Gene Page: TIMP3

Summary
GeneID  7078
Symbol  TIMP3
Synonyms  HSMRK222|K222|K222TA2|SFD
Description  TIMP metallopeptidase inhibitor 3
See related  HGNC:11822|MIM:188826|Ensembl:ENSG00000100234|HPRD:01785|
Locus tag  -
Gene type  protein-coding
Map location  22q12.1-q13.2|22q12.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies1Link to SZGene
GSMA_Igenome scan meta-analysisPsr: 0.031 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003674molecular_functionND-
GO:0005515protein bindingIPI18344519 
GO:0004857enzyme inhibitor activityIEA-
GO:0008191metalloendopeptidase inhibitor activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayNAS15609325 
GO:0007601visual perceptionIEA-
GO:0008624induction of apoptosis by extracellular signalsNAS7925969 
GO:0050896response to stimulusIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005578proteinaceous extracellular matrixNAS7925969 
GO:0005604basement membraneIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ADAM17CD156b | MGC71942 | TACE | cSVPADAM metallopeptidase domain 17-HPRD,BioGRID12044879 
MMP13CLG3matrix metallopeptidase 13 (collagenase 3)-HPRD9065415 
MMP14MMP-X1 | MT1-MMP | MTMMP1matrix metallopeptidase 14 (membrane-inserted)-HPRD8663332 
MMP2CLG4 | CLG4A | MMP-II | MONA | TBE-1matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)-HPRD,BioGRID10196161 
MMP3MGC126102 | MGC126103 | MGC126104 | MMP-3 | SL-1 | STMY | STMY1 | STR1matrix metallopeptidase 3 (stromelysin 1, progelatinase)-HPRD,BioGRID11827795 
MMP9CLG4B | GELB | MMP-9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)-HPRD,BioGRID11827795 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
BIOCARTA_P53_PATHWAY 1613All SZGR genes in this pathway
LIU_PROSTATE_CANCER_DN 481290All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_DN 526357All SZGR genes in this pathway
BERTUCCI_MEDULLARY_VS_DUCTAL_BREAST_CANCER_DN 169118All SZGR genes in this pathway
SCHUETZ_BREAST_CANCER_DUCTAL_INVASIVE_UP 351230All SZGR genes in this pathway
PIEPOLI_LGI1_TARGETS_UP 1511All SZGR genes in this pathway
CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_DN 663425All SZGR genes in this pathway
HUTTMANN_B_CLL_POOR_SURVIVAL_UP 276187All SZGR genes in this pathway
RODRIGUES_NTN1_TARGETS_DN 158102All SZGR genes in this pathway
WANG_CLIM2_TARGETS_UP 269146All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_ADVANCED_VS_EARLY_UP 175120All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_10D_UP 194122All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_1_DN 242165All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_HSC_DN 187115All SZGR genes in this pathway
DITTMER_PTHLH_TARGETS_UP 11268All SZGR genes in this pathway
UDAYAKUMAR_MED1_TARGETS_DN 240171All SZGR genes in this pathway
SENESE_HDAC1_AND_HDAC2_TARGETS_DN 232139All SZGR genes in this pathway
SENESE_HDAC2_TARGETS_DN 13377All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_UP 501327All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
SABATES_COLORECTAL_ADENOMA_SIZE_UP 2312All SZGR genes in this pathway
KIM_WT1_TARGETS_UP 214155All SZGR genes in this pathway
KIM_WT1_TARGETS_8HR_UP 164122All SZGR genes in this pathway
KIM_WT1_TARGETS_12HR_UP 162116All SZGR genes in this pathway
WAMUNYOKOLI_OVARIAN_CANCER_LMP_DN 199124All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_DN 537339All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_48HR_UP 12895All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_96HR_UP 11784All SZGR genes in this pathway
CHIARADONNA_NEOPLASTIC_TRANSFORMATION_KRAS_DN 14295All SZGR genes in this pathway
CHIARADONNA_NEOPLASTIC_TRANSFORMATION_CDC25_DN 153100All SZGR genes in this pathway
