Gene Page: TCF7L2

Summary
GeneID  6934
Symbol  TCF7L2
Synonyms  TCF-4|TCF4
Description  transcription factor 7-like 2 (T-cell specific, HMG-box)
See related  HGNC:11641|MIM:602228|Ensembl:ENSG00000148737|HPRD:03751|
Locus tag  RP11-357H24.1
Gene type  protein-coding
Map location  10q25.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
ExpressionExpressionP value: 2.33 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003677DNA bindingIEA-
GO:0003700transcription factor activityIDA9727977 
GO:0003702RNA polymerase II transcription factor activityIDA9065401 
GO:0008013beta-catenin bindingIDA9065401 
GO:0016566specific transcriptional repressor activityIDA15525634 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001568blood vessel developmentIMP15578569 
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006357regulation of transcription from RNA polymerase II promoterIDA9065401 |9727977 
GO:0006350transcriptionIEA-
GO:0007050cell cycle arrestIMP12408868 
GO:0008283cell proliferationIMP12408868 
GO:0006916anti-apoptosisIDA18071026 
GO:0031016pancreas developmentTAS18216022 
GO:0032024positive regulation of insulin secretionIDA18071026 
GO:0042593glucose homeostasisIDA15525634 
GO:0032350regulation of hormone metabolic processIDA15525634 
GO:0048625myoblast cell fate commitmentIDA10937998 
GO:0045444fat cell differentiationIDA10937998 
GO:0060070Wnt receptor signaling pathway through beta-cateninIC9065401 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CTBP1BARS | MGC104684C-terminal binding protein 1CtBP does not interacts with TCF-4 in mammalian cells.BIND15525529 
CTNNB1CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923catenin (cadherin-associated protein), beta 1, 88kDaAffinity Capture-WesternBioGRID12861022 
-HPRD11713476 
TCF-4 interacts with Beta-catenin.BIND15525529 
Beta-catenin interacts with TCF4.BIND15294866 
JUPARVD12 | CTNNG | DP3 | DPIII | PDGB | PKGBjunction plakoglobin-HPRD,BioGRID11711551 
NLKDKFZp761G1211 | FLJ21033nemo-like kinaseAffinity Capture-WesternBioGRID12556497 
PSEN1AD3 | FAD | PS1 | S182presenilin 1-HPRD,BioGRID11504726 
RAC1MGC111543 | MIG5 | TC-25 | p21-Rac1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)Rac1 interacts with TCF4.BIND15377999 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_WNT_SIGNALING_PATHWAY 151112All SZGR genes in this pathway
KEGG_ADHERENS_JUNCTION 7553All SZGR genes in this pathway
KEGG_MELANOGENESIS 10280All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_COLORECTAL_CANCER 6247All SZGR genes in this pathway
KEGG_ENDOMETRIAL_CANCER 5245All SZGR genes in this pathway
KEGG_PROSTATE_CANCER 8975All SZGR genes in this pathway
KEGG_THYROID_CANCER 2926All SZGR genes in this pathway
KEGG_BASAL_CELL_CARCINOMA 5544All SZGR genes in this pathway
KEGG_ACUTE_MYELOID_LEUKEMIA 6047All SZGR genes in this pathway
KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC 7659All SZGR genes in this pathway
PID_AP1_PATHWAY 7060All SZGR genes in this pathway
PID_BETA_CATENIN_NUC_PATHWAY 8060All SZGR genes in this pathway
DAVICIONI_PAX_FOXO1_SIGNATURE_IN_ARMS_UP 5938All SZGR genes in this pathway
DAVICIONI_TARGETS_OF_PAX_FOXO1_FUSIONS_UP 255177All SZGR genes in this pathway
DAVICIONI_RHABDOMYOSARCOMA_PAX_FOXO1_FUSION_UP 6437All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP 485293All SZGR genes in this pathway
CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_UP 177110All SZGR genes in this pathway
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_UP 368234All SZGR genes in this pathway
OSMAN_BLADDER_CANCER_UP 404246All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_HSC_UP 185126All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_MONOCYTE_UP 204140All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_ERYTHROCYTE_UP 157104All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_SUSTAINDED_IN_ERYTHROCYTE_UP 4430All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_DN 329219All SZGR genes in this pathway
