Gene Page: ZYX

Summary
GeneID  7791
Symbol  ZYX
Synonyms  ESP-2|HED-2
Description  zyxin
See related  HGNC:13200|MIM:602002|Ensembl:ENSG00000159840|HPRD:03592|
Locus tag  -
Gene type  protein-coding
Map location  7q32
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.01 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
WDR270.910.88
ANKRD100.910.88
FBN30.900.92
POLE0.900.93
TRPV10.900.85
MYO190.890.79
CCNL20.890.84
RAD520.890.80
RBM50.890.89
GAL3ST40.890.85
Top 10 negatively co-expressed genes
HLA-F-0.57-0.69
FBXO2-0.57-0.65
C5orf53-0.56-0.76
ACYP2-0.56-0.66
ALDOC-0.56-0.64
S100B-0.55-0.76
CA4-0.55-0.72
ACOT13-0.55-0.70
AIFM3-0.55-0.65
HLA-C-0.54-0.68
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI10831611 
GO:0008270zinc ion bindingIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007155cell adhesionTAS8940160 
GO:0007267cell-cell signalingTAS8940160 
GO:0007165signal transductionTAS8940160 
GO:0044419interspecies interaction between organismsIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0001725stress fiberIDA18297730 
GO:0005856cytoskeletonIEA-
GO:0005634nucleusIEA-
GO:0005737cytoplasmIDA18029348 
GO:0005737cytoplasmIEA-
GO:0005925focal adhesionIDA18029348 |18297730 
GO:0005913cell-cell adherens junctionIDA8940160 
GO:0005886plasma membraneTAS8940160 
GO:0005887integral to plasma membraneTAS8940160 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACTN1FLJ40884actinin, alpha 1-HPRD,BioGRID10224105 |11423549 
BCAR1CAS | CAS1 | CASS1 | CRKAS | P130Casbreast cancer anti-estrogen resistance 1Affinity Capture-WesternBioGRID11782456 
BSPRYFLJ20150B-box and SPRY domain containing-HPRD10978534 
ENAHENA | MENA | NDPP1enabled homolog (Drosophila)-HPRD,BioGRID10801818 
LASP1Lasp-1 | MLN50LIM and SH3 protein 1Reconstituted Complex
Two-hybrid		BioGRID15004028 
LATS1WARTS | wtsLATS, large tumor suppressor, homolog 1 (Drosophila)Affinity Capture-Western
Reconstituted Complex		BioGRID10831611 
NEBLFLJ53769 | LNEBL | MGC119746 | MGC119747 | bA56H7.1nebulette-HPRD,BioGRID15004028 
NEDD9CAS-L | CAS2 | CASL | CASS2 | HEF1 | dJ49G10.2 | dJ761I2.1neural precursor cell expressed, developmentally down-regulated 9-HPRD,BioGRID11782456 
RPH3ALNOC2rabphilin 3A-like (without C2 domains)-HPRD9367993 
TESDKFZp586B2022 | MGC1146 | TESS | TESS-2testis derived transcript (3 LIM domains)Reconstituted ComplexBioGRID12695497 
VASP-vasodilator-stimulated phosphoprotein-HPRD7644520 |10801818 
|10851246 |10882740 
Affinity Capture-Western
in vitro
in vivo
Two-hybrid		BioGRID10801818 |10882740 
VAV1VAVvav 1 guanine nucleotide exchange factor-HPRD8622875 
VAV3FLJ40431vav 3 guanine nucleotide exchange factor-HPRD8622875 
ZHX1-zinc fingers and homeoboxes 1Two-hybridBioGRID12659632 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_FOCAL_ADHESION 201138All SZGR genes in this pathway
BIOCARTA_INTEGRIN_PATHWAY 3829All SZGR genes in this pathway
ST_INTEGRIN_SIGNALING_PATHWAY 8262All SZGR genes in this pathway
PID_ILK_PATHWAY 4532All SZGR genes in this pathway
PID_ECADHERIN_KERATINOCYTE_PATHWAY 2119All SZGR genes in this pathway
PID_ECADHERIN_STABILIZATION_PATHWAY 4234All SZGR genes in this pathway
PID_THROMBIN_PAR1_PATHWAY 4332All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_UP 579346All SZGR genes in this pathway
HUTTMANN_B_CLL_POOR_SURVIVAL_UP 276187All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_DN 329219All SZGR genes in this pathway
