Gene Page: TWIST1

Summary
GeneID  7291
Symbol  TWIST1
Synonyms  ACS3|BPES2|BPES3|SCS|TWIST|bHLHa38
Description  twist homolog 1 (Drosophila)
See related  HGNC:12428|MIM:601622|Ensembl:ENSG00000122691|HPRD:03374|
Locus tag  -
Gene type  protein-coding
Map location  7p21.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
UBE2D30.930.91
MOBKL30.930.93
TMED20.920.90
STRAP0.910.88
RAB2A0.910.89
PPP1CB0.910.87
COPS30.900.85
PTGES30.900.86
OLA10.900.87
RAN0.900.89
Top 10 negatively co-expressed genes
MT-CO2-0.71-0.68
AF347015.26-0.71-0.69
AF347015.33-0.70-0.68
AF347015.8-0.69-0.68
AF347015.2-0.69-0.66
MT-CYB-0.69-0.67
AF347015.15-0.66-0.66
FXYD1-0.65-0.68
GPT-0.65-0.69
AF347015.31-0.64-0.63
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003677DNA bindingIEA-
GO:0005515protein bindingIPI18598946 
GO:0004857enzyme inhibitor activityTAS10025406 
GO:0030528transcription regulator activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001764neuron migrationIEAneuron (GO term level: 8)-
GO:0000122negative regulation of transcription from RNA polymerase II promoterTAS10025406 
GO:0001501skeletal system developmentTAS8988166 
GO:0001843neural tube closureIEA-
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0009653anatomical structure morphogenesisTAS8988166 
GO:0006915apoptosisIEA-
GO:0007275multicellular organismal developmentIEA-
GO:0035115embryonic forelimb morphogenesisIEA-
GO:0035137hindlimb morphogenesisIEA-
GO:0045843negative regulation of striated muscle developmentIEA-
GO:0045596negative regulation of cell differentiationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
EP300KAT3B | p300E1A binding protein p300-HPRD,BioGRID10025406 
GLI3ACLS | GCPS | PAP-A | PAPA | PAPA1 | PAPB | PHS | PPDIVGLI-Kruppel family member GLI3-HPRD12142027 
HOXA5HOX1 | HOX1.3 | HOX1C | MGC9376homeobox A5HOXA5 interacts with Twist.BIND15545268 
KAT2BCAF | P | P/CAF | PCAFK(lysine) acetyltransferase 2B-HPRD,BioGRID10025406 
MYOD1MYF3 | MYOD | PUM | bHLHc1myogenic differentiation 1-HPRD9343420 
RELAMGC131774 | NFKB3 | p65v-rel reticuloendotheliosis viral oncogene homolog A (avian)-HPRD,BioGRID12553906 
TCF3E2A | ITF1 | MGC129647 | MGC129648 | bHLHb21transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)-HPRD,BioGRID10749989 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
BIOCARTA_ARF_PATHWAY 1713All SZGR genes in this pathway
PID_HIF2PATHWAY 3429All SZGR genes in this pathway
PID_HES_HEY_PATHWAY 4839All SZGR genes in this pathway
LU_TUMOR_VASCULATURE_UP 2917All SZGR genes in this pathway
SCHUETZ_BREAST_CANCER_DUCTAL_INVASIVE_UP 351230All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_ADVANCED_VS_EARLY_UP 175120All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_DN 781465All SZGR genes in this pathway
CHIARADONNA_NEOPLASTIC_TRANSFORMATION_CDC25_UP 12073All SZGR genes in this pathway
CONCANNON_APOPTOSIS_BY_EPOXOMICIN_DN 172112All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_DN 394258All SZGR genes in this pathway
LI_CISPLATIN_RESISTANCE_UP 2820All SZGR genes in this pathway
WANG_HCP_PROSTATE_CANCER 11169All SZGR genes in this pathway
HOWLIN_PUBERTAL_MAMMARY_GLAND 6940All SZGR genes in this pathway
HATADA_METHYLATED_IN_LUNG_CANCER_UP 390236All SZGR genes in this pathway
LIAO_METASTASIS 539324All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
ONDER_CDH1_TARGETS_2_UP 256159All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
REN_ALVEOLAR_RHABDOMYOSARCOMA_DN 408274All SZGR genes in this pathway
WANG_SMARCE1_TARGETS_DN 371218All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_8HR_DN 4731All SZGR genes in this pathway
SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1 419273All SZGR genes in this pathway
GENTILE_UV_RESPONSE_CLUSTER_D8 4029All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_DN 911527All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_UP 783442All SZGR genes in this pathway
LOPES_METHYLATED_IN_COLON_CANCER_UP 2720All SZGR genes in this pathway
HOQUE_METHYLATED_IN_CANCER 5645All SZGR genes in this pathway
NADELLA_PRKAR1A_TARGETS_UP 95All SZGR genes in this pathway
WHITEFORD_PEDIATRIC_CANCER_MARKERS 11663All SZGR genes in this pathway
BOQUEST_STEM_CELL_UP 260174All SZGR genes in this pathway
LU_TUMOR_ENDOTHELIAL_MARKERS_UP 2214All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME2_AND_H3K27ME3 5935All SZGR genes in this pathway
SETLUR_PROSTATE_CANCER_TMPRSS2_ERG_FUSION_UP 6748All SZGR genes in this pathway
FONTAINE_THYROID_TUMOR_UNCERTAIN_MALIGNANCY_DN 2614All SZGR genes in this pathway
FONTAINE_PAPILLARY_THYROID_CARCINOMA_DN 8053All SZGR genes in this pathway
CHICAS_RB1_TARGETS_CONFLUENT 567365All SZGR genes in this pathway
CARD_MIR302A_TARGETS 7762All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-15176831A,m8hsa-miR-151brainACUAGACUGAAGCUCCUUGAGG
miR-25/32/92/363/3676766821Ahsa-miR-25brainCAUUGCACUUGUCUCGGUCUGA
hsa-miR-32UAUUGCACAUUACUAAGUUGC
hsa-miR-92UAUUGCACUUGUCCCGGCCUG
hsa-miR-367AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZUAUUGCACUCGUCCCGGCCUC
miR-32655611Ahsa-miR-326CCUCUGGGCCCUUCCUCCAG
miR-336026081Ahsa-miR-33GUGCAUUGUAGUUGCAUUG
hsa-miR-33bGUGCAUUGCUGUUGCAUUGCA
miR-361265271m8hsa-miR-361brainUUAUCAGAAUCUCCAGGGGUAC
miR-3816636691Ahsa-miR-381UAUACAAGGGCAAGCUCUCUGU
miR-409-3p568574m8hsa-miR-409-3pCGAAUGUUGCUCGGUGAACCCCU
miR-543320326m8hsa-miR-543AAACAUUCGCGGUGCACUUCU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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