Gene Page: TIMP2

Summary
GeneID  7077
Symbol  TIMP2
Synonyms  CSC-21K
Description  TIMP metallopeptidase inhibitor 2
See related  HGNC:11821|MIM:188825|Ensembl:ENSG00000035862|HPRD:01784|
Locus tag  -
Gene type  protein-coding
Map location  17q25
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.01 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005178integrin bindingIEA-
GO:0005515protein bindingIPI17353931 
GO:0004857enzyme inhibitor activityIEA-
GO:0008191metalloendopeptidase inhibitor activityTAS8810321 
GO:0008047enzyme activator activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0045664regulation of neuron differentiationIEAneuron, neurogenesis (GO term level: 9)-
GO:0008285negative regulation of cell proliferationIEA-
GO:0030814regulation of cAMP metabolic processIEA-
GO:0043408regulation of MAPKKK cascadeIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005604basement membraneIEA-
GO:0009986cell surfaceIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ITGA3CD49C | FLJ34631 | FLJ34704 | GAP-B3 | GAPB3 | MSK18 | VCA-2 | VL3A | VLA3aintegrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)TIMP2 interacts with ITGA3 (alpha3).BIND12887919 
MMP14MMP-X1 | MT1-MMP | MTMMP1matrix metallopeptidase 14 (membrane-inserted)-HPRD,BioGRID9422789 
MMP2CLG4 | CLG4A | MMP-II | MONA | TBE-1matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)-HPRD,BioGRID9933646 |10991943 
|12032297 |12374789 
MMP8CLG1 | HNC | PMNL-CLmatrix metallopeptidase 8 (neutrophil collagenase)-HPRD,BioGRID10353844 
PSMA7C6 | HSPC | MGC3755 | RC6-1 | XAPC7proteasome (prosome, macropain) subunit, alpha type, 7Affinity Capture-MSBioGRID17353931 
SNCGBCSG1 | SRsynuclein, gamma (breast cancer-specific protein 1)Affinity Capture-MSBioGRID17353931 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX 2911All SZGR genes in this pathway
REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION 8742All SZGR genes in this pathway
LIU_PROSTATE_CANCER_DN 481290All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_UP 783507All SZGR genes in this pathway
ZHONG_RESPONSE_TO_AZACITIDINE_AND_TSA_UP 183119All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN 460312All SZGR genes in this pathway
DOANE_BREAST_CANCER_CLASSES_DN 3426All SZGR genes in this pathway
GRABARCZYK_BCL11B_TARGETS_DN 5735All SZGR genes in this pathway
BASAKI_YBX1_TARGETS_UP 290177All SZGR genes in this pathway
SMIRNOV_CIRCULATING_ENDOTHELIOCYTES_IN_CANCER_UP 158103All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_DN 329219All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_DN 781465All SZGR genes in this pathway
PROVENZANI_METASTASIS_DN 13694All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_48HR_UP 12895All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_96HR_UP 11784All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_DN 508354All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_1_DN 378231All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_6_7WK_UP 197135All SZGR genes in this pathway
MCBRYAN_PUBERTAL_TGFB1_TARGETS_UP 169127All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_2 12792All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_2B 392251All SZGR genes in this pathway
LUND_SILENCED_BY_METHYLATION 1612All SZGR genes in this pathway
HERNANDEZ_ABERRANT_MITOSIS_BY_DOCETACEL_2NM_UP 8157All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN 514319All SZGR genes in this pathway
HASINA_NOL7_TARGETS_UP 1311All SZGR genes in this pathway
GROSS_ELK3_TARGETS_UP 2716All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_UP 209139All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN 514330All SZGR genes in this pathway
STARK_PREFRONTAL_CORTEX_22Q11_DELETION_UP 195138All SZGR genes in this pathway
JEON_SMAD6_TARGETS_UP 2415All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_17Q21_Q25_AMPLICON 335181All SZGR genes in this pathway
NING_CHRONIC_OBSTRUCTIVE_PULMONARY_DISEASE_DN 12179All SZGR genes in this pathway
KENNY_CTNNB1_TARGETS_DN 5234All SZGR genes in this pathway
SHEPARD_BMYB_MORPHOLINO_UP 205126All SZGR genes in this pathway
YAGI_AML_FAB_MARKERS 191131All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_EARLY_PROGENITOR 532309All SZGR genes in this pathway
REN_ALVEOLAR_RHABDOMYOSARCOMA_DN 408274All SZGR genes in this pathway
SUZUKI_RESPONSE_TO_TSA_AND_DECITABINE_1A 2316All SZGR genes in this pathway
CHIBA_RESPONSE_TO_TSA_UP 5233All SZGR genes in this pathway
