Gene Page: KLF5

Summary
GeneID  688
Symbol  KLF5
Synonyms  BTEB2|CKLF|IKLF
Description  Kruppel-like factor 5 (intestinal)
See related  HGNC:6349|MIM:602903|Ensembl:ENSG00000102554|HPRD:04212|
Locus tag  -
Gene type  protein-coding
Map location  13q22.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies1Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityIEA-
GO:0003702RNA polymerase II transcription factor activityTAS8479902 
GO:0005515protein bindingIEA-
GO:0008270zinc ion bindingIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001525angiogenesisIEA-
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006366transcription from RNA polymerase II promoterTAS8479902 
GO:0030033microvillus biogenesisIEA-
GO:0045941positive regulation of transcriptionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005622intracellularIEA-
GO:0005634nucleusIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CREBBPCBP | KAT3A | RSTSCREB binding protein-HPRD,BioGRID12682370 
EP300KAT3B | p300E1A binding protein p300Affinity Capture-WesternBioGRID14612398 
GTF2BTF2B | TFIIBgeneral transcription factor IIBReconstituted ComplexBioGRID9089417 
GTF2E2FE | TF2E2 | TFIIE-Bgeneral transcription factor IIE, polypeptide 2, beta 34kDa-HPRD9089417 
GTF2F1BTF4 | RAP74 | TF2F1 | TFIIFgeneral transcription factor IIF, polypeptide 1, 74kDaReconstituted ComplexBioGRID9089417 
GTF2F2BTF4 | RAP30 | TF2F2 | TFIIFgeneral transcription factor IIF, polypeptide 2, 30kDa-HPRD9089417 
NFKB1DKFZp686C01211 | EBP-1 | KBF1 | MGC54151 | NF-kappa-B | NFKB-p105 | NFKB-p50 | p105nuclear factor of kappa light polypeptide gene enhancer in B-cells 1-HPRD,BioGRID14573617 
PRKCAAAG6 | MGC129900 | MGC129901 | PKC-alpha | PKCA | PRKACAprotein kinase C, alphaBiochemical ActivityBioGRID12682370 
RARANR1B1 | RARretinoic acid receptor, alphain vitro
in vivo		BioGRID12101409 
SET2PP2A | I2PP2A | IGAAD | IPP2A2 | PHAPII | TAF-I | TAF-IBETASET nuclear oncogeneAffinity Capture-MS
Affinity Capture-Western
Reconstituted Complex		BioGRID14612398 
TBPGTF2D | GTF2D1 | MGC117320 | MGC126054 | MGC126055 | SCA17 | TFIIDTATA box binding proteinReconstituted ComplexBioGRID9089417 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION 7253All SZGR genes in this pathway
NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_DN 634384All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_DN 526357All SZGR genes in this pathway
SENGUPTA_NASOPHARYNGEAL_CARCINOMA_WITH_LMP1_UP 408247All SZGR genes in this pathway
WILCOX_RESPONSE_TO_PROGESTERONE_UP 15290All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_DN 463290All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP 485293All SZGR genes in this pathway
LIU_TARGETS_OF_VMYB_VS_CMYB_DN 4330All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN 455304All SZGR genes in this pathway
ROY_WOUND_BLOOD_VESSEL_DN 2214All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_EARLY_UP 430232All SZGR genes in this pathway
JAEGER_METASTASIS_DN 258141All SZGR genes in this pathway
GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLUE_UP 13680All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_6HR_UP 8554All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_3D_UP 182110All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_2HR_UP 2719All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_6HR_UP 5534All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_24HR_DN 214133All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_FIMA_UP 544308All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LPS_UP 431237All SZGR genes in this pathway
WAMUNYOKOLI_OVARIAN_CANCER_LMP_UP 265158All SZGR genes in this pathway
WAMUNYOKOLI_OVARIAN_CANCER_GRADES_1_2_UP 13784All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_UP 1821933All SZGR genes in this pathway
LIU_CDX2_TARGETS_UP 3622All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_UP 530342All SZGR genes in this pathway
BERENJENO_ROCK_SIGNALING_NOT_VIA_RHOA_DN 4834All SZGR genes in this pathway
VANHARANTA_UTERINE_FIBROID_DN 6745All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
BARIS_THYROID_CANCER_DN 5945All SZGR genes in this pathway
WANG_BARRETTS_ESOPHAGUS_DN 2513All SZGR genes in this pathway
MCBRYAN_PUBERTAL_TGFB1_TARGETS_DN 6244All SZGR genes in this pathway
RIZ_ERYTHROID_DIFFERENTIATION_HEMGN 3121All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_2 12792All SZGR genes in this pathway
FARMER_BREAST_CANCER_APOCRINE_VS_BASAL 330217All SZGR genes in this pathway