KIM_WT1_TARGETS_DN 459276All SZGR genes in this pathway
GRAHAM_CML_QUIESCENT_VS_NORMAL_DIVIDING_UP 5733All SZGR genes in this pathway
GRAHAM_CML_DIVIDING_VS_NORMAL_QUIESCENT_DN 9557All SZGR genes in this pathway
GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_UP 6647All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_UP 14984All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN 770415All SZGR genes in this pathway
WANG_ESOPHAGUS_CANCER_VS_NORMAL_UP 12172All SZGR genes in this pathway
FARMER_BREAST_CANCER_APOCRINE_VS_BASAL 330217All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN 483336All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN 514319All SZGR genes in this pathway
YANG_BREAST_CANCER_ESR1_LASER_DN 5038All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN 848527All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_DN 1024594All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP 811508All SZGR genes in this pathway
BENPORATH_NANOG_TARGETS 988594All SZGR genes in this pathway
BENPORATH_SOX2_TARGETS 734436All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_10HR_DN 5637All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_14HR_DN 298200All SZGR genes in this pathway
YAMAZAKI_TCEB3_TARGETS_UP 175116All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
VERRECCHIA_RESPONSE_TO_TGFB1_C1 1915All SZGR genes in this pathway
VERRECCHIA_EARLY_RESPONSE_TO_TGFB1 5843All SZGR genes in this pathway
ZHU_CMV_8_HR_DN 5340All SZGR genes in this pathway
ZHU_CMV_ALL_DN 12893All SZGR genes in this pathway
CHENG_RESPONSE_TO_NICKEL_ACETATE 4529All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_6HR_DN 160101All SZGR genes in this pathway
BILD_HRAS_ONCOGENIC_SIGNATURE 261166All SZGR genes in this pathway
LEIN_MIDBRAIN_MARKERS 8255All SZGR genes in this pathway
KYNG_DNA_DAMAGE_BY_4NQO_OR_UV 6344All SZGR genes in this pathway
KYNG_DNA_DAMAGE_DN 195135All SZGR genes in this pathway
IWANAGA_CARCINOGENESIS_BY_KRAS_PTEN_UP 181112All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_DN 564326All SZGR genes in this pathway
BASSO_HAIRY_CELL_LEUKEMIA_DN 8066All SZGR genes in this pathway
TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C 463262All SZGR genes in this pathway
WANG_TUMOR_INVASIVENESS_DN 210128All SZGR genes in this pathway
TOOKER_GEMCITABINE_RESISTANCE_UP 7940All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN 315201All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_DN 235144All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP 408276All SZGR genes in this pathway
HAN_SATB1_TARGETS_UP 395249All SZGR genes in this pathway
HAN_SATB1_TARGETS_DN 442275All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
YAMASHITA_LIVER_CANCER_STEM_CELL_UP 4738All SZGR genes in this pathway
KYNG_WERNER_SYNDROM_AND_NORMAL_AGING_UP 9362All SZGR genes in this pathway
BHAT_ESR1_TARGETS_NOT_VIA_AKT1_DN 8861All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_DN 918550All SZGR genes in this pathway
BILANGES_SERUM_SENSITIVE_GENES 9054All SZGR genes in this pathway
BILANGES_SERUM_RESPONSE_TRANSLATION 3720All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_RXRA_BOUND_8D 882506All SZGR genes in this pathway
PLASARI_TGFB1_TARGETS_10HR_DN 244157All SZGR genes in this pathway
DELACROIX_RAR_BOUND_ES 462273All SZGR genes in this pathway
ALFANO_MYC_TARGETS 239156All SZGR genes in this pathway
PHONG_TNF_RESPONSE_VIA_P38_PARTIAL 160106All SZGR genes in this pathway
PHONG_TNF_RESPONSE_NOT_VIA_P38 337236All SZGR genes in this pathway
PECE_MAMMARY_STEM_CELL_DN 14688All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-132/2122892951Ahsa-miR-212SZUAACAGUCUCCAGUCACGGCC
hsa-miR-132brainUAACAGUCUACAGCCAUGGUCG
miR-3792202261Ahsa-miR-379brainUGGUAGACUAUGGAACGUA
miR-539177183m8hsa-miR-539GGAGAAAUUAUCCUUGGUGUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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