SIMBULAN_PARP1_TARGETS_UP 3123All SZGR genes in this pathway
MACLACHLAN_BRCA1_TARGETS_UP 2116All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_NO_BLOOD_UP 222139All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_UP 487303All SZGR genes in this pathway
BURTON_ADIPOGENESIS_7 5134All SZGR genes in this pathway
HU_GENOTOXIC_DAMAGE_4HR 3528All SZGR genes in this pathway
WANG_SMARCE1_TARGETS_UP 280183All SZGR genes in this pathway
DOUGLAS_BMI1_TARGETS_UP 566371All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_DN 911527All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_UP 783442All SZGR genes in this pathway
ZHONG_SECRETOME_OF_LUNG_CANCER_AND_MACROPHAGE 7750All SZGR genes in this pathway
ZHONG_SECRETOME_OF_LUNG_CANCER_AND_FIBROBLAST 13293All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_5 482296All SZGR genes in this pathway
HILLION_HMGA1_TARGETS 9071All SZGR genes in this pathway
HILLION_HMGA1B_TARGETS 9268All SZGR genes in this pathway
MASSARWEH_TAMOXIFEN_RESISTANCE_UP 578341All SZGR genes in this pathway
HOQUE_METHYLATED_IN_CANCER 5645All SZGR genes in this pathway
BEIER_GLIOMA_STEM_CELL_DN 6642All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_UP 165118All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN 315201All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_UP 418282All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP 408276All SZGR genes in this pathway
CHANG_CORE_SERUM_RESPONSE_DN 209137All SZGR genes in this pathway
LEE_RECENT_THYMIC_EMIGRANT 227128All SZGR genes in this pathway
ZHANG_TLX_TARGETS_36HR_UP 221150All SZGR genes in this pathway
ZHANG_TLX_TARGETS_60HR_UP 293203All SZGR genes in this pathway
ZHANG_TLX_TARGETS_UP 10878All SZGR genes in this pathway
SHAFFER_IRF4_TARGETS_IN_MYELOMA_VS_MATURE_B_LYMPHOCYTE 10176All SZGR genes in this pathway
SHAFFER_IRF4_TARGETS_IN_PLASMA_CELL_VS_MATURE_B_LYMPHOCYTE 6751All SZGR genes in this pathway
SHAFFER_IRF4_TARGETS_IN_ACTIVATED_B_LYMPHOCYTE 8166All SZGR genes in this pathway
MILI_PSEUDOPODIA_CHEMOTAXIS_DN 457302All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_DN 668419All SZGR genes in this pathway
LIU_VAV3_PROSTATE_CARCINOGENESIS_UP 8961All SZGR genes in this pathway
ZHAN_V1_LATE_DIFFERENTIATION_GENES_UP 3225All SZGR genes in this pathway
ROME_INSULIN_TARGETS_IN_MUSCLE_UP 442263All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_CTNNB1_DN 170105All SZGR genes in this pathway
MIKKELSEN_MCV6_HCP_WITH_H3K27ME3 435318All SZGR genes in this pathway
GYORFFY_DOXORUBICIN_RESISTANCE 5634All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S1 237159All SZGR genes in this pathway
DANG_REGULATED_BY_MYC_DN 253192All SZGR genes in this pathway
MARTENS_BOUND_BY_PML_RARA_FUSION 456287All SZGR genes in this pathway
CHICAS_RB1_TARGETS_CONFLUENT 567365All SZGR genes in this pathway
WANG_RESPONSE_TO_GSK3_INHIBITOR_SB216763_UP 397206All SZGR genes in this pathway
FIGUEROA_AML_METHYLATION_CLUSTER_5_DN 5031All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_UP 430288All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_B 549316All SZGR genes in this pathway
STEGER_ADIPOGENESIS_DN 2515All SZGR genes in this pathway
PASINI_SUZ12_TARGETS_DN 315215All SZGR genes in this pathway
DELPUECH_FOXO3_TARGETS_UP 6849All SZGR genes in this pathway
LEE_BMP2_TARGETS_UP 745475All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
SERVITJA_ISLET_HNF1A_TARGETS_UP 163111All SZGR genes in this pathway
PEDERSEN_METASTASIS_BY_ERBB2_ISOFORM_4 11066All SZGR genes in this pathway
ALFANO_MYC_TARGETS 239156All SZGR genes in this pathway
ACEVEDO_FGFR1_TARGETS_IN_PROSTATE_CANCER_MODEL_UP 289184All SZGR genes in this pathway
NABA_ECM_REGULATORS 238125All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-130/30119591965m8hsa-miR-130abrainCAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrainCAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3pUAGUGCAAUAUUGCUUAUAGGGUUU
miR-17-5p/20/93.mr/106/519.d19611967m8hsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
miR-214186418701Ahsa-miR-214brainACAGCAGGCACAGACAGGCAG
miR-30-5p241024161Ahsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-49518901896m8hsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
miR-505259025961Ahsa-miR-505GUCAACACUUGCUGGUUUCCUC
miR-5443763831A,m8hsa-miR-544AUUCUGCAUUUUUAGCAAGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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