa-miR-377AUCACACAAAGGCAACUUUUGU
miR-409-5p168816941Ahsa-miR-409-5pAGGUUACCCGAGCAACUUUGCA
miR-4101711771Ahsa-miR-410AAUAUAACACAGAUGGCCUGU
miR-4483263321Ahsa-miR-448UUGCAUAUGUAGGAUGUCCCAU
miR-491148114871Ahsa-miR-491brainAGUGGGGAACCCUUCCAUGAGGA
miR-493-5p166616731A,m8hsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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