NAGASHIMA_NRG1_SIGNALING_UP 176123All SZGR genes in this pathway
KIM_WT1_TARGETS_UP 214155All SZGR genes in this pathway
KIM_WT1_TARGETS_8HR_UP 164122All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_UP 293179All SZGR genes in this pathway
CONCANNON_APOPTOSIS_BY_EPOXOMICIN_UP 239157All SZGR genes in this pathway
HUMMERICH_SKIN_CANCER_PROGRESSION_DN 10064All SZGR genes in this pathway
LUI_THYROID_CANCER_CLUSTER_4 169All SZGR genes in this pathway
WANG_METHYLATED_IN_BREAST_CANCER 3525All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN 848527All SZGR genes in this pathway
LIU_LIVER_CANCER 3818All SZGR genes in this pathway
AMIT_EGF_RESPONSE_480_HELA 164118All SZGR genes in this pathway
MORI_SMALL_PRE_BII_LYMPHOCYTE_DN 7652All SZGR genes in this pathway
ZUCCHI_METASTASIS_DN 4429All SZGR genes in this pathway
BASSO_B_LYMPHOCYTE_NETWORK 14396All SZGR genes in this pathway
YAGI_AML_RELAPSE_PROGNOSIS 3524All SZGR genes in this pathway
GOLUB_ALL_VS_AML_DN 2414All SZGR genes in this pathway
BROWN_MYELOID_CELL_DEVELOPMENT_UP 165100All SZGR genes in this pathway
ASTIER_INTEGRIN_SIGNALING 5944All SZGR genes in this pathway
YAGI_AML_SURVIVAL 12987All SZGR genes in this pathway
WEIGEL_OXIDATIVE_STRESS_BY_TBH_AND_H2O2 3624All SZGR genes in this pathway
REN_ALVEOLAR_RHABDOMYOSARCOMA_DN 408274All SZGR genes in this pathway
YAMAZAKI_TCEB3_TARGETS_UP 175116All SZGR genes in this pathway
MACLACHLAN_BRCA1_TARGETS_DN 1612All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_DN 504323All SZGR genes in this pathway
VERRECCHIA_EARLY_RESPONSE_TO_TGFB1 5843All SZGR genes in this pathway
LEE_CALORIE_RESTRICTION_NEOCORTEX_DN 8858All SZGR genes in this pathway
VERRECCHIA_RESPONSE_TO_TGFB1_C3 1410All SZGR genes in this pathway
DOUGLAS_BMI1_TARGETS_UP 566371All SZGR genes in this pathway
FOSTER_TOLERANT_MACROPHAGE_DN 409268All SZGR genes in this pathway
GRADE_COLON_CANCER_UP 871505All SZGR genes in this pathway
LABBE_TARGETS_OF_TGFB1_AND_WNT3A_UP 11170All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_DN 546362All SZGR genes in this pathway
HUANG_DASATINIB_RESISTANCE_UP 8153All SZGR genes in this pathway
QI_PLASMACYTOMA_UP 259185All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_UP 245159All SZGR genes in this pathway
JIANG_TIP30_TARGETS_DN 2414All SZGR genes in this pathway
PARK_APL_PATHOGENESIS_DN 5035All SZGR genes in this pathway
HOFFMANN_PRE_BI_TO_LARGE_PRE_BII_LYMPHOCYTE_DN 7561All SZGR genes in this pathway
KARLSSON_TGFB1_TARGETS_UP 12778All SZGR genes in this pathway
CHICAS_RB1_TARGETS_LOW_SERUM 10051All SZGR genes in this pathway
CHICAS_RB1_TARGETS_CONFLUENT 567365All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN 505328All SZGR genes in this pathway
WIERENGA_STAT5A_TARGETS_DN 213127All SZGR genes in this pathway
WIERENGA_PML_INTERACTOME 4223All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_2_UP 14094All SZGR genes in this pathway
PASINI_SUZ12_TARGETS_DN 315215All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_UP 682433All SZGR genes in this pathway
KRIEG_HYPOXIA_NOT_VIA_KDM3A 770480All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-103/1072802861Ahsa-miR-103brainAGCAGCAUUGUACAGGGCUAUGA
hsa-miR-107brainAGCAGCAUUGUACAGGGCUAUCA
miR-15/16/195/424/497268274m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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