FARMER_BREAST_CANCER_BASAL_VS_LULMINAL 330215All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_UP 358245All SZGR genes in this pathway
KIM_MYC_AMPLIFICATION_TARGETS_DN 9751All SZGR genes in this pathway
KIM_MYCN_AMPLIFICATION_TARGETS_DN 10359All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN 848527All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP 811508All SZGR genes in this pathway
WU_CELL_MIGRATION 184114All SZGR genes in this pathway
BENPORATH_NANOG_TARGETS 988594All SZGR genes in this pathway
BENPORATH_OCT4_TARGETS 290172All SZGR genes in this pathway
BENPORATH_SOX2_TARGETS 734436All SZGR genes in this pathway
BENPORATH_NOS_TARGETS 179105All SZGR genes in this pathway
BENPORATH_ES_CORE_NINE_CORRELATED 10068All SZGR genes in this pathway
AMIT_SERUM_RESPONSE_120_MCF10A 6544All SZGR genes in this pathway
ONDER_CDH1_TARGETS_2_DN 464276All SZGR genes in this pathway
SMITH_TERT_TARGETS_UP 14591All SZGR genes in this pathway
HALMOS_CEBPA_TARGETS_UP 5234All SZGR genes in this pathway
NGUYEN_NOTCH1_TARGETS_DN 8667All SZGR genes in this pathway
CROMER_METASTASIS_DN 8158All SZGR genes in this pathway
TAVOR_CEBPA_TARGETS_UP 4836All SZGR genes in this pathway
TRAYNOR_RETT_SYNDROM_DN 1914All SZGR genes in this pathway
WANG_CISPLATIN_RESPONSE_AND_XPC_DN 228146All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
DELASERNA_MYOD_TARGETS_UP 8951All SZGR genes in this pathway
BURTON_ADIPOGENESIS_3 10164All SZGR genes in this pathway
TAKAO_RESPONSE_TO_UVB_RADIATION_DN 9867All SZGR genes in this pathway
MCCLUNG_COCAIN_REWARD_4WK 7547All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_UP 428266All SZGR genes in this pathway
BURTON_ADIPOGENESIS_PEAK_AT_8HR 3931All SZGR genes in this pathway
BILD_HRAS_ONCOGENIC_SIGNATURE 261166All SZGR genes in this pathway
OSADA_ASCL1_TARGETS_DN 2420All SZGR genes in this pathway
MCCABE_BOUND_BY_HOXC6 469239All SZGR genes in this pathway
SMID_BREAST_CANCER_RELAPSE_IN_BONE_DN 315197All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_DN 564326All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_UP 648398All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_DN 546362All SZGR genes in this pathway
CHEN_HOXA5_TARGETS_9HR_UP 223132All SZGR genes in this pathway
CONRAD_STEM_CELL 3927All SZGR genes in this pathway
LEE_LIVER_CANCER_SURVIVAL_DN 175103All SZGR genes in this pathway
LINDSTEDT_DENDRITIC_CELL_MATURATION_B 5336All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_UP 491316All SZGR genes in this pathway
MELLMAN_TUT1_TARGETS_DN 4729All SZGR genes in this pathway
HAN_SATB1_TARGETS_DN 442275All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S1 237159All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN 505328All SZGR genes in this pathway
GABRIELY_MIR21_TARGETS 289187All SZGR genes in this pathway
CHYLA_CBFA2T3_TARGETS_DN 242146All SZGR genes in this pathway
DELPUECH_FOXO3_TARGETS_UP 6849All SZGR genes in this pathway
LEE_BMP2_TARGETS_DN 882538All SZGR genes in this pathway
PEDRIOLI_MIR31_TARGETS_DN 418245All SZGR genes in this pathway
ACEVEDO_FGFR1_TARGETS_IN_PROSTATE_CANCER_MODEL_UP 289184All SZGR genes in this pathway
SMIRNOV_RESPONSE_TO_IR_2HR_UP 5333All SZGR genes in this pathway
ZWANG_CLASS_2_TRANSIENTLY_INDUCED_BY_EGF 5129All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-142-5p5345401Ahsa-miR-142-5pCAUAAAGUAGAAAGCACUAC
miR-14578851A,m8hsa-miR-145GUCCAGUUUUCCCAGGAAUCCCUU
miR-153150715141A,m8hsa-miR-153UUGCAUAGUCACAAAAGUGA
hsa-miR-153UUGCAUAGUCACAAAAGUGA
hsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-182120612121Ahsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-2311581164m8hsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
miR-3205315381A,m8hsa-miR-320AAAAGCUGGGUUGAGAGGGCGAA
miR-323115711641A,m8hsa-miR-323brainGCACAUUACACGGUCGACCUCU
miR-3391111171Ahsa-miR-339UCCCUGUCCUCCAGGAGCUCA
miR-3754484541Ahsa-miR-375UUUGUUCGUUCGGCUCGCGUGA
miR-410156815741Ahsa-miR-410AAUAUAACACAGAUGGCCUGU
miR-4485215281A,m8hsa-miR-448UUGCAUAUGUAGGAUGUCCCAU
hsa-miR-448UUGCAUAUGUAGGAUGUCCCAU
hsa-miR-448UUGCAUAUGUAGGAUGUCCCAU
miR-495133813451A,m8hsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
miR-505110811141Ahsa-miR-505GUCAACACUUGCUGGUUUCCUC
miR-911791185m8hsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
hsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
miR-96120612121Ahsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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