MARKEY_RB1_CHRONIC_LOF_DN 11878All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN 770415All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_C_UP 170114All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_FOREVER_UP 1913All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_DN 394258All SZGR genes in this pathway
HAMAI_APOPTOSIS_VIA_TRAIL_DN 186107All SZGR genes in this pathway
BEGUM_TARGETS_OF_PAX3_FOXO1_FUSION_DN 4534All SZGR genes in this pathway
OLSSON_E2F3_TARGETS_DN 4933All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_2 12792All SZGR genes in this pathway
HERNANDEZ_ABERRANT_MITOSIS_BY_DOCETACEL_4NM_UP 2315All SZGR genes in this pathway
HERNANDEZ_MITOTIC_ARREST_BY_DOCETAXEL_1_UP 3618All SZGR genes in this pathway
SEITZ_NEOPLASTIC_TRANSFORMATION_BY_8P_DELETION_UP 7347All SZGR genes in this pathway
MOHANKUMAR_TLX1_TARGETS_UP 414287All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_UP 358245All SZGR genes in this pathway
LI_WILMS_TUMOR_VS_FETAL_KIDNEY_2_DN 5142All SZGR genes in this pathway
LIEN_BREAST_CARCINOMA_METAPLASTIC 3525All SZGR genes in this pathway
OHM_METHYLATED_IN_ADULT_CANCERS 2723All SZGR genes in this pathway
OHM_EMBRYONIC_CARCINOMA_DN 86All SZGR genes in this pathway
WU_CELL_MIGRATION 184114All SZGR genes in this pathway
COLIN_PILOCYTIC_ASTROCYTOMA_VS_GLIOBLASTOMA_DN 2821All SZGR genes in this pathway
GOTZMANN_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_UP 6955All SZGR genes in this pathway
SUNG_METASTASIS_STROMA_UP 11070All SZGR genes in this pathway
ONDER_CDH1_TARGETS_2_DN 464276All SZGR genes in this pathway
ROZANOV_MMP14_TARGETS_SUBSET 3320All SZGR genes in this pathway
ROZANOV_MMP14_TARGETS_UP 266171All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_UP 398262All SZGR genes in this pathway
JECHLINGER_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_DN 6647All SZGR genes in this pathway
ROSS_AML_OF_FAB_M7_TYPE 6844All SZGR genes in this pathway
SWEET_KRAS_TARGETS_UP 8451All SZGR genes in this pathway
GRANDVAUX_IRF3_TARGETS_DN 1914All SZGR genes in this pathway
HADDAD_T_LYMPHOCYTE_AND_NK_PROGENITOR_UP 7856All SZGR genes in this pathway
GILDEA_METASTASIS 3014All SZGR genes in this pathway
LEI_MYB_TARGETS 318215All SZGR genes in this pathway
PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_UP 13187All SZGR genes in this pathway
YAGI_AML_FAB_MARKERS 191131All SZGR genes in this pathway
SUZUKI_RESPONSE_TO_TSA_AND_DECITABINE_1A 2316All SZGR genes in this pathway
NATSUME_RESPONSE_TO_INTERFERON_BETA_UP 7149All SZGR genes in this pathway
JIANG_AGING_CEREBRAL_CORTEX_UP 3627All SZGR genes in this pathway
JOSEPH_RESPONSE_TO_SODIUM_BUTYRATE_DN 6445All SZGR genes in this pathway
KAAB_HEART_ATRIUM_VS_VENTRICLE_UP 249170All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN 830547All SZGR genes in this pathway
SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_2 5034All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_24HR_DN 148102All SZGR genes in this pathway
CHIBA_RESPONSE_TO_TSA_UP 5233All SZGR genes in this pathway
YAMAZAKI_TCEB3_TARGETS_UP 175116All SZGR genes in this pathway
SIMBULAN_PARP1_TARGETS_UP 3123All SZGR genes in this pathway
CHEN_LVAD_SUPPORT_OF_FAILING_HEART_UP 10369All SZGR genes in this pathway
VERRECCHIA_RESPONSE_TO_TGFB1_C2 2518All SZGR genes in this pathway
BURTON_ADIPOGENESIS_8 8657All SZGR genes in this pathway
VERRECCHIA_EARLY_RESPONSE_TO_TGFB1 5843All SZGR genes in this pathway
ZHU_CMV_24_HR_DN 9164All SZGR genes in this pathway
ZHU_CMV_ALL_DN 12893All SZGR genes in this pathway
LIANG_SILENCED_BY_METHYLATION_UP 3218All SZGR genes in this pathway
HEDENFALK_BREAST_CANCER_BRCA1_VS_BRCA2 163113All SZGR genes in this pathway
BURTON_ADIPOGENESIS_PEAK_AT_0HR 6348All SZGR genes in this pathway
XU_GH1_AUTOCRINE_TARGETS_DN 14294All SZGR genes in this pathway
SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1 419273All SZGR genes in this pathway
