Gene Page: VARS

Summary
GeneID  7407
Symbol  VARS
Synonyms  G7A|VARS1|VARS2
Description  valyl-tRNA synthetase
See related  HGNC:12651|MIM:192150|Ensembl:ENSG00000204394|HPRD:10362|
Locus tag  DADB-149K5.2
Gene type  protein-coding
Map location  6p21.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.033 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0113 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
SLCO2B10.830.84
MMRN20.830.87
A2M0.780.79
ITIH50.770.83
TNFRSF1B0.770.78
CDH50.740.80
BGN0.740.76
ENG0.740.80
CLEC14A0.740.75
LRRC320.730.80
Top 10 negatively co-expressed genes
ZNF32-0.52-0.58
C8orf59-0.51-0.59
SNHG12-0.51-0.56
OXSM-0.50-0.57
NDUFAF2-0.50-0.56
C12orf45-0.49-0.58
ST20-0.49-0.55
MTIF3-0.47-0.52
ATP5E-0.47-0.60
MRPL21-0.46-0.52
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005515protein bindingIPI17353931 
GO:0005524ATP bindingIEA-
GO:0004832valine-tRNA ligase activityIDA8428657 
GO:0004832valine-tRNA ligase activityIEA-
GO:0016874ligase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006414translational elongationNAS-
GO:0006438valyl-tRNA aminoacylationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005622intracellularNAS-
GO:0005737cytoplasmIEA-
GO:0005739mitochondrionIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
EEF1A1CCS-3 | CCS3 | EEF-1 | EEF1A | EF-Tu | EF1A | FLJ25721 | GRAF-1EF | HNGC:16303 | LENG7 | MGC102687 | MGC131894 | MGC16224 | PTI1 | eEF1A-1eukaryotic translation elongation factor 1 alpha 1-HPRD,BioGRID2556394 |3169261 
EEF1A2EEF1AL | EF-1-alpha-2 | EF1A | FLJ41696 | HS1 | STN | STNLeukaryotic translation elongation factor 1 alpha 2Affinity Capture-MSBioGRID17353931 
EEF1B2EEF1B | EEF1B1 | EF1Beukaryotic translation elongation factor 1 beta 2-HPRD,BioGRID2556394 |3169261 
EEF1DEF-1D | EF1D | FLJ20897 | FP1047eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)-HPRD2556394 |3169261 
-HPRD,BioGRID2556394 |3169261|8294461 
EEF1GEF1G | GIG35eukaryotic translation elongation factor 1 gammaCo-purificationBioGRID3169261 
EPB414.1R | EL1 | HEerythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)Affinity Capture-MSBioGRID17353931 
GFM1COXPD1 | EFG | EFG1 | EFGM | EGF1 | FLJ12662 | FLJ13632 | FLJ20773 | GFM | hEFG1G elongation factor, mitochondrial 1-HPRD2556394 |3169261 
HLA-BAS | HLA-B-7301 | HLA-B73 | HLAB | HLAC | SPDA1major histocompatibility complex, class I, BAffinity Capture-MSBioGRID17353931 
IKBKGAMCBX1 | FIP-3 | FIP3 | Fip3p | IKK-gamma | IP | IP1 | IP2 | IPD2 | NEMOinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma-HPRD14743216 
TFE3RCCP2 | TFEA | bHLHe33transcription factor binding to IGHM enhancer 3Affinity Capture-MSBioGRID17353931 
TRAF6MGC:3310 | RNF85TNF receptor-associated factor 6Affinity Capture-MSBioGRID17353931 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS 118All SZGR genes in this pathway
KEGG_AMINOACYL_TRNA_BIOSYNTHESIS 4133All SZGR genes in this pathway
REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION 2419All SZGR genes in this pathway
REACTOME_TRNA_AMINOACYLATION 4234All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_UP 368234All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_EARLY_UP 430232All SZGR genes in this pathway
GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN 335193All SZGR genes in this pathway
PROVENZANI_METASTASIS_UP 194112All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_UP 536340All SZGR genes in this pathway
EBAUER_TARGETS_OF_PAX3_FOXO1_FUSION_UP 207128All SZGR genes in this pathway
PATIL_LIVER_CANCER 747453All SZGR genes in this pathway
CEBALLOS_TARGETS_OF_TP53_AND_MYC_DN 3831All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
NING_CHRONIC_OBSTRUCTIVE_PULMONARY_DISEASE_DN 12179All SZGR genes in this pathway
MANALO_HYPOXIA_DN 289166All SZGR genes in this pathway
SCHUHMACHER_MYC_TARGETS_UP 8057All SZGR genes in this pathway
KLEIN_PRIMARY_EFFUSION_LYMPHOMA_UP 5129All SZGR genes in this pathway
PENG_GLUTAMINE_DEPRIVATION_DN 337230All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_NO_BLOOD_UP 222139All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_UP 487303All SZGR genes in this pathway
LEE_CALORIE_RESTRICTION_NEOCORTEX_DN 8858All SZGR genes in this pathway
ABE_VEGFA_TARGETS_30MIN 2921All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_UP 953554All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_DN 911527All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_DN 1011592All SZGR genes in this pathway
SANSOM_APC_MYC_TARGETS 217138All SZGR genes in this pathway
SANSOM_APC_TARGETS_REQUIRE_MYC 210123All SZGR genes in this pathway
HELLER_HDAC_TARGETS_DN 292189All SZGR genes in this pathway
BOCHKIS_FOXA2_TARGETS 425261All SZGR genes in this pathway
ZHANG_TLX_TARGETS_60HR_DN 277166All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_DN 668419All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_UP 605377All SZGR genes in this pathway
DANG_REGULATED_BY_MYC_UP 7253All SZGR genes in this pathway
DANG_REGULATED_BY_MYC_DN 253192All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_14 14386All SZGR genes in this pathway
KYNG_RESPONSE_TO_H2O2_VIA_ERCC6_UP 4030All SZGR genes in this pathway
KASLER_HDAC7_TARGETS_1_UP 194133All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP 570339All SZGR genes in this pathway
DELACROIX_RAR_BOUND_ES 462273All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-13752581Ahsa-miR-137UAUUGCUUAAGAAUACGCGUAG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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