DOUGLAS_BMI1_TARGETS_UP 566371All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_5 482296All SZGR genes in this pathway
HELLER_HDAC_TARGETS_UP 317208All SZGR genes in this pathway
HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_UP 461298All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP 673430All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_DN 593372All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_DN 591366All SZGR genes in this pathway
FUJII_YBX1_TARGETS_DN 202132All SZGR genes in this pathway
HOQUE_METHYLATED_IN_CANCER 5645All SZGR genes in this pathway
LE_SKI_TARGETS_DN 86All SZGR genes in this pathway
WILSON_PROTEASES_AT_TUMOR_BONE_INTERFACE_UP 2114All SZGR genes in this pathway
ZHENG_GLIOBLASTOMA_PLASTICITY_DN 5839All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_UP 165118All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_DN 13892All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_DN 366257All SZGR genes in this pathway
AGUIRRE_PANCREATIC_CANCER_COPY_NUMBER_DN 238145All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_DN 435289All SZGR genes in this pathway
MILI_PSEUDOPODIA_CHEMOTAXIS_DN 457302All SZGR genes in this pathway
ROME_INSULIN_TARGETS_IN_MUSCLE_UP 442263All SZGR genes in this pathway
YAGI_AML_WITH_11Q23_REARRANGED 351238All SZGR genes in this pathway
TSAI_DNAJB4_TARGETS_UP 138All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
NAKAMURA_ADIPOGENESIS_EARLY_DN 3827All SZGR genes in this pathway
NAKAMURA_ADIPOGENESIS_LATE_DN 3825All SZGR genes in this pathway
BAUS_TFF2_TARGETS_DN 117All SZGR genes in this pathway
WANG_RESPONSE_TO_GSK3_INHIBITOR_SB216763_DN 374217All SZGR genes in this pathway
GABRIELY_MIR21_TARGETS 289187All SZGR genes in this pathway
PILON_KLF1_TARGETS_UP 504321All SZGR genes in this pathway
STEGER_ADIPOGENESIS_DN 2515All SZGR genes in this pathway
WIEDERSCHAIN_TARGETS_OF_BMI1_AND_PCGF2 5739All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
PLASARI_TGFB1_TARGETS_10HR_UP 199143All SZGR genes in this pathway
DELACROIX_RARG_BOUND_MEF 367231All SZGR genes in this pathway
DELACROIX_RAR_TARGETS_DN 2416All SZGR genes in this pathway
FORTSCHEGGER_PHF8_TARGETS_DN 784464All SZGR genes in this pathway
PEDRIOLI_MIR31_TARGETS_DN 418245All SZGR genes in this pathway
ANASTASSIOU_CANCER_MESENCHYMAL_TRANSITION_SIGNATURE 6440All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_UP 489314All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY 1839928All SZGR genes in this pathway
ZWANG_EGF_INTERVAL_DN 214124All SZGR genes in this pathway
NABA_ECM_REGULATORS 238125All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1/206175617621Ahsa-miR-1UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZUGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613AGGAAUGUUCCUUCUUUGCC
hsa-miR-1UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZUGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613AGGAAUGUUCCUUCUUUGCC
miR-101242024261Ahsa-miR-101UACAGUACUGUGAUAACUGAAG
miR-144242024261Ahsa-miR-144UACAGUAUAGAUGAUGUACUAG
miR-17-5p/20/93.mr/106/519.d176117671Ahsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
miR-181349935051Ahsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
hsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-21238523921A,m8hsa-miR-21brainUAGCUUAUCAGACUGAUGUUGA
hsa-miR-590GAGCUUAUUCAUAAAAGUGCAG
miR-221/22224432449m8hsa-miR-221brainAGCUACAUUGUCUGCUGGGUUUC
hsa-miR-222brainAGCUACAUCUGGCUACUGGGUCUC
miR-299-3p25572563m8hsa-miR-299-3pUAUGUGGGAUGGUAAACCGCUU
miR-30-5p352935361A,m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-3843053111Ahsa-miR-384AUUCCUAGAAAUUGUUCAUA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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